Biography
Richard Chen, M.D. M.S., is Clinical Assistant Professor of Dermatology at Stanford and Chief Scientific Officer at Personalis, Inc. He attended medical school and completed residency at Stanford University, serving as Chief Resident in his final year. His interests include general dermatology, cancer genomics, precision medicine, genetics, bioinformatics and technology innovation for improved health care delivery and therapy.
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Professional Summary
Education & Certifications
- Medical Education: Stanford University School of Medicine (2007) CA
- Internship: Santa Clara Valley Medical Center (2008) CA
- Residency: Stanford University Dept of Dermatology (2011) CA
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- Board Certification: American Board of Dermatology, Dermatology (2011)
Publications
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Automated diagnosis of data-model conflicts using metadata
Chen, R. O., & Altman, R. B. (1999). Automated diagnosis of data-model conflicts using metadata. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 6(5), 374–92. -
The direct cellular target of topically applied pimecrolimus may not be infiltrating lymphocytes
Fiorentino, D. F., Chen, R. O., STEWART, D. B., Brown, K. K., & Sundram, U. N. (2011). The direct cellular target of topically applied pimecrolimus may not be infiltrating lymphocytes. BRITISH JOURNAL OF DERMATOLOGY, 164(5), 996–1003. -
Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts
Lee, C. S., Ungewickell, A., Bhaduri, A., Qu, K., Webster, D. E., Armstrong, R., … Khavari, P. A. (2012). Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts. BLOOD, 120(16), 3288–97. -
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Computational methods for defining the allowed conformational space of 16S rRNA based on chemical footprinting data
Fink, D. L., Chen, R. O., Noller, H. F., & Altman, R. B. (1996). Computational methods for defining the allowed conformational space of 16S rRNA based on chemical footprinting data. RNA-A PUBLICATION OF THE RNA SOCIETY, 2(9), 851–66. -
Constraining volume by matching the moments of a distance distribution
Chen, C. C., Chen, R. O., & Altman, R. B. (1996). Constraining volume by matching the moments of a distance distribution. COMPUTER APPLICATIONS IN THE BIOSCIENCES, 12(4), 319–26. -
RNA secondary structure as a reusable interface to biological information resources
Felciano, R. M., Chen, R. O., & Altman, R. B. (1997). RNA secondary structure as a reusable interface to biological information resources. GENE-COMBIS, 190, GC59–GC70. -
Standardized representations of the literature: Combining diverse sources of ribosomal data
Altman, R. B., Abernethy, N. F., & Chen, R. O. (1997). Standardized representations of the literature: Combining diverse sources of ribosomal data. Presented at the 5th International Conference on Intelligent Systems for Molecular Biology (ISMB-97), HALKIDIKI,GREECE: AMER ASSOC ARTIFICIAL INTELLIGENCE. -
RIBOWEB: Linking structural computations to a knowledge base of published experimental data
Chen, R. O., Felciano, R., & Altman, R. B. (1997). RIBOWEB: Linking structural computations to a knowledge base of published experimental data. Presented at the 5th International Conference on Intelligent Systems for Molecular Biology (ISMB-97), HALKIDIKI,GREECE,GREECE,GREECE,GREECE,GREECE,GREECE: AMER ASSOC ARTIFICIAL INTELLIGENCE. -
Achieving high-sensitivity for clinical applications using augmented exome sequencing.
