Professional Summary
Education & Certifications
- Board Certification: United Council for Neurologic Subspecialties, Neurocritical Care (2008)
- Board Certification: American Board of Psychiatry and Neurology, Neurology (2001)
- Board Certification, United Council for Neurologic Subspecialties, Neurocritical care re-certification (2018)
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- Board Certification, United Council for Neurologic Subspecialties, Neurocritical Care (2008)
- Medical Education: University of Michigan School of Medicine (1996) MI
- MD PhD, University of Michigan, Human Genetics (1996)
- Internship, UCSF, Medicine (1997)
- Residency, UCSF, Neurology (2000)
- Fellowship, UCSF, Neurological Critical Care (2002)
Publications
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Molecular and functional dissection of TGF-beta 1-induced cerebrovascular abnormalities in transgenic mice
Buckwalter, M., Pepper, J. P., Gaertner, R. F., Von Euw, D., Lacombe, P., & Wyss-Coray, T. (2002). Molecular and functional dissection of TGF-beta 1-induced cerebrovascular abnormalities in transgenic mice. Presented at the 3rd World Congress on Vascular Factors in Alzheimers Disease, KYOTO,JAPAN,JAPAN,JAPAN: NEW YORK ACAD SCIENCES. -
LOCALIZATION OF THE HUMAN CHROMOSOME-5Q GENES GABRA-1, GABRG-2, IL-4, IL-5, AND IRF-1 ON MOUSE CHROMOSOME-11
Buckwalter, M. S., Lossie, A. C., SCARLETT, L. M., & Camper, S. A. (1992). LOCALIZATION OF THE HUMAN CHROMOSOME-5Q GENES GABRA-1, GABRG-2, IL-4, IL-5, AND IRF-1 ON MOUSE CHROMOSOME-11. MAMMALIAN GENOME, 3(10), 604–607. -
MOUSE CHROMOSOME-11
BUCHBERG, A. M., Buckwalter, M. S., & Camper, S. A. (1992). MOUSE CHROMOSOME-11. Presented at the 6TH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING, BUFFALO,NY: SPRINGER VERLAG. -
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Modelling neuroinflammatory phenotypes in vivo.
Buckwalter, M. S., & Wyss-Coray, T. (2004). Modelling neuroinflammatory phenotypes in vivo. Journal of Neuroinflammation, 1(1), 10. -
Chronically increased transforming growth factor-beta 1 strongly inhibits hippocampal neurogenesis in aged mice
Buckwalter, M. S., Yamane, M., Coleman, B. S., Ormerod, B. K., Chin, J. T., Palmer, T., & Wyss-Coray, T. (2006). Chronically increased transforming growth factor-beta 1 strongly inhibits hippocampal neurogenesis in aged mice. AMERICAN JOURNAL OF PATHOLOGY, 169(1), 154–64. -
Increased T cell recruitment to the CNS after amyloid beta(1-42) immunization in Alzheimer's mice overproducing transforming growth factor-beta 1
Buckwalter, M. S., Coleman, B. S., Buttini, M., Barbour, R., Schenk, D., Games, D., … Wyss-Coray, T. (2006). Increased T cell recruitment to the CNS after amyloid beta(1-42) immunization in Alzheimer's mice overproducing transforming growth factor-beta 1. JOURNAL OF NEUROSCIENCE, 26(44), 11437–41. -
Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis
Luo, J., Ho, P. P., Buckwalter, M. S., Hsu, T., Lee, L. Y., Zhang, H., … Wyss-Coray, T. (2007). Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. JOURNAL OF CLINICAL INVESTIGATION, 117(11), 3306–15. -
Mouse chromosome 11.
BUCHBERG, A. M., Moskow, J. J., Buckwalter, M. S., & Camper, S. A. (1991). Mouse chromosome 11. Mammalian Genome , 1, S158–91. -
LOCALIZATION OF THE PANHYPOPITUITARY DWARF MUTATION (DF) ON MOUSE CHROMOSOME-11 IN AN INTERSUBSPECIFIC BACKCROSS
Buckwalter, M. S., Katz, R. W., & Camper, S. A. (1991). LOCALIZATION OF THE PANHYPOPITUITARY DWARF MUTATION (DF) ON MOUSE CHROMOSOME-11 IN AN INTERSUBSPECIFIC BACKCROSS. GENOMICS, 10(3), 515–526. -
Outcome prediction in mechanically ventilated neurologic patients by junior neurointensivists
Caulfield, A. F., GABLER, L., Lansberg, M. G., Eyngorn, I., Mlynash, M., Buckwalter, M. S., … Wijman, C. A. C. (2010). Outcome prediction in mechanically ventilated neurologic patients by junior neurointensivists. NEUROLOGY, 74(14), 1096–1101. -
Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke (ICTuS-L) Final Results
Hemmen, T. M., Raman, R., Guluma, K. Z., Meyer, B. C., Gomes, J. A., Cruz-Flores, S., … Lyden, P. D. (2010). Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke (ICTuS-L) Final Results. STROKE, 41(10), 2265–70. -
TGF beta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke
Doyle, K. P., Cekanaviciute, E., Mamer, L. E., & Buckwalter, M. S. (2010). TGF beta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. JOURNAL OF NEUROINFLAMMATION, 7. -
A comparison of cooling techniques to treat cardiac arrest patients with hypothermia.
