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Specializing In
- Pulmonary Function Tests
- Pulmonary Hypertension
- Resting 12-Lead EKG
- Right Heart Catheterization
Biography
Dr. Vinicio de Jesus Perez received his MD from the University of Puerto Rico Medical School and completed an internal medicine residency at Massachusetts General Hospital. He completed a fellowship in pulmonary and critical care medicine in Denver, followed by postdoctoral research training at Stanford University. He focused on researching genetic and molecular mechanisms of pulmonary hypertension (PH) and idiopathic pulmonary fibrosis (IPF) and has devoted his clinical practice to diagnosis and management of these conditions. He is presently associate professor of medicine and staff physician of the Stanford Adult PH Clinic where he trains fellows pursuing careers in PH and IPF. He is principal investigator of a research program with the ultimate goal of identifying new therapeutic targets to treat PH and IPF.
As a medical professional belonging to a minority group, Dr. de Jesus Perez is involved in academic endeavors seeking to improve access of care for patients with disadvantageous ethnic backgrounds and promote diversity in medicine.
As a medical professional belonging to a minority group, Dr. de Jesus Perez is involved in academic endeavors seeking to improve access of care for patients with disadvantageous ethnic backgrounds and promote diversity in medicine.
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Professional Summary
Education & Certifications
- Medical Education: University of Puerto Rico Medical University (2000) Puerto Rico
- Fellowship: Univ Of Colorado (2004) CO
- Residency: Massachusetts General Hospital (2003) MA
- Internship: Massachusetts General Hospital (2001) MA
- Board Certification: American Board of Internal Medicine, Critical Care Medicine (2007)
- Board Certification: American Board of Internal Medicine, Pulmonary Disease (2006)
- Fellowship: Stanford University Medical Center (2006) CA
- MD, Stanford University, Pulmonary/CCM (2006)
- MD, University of Colorado-Denver, Pulmonary/CCM (2004)
- MD, Massachussetts General Hospital, Internal Medicine (2003)
- MD, University of Puerto Rico, Medicine (2000)
- BS, University of Puerto Rico, Biology (1996)
Honors & Awards
- 1R03HL133423, NIH (2016-2018)
- 2008 Professional of the year, Madison Who's who among pofessionals in America (2009)
- AHA 2007 Junior Investigator Travel Award, American Heart Association (2007)
- AHA Beginning Grant in Aid, American Heart Association (2015-2017)
- AHA Scientific Sessions 2008 Best Basic Science Abstract, American Heart Association (2008)
- AHA Scientist Development Award (Mentor), American Heart Association (2015-2019)
- American Lung Association Biomedical Research Grant, American Lung Association (2013-2015)
- American Lung Association Career Development Award, American Lung Association (2008)
- American Lung Association Postdoctoral Fellowship Award, American Lung Association (2006)
- ATS 2007 Travel award, American Thoracic Society (2007)
- ATS travel award, ATS (2009)
- Be HEARD rare disease challenge award, Assay Depot/Sigma (2013-2015)
- BeHeard 2015 Award for LAM Research, Rare Genomics Institute (2016-2017)
- BeHeard Award in PAH, Rare Genomics Institute (2017)
- Best Fellow, University of Colorado-Denver (2003)
- Best Intern in Medicine, Massachusetts General Hospital (2001)
- Beta Beta Beta Award, Beta Beta Beta (1996)
- Cardiovascular Medical Research and Education Fund (CMREF) Educational Grant, The Cardiovascular Medical Research and Education Fund (2019-2020)
- Career Development Program in the Genetics and Genomics of Lung Diseases (K12), NIH (2008)
- Chair, Diversity Subcommittee of the Council Operations Committee, American Heart Association (2020-)
- CHRI Pilot Study on LAM/TSC, Stanford CHRI (2015-2017)
- Co-Chair, Education Committee, Stanford CVI (2020)
- Coherus Innovation Award, Coherus Biosciences (2021-2025)
- Cournand and Comroe Award (mentor), American Heart Association (2014)
- CVI Seed Grant, Cardiovascular Research Institute (2016-2017)
- CVI seed grant, Stanford CVI (2013)
- Distinguished Faculty Fellow, Stanford University (2013)
- Dorothy Dee and Marjorie Helene Boring Trust Award, Cardiovascular Institute (2016-2017)
- Early Career Award, ATS Pulmonary Circulation Assembly (2016)
- Faculty Member, Faculty of 1000, Pulmonary Vascular Diseases (2013)
- Faculty Member, Faculty Row (2013)
- Faculty of 1000 Faculty Member of the Year for Respiratory Disorders, Faculty of 1000 (2014)
- Faculty of 1000 Reviewer of the year, Faculty of 1000 Prime (2013)
- Faculty, AHA Research Leaders Academy, AHA (2017)
- Fellow, American College of Chest Physicians (2012)
- Fellow, American Thoracic Society (2018)
- Fellow, Pulmonary Vascular Research Institute (2008)
- Fellow, American Heart Association, American Heart Association (2013)
- Finalist, BWF award, Burroughs Wellcome Fund (2009)
- Finalist, Young Investigator Award, Stanford University Medical Center-Cardiovascular Institute (2007)
- IM Rosenzweig Junior Investigator award, Pulmonary Fibrosis Foundation (2016-2018)
- InterMune/Genentech Young Faculty Scholar in Pulmonary Fibrosis, Genentech (2015-2017)
- Keystone Symposia Fellowship, Keystone Symposia (2013)
- Manuscript of the Year, Stanford CVI (2019)
- Marquis Who's Who in America, Marquis Who's Who (2016)
- MED223 co-director, Stanford CVI (2019-)
- Member, American Society for Clinical Investigation (ASCI) (2020)
- Member, Sigma Xi Scientific Honor Society (2020)
- Member of the Planning Committee, 2014 Keystone Symposia Series, Keystone Symposia (2013-2015)
- Member, Scientific Research Committee, Pulmonary Hypertension Association (2012-)
- Member-at-large, Cardiopulmonary, Critical Care, Perioperative & Resuscitation Council, American Heart Association (2010-)
- Mentor, CHRI postdoctoral award, Stanford Child Health Research Institute (2015-2018)
- Minority Travel Award, ATS (2010)
- Most Promising Young Profesional 2000, El Nuevo Dia (2000)
- NIH Career Development Award (1 K08 HL105884-01), NIH (7/2012-7/2017)
- NIH R01 HL134776, NIH (2017-2022)
- Oak Foundation Grant, Oak Foundation (2008)
- OCT as a novel tool in the diagnosis of PAH, CBIS (2012-2013)
- Primary Mentor, Hispanic-Serving Health Professions Schools (2015)
- Proof of Concept Award (Mentor), ATS/Pulmonary Hypertension Association (2016-2017)
- Pulmonary Circulation Assembly Project, American Thoracic Society (2016-2017)
- Pulmonary Hypertension Breakthrough Initiative, CMREF (2012-)
- R01HL139664, NIH (2017-2021)
- Research Leaders Academy, American Heart Association (2016)
- Scholar, Harold Amos Career Development Award, Robert Wood Johnson Foundation (2010-2014)
- Stanford-Karolinska Institute Collaborative Award, Swedish Foundation for International Collaboration (2014-2016)
- Summa cum Laude-Biology, University of Puerto Rico (1996)
- Summa cum Laude-Medicine, University of Puerto Rico (2000)
- Supplemental Award to Outstanding K08, Pulmonary Hypertension Association (2012-2017)