Patwardhan, A., Harris, J., Leng, N., Bartha, G., Church, D. M., Luo, S., … Chen, R. (2015). Achieving high-sensitivity for clinical applications using augmented exome sequencing. Genome Medicine, 7(1), 71-? -
Achieving high-sensitivity for clinical applications using augmented exome sequencing
Patwardhan, A., Harris, J., Leng, N., Bartha, G., Church, D. M., Luo, S., … Chen, R. (2015). Achieving high-sensitivity for clinical applications using augmented exome sequencing. GENOME MEDICINE, 7. -
Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing
Shoemaker, L. D., Clark, M. J., Patwardhan, A., Chandratillake, G., Garcia, S., Chen, R., … Steinberg, G. K. (2016). Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing. G3-GENES GENOMES GENETICS, 6(1), 41–49. -
Genetic analysis in a patient with nine primary malignant neoplasms: A rare case of Li-Fraumeni syndrome
Li, X., Kang, J., Pan, Q., Sikora-Wohlfeld, W., Zhao, D., Meng, C., … Ding, K. (2016). Genetic analysis in a patient with nine primary malignant neoplasms: A rare case of Li-Fraumeni syndrome. ONCOLOGY REPORTS, 35(3), 1519–28. -
Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing.
Shoemaker, L. D., Clark, M. J., Patwardhan, A., Chandratillake, G., Garcia, S., Chen, R., … Steinberg, G. K. (2015). Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing. G3 (Bethesda, Md.), 6(1), 41–49. -
Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants
Bagley, S. C., Sirota, M., Chen, R., Butte, A. J., & Altman, R. B. (2016). Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants. PLOS COMPUTATIONAL BIOLOGY, 12(4). -
Early somatic mosaicism is a rare cause of long-QT syndrome
Priest, J. R., Gawad, C., Kahlig, K. M., Yu, J. K., O'Hara, T., Boyle, P. M., … Ashley, E. A. (2016). Early somatic mosaicism is a rare cause of long-QT syndrome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(41), 11555–60. -
Are minor alleles more likely to be risk alleles?
Kido, T., Sikora-Wohlfeld, W., Kawashima, M., Kikuchi, S., Kamatani, N., Patwardhan, A., … Butte, A. J. (2018). Are minor alleles more likely to be risk alleles? BMC MEDICAL GENOMICS, 11, 3. -
Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome.
Li, X., Kang, J., Pan, Q., Sikora-Wohlfeld, W., Zhao, D., Meng, C., … Ding, K. (2016). Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome. Oncology Reports, 35(3), 1519–28. -
Exome scale liquid biopsy monitoring of putative neoantigens and genomic biomarkers in patients on anti-PD-1 therapy in squamous cell carcinoma of the head and neck.
Abbott, C. W., Bedi, N., Zhang, S. V., Li, R., Pyke, R. M., Levy, E., … Boyle, S. M. (2020). Exome scale liquid biopsy monitoring of putative neoantigens and genomic biomarkers in patients on anti-PD-1 therapy in squamous cell carcinoma of the head and neck. CANCER IMMUNOLOGY RESEARCH. AMER ASSOC CANCER RESEARCH. -
Exome scale liquid biopsy characterization of putative neoantigens and genomic biomarkers pre- and post anti-PD-1 therapy in squamous cell carcinoma of the head and neck.
Abbott, C., Bedi, N., Zhang, S., Li, R., Pyke, R., Levy, E., … Boyle, S. M. (2020). Exome scale liquid biopsy characterization of putative neoantigens and genomic biomarkers pre- and post anti-PD-1 therapy in squamous cell carcinoma of the head and neck. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Sensitive HLA loss of heterozygosity detection reveals allele-specific neoantigen expansion as resistance mechanism to anti-PD-1 therapy
Pyke, R. M., Abbott, C., Mellacheruvu, D., Zhang, S., Bedi, N., Colevas, A. D., … Boyle, S. M. (2020). Sensitive HLA loss of heterozygosity detection reveals allele-specific neoantigen expansion as resistance mechanism to anti-PD-1 therapy. CANCER RESEARCH. AMER ASSOC CANCER RESEARCH. -
Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentation.
Pyke, R. M., Mellacheruvu, D., Dea, S., Abbott, C., Zhang, S. V., Phillips, N. A., … Boyle, S. M. (2021). Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentation. Molecular & Cellular Proteomics : MCP, 100111. -
Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms.
Abbott, C. W., Boyle, S. M., Pyke, R. M., McDaniel, L. D., Levy, E., Navarro, F. C., … Chen, R. (2021). Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 27(15), 4265–4276. -
Pan-cancer survey of HLA loss of heterozygosity using a robustly validated NGS-based machine learning algorithm.