Finley Caulfield, A., Rachabattula, S., Eyngorn, I., Hamilton, S. A., Kalimuthu, R., Hsia, A. W., … Wijman, C. A. C. (2011). A comparison of cooling techniques to treat cardiac arrest patients with hypothermia. Stroke Research and Treatment, 2011, 690506-? -
Distal hypoxic stroke: A new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit
Doyle, K. P., Fathali, N., Siddiqui, M. R., & Buckwalter, M. S. (2012). Distal hypoxic stroke: A new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit. JOURNAL OF NEUROSCIENCE METHODS, 207(1), 31–40. -
Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke
Han, J., Pollak, J., Yang, T., Siddiqui, M. R., Doyle, K. P., Taravosh-Lahn, K., … Buckwalter, M. S. (2012). Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke. STROKE, 43(7), 1918–24. -
The double-edged sword of inflammation after stroke: What sharpens each edge?
Doyle, K. P., & Buckwalter, M. S. (2012). The double-edged sword of inflammation after stroke: What sharpens each edge? ANNALS OF NEUROLOGY, 71(6), 729–31. -
Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model.
Pollak, J., Doyle, K. P., Mamer, L., Shamloo, M., & Buckwalter, M. S. (2012). Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model. Brain and Behavior, 2(5), 698–706. -
A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.
Knowles, J. K., Simmons, D. A., Nguyen, T.-V. V., Vander Griend, L., Xie, Y., Zhang, H., … Longo, F. M. (2013). A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiology of Aging, 34(8), 2052–63. -
BACTERIOPHAGE-MU SITES REQUIRED FOR TRANSPOSITION IMMUNITY
Darzins, A., KENT, N. E., Buckwalter, M. S., & CASADABAN, M. J. (1988). BACTERIOPHAGE-MU SITES REQUIRED FOR TRANSPOSITION IMMUNITY. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 85(18), 6826–6830. -
A FRAMESHIFT MUTATION IN THE MOUSE ALPHA(1) GLYCINE RECEPTOR GENE (GLRA1) RESULTS IN PROGRESSIVE NEUROLOGICAL SYMPTOMS AND JUVENILE DEATH
Buckwalter, M. S., Cook, S. A., Davisson, M. T., White, W. F., & Camper, S. A. (1994). A FRAMESHIFT MUTATION IN THE MOUSE ALPHA(1) GLYCINE RECEPTOR GENE (GLRA1) RESULTS IN PROGRESSIVE NEUROLOGICAL SYMPTOMS AND JUVENILE DEATH. HUMAN MOLECULAR GENETICS, 3(11), 2025–2030. -
A MISSENSE MUTATION IN THE GENE ENCODING THE ALPHA(1) SUBUNIT OF THE INHIBITORY GLYCINE RECEPTOR IN THE SPASMODIC MOUSE
Ryan, S. G., Buckwalter, M. S., LYNCH, J. W., Handford, C. A., Segura, L., Shiang, R., … OCONNELL, P. (1994). A MISSENSE MUTATION IN THE GENE ENCODING THE ALPHA(1) SUBUNIT OF THE INHIBITORY GLYCINE RECEPTOR IN THE SPASMODIC MOUSE. NATURE GENETICS, 7(2), 131–135. -
LYSYL OXIDASE (LOX) MAPS BETWEEN GRL-1 AND ADRB-2 ON MOUSE CHROMOSOME-18
Lossie, A. C., Buckwalter, M. S., & Camper, S. A. (1993). LYSYL OXIDASE (LOX) MAPS BETWEEN GRL-1 AND ADRB-2 ON MOUSE CHROMOSOME-18. MAMMALIAN GENOME, 4(3), 177–178. -
GENETIC-MAPPING AND EVALUATION OF CANDIDATE GENES FOR SPASMODIC, A NEUROLOGICAL MOUSE MUTATION WITH ABNORMAL STARTLE RESPONSE
Buckwalter, M. S., Testa, C. M., Noebels, J. L., & Camper, S. A. (1993). GENETIC-MAPPING AND EVALUATION OF CANDIDATE GENES FOR SPASMODIC, A NEUROLOGICAL MOUSE MUTATION WITH ABNORMAL STARTLE RESPONSE. GENOMICS, 17(2), 279–286. -
Genetic mapping of 21 genes on mouse chromosome 11 reveals disruptions in linkage conservation with human chromosome 5