- The Role of Angiogenesis in Lung development, Stanford Child Health Research Institute (2014-2016)
- TRAM award, Translational Research and Applied Medicine Program, Stanford University (2012-2013)
- Wall Center Genomics Research Grant, Vera Moulton Wall Center for Pulmonary Vascular Research (2011-2012)
- Who's Who in America, Madison's Who's Who (2007)
- Who's Who in Medicine in America 2007, Marquis Who's Who in America (2007)
- Young Physician Scientist Award, ASCI (2016)
Memberships
- Member at Large, Pulmonary Circulation Assembly, American Thoracic Society (2009 - Present)
- Member at Large, European Respiratory Society (2011 - Present)
- Editorial Board, American Journal of Respiratory and Critical Care Medicine (2012 - Present)
- Scientific Advisory Council, Pulmonary Hypertension Association (2012 - Present)
- Editorial Board, Pulmonary Circulation (2013 - Present)
- Member at Large, 3CPR Council, American Heart Association (2013 - Present)
- Member at large, Early Diagnosis Committee, Pulmonary Hypertension Association (2013 - Present)
- Member, 3CPR Early Career Advisory Committee, American Heart Association (2013 - Present)
- PHA Early Diagnosis Campaign, Pulmonary Hypertension Association (2013 - Present)
- 3CPR Leadership Committee, American Heart Association (2014 - Present)
- AHA Diversity Focus Committee, American Heart Association (2014 - Present)
- Advisory Board Member, Faculty of 1000 (2014 - Present)
- Early Career Committee, American Heart Association (2014 - Present)
- Editorial Board, Faculty of 1000 (2014 - Present)
- Keystone Symposia Scientific Advisory Board, ad-hoc member, Keystone Symposia (2014 - Present)
- Primary Mentor, Hispanic-Serving Health Professions Schools (2014 - Present)
- Ad-Hoc Reviewer, Veni, Netherlands Organisation for Health Research and Development (2015 - Present)
- Assembly Chair for Health Disparities in PAH, American Thoracic Society (2015 - Present)
- Chair, PH Care for All Initiative (2015 - Present)
- Chair, Committee on barriers to PH care for disadvantaged populations, Pulmonary Hypertension Association (2015 - Present)
- Member, 2016 Scientific Sessions planning committee, American Heart Association (2015 - Present)
- Member, planning committee, 2016 International PH Conference and Scientific Sessions (2015 - Present)
- Science to Science Committee, American Heart Association (2015 - Present)
- Vascular BioBP Bsc 2 Peer Review Committee, American Heart Association (2015 - Present)
- Ad-Hoc Reviewer, Agence Nationale de la Recherche (ANR) (2016 - Present)
- Ad-Hoc Reviewer, Dutch Heart Foundation (2016 - Present)
- Ad-Hoc Reviewer, Austrian Science Fund (2016 - Present)
- Advisory Board Member, F1000Research (2016 - Present)
- Member, Keystone Symposia Diversity in Science Committee (2016 - Present)
- Member, Mentor, AWIS (2016 - Present)
- Academic Editor, Plos One (2017 - Present)
- Ad-Hoc Reviewer, Research Lung Foundation, Netherlands (2017 - Present)
- Chair Elect, ATS Pulmonary Circulation AssemblyProgramming Committee, American Thoracic Society (2017 - Present)
- Chair, 2018 PHA Scientific Sessions, Pulmonary Hypertension Association (2017 - Present)
- Member, PVRI Task Force (2017 - Present)
- Member, Science and Clinical Education Lifelong Learning (SCILL), AHA (2017 - Present)
- Editorial Board, Circulation Research (2018 - Present)
- Editorial Board, American Journal of Physiology – Lung Cellular and Molecular Physiology (2018 - Present)
- Member, Diversity and Inclusion Committee, Stanford Department of Medicine (2018 - Present)
- Member, Scientific Leadership Committee, Pulmonary Hypertension Association (2018 - Present)
- Ad-Hoc Reviewer, NHLBI RIBT Committee NHLBI Special Emphasis Panels (2019 - Present)
- Associate Editor, BMC Pulmonary Medicine (2019 - Present)
- Co-chair, Stanford DOM Diversity and Inclusion Committee (2019 - Present)
- Member, NAVBO Educational Committee (2019 - Present)
- Member, National Leadership Council, AHA (2019 - Present)
- Member, Assembly Programs & Program Review Subcommittee, ATS (2019 - Present)
- Member, ATS PC Planning Committee, ATS (2020 - Present)
Administrative Appointments
- Assistant Professor of Medicine, Stanford University (2011 - Present)
- Associate Dean of MD Admissions, Stanford School of Medicine (2024 - Present)
- Co-Chair, CVI Education Committee (2020 - Present)
- Co-Director, Stanford Translational Investigator Program (TIP), Stanford School of Medicine (2016 - 2024)
- Faculty, TRAM (2016 - Present)
- Faculty Member, Stanford Cardiovascular Institute (2011 - Present)
- Faculty Member, Bio-X (2012 - Present)
- Faculty Member, CHRI (2012 - Present)
- Faculty Member, iBioinformatics (2015 - Present)
- Faculty Senator, Stanford University (2018 - Present)
- Member, Student Scholarship Committee (2018 - Present)
- Member, Admissions Committee, Stanford Medical Scientist Training Program (MSTP) (2016 - Present)
- Staff Physician, Adult Pulmonary Hypertension Clinic (2006 - Present)
Publications
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Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation
Hansmann, G., Wagner, R. A., Schellong, S., Perez, V. A. J., Urashima, T., Wang, L., … Rabinovitch, M. (2007). Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. CIRCULATION, 115(10), 1275–84. -
An antiproliferative BMP-2/PPAR gamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension
Hansmann, G., de Jesus Perez, V. A., Alastalo, T.-P., Alvira, C. M., Guignabert, C., Bekker, J. M., … Rabinovitch, M. (2008). An antiproliferative BMP-2/PPAR gamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. JOURNAL OF CLINICAL INVESTIGATION, 118(5), 1846–57. -
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways
Perez, V. A. J., Alastalo, T.-P., Wu, J. C., Axelrod, J. D., Cooke, J. P., Amieva, M., & Rabinovitch, M. (2009). Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. JOURNAL OF CELL BIOLOGY, 184(1), 83–99. -
Angina Associated With Left Main Coronary Artery Compression in Pulmonary Hypertension
Perez, V. A. J., Haddad, F., Vagelos, R. H., Fearon, W., Feinstein, J., & Zamanian, R. T. (2009). Angina Associated With Left Main Coronary Artery Compression in Pulmonary Hypertension. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 28(5), 527–30. -
Cholinergic Modulation of Angiogenesis: Role of the 7 Nicotinic Acetylcholine Receptor
Wu, J. C. F., Chruscinski, A., Perez, V. A. J., Singh, H., Pitsiouni, M., Rabinovitch, M., … Cooke, J. P. (2009). Cholinergic Modulation of Angiogenesis: Role of the 7 Nicotinic Acetylcholine Receptor. JOURNAL OF CELLULAR BIOCHEMISTRY, 108(2), 433–46. -
S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho-Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4
Spiekerkoetter, E., Guignabert, C., Perez, V. D. J., Alastalo, T.-P., Powers, J. M., Wang, L., … Rabinovitch, M. (2009). S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho-Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4. CIRCULATION RESEARCH, 105(7), 639–U37. -
Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay.
