Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids

Trial ID or NCT#

NCT01222091

Status

not recruiting iconNOT RECRUITING

Purpose

This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil). Beta blockers inhibit the sympathetic (fight or flight) response and are often used to treat angina and high blood pressure. In a previous study in human volunteers, the investigators demonstrated an increased sensitivity to pain after a 60-minute infusion of the opioid remifentanil. The goal of this study is to identify a possible inhibitor of this phenomenon.

Official Title

Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans

Eligibility Criteria

Ages Eligible for Study: 18 Years to 45 Years
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
  1. 1. Healthy men, 2. Age between 18 and 45 years 3. Normal weight (according to the table provided by Metropolitan Life Insurance).
Exclusion Criteria:
  1. 1. Hypersensitivity to opioids or naloxone, 2. History of addictive disease, 3. Significant cardiac, respiratory, gastrointestinal, neurological, dermatological, and psychiatric diseases, 4. Concurrent medication with an analgesic drug, 5. Student and employees affiliated with our laboratory
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Investigator(s)

Lawrence Chu, MD, MS
Lawrence Chu, MD, MS
Anesthesiologist
Professor of Anesthesiology, Perioperative and Pain Medicine

Contact us to find out if this trial is right for you.

Contact

Larry Chu, MD, MS
650-723-5439

View on ClinicalTrials.gov