WATKINSCHOW, D. E., Buckwalter, M. S., Newhouse, M. M., Lossie, A. C., Brinkmeier, M. L., & Camper, S. A. (1997). Genetic mapping of 21 genes on mouse chromosome 11 reveals disruptions in linkage conservation with human chromosome 5. GENOMICS, 40(1), 114–122. -
Construction of a 3-Mb contig and partial transcript map of the central region of mouse chromosome 11
WATKINSCHOW, D. E., Douglas, K. R., Buckwalter, M. S., Probst, F. J., & Camper, S. A. (1997). Construction of a 3-Mb contig and partial transcript map of the central region of mouse chromosome 11. GENOMICS, 45(1), 147–157. -
Real-time Imaging of molecular signaling after stroke - Novel reporter mice for dissection of in vivo responses to TGF-beta
Buckwalter, M. S., Luo, J., Debsi, B., & Wyss-Coray, T. (2008). Real-time Imaging of molecular signaling after stroke - Novel reporter mice for dissection of in vivo responses to TGF-beta. STROKE, 39(2), 659–59. -
Diagnostic Accuracy of MRI in Spontaneous Intra-cerebral Hemorrhage (DASH): Initial Results
Wijman, C. A., Snider, R. W., Venkatasubramanian, C., Caulfield, A. F., Buckwalter, M., Eyngorn, I., … Albers, G. W. (2010). Diagnostic Accuracy of MRI in Spontaneous Intra-cerebral Hemorrhage (DASH): Initial Results. STROKE, 41(4), E210–E211. -
Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis
Kim, S. Y., Buckwalter, M., Soreq, H., Vezzani, A., & Kaufer, D. (2012). Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis. EPILEPSIA, 53, 37–44. -
Chronic Over-Expression of TGF beta 1 Alters Hippocampal Structure and Causes Learning Deficits
Martinez-Canabal, A., Wheeler, A. L., Sarkis, D., Lerch, J. P., Lu, W.-Y., Buckwalter, M. S., … Frankland, P. W. (2013). Chronic Over-Expression of TGF beta 1 Alters Hippocampal Structure and Causes Learning Deficits. HIPPOCAMPUS, 23(12), 1198–1211. -
Serum Neuron-Specific Enolase Levels from the Same Patients Differ Between Laboratories: Assessment of a Prospective Post-cardiac Arrest Cohort.
Mlynash, M., Buckwalter, M. S., Okada, A., Caulfield, A. F., Venkatasubramanian, C., Eyngorn, I., … Wijman, C. A. C. (2013). Serum Neuron-Specific Enolase Levels from the Same Patients Differ Between Laboratories: Assessment of a Prospective Post-cardiac Arrest Cohort. Neurocritical Care, 19(2), 161–66. -
Modelling neuroinflammatory phenotypes in vivo
Buckwalter, M. S., & Wyss-Coray, T. (2004). Modelling neuroinflammatory phenotypes in vivo. JOURNAL OF NEUROINFLAMMATION, 1. -
Suppression of Inflammation with Conditional Deletion of the Prostaglandin E-2 EP2 Receptor in Macrophages and Brain Microglia
Johansson, J. U., Pradhan, S., Lokteva, L. A., Woodling, N. S., Ko, N., Brown, H. D., … Andreasson, K. I. (2013). Suppression of Inflammation with Conditional Deletion of the Prostaglandin E-2 EP2 Receptor in Macrophages and Brain Microglia. JOURNAL OF NEUROSCIENCE, 33(40), 16016–32. -
A mouse model of permanent focal ischemia: distal middle cerebral artery occlusion.
Doyle, K. P., & Buckwalter, M. S. (2014). A mouse model of permanent focal ischemia: distal middle cerebral artery occlusion. Methods in Molecular Biology (Clifton, N.J.), 1135, 103–10. -
Astrocytic TGF-ß signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.
Cekanaviciute, E., Dietrich, H. K., Axtell, R. C., Williams, A. M., Egusquiza, R., Wai, K. M., … Buckwalter, M. S. (2014). Astrocytic TGF-ß signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. Journal of Immunology , 193(1), 139–49. -
Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice.
