Biography
Professional Summary
Education & Certifications
- Residency: UCSF Dept of Internal Medicine (2013) CA
- Board Certification: American Board of Internal Medicine, Medical Oncology (2018)
- Fellowship: Stanford University Hematology and Oncology Fellowship (2017) CA
- Board Certification: American Board of Internal Medicine, Internal Medicine (2013)
- Medical Education: Harvard Medical School (2010) MA
- A.B., Harvard College, Biological Anthropology (2006)
Honors & Awards
- AACR Associate Member Award, San Antonio Breast Cancer Symposium (2018)
- ASCO Young Investigator Award, Conquer Cancer Foundation (2017)
- Physician Scientist Training Award, Damon Runyon Cancer Research Foundation (2017)
- Postdoctoral Fellowship Award, Susan G. Komen (2017)
- SCI Fellowship Award, Stanford Cancer Institute (2017)
Publications
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Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25
Fejerman, L., Ahmadiyeh, N., Hu, D., Huntsman, S., Beckman, K. B., Caswell, J. L., … Ziv, E. (2014). Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. NATURE COMMUNICATIONS, 5. -
Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors
Caswell, J. L., Camarda, R., Zhou, A. Y., Huntsman, S., Hu, D., Brenner, S. E., … Ziv, E. (2015). Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors. HUMAN MOLECULAR GENETICS, 24(25), 7421–31. -
High mammographic density in women of Ashkenazi Jewish descent
Caswell, J. L., Kerlikowske, K., Shepherd, J. A., Cummings, S. R., Hu, D., Huntsman, S., & Ziv, E. (2013). High mammographic density in women of Ashkenazi Jewish descent. BREAST CANCER RESEARCH, 15(3). -
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients
Ziv, E., Dean, E., Hu, D., Martino, A., Serie, D., Curtin, K., … Vachon, C. (2015). Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients. NATURE COMMUNICATIONS, 6. -
Analysis of chimpanzee history based on genome sequence alignments
Caswell, J. L., Mallick, S., Richter, D. J., Neubauer, J., Gnerre, C. S. S., Gnerre, S., & Reich, D. (2008). Analysis of chimpanzee history based on genome sequence alignments. PLOS GENETICS, 4(4). -
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
Ahmadiyeh, N., Pomerantz, M. M., Grisanzio, C., Herman, P., Jia, L., Almendro, V., … Freedman, M. L. (2010). 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(21), 9742–9746. -
Acute, Unilateral Breast Toxicity From Gemcitabine in the Setting of Thoracic Inlet Obstruction.
Weiskopf, K., Creighton, D., Lew, T., Caswell, J. L., Ouyang, D., Shah, A. T., … Telli, M. L. (2016). Acute, Unilateral Breast Toxicity From Gemcitabine in the Setting of Thoracic Inlet Obstruction. Journal of Oncology Practice / American Society of Clinical Oncology, 12(8), 763–64. -
Racial/ethnic differences in multiple-gene sequencing results for hereditary cancer risk.
Caswell-Jin, J. L., Gupta, T., Hall, E., Petrovchich, I. M., Mills, M. A., Kingham, K. E., … Kurian, A. W. (2017). Racial/ethnic differences in multiple-gene sequencing results for hereditary cancer risk. Genetics in Medicine : Official Journal of the American College of Medical Genetics. -
Pathogenic variants in less familiar cancer susceptibility genes: what happens after genetic testing?
Hall, E. T., Parikh, D., Caswell-Jin, J. L., Gupta, T., Mills, M. A., Kingham, K. E., … Kurian, A. W. (2018). Pathogenic variants in less familiar cancer susceptibility genes: what happens after genetic testing? JCO Precision Oncology. -
Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy.
Caswell-Jin, J. L., McNamara, K., Reiter, J. G., Sun, R., Hu, Z., Ma, Z., … Curtis, C. (2019). Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy. Nature Communications, 10(1), 657. -
Response to Peshkin, Isaacs, and Schwartz.
Caswell-Jin, J. L., & Kurian, A. W. (2019). Response to Peshkin, Isaacs, and Schwartz. Journal of the National Cancer Institute. -
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.