Pyke, R. M., Mellacheruvu, D., Abbott, C., Dea, S., Levy, E., Zhang, S. V., … Boyle, S. M. (2021). Pan-cancer survey of HLA loss of heterozygosity using a robustly validated NGS-based machine learning algorithm. CANCER RESEARCH. AMER ASSOC CANCER RESEARCH. -
Longitudinal exome-scale liquid biopsy monitoring of evolving therapeutic resistance mechanisms in head and neck squamous cell carcinoma patients receiving anti-PD-1 therapy.
Abbott, C. W., Bedi, N., Zhang, S. V., Northcott, J., Li, R., Pyke, R. M., … Chen, R. (2021). Longitudinal exome-scale liquid biopsy monitoring of evolving therapeutic resistance mechanisms in head and neck squamous cell carcinoma patients receiving anti-PD-1 therapy. CANCER RESEARCH. AMER ASSOC CANCER RESEARCH. -
Association of HLA loss of heterozygosity with allele-specific neoantigen expansion in response to immunotherapy.
Pyke, R. M., Abbott, C., Dea, S., Bedi, N., Colevas, A. D., Levy, E., … Boyle, S. M. (2021). Association of HLA loss of heterozygosity with allele-specific neoantigen expansion in response to immunotherapy. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Robust prediction of response to immunotherapy in a mixed cohort of previously treated and immunotherapy-naive melanoma patients.
Abbott, C., McDaniel, L., Pyke, R., Levy, E., Navarro, F., Wang, S. V. Z. J., … Chen, R. (2021). Robust prediction of response to immunotherapy in a mixed cohort of previously treated and immunotherapy-naive melanoma patients. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
TUMOR-INFORMED LIQUID BIOPSY MONITORING OF EVOLVING THERAPEUTIC RESISTANCE MECHANISMS IN HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENTS RECEIVING ANTI-PD-1 THERAPY
Abbott, C., Bedi, N., Wang, J., Northcott, J., Pyke, R., Li, R., … Chen, R. (2021). TUMOR-INFORMED LIQUID BIOPSY MONITORING OF EVOLVING THERAPEUTIC RESISTANCE MECHANISMS IN HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENTS RECEIVING ANTI-PD-1 THERAPY. JOURNAL FOR IMMUNOTHERAPY OF CANCER. BMJ PUBLISHING GROUP. -
EXTENSIVELY VALIDATED HLA LOH ALGORITHM DEMONSTRATES AN ASSOCIATION BETWEEN HLA LOH AND GENOMIC INSTABILITY
Pyke, R., Dea, S., Mellacheruvu, D., Abbott, C., Zhang, S., McDaniel, L., … Boyle, S. (2021). EXTENSIVELY VALIDATED HLA LOH ALGORITHM DEMONSTRATES AN ASSOCIATION BETWEEN HLA LOH AND GENOMIC INSTABILITY. JOURNAL FOR IMMUNOTHERAPY OF CANCER. BMJ PUBLISHING GROUP. -
A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity.
Pyke, R. M., Mellacheruvu, D., Dea, S., Abbott, C. W., McDaniel, L., Bhave, D. P., … Boyle, S. M. (2022). A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity. Nature Communications, 13(1), 1925. -
Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial.
Padron, L. J., Maurer, D. M., O'Hara, M. H., O'Reilly, E. M., Wolff, R. A., Wainberg, Z. A., … Vonderheide, R. H. (2022). Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial. Nature Medicine. -
Distinct biosignatures associate with survival after chemoimmunotherapy in a randomized, three-arm phase II study in patients with metastatic pancreatic cancer.
Padron, L. J., Maurer, D. M., O'Hara, M. H., O'Reilly, E. M., Wolff, R. A., Wainberg, Z. A., … Vonderheide, R. H. (2022). Distinct biosignatures associate with survival after chemoimmunotherapy in a randomized, three-arm phase II study in patients with metastatic pancreatic cancer. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS.