Kudelko, K. T., Nadeau, K., Leung, A. N., Liu, J., Haddad, F., Zamanian, R. T., & de Jesus Perez, V. (2010). Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay. Journal of Heart and Lung Transplantation , 29(9), 1071–75. -
Drugs and toxins-associated pulmonary arterial hypertension: lessons learned and challenges ahead.
de Jesus Perez, V., Kudelko, K., Snook, S., & Zamanian, R. T. (2011). Drugs and toxins-associated pulmonary arterial hypertension: lessons learned and challenges ahead. International Journal of Clinical Practice. Supplement, (169), 8–10. -
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
Perez, V. A. J., Ali, Z., Alastalo, T.-P., Ikeno, F., Sawada, H., Lai, Y.-J., … Rabinovitch, M. (2011). BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. JOURNAL OF CELL BIOLOGY, 192(1), 171–88. -
Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension
Chandra, S. M., Razavi, H., Kim, J. M., Agrawal, R., Kundu, R. K., Perez, V. D. J., … Chun, H. J. (2011). Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(4), 814–U212. -
Chronic Thromboembolic Pulmonary Hypertension
Perez, V. A. J., & Zamanian, R. T. (2011). Chronic Thromboembolic Pulmonary Hypertension. NEW ENGLAND JOURNAL OF MEDICINE, 364(17), 1677–77. -
Incidence, Correlates, and Consequences of Acute Kidney Injury in Patients With Pulmonary Arterial Hypertension Hospitalized With Acute Right-Side Heart Failure
Haddad, F., Fuh, E., Peterson, T., Skhiri, M., Kudelko, K. T., Perez, V. D. J., … Zamanian, R. T. (2011). Incidence, Correlates, and Consequences of Acute Kidney Injury in Patients With Pulmonary Arterial Hypertension Hospitalized With Acute Right-Side Heart Failure. JOURNAL OF CARDIAC FAILURE, 17(7), 533–39. -
Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
Alastalo, T.-P., Li, M., Perez, V. D. J., Pham, D., Sawada, H., Wang, J. K., … Rabinovitch, M. (2011). Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. JOURNAL OF CLINICAL INVESTIGATION, 121(9), 3735–46. -
Pulmonary Hypertension Associated With Left Heart Disease: Characteristics, Emerging Concepts, and Treatment Strategies
Haddad, F., Kudelko, K., Mercier, O., Vrtovec, B., Zamanian, R. T., & Perez, V. D. J. (2011). Pulmonary Hypertension Associated With Left Heart Disease: Characteristics, Emerging Concepts, and Treatment Strategies. PROGRESS IN CARDIOVASCULAR DISEASES, 54(2), 154–67. -
Characteristics and Outcome After Hospitalization for Acute Right Heart Failure in Patients With Pulmonary Arterial Hypertension
Haddad, F., Peterson, T., Fuh, E., Kudelko, K. T., Perez, V. D. J., Skhiri, M., … Zamanian, R. T. (2011). Characteristics and Outcome After Hospitalization for Acute Right Heart Failure in Patients With Pulmonary Arterial Hypertension. CIRCULATION-HEART FAILURE, 4(6), 692–99. -
The Intersection of Genes and Environment Development of Pulmonary Arterial Hypertension in a Patient With Hereditary Hemorrhagic Telangiectasia and Stimulant Exposure
Ayala, E., Kudelko, K. T., Haddad, F., Zamanian, R. T., & Perez, V. de J. (2012). The Intersection of Genes and Environment Development of Pulmonary Arterial Hypertension in a Patient With Hereditary Hemorrhagic Telangiectasia and Stimulant Exposure. CHEST, 141(6), 1598–1600. -
Safety and efficacy of transition from systemic prostanoids to inhaled treprostinil in pulmonary arterial hypertension.
de Jesus Perez, V. A., Rosenzweig, E., Rubin, L. J., Poch, D., Bajwa, A., Park, M., … Zamanian, R. T. (2012). Safety and efficacy of transition from systemic prostanoids to inhaled treprostinil in pulmonary arterial hypertension. American Journal of Cardiology, 110(10), 1546–50. -
Loss of adenomatous poliposis coli-a3 integrin interaction promotes endothelial apoptosis in mice and humans.
de Jesus Perez, V. A., Yuan, K., Orcholski, M. E., Sawada, H., Zhao, M., Li, C. G., … Rabinovitch, M. (2012). Loss of adenomatous poliposis coli-a3 integrin interaction promotes endothelial apoptosis in mice and humans. Circulation Research, 111(12), 1551–64. -
MicroRNAs: promising therapeutic targets for the treatment of pulmonary arterial hypertension.
Yuan, K., Orcholski, M., Tian, X., Liao, X., & de Jesus Perez, V. A. (2013). MicroRNAs: promising therapeutic targets for the treatment of pulmonary arterial hypertension. Expert Opinion on Therapeutic Targets, 17(5), 557–64. -
Understanding the pharmacokinetics of oral treprostinil in patients with pulmonary arterial hypertension.
de Jesus Perez, V. A. (2013). Understanding the pharmacokinetics of oral treprostinil in patients with pulmonary arterial hypertension. Journal of Cardiovascular Pharmacology, 61(6), 471–73. -
Coexistence of Primary adenocarcinoma of the lung and Tsukamurella pneumonia: a case report and review of the literature
Coexistence of Primary adenocarcinoma of the lung and Tsukamurella pneumonia: a case report and review of the literature. (2008). Journal of Medical Case Reports, 207(2). -
Making Sense of the Estrogen Paradox in Pulmonary Arterial Hypertension
Making Sense of the Estrogen Paradox in Pulmonary Arterial Hypertension. (2011). American Journal of Respiratory and Critical Care Medicine, 184. -
Development of a recurrent pleural effusion in a patient with pulmonary arterial hypertension treated with imatinib
Development of a recurrent pleural effusion in a patient with pulmonary arterial hypertension treated with imatinib. (2012). Case Reports in Clinical Medicine, 1(2). -
Diagnosis and management of pulmonary hypertension associated with left ventricular diastolic dysfunction
Diagnosis and management of pulmonary hypertension associated with left ventricular diastolic dysfunction. (2012). Pulmonary Circulation, 2(2). -
Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus.
Jiang, X., Hsu, J. L., Tian, W., Yuan, K., Olcholski, M., de Jesus Perez, V., … Nicolls, M. R. (2013). Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus. Journal of Molecular Medicine (Berlin, Germany). -
MiR-133a modulates osteogenic differentiation of vascular smooth muscle cells.
Liao, X.-B. B., Zhang, Z.-Y. Y., Yuan, K., Liu, Y., Feng, X., Cui, R.-R. R., … Yuan, L.-Q. Q. (2013). MiR-133a modulates osteogenic differentiation of vascular smooth muscle cells. Endocrinology. -
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter, E., Tian, X., Cai, J., Hopper, R. K., Sudheendra, D., Li, C. G., … Rabinovitch, M. (2013). FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. Journal of Clinical Investigation, 123(8), 3600–3613. -
A case of recurrent pericardial constriction presenting with severe pulmonary hypertension
A case of recurrent pericardial constriction presenting with severe pulmonary hypertension. (2013). Pulmonary Circulation, 3(2). -
Loss-of BMPR2 is Associated With Abnormal DNA Repair in Pulmonary Arterial Hypertension.
Li, M., Vattulainen, S., Aho, J., Orcholski, M., Rojas, V., Yuan, K., … Alastalo, T.-P. P. (2014). Loss-of BMPR2 is Associated With Abnormal DNA Repair in Pulmonary Arterial Hypertension. American Journal of Respiratory Cell and Molecular Biology. -
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.
Sawada, H., Saito, T., Nickel, N. P., Alastalo, T.-P., Glotzbach, J. P., Chan, R., … Rabinovitch, M. (2014). Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. Journal of Experimental Medicine, 211(2), 263–80. -
Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension
Perez, V. A. J., Yuan, K., Lyuksyutova, M. A., Dewey, F., Orcholski, M. E., Shuffle, E. M., … Zamanian, R. T. (2014). Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 189(10), 1260–72. -
Targeting the Wnt signaling pathways in pulmonary arterial hypertension.
de Jesus Perez, V., Yuan, K., Alastalo, T.-P., Spiekerkoetter, E., & Rabinovitch, M. (2014). Targeting the Wnt signaling pathways in pulmonary arterial hypertension. Drug Discovery Today, 19(8), 1270–76. -
Current Clinical Management of Pulmonary Arterial Hypertension
Zamanian, R. T., Kudelko, K. T., Sung, Y. K., Perez, V. D. J., Liu, J., & Spiekerkoetter, E. (2014). Current Clinical Management of Pulmonary Arterial Hypertension. CIRCULATION RESEARCH, 115(1), 131–47. -
Effectiveness of YouTube as a Source of Medical Information on Heart Transplantation.