Rueda, O. M., Sammut, S.-J., Seoane, J. A., Chin, S.-F., Caswell-Jin, J. L., Callari, M., … Curtis, C. (2019). Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups. Nature. -
Change in Survival in Metastatic Breast Cancer with Treatment Advances: Meta-Analysis and Systematic Review.
Caswell-Jin, J. L., Plevritis, S. K., Tian, L., Cadham, C. J., Xu, C., Stout, N. K., … Kurian, A. W. (2018). Change in Survival in Metastatic Breast Cancer with Treatment Advances: Meta-Analysis and Systematic Review. JNCI Cancer Spectrum, 2(4), pky062. -
Using natural language processing to construct a metastatic breast cancer cohort from linked cancer registry and electronic medical records data.
Ling, A. Y., Kurian, A. W., Caswell-Jin, J. L., Sledge, G. W., Shah, N. H., & Tamang, S. R. (2019). Using natural language processing to construct a metastatic breast cancer cohort from linked cancer registry and electronic medical records data. . JAMIA Open. -
Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative
Caswell-Jin, J. L., Zimmer, A. D., Stedden, W., Kingham, K. E., Zhou, A. Y., & Kurian, A. W. (2019). Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 111(1), 95–98. -
Natural Language Processing Approaches to Detect the Timeline of Metastatic Recurrence of Breast Cancer.
Banerjee, I., Bozkurt, S., Caswell-Jin, J. L., Kurian, A. W., & Rubin, D. L. (2019). Natural Language Processing Approaches to Detect the Timeline of Metastatic Recurrence of Breast Cancer. JCO Clinical Cancer Informatics, 3, 1–12. -
Chromatin regulators mediate anthracycline sensitivity in breast cancer.
Seoane, J. A., Kirkland, J. G., Caswell-Jin, J. L., Crabtree, G. R., & Curtis, C. (2019). Chromatin regulators mediate anthracycline sensitivity in breast cancer. Nature Medicine. -
Re: Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative Response
Caswell-Jin, J. L., & Kurian, A. W. (2019). Re: Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative Response. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 111(8), 874. -
Using natural language processing to construct a metastatic breast cancer cohort from linked cancer registry and electronic medical records data.
Ling, A. Y., Kurian, A. W., Caswell-Jin, J. L., Sledge, G. W., Shah, N. H., & Tamang, S. R. (2019). Using natural language processing to construct a metastatic breast cancer cohort from linked cancer registry and electronic medical records data. JAMIA Open, 2(4), 528–37. -
Prevalence of Pathogenic Variants in Cancer Susceptibility Genes Among Women With Postmenopausal Breast Cancer.
Kurian, A. W., Bernhisel, R., Larson, K., Caswell-Jin, J. L., Shadyab, A. H., Ochs-Balcom, H., & Stefanick, M. L. (2020). Prevalence of Pathogenic Variants in Cancer Susceptibility Genes Among Women With Postmenopausal Breast Cancer. JAMA, 323(10), 995–97. -
Tumor expression and microenvironment in HER2-positive breast cancer before and on HER2-targeted therapy: Analysis of microarray expression data from the TRIO-US B07 trial
Caswell-Jin, J. L., McNamara, K. L., Dering, J., Chen, H.-W., Dichmann, R., Perez, A., … Hurvitz, S. A. (2020). Tumor expression and microenvironment in HER2-positive breast cancer before and on HER2-targeted therapy: Analysis of microarray expression data from the TRIO-US B07 trial. CANCER RESEARCH, 80(4). -
Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07).
Hurvitz, S. A., Caswell-Jin, J. L., McNamara, K. L., Zoeller, J. J., Bean, G. R., Dichmann, R., … Slamon, D. J. (2020). Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07). Nature Communications, 11(1), 5824. -
Androgen receptor agonists as breast cancer therapeutics.