Cekanaviciute, E., Fathali, N., Doyle, K. P., Williams, A. M., Han, J., & Buckwalter, M. S. (2014). Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia, 62(8), 1227–40. -
Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice.
Doyle, K. P., Quach, L. N., Arceuil, H. E. D., & Buckwalter, M. S. (2015). Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice. Neuroscience Letters, 584, 236–40. -
B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke.
Doyle, K. P., Quach, L. N., Solé, M., Axtell, R. C., Nguyen, T.-V. V., Soler-Llavina, G. J., … Buckwalter, M. S. (2015). B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke. Journal of Neuroscience , 35(5), 2133–45. -
Albumin induces excitatory synaptogenesis through astrocytic TGF-beta/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction
Weissberg, I., Wood, L., Kamintsky, L., Vazquez, O., Milikovsky, D. Z., Alexander, A., … Kaufer, D. (2015). Albumin induces excitatory synaptogenesis through astrocytic TGF-beta/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction. NEUROBIOLOGY OF DISEASE, 78, 115–25. -
Metronidazole-Induced Encephalopathy: Not Always a Reversible Situation
Hobbs, K., Stern-Nezer, S., Buckwalter, M. S., Fischbein, N., & Caulfield, A. F. (2015). Metronidazole-Induced Encephalopathy: Not Always a Reversible Situation. NEUROCRITICAL CARE, 22(3), 429–36. -
Glial Fibrillary Acidic Protein-Expressing Glia in the Mouse Lung
Suarez-Mier, G. B., & Buckwalter, M. S. (2015). Glial Fibrillary Acidic Protein-Expressing Glia in the Mouse Lung. ASN NEURO, 7(5). -
Antibodies to myelin basic protein are associated with cognitive decline after stroke
Becker, K. J., Tanzi, P., Zierath, D., & Buckwalter, M. S. (2016). Antibodies to myelin basic protein are associated with cognitive decline after stroke. JOURNAL OF NEUROIMMUNOLOGY, 295, 9–11. -
Antibodies to myelin basic protein are associated with cognitive decline after stroke.
Becker, K. J., Tanzi, P., Zierath, D., & Buckwalter, M. S. (2016). Antibodies to myelin basic protein are associated with cognitive decline after stroke. Journal of Neuroimmunology, 295-296, 9–11. -
Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model
Pollak, J., Doyle, K. P., Mamer, L., Shamloo, M., & Buckwalter, M. S. (2012). Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model. BRAIN AND BEHAVIOR, 2(5), 698–706. -
Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?
Doyle, K. P., & Buckwalter, M. S. (2016). Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia? Brain, Behavior, and Immunity. -
Astrocytes: Integrative Regulators of Neuroinflammation in Stroke and Other Neurological Diseases.
Cekanaviciute, E., & Buckwalter, M. S. (2016). Astrocytes: Integrative Regulators of Neuroinflammation in Stroke and Other Neurological Diseases. Neurotherapeutics , 13(4), 685–701. -
Neurotoxic reactive astrocytes are induced by activated microglia.
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., … Barres, B. A. (2017). Neurotoxic reactive astrocytes are induced by activated microglia. Nature, 541(7638), 481–87. -
Depression one year after hemorrhagic stroke is associated with late worsening of outcomes.
Stern-Nezer, S., Eyngorn, I., Mlynash, M., Snider, R. W., Venkatsubramanian, C., Wijman, C. A. C., & Buckwalter, M. S. (2017). Depression one year after hemorrhagic stroke is associated with late worsening of outcomes. NeuroRehabilitation. -
Imaging B cells in a mouse model of multiple sclerosis using (64)Cu-Rituximab-PET.
James, M. L., Hoehne, A., Mayer, A. T., Lechtenberg, K., Moreno, M., Gowrishankar, G., … Gambhir, S. S. (2017). Imaging B cells in a mouse model of multiple sclerosis using (64)Cu-Rituximab-PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. -
Diagnostic Yield of CT Angiography in Addition to MRI/MRA in Spontaneous Intracerebral Hemorrhage
Snider, R. W., Thai, D., Narayana, R. K., Mlynash, M., Caulfield, A. F., Venkatasubramanian, C., … Wijman, C. A. (2010). Diagnostic Yield of CT Angiography in Addition to MRI/MRA in Spontaneous Intracerebral Hemorrhage. STROKE, 41(4), E310. -
Prognostic Accuracy of Serum Neuron-Specific Enolase Levels in Comatose Post-Cardiac Arrest Patients
Mlynash, M., Caulfield, A. F., Eyngorn, I., Buckwalter, M. S., & Wijman, C. A. (2009). Prognostic Accuracy of Serum Neuron-Specific Enolase Levels in Comatose Post-Cardiac Arrest Patients. STROKE, 40(4), E146–E147. -
Accuracy of Serum NSE and S-100 Protein in Predicting Outcome After Cardiac Arrest
Mlynash, M., Caulfield, A. F., Eyngorn, I., Buckwalter, M. S., & Wijman, C. A. (2010). Accuracy of Serum NSE and S-100 Protein in Predicting Outcome After Cardiac Arrest. STROKE, 41(4), E307. -
TGF-beta Production And Signaling After Stroke.
