Risk Factors and Molecular Genomics of U.S. Patients With Chronic Liver Disease and Hepatocellular Cancer

Trial ID or NCT#

NCT01034865

Status

not recruiting iconNOT RECRUITING

Purpose

To identify risk factors for the development and diagnosis of hepatocellular CA in patients with chronic hepatitis C and to use the data to ultimately develop an effective screening program.

Official Title

Risk Factors and Molecular Genomics for Hepatocellular Carcinoma in U.S. Patients With Chronic Liver Disease: A Case Control Study

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - For both experimental subjects and controls: 1. Patients between older than 18 years of age of all ethnic backgrounds and genders. 2. Patients with chronic liver disease - For Experimental Subjects Only: 1. Patients with HCC with a hepatic mass larger or equal to 5cm 2. Patients with HCC with a hepatic mass lesion confirmed by fine needle aspirate (FNA) or by pathology in the cases of surgical resection 3. Patients with HCC with a hepatic mass lesion with characteristic CT or MRI or angiographic appearance. - For Controls Only: Patients with chronic liver disease without evidence of HCC confirmed by either : 1. A normal AFP level 2. a negative imaging study (ultrasound, CT, or MR imaging). 3. Negative liver cancer on explants. *
Exclusion Criteria:
  1. 1. Patients who declined to participate in the study 2. Patients with a history of HIV infection 3. Patients with concurrent advanced malignancy of non-hepatic origin. 4. Patients with significant use of androgenic steroid. 5. Patients with exposure to vinyl chloride.
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Investigator(s)

Mindie H. Nguyen, MD, MAS, AGAF, FAASLD
Mindie H. Nguyen, MD, MAS, AGAF, FAASLD
Hepatologist, Transplant hepatologist
Professor of Medicine (Gastroenterology and Hepatology) and, by courtesy, of Epidemiology and Population Health
Ramsey Cheung
Carlos O. Esquivel, M.D., Ph.D.,FACS
Carlos O. Esquivel, M.D., Ph.D.,FACS
Transplant surgeon, Liver transplant surgeon, Kidney transplant surgeon, Hepatobiliary surgeon, Pancreatic surgeon, Pancreas transplant surgeon
Arnold and Barbara Silverman Professor in Pediatric Transplantation and Professor of Surgery (Abdominal Transplantation) and of Pediatrics (Gastroenterology, Hepatology and Nutrition)

Contact us to find out if this trial is right for you.

Contact

Andrea Linder
6507254047

View on ClinicalTrials.gov