Caswell-Jin, J. L., & Curtis, C. (2021). Androgen receptor agonists as breast cancer therapeutics. Nature Medicine. -
Molecular Heterogeneity and Evolution in Breast Cancer
Caswell-Jin, J. L., Lorenz, C., & Curtis, C. (2021). Molecular Heterogeneity and Evolution in Breast Cancer. Annual Review of Cancer Biology, 5. -
Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response
McNamara, K. L., Caswell-Jin, J. L., Joshi, R., Ma, Z., Kotler, E., Bean, G. R., … Curtis, C. (2021). Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response. NATURE CANCER, 2(4), 400-+. -
Treatment and Monitoring Variability in US Metastatic Breast Cancer Care.
Caswell-Jin, J. L., Callahan, A., Purington, N., Han, S. S., Itakura, H., John, E. M., … Kurian, A. W. (2021). Treatment and Monitoring Variability in US Metastatic Breast Cancer Care. JCO Clinical Cancer Informatics, 5, 600–614. -
Performance of the IBIS/Tyrer-Cuzick model of breast cancer risk by race and ethnicity in the Women's Health Initiative.
Kurian, A. W., Hughes, E., Simmons, T., Bernhisel, R., Probst, B., Meek, S., … Stefanick, M. L. (2021). Performance of the IBIS/Tyrer-Cuzick model of breast cancer risk by race and ethnicity in the Women's Health Initiative. Cancer. -
Twenty-one-gene recurrence score (RS) in germline (g)CHEK2 mutation-associated versus sporadic breast cancers (BC): A multi-site case-control study.
Afghahi, A., Marsh, S., Winchester, A., Gao, D., Parris, H., Axell, L., … Tung, N. M. (2021). Twenty-one-gene recurrence score (RS) in germline (g)CHEK2 mutation-associated versus sporadic breast cancers (BC): A multi-site case-control study. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Pathogenic Variants in Less Familiar Cancer Susceptibility Genes: What Happens After Genetic Testing?
Hall, E. T., Parikh, D., Caswell-Jin, J. L., Gupta, T., Mills, M. A., Kingham, K. E., … Kurian, A. W. (2018). Pathogenic Variants in Less Familiar Cancer Susceptibility Genes: What Happens After Genetic Testing? JCO Precision Oncology, 2, 1–10. -
Patient perspectives on window of opportunity clinical trials in early-stage breast cancer.
Parikh, D. A., Kody, L., Brain, S., Heditsian, D., Lee, V., Curtis, C., … Caswell-Jin, J. L. (2022). Patient perspectives on window of opportunity clinical trials in early-stage breast cancer. Breast Cancer Research and Treatment. -
Genetic and immunohistochemical profiling of small cell and large cell neuroendocrine carcinomas of the breast.
Bean, G. R., Najjar, S., Shin, S. J., Hosfield, E. M., Caswell-Jin, J. L., Urisman, A., … Krings, G. (2022). Genetic and immunohistochemical profiling of small cell and large cell neuroendocrine carcinomas of the breast. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. -
Breast cancer diagnosis and treatment during the COVID-19 pandemic in a nationwide, insured population.
Caswell-Jin, J. L., Shafaee, M. N., Xiao, L., Liu, M., John, E. M., Bondy, M. L., & Kurian, A. W. (2022). Breast cancer diagnosis and treatment during the COVID-19 pandemic in a nationwide, insured population. Breast Cancer Research and Treatment. -
Chemotherapy Regimens Received by Women with BRCA1/2 Pathogenic Variants for Early-Stage Breast Cancer Treatment.
Kurian, A. W., Abrahamse, P., Hamilton, A. S., Caswell-Jin, J. L., Gomez, S. L., Hofer, T. J., … Katz, S. J. (2022). Chemotherapy Regimens Received by Women with BRCA1/2 Pathogenic Variants for Early-Stage Breast Cancer Treatment. JNCI Cancer Spectrum. -
Contributions of screening, early-stage treatment, and metastatic treatment to breast cancer mortality reduction by molecular subtype in US women, 2000-2017.
Caswell-Jin, J. L., Sun, L., Munoz, D., Lu, Y., Li, Y., Huang, H., … Plevritis, S. (2022). Contributions of screening, early-stage treatment, and metastatic treatment to breast cancer mortality reduction by molecular subtype in US women, 2000-2017. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
First-in-human phase 1/2 dose escalation and expansion study evaluating first-in-class eIF4A inhibitor zotatifin in patients with solid tumors.