Chen, H.-ming, Hu, Z.-K., Zheng, X.-L., Yuan, Z.-S., Xu, Z.-B., Yuan, L.-Q., … Liao, X.-B. (2013). Effectiveness of YouTube as a Source of Medical Information on Heart Transplantation. Interactive Journal of Medical Research, 2(2). -
Pumping it up! Angiogenesis and muscle deconditioning in pulmonary hypertension.
de Jesus Perez, V. A. (2014). Pumping it up! Angiogenesis and muscle deconditioning in pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 190(3), 250–51. -
Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery.
Brunner, N., de Jesus Perez, V. A., Richter, A., Haddad, F., Denault, A., Rojas, V., … Liao, X. (2014). Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery. Pulmonary Circulation, 4(1), 10–24. -
Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis.
Yuan, K., Orcholski, M. E., Panaroni, C., Shuffle, E. M., Huang, N. F., Jiang, X., … de Jesus Perez, V. A. (2015). Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. American Journal of Pathology, 185(1), 69–84. -
Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1
Ali, Z. A., Perez, V. D. J., Yuan, K., Orcholski, M., Pan, S., Qi, W., … Ashley, E. A. (2014). Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. JOURNAL OF CLINICAL INVESTIGATION, 124(12), 5159–74. -
Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection
Jiang, X., Nguyen, T. T., Tian, W., Sung, Y. K., Yuan, K., Qian, J., … Nicolls, M. R. (2015). Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection. AMERICAN JOURNAL OF TRANSPLANTATION, 15(7), 1768–81. -
Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension.
Helenius, M. H., Vattulainen, S., Orcholski, M., Aho, J., Komulainen, A., Taimen, P., … Alastalo, T.-P. (2015). Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology, 308(10), L1046–57. -
Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension.
Chang, Y.-T., Tseng, C.-N., Tannenberg, P., Eriksson, L., Yuan, K., de Jesus Perez, V. A., … Tran-Lundmark, K. (2015). Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension. Cardiovascular Research, 107(1), 20–31. -
Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension.
Haddad, F., Spruijt, O. A., Denault, A. Y., Mercier, O., Brunner, N., Furman, D., … Zamanian, R. T. (2015). Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension. JACC. Cardiovascular Imaging, 8(6), 627–38. -
Optical Coherence Tomography of Pulmonary Arterial Walls in Humans and Pigs (Sus scrofa domesticus).
Brunner, N. W., Zamanian, R. T., Ikeno, F., Mitsutake, Y., Connolly, A. J., Shuffle, E., … de Jesus Perez, V. A. (2015). Optical Coherence Tomography of Pulmonary Arterial Walls in Humans and Pigs (Sus scrofa domesticus). Comparative Medicine, 65(3), 217–24. -
First among Equals: Nerve Growth Factor in the Pathogenesis of Pulmonary Arterial Hypertension.
de Jesus Perez, V. A. (2015). First among Equals: Nerve Growth Factor in the Pathogenesis of Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 192(3), 274–75. -
MicroRNA and Cardiovascular Disease
Liao, X.-B., Perez, V. A. J., Krol, M., Yeh, C.-H., & Yuan, L.-qing. (2015). MicroRNA and Cardiovascular Disease. BIOMED RESEARCH INTERNATIONAL. -
Molecular pathogenesis and current pathology of pulmonary hypertension.
de Jesus Perez, V. A. (2015). Molecular pathogenesis and current pathology of pulmonary hypertension. Heart Failure Reviews. -
Loss of PPAR? in endothelial cells leads to impaired angiogenesis.
Vattulainen-Collanus, S., Akinrinade, O., Li, M., Koskenvuo, M., Li, C. G., Rao, S. P., … Alastalo, T.-P. (2016). Loss of PPAR? in endothelial cells leads to impaired angiogenesis. Journal of Cell Science, 129(4), 693–705. -
PDGF-dependent ß-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension.
Takahashi, J., Orcholski, M., Yuan, K., & de Jesus Perez, V. (2016). PDGF-dependent ß-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension. FEBS Letters, 590(1), 101–9. -
Novel approaches to pulmonary arterial hypertension drug discovery.
Sung, Y. K., Yuan, K., & de Jesus Perez, V. A. (2016). Novel approaches to pulmonary arterial hypertension drug discovery. Expert Opinion on Drug Discovery, 11(4), 407–14. -
Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension.
Yuan, K., Shao, N.-Y., Hennigs, J. K., Discipulo, M., Orcholski, M. E., Shamskhou, E., … de Jesus Perez, V. A. (2016). Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. American Journal of Pathology, 186(9), 2500–2514. -
Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance.
Gebe, J. A., Yadava, K., Ruppert, S. M., Marshall, P., Hill, P., Falk, B. A., … Bollyky, P. L. (2016). Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. American Journal of Respiratory Cell and Molecular Biology, -? -
Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series).
Awad, K. S., West, J. D., de Jesus Perez, V., & Maclean, M. (2016). Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series). Pulmonary Circulation, 6(3), 285–94. -
fibroblast-specific STAT3 signaling.
Balaji, S., Wang, X., King, A., Le, L. D., Bhattacharya, S. S., Moles, C. M., … Keswani, S. G. (2017). fibroblast-specific STAT3 signaling. FASEB Journal , 31(3), 868–81. -
Recent advances in the management of pulmonary arterial hypertension.
Tsai, H., Sung, Y. K., & de Jesus Perez, V. (2016). Recent advances in the management of pulmonary arterial hypertension. F1000Research, 5, 2755-? -
In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse.
Yuan, K., Orcholski, M. E., Huang, N. F., & de Jesus Perez, V. A. (2016). In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse. Journal of Visualized Experiments : JoVE, (118). -
Long-Term Right Ventricular Adaptation to Postnatal Hyperoxia: Too Much of a Good Thing?
Perez, V. inicio A. (2017). Long-Term Right Ventricular Adaptation to Postnatal Hyperoxia: Too Much of a Good Thing? American Journal of Respiratory Cell and Molecular Biology, 56(5), 559–560. -
Drug induced Pulmonary Hypertension: The First 50 Years
de Jesus Perez, V. A. (2017). Drug induced Pulmonary Hypertension: The First 50 Years. Advances in Pulmonary Hypertension, 15(3). -
Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
Tojais, N. F., Cao, A., Lai, Y.-J. J., Wang, L., Chen, P.-I. I., Alcazar, M. A., … Rabinovitch, M. (2017). Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. -
REDUCED CARBOXYLESTERASE 1 IS ASSOCIATED WITH ENDOTHELIAL INJURY IN METHAMPHETAMINE INDUCED PULMONARY ARTERIAL HYPERTENSION.
Orcholski, M. E., Khurshudyan, A., Shamskhou, E. A., Yuan, K., Chen, I. Y., Kodani, S. D., … de Jesus Perez, V. A. (2017). REDUCED CARBOXYLESTERASE 1 IS ASSOCIATED WITH ENDOTHELIAL INJURY IN METHAMPHETAMINE INDUCED PULMONARY ARTERIAL HYPERTENSION. American Journal of Physiology. Lung Cellular and Molecular Physiology, ajplung 00453 2016-? -
Features and Outcomes of Methamphetamine Associated Pulmonary Arterial Hypertension.