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Computational methods for defining the allowed conformational space of 16S rRNA based on chemical footprinting data
Practice Locations
General Dermatology Clinic in Redwood City Redwood City, CA
Redwood City, CA
General Dermatology Clinic in Redwood City
450 Broadway Street, Pavilion B 4th Floor
Redwood City , CA 94063
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Patient Reviews
(103 reviews)
He was friendly and knowledgeable
Dr Chen was thorough and listened to my issues
A very professional attitude looking out for my well-being.
Dr Chen is super kind. He answered all my questions with infinite patience.
Dr. Chen has a wonderful bedside manner. He is patient he listens and has empathy which is very valuable when you are treating persons with various types of illnesses.
Very helpful
Everyone was Awesome 👠😻 Dr Chen is great and the Medical Student was very thorough 👠♥ï¸
Dr. Chen is not only professional and knowledgeable he is a caring doctor who always answers my concerns.
Well informed and thorough
Very professional- Great bedside manner
Every part of the experience was positive and excellent
professional and efficient - all concerned
Excellwnt
Dr Chen is an outstanding Dermatoligist
Dr. Chen listens to what you tell him. You never feel rushed - he is respectful.
Great apt
Friendly efficient front desk. Very clean and comfortable setting. Doctor Chen is an excellent doctor.
Doctor Chen is the best!
RICHARD CHEN IS AN EXCELLENT DERMATOLOGIST
He was friendly and thorough.
Dr. Chen also introduced me to a new (to me) facial treatment (via prescription) to disclose & treat pre-cancerous spots in the period between my 6-month appointments with him.
Dr. Richard Chen is an excellent physician and extremely helpful in working to assure my health is the best possible.
Best Dr. ever. Takes time to explain your problem and its cure
Like very much
I appreciate Dr. Chen's caring and professional treatment
Dr. Chen’s care and concerns for my situation exceeded my expectations. He’s making me reconsider moving my care to our competitors.
Dr. Chen is professional, knowledgeable and caring-He takes his time explaining my case and what I need to do. I would definitely recommend him to others.
All staff, including Dr. Chen, were friendly and patient.
good communication and efficient
Dr. Richard Chen is an excellent, professional, and empathetic doctor! (Just a note on the survey - the answer choices don’t match the question above.)
Dr. Chen is very professional and attentive.
Excellent personality and communication - wonderful!
Dr. Chen always listens to all your concerns. His student physician was very knowledgeable and pleasant.
Dr. Chen is an amazing dermatologist. He somehow manages to prevent or lessen the burn when he freezes spots. Very patient, friendly!
Time spent with provider less than 15 min. wait time to see provider 10 min. waiting room outside over 20 min. waiting in patient's room.
Was in and out and very happy with the whole experience.
Quick. Thorough. Friendly. Explained everything in a way I understood. Gave me choices. I was expecting baseline photos from my last appointment recommendations but trust that he did what was best.
Great doctor! Very knowledgeable and empathetic bedside manner.
Dr. Chen is a true healer I am very grateful to have him care for me.
Excellent. I'll be using him as my regular provider from now on.
Dr. Chen is always kind and helpful.
Dr. Chen is very professional and render excellent care.
Greatest skin doctor ever.
Every thing was great.
Dr. Chen - easy to communicate with.
Dr. Chen is amazing!
dr Chen is a true healer. I am so honored to have him as my doctor
Dr Chen has always encluded me in all decisions, he is very good.
Dr. Kossler did a great job on my eye. guess it's time for me to move on.
He is very accommodating as we live 4 hrs. away.
Dr. Chen - the resident & the guest physician were all awesome.
Out standing care.
Dr. Chen was extremely helpful. I had requested information about my options, potential scarring, etc. He followed up my inquiry by calling me and spent 15 minutes patiently explaining what I could expect at my appointment.
Dr. Chen is a good provider. He made sure to address all my concerns.
liked that they give you a typed form of the instructions
All done by Dr. Chen.