Meric-Bernstam, F., Sharma, M., Sommerhalder, D., Skeel, R. T., El-Khoueiry, A. B., Caswell-Jin, J. L., … Rosen, E. (2022). First-in-human phase 1/2 dose escalation and expansion study evaluating first-in-class eIF4A inhibitor zotatifin in patients with solid tumors. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Pharmacovigilance Analysis of HeartFailure Associated With Anti-HER2 Monotherapies and Combination Regimens for Cancer.
Waliany, S., Caswell-Jin, J., Riaz, F., Myall, N., Zhu, H., Witteles, R. M., & Neal, J. W. (2023). Pharmacovigilance Analysis of HeartFailure Associated With Anti-HER2 Monotherapies and Combination Regimens for Cancer. JACC. CardioOncology, 5(1), 85–98. -
Phase 1/2 dose expansion study evaluating first-in-class eIF4A inhibitor zotatifin in patients with ER plus metastatic breast cancer.
Rosen, E., Sharma, M., Berz, D., Caswell-Jin, J. L., Spira, A. I., Fulgar, G. A., … Meric-Bernstam, F. (2023). Phase 1/2 dose expansion study evaluating first-in-class eIF4A inhibitor zotatifin in patients with ER plus metastatic breast cancer. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Analysis of Breast Cancer Mortality in the US-1975 to 2019.
Caswell-Jin, J. L., Sun, L. P., Munoz, D., Lu, Y., Li, Y., Huang, H., … Plevritis, S. K. (2024). Analysis of Breast Cancer Mortality in the US-1975 to 2019. JAMA, 331(3), 233–241. -
US Breast Cancer Mortality-Reply.
Caswell-Jin, J. L., Kurian, A. W., & Plevritis, S. K. (2024). US Breast Cancer Mortality-Reply. JAMA. -
Collaborative Modeling to Compare Different Breast Cancer Screening Strategies: A Decision Analysis for the US Preventive Services Task Force.
Trentham-Dietz, A., Chapman, C. H., Jayasekera, J., Lowry, K. P., Heckman-Stoddard, B. M., Hampton, J. M., … Mandelblatt, J. S. (2024). Collaborative Modeling to Compare Different Breast Cancer Screening Strategies: A Decision Analysis for the US Preventive Services Task Force. JAMA. -
Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer-Cyclin-Dependent Kinase 4 and 6 Inhibitors: ASCO Guideline Rapid Recommendation Update.
Freedman, R. A., Caswell-Jin, J. L., Hassett, M., Somerfield, M. R., & Giordano, S. H. (2024). Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer-Cyclin-Dependent Kinase 4 and 6 Inhibitors: ASCO Guideline Rapid Recommendation Update. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, JCO2400886. -
The population-level effects of omitting chemotherapy guided by a 21-gene expression assay in node-positive breast cancer: a simulation modeling study.
Wojcik, K. M., Caswell-Jin, J. L., Wilson, O. W., Schechter, C., Kamil, D., Kurian, A. W., & Jayasekera, J. (2024). The population-level effects of omitting chemotherapy guided by a 21-gene expression assay in node-positive breast cancer: a simulation modeling study. BMC Cancer, 24(1), 975. -
Use of surgery for de novo metastatic breast cancer (mBC)
Dickerson, J., Tang, H., Thompson, C., Gomez, S. L., Satoyoshi, M., Kurian, A. W., & Caswell-Jin, J. L. (2024). Use of surgery for de novo metastatic breast cancer (mBC). JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer-CDK4/6 Inhibitors: ASCO Rapid Guideline Update Clinical Insights.
Caswell-Jin, J. L., Freedman, R. A., Hassett, M. J., Tang, H., Garrett-Mayer, E., Somerfield, M. R., & Giordano, S. H. (2024). Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer-CDK4/6 Inhibitors: ASCO Rapid Guideline Update Clinical Insights. JCO Oncology Practice, OP2400663.
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Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
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