Zamanian, R. T., Hedlin, H., Greuenwald, P., Wilson, D. M., Segal, J. I., Jorden, M., … Kawut, S. M. (2017). Features and Outcomes of Methamphetamine Associated Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. -
Health Disparities in Patients with Pulmonary Arterial Hypertension: A Blueprint for Action. An Official American Thoracic Society Statement.
Talwar, A., Garcia, J. G., Tsai, H., Moreno, M., Lahm, T., Zamanian, R. T., … de Jesus Perez, V. (2017). Health Disparities in Patients with Pulmonary Arterial Hypertension: A Blueprint for Action. An Official American Thoracic Society Statement. American Journal of Respiratory and Critical Care Medicine, 196(8), e32–e47. -
The emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.
Frump, A. L., Bonnet, S., de Jesus Perez, V. A., & Lahm, T. (2017). The emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology, ajplung.00374.2017. -
EXPRESS: Endothelial Dysfunction in Pulmonary Arterial Hypertension: An Evolving Landscape (2017 Grover Conference Series).
Ranchoux, B., Harvey, L. D., Ayon, R. J., Babicheva, A., Bonnet, S., Chan, S. Y., … Perez, V. inicio A. (2017). EXPRESS: Endothelial Dysfunction in Pulmonary Arterial Hypertension: An Evolving Landscape (2017 Grover Conference Series). Pulmonary Circulation, 2045893217752912. -
DRUG INDUCED PULMONARY ARTERIAL HYPERTENSION: A PRIMER FOR CLINICIANS AND SCIENTISTS.
Orcholski, M. E., Yuan, K., Rajasingh, C., Tsai, H., Shamskhou, E. A., Dhillon, N. K., … de Jesus Perez, V. A. (2018). DRUG INDUCED PULMONARY ARTERIAL HYPERTENSION: A PRIMER FOR CLINICIANS AND SCIENTISTS. American Journal of Physiology. Lung Cellular and Molecular Physiology. -
Career Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association.
Agarwal, S., Spiekerkoetter, E., Austin, E. D., de Jesus Perez, V., Dezfulian, C., Maron, B. A., … Perman, S. M. (2018). Career Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association. Circulation Research, 122(10), 1330–33. -
Methamphetamine and the risk of pulmonary arterial hypertension.
Ramirez, R. L., Perez, V. D., & Zamanian, R. T. (2018). Methamphetamine and the risk of pulmonary arterial hypertension. Current Opinion in Pulmonary Medicine. -
Pulmonary Vascular Complications of Liver Disease.
Lam, K., & de Jesus Perez, V. (2018). Pulmonary Vascular Complications of Liver Disease. American Journal of Respiratory and Critical Care Medicine, 198(3), P5–P6. -
Stimulants and Pulmonary Arterial Hypertension: An Update
Ramirez III, R., de Jesus Perez, V., & Zamanian, R. (2018). Stimulants and Pulmonary Arterial Hypertension: An Update. Advances in Pulmonary Hypertension, 17(2). -
EMAPII: A Key Player in HIV-Nef Induced Pulmonary Vasculopathy.
Shamskhou, E. A., Verghese, L., Yuan, K., & De Jesus Perez, V. A. (2018). EMAPII: A Key Player in HIV-Nef Induced Pulmonary Vasculopathy. American Journal of Respiratory Cell and Molecular Biology. -
PH Roundtable: Pulmonary Hypertension Roundtable: Clinical Experiences With Drug- and Toxin-Related PH
Bartolome, S., Zamanian, R., de Jesus Perez, V., & Chin, K. (2018). PH Roundtable: Pulmonary Hypertension Roundtable: Clinical Experiences With Drug- and Toxin-Related PH. Advances in Pulmonary Hypertension, 17(2). -
EXPRESS: Low-Grade Albuminuria in Pulmonary Arterial Hypertension.
Nickel, N., Perez, V. inicio A., Fessel, J. P., Cogan, J., Hamid, R., West, J. D., … Austin, E. (2019). EXPRESS: Low-Grade Albuminuria in Pulmonary Arterial Hypertension. Pulmonary Circulation, 2045894018824564. -
A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration.
Das, S., Goldstone, A. B., Wang, H., Farry, J., D'Amato, G., Paulsen, M. J., … Red-Horse, K. (2019). A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration. Cell. -
Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice.
Shamskhou, E. A., Kratochvil, M. J., Orcholski, M. E., Nagy, N., Kaber, G., Steen, E., … De Jesus Perez, V. A. (2019). Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice. Biomaterials, 203, 52–62. -
New and Emerging Therapies for Pulmonary Arterial Hypertension.
Spiekerkoetter, E., Kawut, S. M., & de Jesus Perez, V. A. (2019). New and Emerging Therapies for Pulmonary Arterial Hypertension. Annual Review of Medicine, 70, 45–59. -
Inducible pluripotent stem cells and pulmonary arterial hypertension: the future is now!
Lopez, M. R., & de Jesus Perez, V. (2017). Inducible pluripotent stem cells and pulmonary arterial hypertension: the future is now! Stem Cell Investigation, 4, 53. -
MicroRNA and Cardiovascular Disease 2016.
Yuan, L.-Q. Q., de Jesus Perez, V., Liao, X.-B. B., Król, M., & Yeh, C.-H. H. (2017). MicroRNA and Cardiovascular Disease 2016. BioMed Research International, 2017, 3780513. -
EXPRESS: Myocardial Bridge - An Unrecognized Cause of Chest Pain in Pulmonary Arterial Hypertension.
Rajmohan, D., Sung, Y. K., Kudelko, K., Perez, V. inicio A., Haddad, F., Tremmel, J., … Spiekerkoetter, E. F. (2019). EXPRESS: Myocardial Bridge - An Unrecognized Cause of Chest Pain in Pulmonary Arterial Hypertension. Pulmonary Circulation, 2045894019860738. -
Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension
Yuan, K., Shamskhou, E. A., Orcholski, M. E., Nathan, A., Reddy, S., Honda, H., … Perez, V. A. de J. (2019). Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension. CIRCULATION, 139(14), 1710–24. -
The 6th World Symposium on Pulmonary Hypertension: what's old is new.
Condon, D. F., Nickel, N. P., Anderson, R., Mirza, S., & de Jesus Perez, V. A. (2019). The 6th World Symposium on Pulmonary Hypertension: what's old is new. F1000Research, 8. -
EpiHope for the Treatment of Pulmonary Arterial Hypertension: Selective vs Non-selective BET Inhibition.
Pullamsetti, S. S., & de Jesus Perez, V. A. (2019). EpiHope for the Treatment of Pulmonary Arterial Hypertension: Selective vs Non-selective BET Inhibition. American Journal of Respiratory and Critical Care Medicine. -
BEYOND THE LUNGS: SYSTEMIC MANIFESTATIONS OF PULMONARY ARTERIAL HYPERTENSION.
Nickel, N. P., Yuan, K., Dorfmuller, P., Provencher, S., Lai, Y.-C. C., Bonnet, S., … de Jesus Perez, V. A. (2019). BEYOND THE LUNGS: SYSTEMIC MANIFESTATIONS OF PULMONARY ARTERIAL HYPERTENSION. American Journal of Respiratory and Critical Care Medicine. -
Clinical Outcomes of Inferior Vena Cava Filter in Complicated Pulmonary Embolism
Htun, Z. M., Gul, M. H., Rigdon, J., & de Jesus Perez, V. A. (2019). Clinical Outcomes of Inferior Vena Cava Filter in Complicated Pulmonary Embolism. Pulmonary Circulation, 2045894019882636. -
Methamphetamine use association with pulmonary diseases: a retrospective investigation of hospital discharges in California from 2005 to 2011
Tsai, H., Lee, J., Hedlin, H., Zamanian, R., & de Jesus Perez, V. (2019). Methamphetamine use association with pulmonary diseases: a retrospective investigation of hospital discharges in California from 2005 to 2011. European Respiratory Journal Open Research. -
Diagnosis and Management of Pulmonary Hypertension in the Modern Era: Insights from the 6th World Symposium
Thomas, C., Anderson, R., Condon, D., & de Jesus Perez, V. (2019). Diagnosis and Management of Pulmonary Hypertension in the Modern Era: Insights from the 6th World Symposium. Pulmonary Therapy. -
Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension.