Doyle, K. P., Mamer, L. E., & Buckwalter, M. S. (2009). TGF-beta Production And Signaling After Stroke. STROKE, 40(4), E174. -
A Mouse Model for Studying Functional Recovery from Stroke
Pollak, J., Debsi, B., Mamer, L. E., Liu, S., Doyle, K. P., Jones, B., … Buckwalter, M. (2009). A Mouse Model for Studying Functional Recovery from Stroke. STROKE, 40(4), E214. -
Stroke, Inflammation and the Immune Response: Dawn of a New Era
Becker, K. J., & Buckwalter, M. (2016). Stroke, Inflammation and the Immune Response: Dawn of a New Era. NEUROTHERAPEUTICS, 13(4), 659–60. -
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Johnston, S. C., Easton, J. D., Farrant, M., Barsan, W., Conwit, R. A., Elm, J. J., … Palesch, Y. Y. (2018). Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. The New England Journal of Medicine. -
11C-DPA-713 versus 18F-GE-180: A preclinical comparison of TSPO-PET tracers to visualize acute and chronic neuroinflammation in a mouse model of ischemic stroke.
Chaney, A., Cropper, H. C., Johnson, E. M., Lechtenberg, K. J., Peterson, T. C., Stevens, M. Y., … James, M. L. (2018). 11C-DPA-713 versus 18F-GE-180: A preclinical comparison of TSPO-PET tracers to visualize acute and chronic neuroinflammation in a mouse model of ischemic stroke. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. -
A year-long immune profile of the systemic response in acute stroke survivors.
Tsai, A. S., Berry, K., Beneyto, M. M., Gaudilliere, D., Ganio, E. A., Culos, A., … Aghaeepour, N. (2019). A year-long immune profile of the systemic response in acute stroke survivors. Brain : a Journal of Neurology. -
Immune Regulation of Regenerative Responses to Stroke: TGF-b1 and Neurogencsis
Buckwalter, M. S., Yamane, M., & Wyss-Coray, T. (2007). Immune Regulation of Regenerative Responses to Stroke: TGF-b1 and Neurogencsis. ANNALS OF NEUROLOGY, 62(5), 532. -
Chronically increased brain TGF beta-1 leads to hippocampal microgliosis and decreased hippocampal neurogenesis in adult mice
Buckwalter, M. S., Yamane, M., Lee, S., Palmer, T. D., & Wyss-Coray, T. (2004). Chronically increased brain TGF beta-1 leads to hippocampal microgliosis and decreased hippocampal neurogenesis in adult mice. NEUROBIOLOGY OF AGING. ELSEVIER SCIENCE INC. -
A Comparison of Cooling Techniques to Treat Cardiac Arrest Patients with Hypothermia
Caulfield, A. F., Rachabattula, S., Eyngorn, I., Hamilton, S. A., Kalimuthu, R., Hsia, A. W., … Wijman, C. A. C. (2011). A Comparison of Cooling Techniques to Treat Cardiac Arrest Patients with Hypothermia. STROKE RESEARCH AND TREATMENT. -
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.
Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., … Wyss-Coray, T. (2019). Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nature Medicine. -
Augmented beta2-adrenergic signaling dampens the neuroinflammatory response following ischemic stroke and increases stroke size.