I have been seeing Dr. Chen for years. He is great. My husband and mom see him as well.
I simply cannot say enough about the exceptional care I received and continue to get from Dr. Richard Chen. He is perhaps the most responsive, competent and caring doctor I have ever had. He has been so thorough with me in communications in person and on the phone. He has called me twice to give me reports on my dermatology issues. He is relentless in making sure that I have outstanding care as we move forward towards surgery.
Dr Chen is always so informative about the procedure, very understanding.
Dr. Chen is the best!
Kristin Danielle Kennedy (NP) is outstanding! Dr. Richard Owguan Chen (MD) great caring doctor who has been able to get my psoriasis under control. Thank you both!
Noticed a skin issue after dr. had left. Mentioned it to a nurse. He came back in and looked. Awesome.
Dr. Chen is very good. Very happy with dealing with him.
Dr. Chen is very gentle & kind! When he freezes pre cancer spots, he works "magic". There is NO burning sensation afterward!
Dr. Chen is very kind and sincere, he suggested me to neuro science department after his primary examination.
The doctor was good and had some new ideas about how to help me.
Very good.
Dr. Chen is very kind and gentle.
Good dr.
Dr. C was excellent; afterwards I wished he had written down the name of the medicine he prescribed as I didn't remember the name. It would have been helpful to have it written down.
I am grateful to be seen by Dr. Chen and his support staff.
Very thorough - thanks!
I really appreciate Dr. Chen's concern and empathy, and that he recognized how distressing my condition was for me. More importantly, he was very thorough, followed-up with both myself and reached out to another physcian to ensure prescribed medicine would not interefere negatively with my gastrointestinal condition. His thoroughness has finally enabled me to get some relief after years of suffering.
I have been receiving care from Dr. Chen for several years now. He knows me and knows my condition and concerns very well and I feel extremely comfortable in his care.
It was an excellent experience.
Excellent, direct, personable, professional, compassionate about his profession.
Dr. Richard Chen is very personable and he calls me with updates and any concerns he may have. I do not receive this type of treatment from any other facility or doctor.
Professional yet personable.
This was my first visit with Dr. Richard Chen. He is an outstanding physician. Thoughtful, caring, and very kind. I am thankful for his care regarding my health.
Very, very good experience.
Good.
Even though I've only been seen by Dr. Chen twice, I feel as though I've been coming in for quite some time.
Dr. Richard Chen is always professional, compassionate, willing to listen and truly cares about my health
Very good experience.
Listens - cares - understand.
My previous doctor had left and this is my first visit with Dr. Chen. I was very impressed when he called to follow up!
My visit was great, the doctor and his helpers where concerned & took great care of me.
Dr. Chen previously called me back out of office hours and left his cell phone # for my return call. 1st & only time a physician has given me a direct number to reach him.
Very good MD. (All my derm. MD's always have impressed me). Very personable, patient, explains issues and addresses all concerns.
Dr. Chen is extremely professional MD courteous. He called and texted me with my biopsy results. Incredible care and concern excellent!
Good working relationship with doctor.
Dr. Chen provided exceptional care. He was attentive, thoroughly explained the treatment plan and medication, spoke to me in language I could understand and I never felt rushed during my appt.
I find Dr Chen to be a very gentle and caring doctor!
Dr. Chen provided excellent care. He was extremely attentive to my issues and was very patient in anwering my questions regarding follow-up care. I never one felt rushed during my visit with Dr. Chen. He is an exceptional care provider.
Dr. Chen is great!
I have had excellent care on each visit over the last 2 years.
He is a very good provider. I like him.
Dr. Chen is excellent!! He carefully examined my symptoms and prescribed me the medication that worked effectively. I will stick with him as long as my insurance allows! A +++
Excellent results with the recommended treatment and medication.
Great physician; very knowledgeable. He always remembers medical history!
Fast & understandable.
Dr. Chen is fun, nice, smart - great doctor!
I've already recommended this dr. & the facility!
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