Karnes, J. H., Wiener, H. W., Schwantes-An, T.-H. H., Natarajan, B., Sweatt, A. J., Chaturvedi, A., … Desai, A. A. (2020). Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. -
Systemic hypoxia led to little retinal neuronal loss and dramatic optic nerve glial response.
Mesentier Louro, L. A., Shariati, M. A., Dalal, R., Camargo, A., Kumar, V., Shamskhou, E. A., … Liao, Y. J. (2020). Systemic hypoxia led to little retinal neuronal loss and dramatic optic nerve glial response. Experimental Eye Research, 107957. -
Diagnosis and Management of Pulmonary Hypertension in the Modern Era: Insights from the 6th World Symposium.
Thomas, C. A., Anderson, R. J., Condon, D. F., & de Jesus Perez, V. A. (2019). Diagnosis and Management of Pulmonary Hypertension in the Modern Era: Insights from the 6th World Symposium. Pulmonary Therapy. -
Mural Cell SDF1 Signaling is Associated with the Pathogenesis of Pulmonary Arterial Hypertension.
Yuan, K., Liu, Y., Zhang, Y., Nathan, A., Tian, W., Yu, J., … de Jesus Perez, V. A. (2020). Mural Cell SDF1 Signaling is Associated with the Pathogenesis of Pulmonary Arterial Hypertension. American Journal of Respiratory Cell and Molecular Biology. -
Drug- and toxin-induced pulmonary arterial hypertension: Current state of the literature
Ramirez III, R., Thomas, C., Anderson, R., Bernardo, R., Al-Motarreb, A., Al-Suwaidi, J., … de Jesus Perez, V. (2020). Drug- and toxin-induced pulmonary arterial hypertension: Current state of the literature. Global Cardiology Science and Practice, 2019(3). -
THE CANCER HYPOTHESIS OF PULMONARY ARTERIAL HYPERTENSION: THE NEXT TEN YEARS.
Condon, D., Agarwal, S., Chakraborty, A., & de Jesus Perez, V. A. (2020). THE CANCER HYPOTHESIS OF PULMONARY ARTERIAL HYPERTENSION: THE NEXT TEN YEARS. American Journal of Physiology. Lung Cellular and Molecular Physiology. -
Hiding in Plain Sight: The Basement Membrane in Pulmonary Vascular Remodeling.
Chakraborty, A., & de Jesus Perez, V. A. (2020). Hiding in Plain Sight: The Basement Membrane in Pulmonary Vascular Remodeling. American Journal of Respiratory Cell and Molecular Biology. -
ANATOMIC, GENETIC AND FUNCTIONAL PROPERTIES OF THE RETINAL CIRCULATION IN PULMONARY HYPERTENSION
Nickel, N. P., Shamskhou, E. A., Razeen, M., Condon, D., Messentier, L., Dubra, A., … de Jesus Perez, V. A. (2020). ANATOMIC, GENETIC AND FUNCTIONAL PROPERTIES OF THE RETINAL CIRCULATION IN PULMONARY HYPERTENSION. Pulmonary Circulation. -
Outpatient Inhaled Nitric Oxide in a Patient with Vasoreactive IPAH and COVID-19 Infection.
Zamanian, R. T., Pollack, C. V., Gentile, M. A., Rashid, M., Fox, J. C., Mahaffey, K. W., & de Jesus Perez, V. (2020). Outpatient Inhaled Nitric Oxide in a Patient with Vasoreactive IPAH and COVID-19 Infection. American Journal of Respiratory and Critical Care Medicine. -
Perspectives on Cardiopulmonary Critical Care for COVID-19 Patients: From Members of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation.
Maron, B. A., Gladwin, M. T., Bonnet, S., De Jesus Perez, V., Perman, S. M., Yu, P. B., & Ichinose, F. (2020). Perspectives on Cardiopulmonary Critical Care for COVID-19 Patients: From Members of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. Journal of the American Heart Association, e017111. -
Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-Mediated Regulation of PDGFRß.
Zehendner, C. M., Valasarajan, C., Werner, A., Boeckel, J.-N. N., Bischoff, F. C., John, D., … Pullamsetti, S. S. (2020). Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-Mediated Regulation of PDGFRß. American Journal of Respiratory and Critical Care Medicine. -
Pulmonary Vein Stenosis and Pulmonary Hypertension Following a Catheter-Based Radiofrequency Ablation for Atrial Fibrillation: A Case Report.
Thomas, C. A., Cruz Morel, K. J., Viswanathan, M. N., & de Jesus Perez, V. A. (2020). Pulmonary Vein Stenosis and Pulmonary Hypertension Following a Catheter-Based Radiofrequency Ablation for Atrial Fibrillation: A Case Report. The American Journal of Case Reports, 21, e924709. -
Pulmonary Vascular Fellowship Training to Promote Excellence in PH Clinical Care: The Stanford Perspective.
Kudelko, K., Zamanian, R., & de Jesus Perez, V. (2020). Pulmonary Vascular Fellowship Training to Promote Excellence in PH Clinical Care: The Stanford Perspective. American College of Cardiology (Acc.org). -
Hyaluronan is abundant in COVID-19 respiratory secretions.
Kaber, G., Kratochvil, M. J., Burgener, E. B., Peltan, E. L., Barlow, G., Yang, S., … Bollyky, P. L. (2020). Hyaluronan is abundant in COVID-19 respiratory secretions. MedRxiv : the Preprint Server for Health Sciences. -
Puerto Rico Health System Resilience After Hurricane Maria: Implications for Disaster Preparedness in the COVID-19 Era.
Rios, C., Ling, E., Rivera Gutierrez, R., Gonzalez, J., Bruce, J., Barry, M., & de Jesus Perez, V. (2020). Puerto Rico Health System Resilience After Hurricane Maria: Implications for Disaster Preparedness in the COVID-19 Era. MedRxiv : the Preprint Server for Health Sciences. -
Clinical Differences and Outcomes between Methamphetamine-Associated and Idiopathic Pulmonary Arterial Hypertension in the PHAR.
Kolaitis, N. A., Zamanian, R. T., de Jesus Perez, V. A., Badesch, D. B., Benza, R. L., Burger, C. D., … De Marco, T. (2020). Clinical Differences and Outcomes between Methamphetamine-Associated and Idiopathic Pulmonary Arterial Hypertension in the PHAR. Annals of the American Thoracic Society. -
In Defense of the Nucleus: NUDT1 and Oxidative DNA Damage in Pulmonary Arterial Hypertension.
Agarwal, S., & de Jesus Perez, V. A. (2020). In Defense of the Nucleus: NUDT1 and Oxidative DNA Damage in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. -
Racial and ethnic disparities in PAH
Cruz Morel, K., Talwar, A., & de Jesus Perez, V. (2020). Racial and ethnic disparities in PAH. Pulmonary Hypertension: Controversial and Emerging Topics (pp. 197–202). Springer Nature. -
Portopulmonary Hypertension: From Bench to Bedside
Thomas, C., Ginskii, V., de Jesus Perez, V., & Sahay, S. (2020). Portopulmonary Hypertension: From Bench to Bedside. Frontiers in Medicine. -
Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction.