Lechtenberg, K. J., Meyer, S. T., Doyle, J. B., Peterson, T. C., & Buckwalter, M. S. (2019). Augmented beta2-adrenergic signaling dampens the neuroinflammatory response following ischemic stroke and increases stroke size. Journal of Neuroinflammation, 16(1), 112. -
C-11-DPA-713 Versus F-18-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke
Chaney, A., Cropper, H. C., Johnson, E. M., Lechtenberg, K. J., Peterson, T. C., Stevens, M. Y., … James, M. L. (2019). C-11-DPA-713 Versus F-18-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke. JOURNAL OF NUCLEAR MEDICINE, 60(1), 122–28. -
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., … Wyss-Coray, T. (2019). Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. NATURE MEDICINE, 25(6), 988-+. -
Radiolabeling and pre-clinical evaluation of a first-in-class CD19 PET Tracer for imaging B cells in multiple sclerosis
Stevens, M., Cropper, H., Jackson, I., Chaney, A., Lechtenberg, K., Buckwalter, M., & James, M. L. (2019). Radiolabeling and pre-clinical evaluation of a first-in-class CD19 PET Tracer for imaging B cells in multiple sclerosis. JOURNAL OF NUCLEAR MEDICINE, 60. -
Deep Immune Profiling of the Post-Stroke Peripheral Immune Response Reveals Tri-phasic Response and Correlations With Long-Term Cognitive Outcomes
Tsai, A. S., Berry, K., Beneyto, M. M., Gaudilliere, D., Ganio, E. A., Choisy, B., … Aghaeepour, N. (2019). Deep Immune Profiling of the Post-Stroke Peripheral Immune Response Reveals Tri-phasic Response and Correlations With Long-Term Cognitive Outcomes. STROKE. LIPPINCOTT WILLIAMS & WILKINS. -
Feasibility and Utility of Home-Based Gait Analysis Using Body-Worn Sensors
Huang, E., Sharp, M. T., Osborn, E., MacLellan, A., Mlynash, M., Kemp, S., … Lansberg, M. G. (2019). Feasibility and Utility of Home-Based Gait Analysis Using Body-Worn Sensors. STROKE. LIPPINCOTT WILLIAMS & WILKINS. -
A YEAR-LONG IMMUNE PROFILE OF THE SYSTEMIC RESPONSE IN ACUTE STROKE SURVIVORS
Tsai, A., Berry, K., Beneyto, M. M., Gaudilliere, D., Ganio, E. A., Culos, A., … Aghaeepour, N. (2019). A YEAR-LONG IMMUNE PROFILE OF THE SYSTEMIC RESPONSE IN ACUTE STROKE SURVIVORS. SHOCK. LIPPINCOTT WILLIAMS & WILKINS. -
Immunological mechanisms in poststroke dementia.
Doyle, K. P., & Buckwalter, M. S. (2019). Immunological mechanisms in poststroke dementia. Current Opinion in Neurology. -
The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development.
Zera, K. A., & Buckwalter, M. S. (2020). The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. -
Immune responses to stroke: mechanisms, modulation, and therapeutic potential.
Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020). Immune responses to stroke: mechanisms, modulation, and therapeutic potential. The Journal of Clinical Investigation. -
Obesity Drives Delayed Infarct Expansion, Inflammation, and Distinct Gene Networks in a Mouse Stroke Model.
Peterson, T. C., Lechtenberg, K. J., Piening, B. D., Lucas, T. A., Wei, E., Chaib, H., … Buckwalter, M. S. (2020). Obesity Drives Delayed Infarct Expansion, Inflammation, and Distinct Gene Networks in a Mouse Stroke Model. Translational Stroke Research. -
A longitudinal study of the post-stroke immune response and cognitive functioning: the StrokeCog study protocol.
Drag, L. L., Mlynash, M., Nassar, H., Osborn, E., Kim, D. E., Angst, M. S., … Lansberg, M. G. (2020). A longitudinal study of the post-stroke immune response and cognitive functioning: the StrokeCog study protocol. BMC Neurology, 20(1), 313. -
Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke.
Elkind, M. S., Boehme, A. K., Smith, C. J., Meisel, A., & Buckwalter, M. S. (2020). Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke. Stroke, STROKEAHA120030429. -
Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis.
Stevens, M. Y., Cropper, H. C., Lucot, K. L., Chaney, A. M., Lechtenberg, K. J., Jackson, I. M., … James, M. L. (2020). Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis. Journal of Neuroinflammation, 17(1), 275. -
Home-Based Virtual Reality Therapy for Hand Recovery After Stroke
MacLellan, A., Legault, C., Parikh, A., Lugo, L., Kemp, S., Mlynash, M., … Lansberg, M. (2020). Home-Based Virtual Reality Therapy for Hand Recovery After Stroke. STROKE. LIPPINCOTT WILLIAMS & WILKINS. -
Development of a Comprehensive Neuropsychological Battery to Assess Post-Stroke Cognitive Functioning
Drag, L., Aghaeepour, N., Mlynash, M., Osborn, E., Rah, E., Buckwalter, M., & Lansberg, M. (2020). Development of a Comprehensive Neuropsychological Battery to Assess Post-Stroke Cognitive Functioning. STROKE. LIPPINCOTT WILLIAMS & WILKINS. -
New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.