Bernardo, R. J., Haddad, F., Couture, E. J., Hansmann, G., de Jesus Perez, V. A., Denault, A. Y., … Amsallem, M. (2020). Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction. Cardiovascular Diagnosis and Therapy, 10(5), 1580–1603. -
Targeted Proteomics of Right Heart Adaptation to Pulmonary Arterial Hypertension.
Amsallem, M., Sweatt, A. J., Arthur Ataam, J., Guihaire, J., Lecerf, F., Lambert, M., … Zamanian, R. T. (2020). Targeted Proteomics of Right Heart Adaptation to Pulmonary Arterial Hypertension. The European Respiratory Journal. -
Pulmonary Arterial Hypertension Secondary to Drugs and Toxins.
Ramirez, R. L., Pienkos, S. M., de Jesus Perez, V., & Zamanian, R. T. (2021). Pulmonary Arterial Hypertension Secondary to Drugs and Toxins. Clinics in Chest Medicine, 42(1), 19–38. -
Hypoxia-induced inflammation: Profiling the first 24-hour posthypoxic plasma and central nervous system changes.
Mesentier-Louro, L. A., Rangel, B., Stell, L., Shariati, M. A., Dalal, R., Nathan, A., … Liao, Y. J. (2021). Hypoxia-induced inflammation: Profiling the first 24-hour posthypoxic plasma and central nervous system changes. PloS One, 16(3), e0246681. -
No Good Deed Goes Unpunished: Mitomycin-Induced Pulmonary Venoocclusive Disease and Cancer.
De Jesus Perez, V. A., & Zamanian, R. T. (2021). No Good Deed Goes Unpunished: Mitomycin-Induced Pulmonary Venoocclusive Disease and Cancer. Chest, 159(3), 910–11. -
Distinct Types of Plexiform Lesions Identified by Synchrotron-Based Phase Contrast Micro-CT.
Westoo, C., Norvik, C. C., Peruzzi, N., van der Have, O., Lovric, G., Jeremiasen, I., … Tran-Lundmark, K. (2021). Distinct Types of Plexiform Lesions Identified by Synchrotron-Based Phase Contrast Micro-CT. American Journal of Physiology. Lung Cellular and Molecular Physiology. -
Novel TNIP2 and TRAF2 Variants Are Implicated in the Pathogenesis of Pulmonary Arterial Hypertension
Pienkos, S., Gallego, N., Condon, D. F., Cruz-Utrilla, A., Ochoa, N., Nevado, J., … de Jesus Perez, V. A. (2021). Novel TNIP2 and TRAF2 Variants Are Implicated in the Pathogenesis of Pulmonary Arterial Hypertension. FRONTIERS IN MEDICINE, 8, 625763. -
Lung Pericytes in Pulmonary Vascular Physiology and Pathophysiology.
Yuan, K., Agarwal, S., Chakraborty, A., Condon, D. F., Patel, H., Zhang, S., … de Jesus Perez, V. A. (2021). Lung Pericytes in Pulmonary Vascular Physiology and Pathophysiology. Comprehensive Physiology, 11(3), 2227–2247. -
Immunoprofiling of Nonarteritic Anterior Ischemic Optic Neuropathy.
Mesentier-Louro, L. A., Stell, L., Yan, Y., Montague, A. A., de Jesus Perez, V., & Liao, Y. J. (2021). Immunoprofiling of Nonarteritic Anterior Ischemic Optic Neuropathy. Translational Vision Science & Technology, 10(8), 17. -
CHK yourself, before you wreck yourself: targeting the DNA damage response in secondary pulmonary hypertension.
Bryant, A., & de Jesus Perez, V. (2021). CHK yourself, before you wreck yourself: targeting the DNA damage response in secondary pulmonary hypertension. Thorax. -
"NOVEL MECHANISMS TARGETED BY DRUG TRIALS IN PULMONARY ARTERIAL HYPERTENSION".
Condon, D. F., Agarwal, S., Chakraborty, A., Auer, N., Vazquez, R., Patel, H., … Condon, D. F. (2021). "NOVEL MECHANISMS TARGETED BY DRUG TRIALS IN PULMONARY ARTERIAL HYPERTENSION". Chest. -
Recommended Reading from the Pulmonary and Critical Care Medicine Fellowship Program at Stanford University Medical Center.
Glinskii, V., Lyn, R., Thomas, C., & de Jesus Perez, V. A. (2021). Recommended Reading from the Pulmonary and Critical Care Medicine Fellowship Program at Stanford University Medical Center. American Journal of Respiratory and Critical Care Medicine. -
Editorial: Pulmonary Hypertension in the Modern Era: Science and Clinical Practice.
Goncharova, E. A., Bogaard, H. J., & de Jesus Perez, V. A. (2021). Editorial: Pulmonary Hypertension in the Modern Era: Science and Clinical Practice. Frontiers in Medicine, 8, 785181. -
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective.
Halawa, S., Pullamsetti, S. S., Bangham, C. R., Stenmark, K. R., Dorfmuller, P., Frid, M. G., … Yacoub, M. H. (2021). Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective. Nature Reviews. Cardiology. -
Prescription Patterns for Pulmonary Vasodilators in the Treatment of Pulmonary Hypertension Associated With Chronic Lung Diseases: Insights From a Clinician Survey.
Thomas, C. A., Lee, J., Bernardo, R. J., Anderson, R. J., Glinskii, V., Sung, Y. K., … de Jesus Perez, V. (1800). Prescription Patterns for Pulmonary Vasodilators in the Treatment of Pulmonary Hypertension Associated With Chronic Lung Diseases: Insights From a Clinician Survey. Frontiers in Medicine, 8, 764815. -
Hispanic Ethnicity and Social Determinants of Health in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry.
Bernardo, R. J., Lu, D., Ramirez, R. L., Hedlin, H., Kawut, S. M., Bull, T., … de Jesus Perez, V. A. (2022). Hispanic Ethnicity and Social Determinants of Health in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry. Annals of the American Thoracic Society. -
An evidence appraisal of heart organoids in a dish and commensurability to human heart development in vivo.
Thomas, D., de Jesus Perez, V. A., & Sayed, N. (2022). An evidence appraisal of heart organoids in a dish and commensurability to human heart development in vivo. BMC Cardiovascular Disorders, 22(1), 122. -
Health disparity is a global issue: Understanding Latin America
Gomberg-Maitland, M., & Perez, V. de J. (2022). Health disparity is a global issue: Understanding Latin America. PULMONARY CIRCULATION, 12(1), e12049. -
Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
De Jong, H. N., Dewey, F. E., Cordero, P., Victorio, R. A., Kirillova, A., Huang, Y., … Ashley, E. A. (2022). Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy. Circulation. Genomic and Precision Medicine, 101161CIRCGEN121003563. -
Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections.
Kratochvil, M. J., Kaber, G., Demirdjian, S., Cai, P. C., Burgener, E. B., Nagy, N., … Bollyky, P. L. (2022). Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections. JCI Insight, 7(12). -
Prioritizing Equity and Diversity in Academic Medicine Faculty Recruitment and Retention
Ajayi, A. A., Rodriguez, F., & de Jesus Perez, V. (2021). Prioritizing Equity and Diversity in Academic Medicine Faculty Recruitment and Retention. JAMA HEALTH FORUM, 2(9). -
Cardiopulmonary disease as sequelae of long-term COVID-19: Current perspectives and challenges.
Oliveira, R. K., Nyasulu, P. S., Iqbal, A. A., Hamdan Gul, M., Ferreira, E. V., Leclair, J. W., … de Jesus Perez, V. (2022). Cardiopulmonary disease as sequelae of long-term COVID-19: Current perspectives and challenges. Frontiers in Medicine, 9, 1041236. -
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities.
Kumar, R., Aktay-Cetin, Ö., Craddock, V., Morales-Cano, D., Kosanovic, D., Cogolludo, A., … Dhillon, N. K. (2023). Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities. PLoS Pathogens, 19(1), e1011063. -
The social and economic disadvantage in pulmonary hypertension: A work (still) in progress.