Boltze, J., Aronowski, J. A., Badaut, J., Buckwalter, M. S., Caleo, M., Chopp, M., … Zille, M. (2021). New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases. Frontiers in Aging Neuroscience, 13, 623751. -
Spleen glia are a transcriptionally unique glial subtype interposed between immune cells and sympathetic axons.
Lucas, T. A., Zhu, L., & Buckwalter, M. S. (2021). Spleen glia are a transcriptionally unique glial subtype interposed between immune cells and sympathetic axons. Glia. -
Home-based Virtual Reality Therapy for Hand Recovery After Stroke.
Lansberg, M. G., Legault, C., MacLellan, A., Parikh, A., Muccini, J., Mlynash, M., … Flavin, K. (2021). Home-based Virtual Reality Therapy for Hand Recovery After Stroke. PM & R : the Journal of Injury, Function, and Rehabilitation. -
B and T Lymphocyte Densities Remain Stable With Age in Human Cortex.
Berry, K., Farias-Itao, D. S., Grinberg, L. T., Plowey, E. D., Schneider, J. A., Rodriguez, R. D., … Buckwalter, M. S. (2021). B and T Lymphocyte Densities Remain Stable With Age in Human Cortex. ASN Neuro, 13, 17590914211018117. -
Mapping causal circuit dynamics in stroke using simultaneous electroencephalography and transcranial magnetic stimulation.
Rolle, C. E., Baumer, F. M., Jordan, J. T., Berry, K., Garcia, M., Monusko, K., … Etkin, A. (2021). Mapping causal circuit dynamics in stroke using simultaneous electroencephalography and transcranial magnetic stimulation. BMC Neurology, 21(1), 280. -
T cells direct microglial repair of white matter after stroke.
Zera, K. A., & Buckwalter, M. S. (2021). T cells direct microglial repair of white matter after stroke. Trends in Neurosciences. -
Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFalpha as mediators of neuronal hyperexcitability.
Barnes, S. E., Zera, K. A., Ivison, G. T., Buckwalter, M. S., & Engleman, E. G. (2021). Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFalpha as mediators of neuronal hyperexcitability. Journal of Neuroinflammation, 18(1), 199. -
Targeting VCAM1 to reduce neuroinflammation in ischemia-triggered vascular dementia.
Zera, K. A., Peterson, T., Yousef, H., Lee, D., Wyss-Coray, T., & Buckwalter, M. S. (1800). Targeting VCAM1 to reduce neuroinflammation in ischemia-triggered vascular dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 17 Suppl 3, e053849. -
Prognostication of ICU Patients by Providers with and without Neurocritical Care Training.
Finley Caulfield, A., Mlynash, M., Eyngorn, I., Lansberg, M. G., Afjei, A., Venkatasubramanian, C., … Hirsch, K. G. (2022). Prognostication of ICU Patients by Providers with and without Neurocritical Care Training. Neurocritical Care. -
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke.
Endres, M., Moro, M. A., Nolte, C. H., Dames, C., Buckwalter, M. S., & Meisel, A. (2022). Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke. Circulation Research, 130(8), 1167–1186. -
An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury.
Brosius Lutz, A., Lucas, T. A., Carson, G. A., Caneda, C., Zhou, L., Barres, B. A., … Sloan, S. A. (2022). An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury. Journal of Neuroinflammation, 19(1), 105. -
Self-report Does Not Align With Objective Assessments Of Memory And Fine Motor Functioning In Stroke Survivors
Mendez, M. P., Drag, L. L., Mlynash, M., Musabbir, M., Kim, D. E. K., Lansberg, M. G., & Buckwalter, M. S. (2022). Self-report Does Not Align With Objective Assessments Of Memory And Fine Motor Functioning In Stroke Survivors. STROKE. LIPPINCOTT WILLIAMS & WILKINS. -
Higher White Blood Cell Count In The First Week After Stroke Predicts Worse Cognitive Outcomes In A Population With Smaller Ischemic Strokes
Musabbir, M., Kim, D. E., Drag, L., Mlynash, M., Mendez, M., Lansberg, M. G., … Buckwalter, M. S. (2022). Higher White Blood Cell Count In The First Week After Stroke Predicts Worse Cognitive Outcomes In A Population With Smaller Ischemic Strokes. STROKE. LIPPINCOTT WILLIAMS & WILKINS. -
Depression And Not Cognitive Ability Is Most Strongly Associated With Long-term Functional Outcomes Following Stroke.
Drag, L. L., Musabbir, M., Mlynash, M., Mendez, M. P., Kim, D. E. K., Aghaeepour, N., … Buckwalter, M. S. (2022). Depression And Not Cognitive Ability Is Most Strongly Associated With Long-term Functional Outcomes Following Stroke. STROKE. LIPPINCOTT WILLIAMS & WILKINS. -
The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022.
Dwyer, L. J., Stowe, A. M., Doyle, K., Popovich, P., Engler-Chiurazzi, E., LeGuern, C., … Sirbulescu, R. F. (2022). The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 36(8), e22459. -
Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke.
Hernandez, V. G., Lechtenberg, K. J., Peterson, T. C., Zhu, L., Lucas, T. A., Bradshaw, K. P., … Buckwalter, M. S. (2023). Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke. Glia. -
Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke.
Hernandez, V. G., Lechtenberg, K. J., Peterson, T. C., Zhu, L., Lucas, T. A., Owah, J. O., … Buckwalter, M. S. (2023). Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke. BioRxiv : the Preprint Server for Biology. -
Machine learning models of plasma proteomic data predict mood in chronic stroke and tie it to aberrant peripheral immune responses.
Bidoki, N. H., Zera, K. A., Nassar, H., Drag, L. L., Mlynash, M., Osborn, E., … Buckwalter, M. S. (2023). Machine learning models of plasma proteomic data predict mood in chronic stroke and tie it to aberrant peripheral immune responses. Brain, Behavior, and Immunity. -
Ipsilesional Hippocampal GABA Is Elevated and Correlates With Cognitive Impairment and Maladaptive Neurogenesis After Cortical Stroke in Mice.
Torres-López, C., Cuartero, M. I., García-Culebras, A., de la Parra, J., Fernández-Valle, M. E., Benito, M., … Moro, M. A. (2023). Ipsilesional Hippocampal GABA Is Elevated and Correlates With Cognitive Impairment and Maladaptive Neurogenesis After Cortical Stroke in Mice. Stroke. -
Blocking Formation of Neurotoxic Reactive Astrocytes is Beneficial Following Stroke.
Prescott, K., Munch, A. E., Brahms, E., Weigel, M. M., Inoue, K., Buckwalter, M. S., … Peterson, T. C. (2023). Blocking Formation of Neurotoxic Reactive Astrocytes is Beneficial Following Stroke. BioRxiv : the Preprint Server for Biology. -
Blocking of microglia-astrocyte proinflammatory signaling is beneficial following stroke.
Prescott, K., Münch, A. E., Brahms, E., Weigel, M. K., Inoue, K., Buckwalter, M. S., … Peterson, T. C. (2023). Blocking of microglia-astrocyte proinflammatory signaling is beneficial following stroke. Frontiers in Molecular Neuroscience, 16, 1305949. -
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models.
Wilson, E. N., Wang, C., Swarovski, M. S., Zera, K. A., Ennerfelt, H. E., Wang, Q., … Andreasson, K. I. (2024). TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models. Nature Neuroscience. -
The effect of robot-assisted versus standard training on motor function following subacute rehabilitation after ischemic stroke - protocol for a randomised controlled trial nested in a prospective cohort (RoboRehab).
Skovgaard Jensen, J., Sorensen, A. S., Kruuse, C., Nielsen, H. H., Skov, C. D., Jensen, H. B., … Holsgaard-Larsen, A. (2024). The effect of robot-assisted versus standard training on motor function following subacute rehabilitation after ischemic stroke - protocol for a randomised controlled trial nested in a prospective cohort (RoboRehab). BMC Neurology, 24(1), 233. -
Joint and Individual Mitochondrial DNA Variation and Cognitive Outcomes in Black and White Older Adults.
Odden, M. C., Li, Y., Jotwani, V., Dobrota, S., Tan, A., Cummings, S. R., … Tranah, G. J. (2024). Joint and Individual Mitochondrial DNA Variation and Cognitive Outcomes in Black and White Older Adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. -
Evidence of aberrant anti-epstein-barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue.
Mouat, I. C., Zhu, L., Aslan, A., McColl, B. W., Allan, S. M., Smith, C. J., … McCulloch, L. (2024). Evidence of aberrant anti-epstein-barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue. Journal of Inflammation (London, England), 21(1), 30.
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Modelling neuroinflammatory phenotypes in vivo.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- SCAN - Comprehensive Stroke Recovery Study
- Imaging Collaterals in Acute Stroke (iCAS)
- Computed Tomography Perfusion (CTP) to Predict Response to Recanalization in Ischemic Stroke Project (CRISP)
- Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III
- Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)
Practice Locations
Stanford Neuroscience Health Center Palo Alto, CA
Palo Alto, CAStanford Neuroscience Health Center
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Stanford, CANeurocritical Care Program
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Stanford , CA 94305
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
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Referring Physicians
PHYSICIAN HELPLINE
Fax: 650-320-9443
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You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
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