Bernardo, R. J., & de Jesus Perez, V. (2023). The social and economic disadvantage in pulmonary hypertension: A work (still) in progress. Pulmonary Circulation, 13(1), e12196. -
Editorial: Pulmonary hypertension in the modern era: Science and clinical practice, Volume II.
Bogaard, H. J., Goncharova, E. A., & de Jesus Perez, V. A. (2023). Editorial: Pulmonary hypertension in the modern era: Science and clinical practice, Volume II. Frontiers in Medicine, 10, 1136157. -
Predictors and outcomes of acute pulmonary embolism in COVID-19; insights from US National COVID cohort collaborative.
Gul, M. H., Htun, Z. M., de Jesus Perez, V., Suleman, M., Arshad, S., Imran, M., … Morris, P. E. (2023). Predictors and outcomes of acute pulmonary embolism in COVID-19; insights from US National COVID cohort collaborative. Respiratory Research, 24(1), 59. -
Effects of biomechanical and biochemical stimuli on angio- and vasculogenesis in a complex microvasculature-on-chip.
Ferrari, D., Sengupta, A., Heo, L., Petho, L., Michler, J., Geiser, T., … Guenat, O. T. (2023). Effects of biomechanical and biochemical stimuli on angio- and vasculogenesis in a complex microvasculature-on-chip. IScience, 26(3), 106198. -
C-type natriuretic peptide-cGMP signalling attenuates hyperproliferation of lung pericytes from patients with Pulmonary Hypertension
Dabral, S., Noh, M., Krebes, L., Abesser, M., Voelker, K., Novoyatleva, T., … Kuhn, M. (2023). C-type natriuretic peptide-cGMP signalling attenuates hyperproliferation of lung pericytes from patients with Pulmonary Hypertension. JOURNAL OF TRANSLATIONAL MEDICINE. BMC. -
Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH.
Ali, M. K., Zhao, L., Perez, V. de J., Nicolls, M. R., & Spiekerkoetter, E. F. (2023). Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH. BioRxiv : the Preprint Server for Biology. -
WNT7A deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.
Chakraborty, A., Nathan, A., Orcholski, M., Agarwal, S., Shamskhou, E. A., Auer, N., … de Jesus Perez, V. A. (2023). WNT7A deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. The European Respiratory Journal. -
C-type natriuretic peptide-cGMP signalling attenuates hyperproliferation of lung pericytes from patients with Pulmonary Hypertension
Dabral, S., Noh, M., Krebes, L., Abesser, M., Voelker, K., Novoyatleva, T., … Kuhn, M. (2023). C-type natriuretic peptide-cGMP signalling attenuates hyperproliferation of lung pericytes from patients with Pulmonary Hypertension. JOURNAL OF TRANSLATIONAL MEDICINE. BMC. -
UnWNTing the Heart: Targeting WNT Signaling in Pulmonary Arterial Hypertension.
Goncharova, E. A., Kudryashova, T. V., de Jesus Perez, V. A., & Rafikova, O. (2023). UnWNTing the Heart: Targeting WNT Signaling in Pulmonary Arterial Hypertension. Circulation Research, 132(11), 1486–1488. -
Access to Medically Necessary Reproductive Care for Individuals with Pulmonary Hypertension.
Sonntag, E., Akgun, K. M., Bag, R., Rosensweig, E. B., Bernardo, R. J., Burnetti, C., … Hemnes, A. R. (2023). Access to Medically Necessary Reproductive Care for Individuals with Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. -
Health Care Disparities in Pulmonary Arterial Hypertension.
Bernardo, R. J., & de Jesus Perez, V. A. (2023). Health Care Disparities in Pulmonary Arterial Hypertension. Clinics in Chest Medicine, 44(3), 543–554. -
Seven Additional Patients with SOX17 Related Pulmonary Arterial Hypertension and Review of the Literature.
Gallego-Zazo, N., Miranda-Alcaraz, L., Cruz-Utrilla, A., Del Cerro Marín, M. J., Álvarez-Fuente, M., Del Mar Rodríguez Vázquez Del Rey, M., … Tenorio-Castano, J. (2023). Seven Additional Patients with SOX17 Related Pulmonary Arterial Hypertension and Review of the Literature. Genes, 14(10). -
Pericytes contribute to pulmonary vascular remodeling via HIF2a signaling.
Kim, H., Liu, Y., Kim, J., Kim, Y., Klouda, T., Fisch, S., … Yuan, K. (2024). Pericytes contribute to pulmonary vascular remodeling via HIF2a signaling. EMBO Reports. -
Endothelial fatty acid-binding proteins contribute to the pathogenesis of pulmonary hypertension.
Liu, B., Yi, D., Li, S., Ramirez, K., Xia, X., Cao, Y., … Dai, Z. (2024). Endothelial fatty acid-binding proteins contribute to the pathogenesis of pulmonary hypertension. BioRxiv : the Preprint Server for Biology. -
Precision Solutions: A Strategy to Improve Medical Care for Patients With Pulmonary Hypertension in Latin America.
Orozco-Levi, M., & de Jesús Pérez, V. (2024). Precision Solutions: A Strategy to Improve Medical Care for Patients With Pulmonary Hypertension in Latin America. Chest, 165(3), 669–672. -
Constructing the Framework for Disease Modification in Pulmonary Arterial Hypertension.
Zamanian, R. T., Weatherald, J., Sweatt, A. J., Hemnes, A., Rashid, M., Psotka, M. A., … de Jesus Perez, V. (2024). Constructing the Framework for Disease Modification in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. -
VIEWING PULMONARY HYPERTENSION THROUGH A PEDIATRIC LENS.
Agarwal, S., Fineman, J., Cornfield, D. N., Alvira, C. M., Zamanian, R. T., Goss, K., … de Jesús Pérez, V. (2024). VIEWING PULMONARY HYPERTENSION THROUGH A PEDIATRIC LENS. The European Respiratory Journal.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Practice Locations
Chest Clinic in Palo Alto Stanford, CA
Stanford, CA
Chest Clinic in Palo Alto
300 Pasteur Drive, 1st Floor, Room A175
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Important Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Patient Reviews
(17 reviews)
They are very good thanks.
I have had a very good experience.
We loved Dr. Perez (pulmonary). He explained everything to see and was concerned & helpful with my husband's condition.
My MD fellow was a lovely man. But he spoke in such a soft voice I could hardly hear him. I wear hearing aids.
Excellent.
Assistant and Dr. Perez very good - not rushed. Explained my condition and seriousness.
Dr. Perez is outstanding. Answers all questions. Explanations - great. Puts patient at ease Dr. Perez truly cares about patients.
He was very clear about everything, explained everything well and listened to all my questions.
Excellent. I can tell Dr. Perez found his passion.
One of my best doctors all around.
I saw Dr. de Jesus Perez - He was caring & helpful. Thank you.
A lot of friendliness and patience toward me excellent doctors. Thank you for all your care.
Dr. de Jesus Perez is the best. He explains everything very clearly. Always has a smile and seems a very professional and happy person. I really like his as a doctor (the best).
Dr. de Jesus Perez is the reason I'm here today. Thank you!
Dr. de Jesus Perez excellent & very informative. I really appreciated all the information he gave me -
Excellent.
Doctor Perez is my best guardian angel. He helps me to survive my serious illness. He so wonderful.
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Referring Physicians
PHYSICIAN HELPLINE
Phone: 1-866-742-4811
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Stanford Health Care provides comprehensive services to refer and track patients, as well as the latest information and news for physicians and office staff. For help with all referral needs and questions, visit Referral Information.
You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
- Send referrals online
- Place radiology and lab orders
- View referral status
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