Professional Summary
Education & Certifications
- Fellowship: Stanford University Hematology and Oncology Fellowship (2006) CA
- Medical Education: Albany Medical College Office of the Registrar (1998) NY
- Board Certification: American Board of Internal Medicine, Medical Oncology (2004)
- Board Certification: American Board of Internal Medicine, Internal Medicine (2001)
- Residency: Warren Alpert Medical School Brown University (2001) RI
- Internship: Warren Alpert Medical School Brown University (1999) RI
- A.B., Harvard College, Biophysics (1994)
Honors & Awards
- Career Development Award, ConquerCancer/ASCO (2016-2019)
- Center for Cancer Nanotechnology Excellence: leader of the Clinical Translational Core, NIH/NCI (2015-2020)
- Dean's Fellowship, Stanford School of Medicine (April 2004- March 2005)
- Developmental Cancer Research Award, Stanford Cancer Institute (September 2011-August 2012)
- Early Detection of Hereditary Renal Cancer (RCC) Pilot Grant, International Alliance for Cancer Early Detection (June 2020-May 2021)
- Innovation Award, Stanford Cancer Institute (2014-2016)
- K23 Career Development Award, NIH/NCI (July 2010-June 2015)
- R21: Analysis of CTCs for Early Prediction of Response to Treatment in RCC, NIH/NCI (2014-2016)
- R21: Nanoscale proteomic profiles of hypoxia pathways to develop biomarkers of renal cell carcinoma, NIH/NCI (August 2012-July 2014)
- Research Fellowship, Lymphoma Research Foundation (July 2004-June 2006)
- Special Fellow in Clinical Research, Leukemia and Lymphoma Society (July 2006-June 2009)
- TRAM Renewal Grant: Development of blood biomarkers for diagnosis and monitoring of kidney cancer, Stanford Department of Medicine (October 2012-August 2013)
- Translational Research and Applied Medicine Program (TRAM) Pilot Grant, Stanford Department of Medicine (October 2011-September 2012)
Administrative Appointments
- Associate Member, Stanford Cancer Institute Translational Oncology Program (2008 - Present)
- Clinical Mentor, Stanford Molecular Imaging Scholars Program (2010 - Present)
- co-Director, Translational Investigator Program, Department of Medicine, Stanford School of Medicine (2022 - Present)
- Director, "Frontiers in Cancer Clinical Translation" Seminar Series, Division of Oncology, Stanford School of Medicine (2020 - Present)
- Faculty Fellow, ChemH [Chemistry, Engineering & Medicine for Human Health Institute] (2018 - Present)
- Faculty Member, Canary Center, Stanford Radiology (2017 - Present)
- Founding Advisor, Stanford Association for Multidisciplinary Medicine and Science (2008 - 2013)
- Inteviewer, Stanford School of Medicine Internal Medicine Residency (2011 - Present)
- Member, Stanford Lymphoma Disease Management Group (2005 - 2013)
- Member, Stanford Kidney Cancer Research Group (2011 - Present)
- Member, Stanford BioX Program (2016 - Present)
- Research Mentor, NIH/NIDDK Short term education program for under-represented persons (2011 - 2011)
- Research Mentor, Canary Cancer Research Education Summer Training (CREST) Program (2019 - Present)
Publications
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p53 mutations do not predict response to paclitaxel in metastatic nonsmall cell lung carcinoma
King, T. C., Akerley, W., Fan, A. C., Moore, T., Mangray, S., Chen, M. H., & Safran, H. (2000). p53 mutations do not predict response to paclitaxel in metastatic nonsmall cell lung carcinoma. CANCER, 89(4), 769–773. -
Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer
Giuriato, S., Rabin, K., Fan, A. C., Shachaf, C. M., & Felsher, D. W. (2004). Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer. SEMINARS IN CANCER BIOLOGY, 14(1), 3–11. -
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch
Giuriato, S., Ryeom, S., Fan, A. C., Bachireddy, P., Lynch, R. C., Rioth, M. J., … Felsher, D. W. (2006). Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(44), 16266–71. -
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis
Shachaf, C. M., Perez, O. D., Youssef, S., Fan, A. C., Elchuri, S., Goldstein, M. J., … Felsher, D. W. (2007). Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. BLOOD, 110(7), 2674–84. -
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
Wu, C.-H., van Riggelen, J., Yetil, A., Fan, A. C., Bachireddy, P., & Felsher, D. W. (2007). Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(32), 13028–33. -
Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas
Tran, P. T., Fan, A. C., Bendapudi, P. K., Koh, S., Komatsubara, K., Chen, J., … Felsher, D. W. (2008). Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas. PLOS ONE, 3(5). -
A quantitative PCR method to detect blood microRNAs associated with tumorigenesis in transgenic mice
Fan, A. C., Goldrick, M. M., Ho, J., Liang, Y., Bachireddy, P., & Felsher, D. W. (2008). A quantitative PCR method to detect blood microRNAs associated with tumorigenesis in transgenic mice. MOLECULAR CANCER, 7. -
Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds
Kampa, K. M., Acoba, J. D., Chen, D., Gay, J., Lee, H., Beemer, K., … Lopez, C. D. (2009). Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(11), 4390–95. -
Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens
Fan, A. C., Deb-Basu, D., Orban, M. W., Gotlib, J. R., Natkunam, Y., O'Neill, R., … Felsher, D. W. (2009). Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens. NATURE MEDICINE, 15(5), 566–71. -
Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy
Liu, Z., Fan, A. C., Rakhra, K., Sherlock, S., Goodwin, A., Chen, X., … Dai, H. (2009). Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(41), 7668–72. -
Definition of an Enhanced Immune Cell Therapy in Mice That Can Target Stem-Like Lymphoma Cells
Contag, C. H., Sikorski, R., Negrin, R. S., Schmidt, T., Fan, A. C., Bachireddy, P., … Thorne, S. H. (2010). Definition of an Enhanced Immune Cell Therapy in Mice That Can Target Stem-Like Lymphoma Cells. CANCER RESEARCH, 70(23), 9837–45. -
CD4(+) T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation
Rakhra, K., Bachireddy, P., Zabuawala, T., Zeiser, R., Xu, L., Kopelman, A., … Felsher, D. W. (2010). CD4(+) T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation. CANCER CELL, 18(5), 485–98. -
Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.Na
Seetharam, M., Fan, A. C., Tran, M., Xu, L., Renschler, J. P., Felsher, D. W., … Greenberg, P. L. (2012). Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.Na. LEUKEMIA RESEARCH, 36(1), 98–103. -
"Picolog," a Synthetically-Available Bryostatin Analog, Inhibits Growth of MYC-Induced Lymphoma In Vivo
DeChristopher, B. A., Fan, A. C., Felsher, D. W., & Wender, P. A. (2012). "Picolog," a Synthetically-Available Bryostatin Analog, Inhibits Growth of MYC-Induced Lymphoma In Vivo. ONCOTARGET, 3(1), 58–66. -
Cryptococcal osteomyelitis and meningitis in a patient with non-hodgkin's lymphoma treated with PEP-C.
To, C. A., Hsieh, R. W., McClellan, J. S., Howard, W., Fischbein, N. J., Brown, J. M. Y., … Fan, A. C. (2012). Cryptococcal osteomyelitis and meningitis in a patient with non-hodgkin's lymphoma treated with PEP-C. BMJ Case Reports, 2012. -
A novel nano-immunoassay system capable of absolute protein measurements from 400 tumor-derived stem cells.
Voehringer, D. W., Deb-Basu, D., Weissman, I., Fan, A., Nguyen, U., Bhamidipati, A., & Felsher, D. W. (2007). A novel nano-immunoassay system capable of absolute protein measurements from 400 tumor-derived stem cells. MOLECULAR CANCER THERAPEUTICS, 6(12), 3556S–3556S. -
ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2-Mediated Acute Myeloid Leukemia progression with Increased Survival
Padua, R. A., Beurlet, S., Krief, P., Omidvar, N., Le Pogam, C., Auboeuf, D., … Chomienne, C. (2010). ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2-Mediated Acute Myeloid Leukemia progression with Increased Survival. BLOOD, 116(21), 1355–56. -
ASPP2 haploinsufficiency promotes tumor formation in a mouse model.
Kampa, K. M., Acoba, J. D., Chen, D., Beemer, K., Gay, J., Zhu, Z., … Lopez, C. D. (2006). ASPP2 haploinsufficiency promotes tumor formation in a mouse model. BLOOD, 108(11), 162B–162B. -
A Novel Nano-Immunoassay (NIA) Reveals Inhibition of PI3K and MAPK Pathways in CD34+Bone Marrow Cells of Patients with Myelodysplastic Syndrome (MDS) Treated with the Multi-Kinase Inhibitor On 01910.Na (Rigosertib)
Fan, A. C., Xu, L., Sridhar, K. J., Tran, M., Banerjee, P., Renschler, J. P., … Felsher, D. W. (2011). A Novel Nano-Immunoassay (NIA) Reveals Inhibition of PI3K and MAPK Pathways in CD34+Bone Marrow Cells of Patients with Myelodysplastic Syndrome (MDS) Treated with the Multi-Kinase Inhibitor On 01910.Na (Rigosertib). BLOOD, 118(21), 1626–26. -
Treatment of Higher Risk Myelodysplastic Syndrome Patients Unresponsive to Hypomethylating Agents with ON 01910.Na
Seetharam, M., Tran, M., Fan, A. C., Xu, L., Renschler, J. P., Felsher, D. W., … Greenberg, P. L. (2010). Treatment of Higher Risk Myelodysplastic Syndrome Patients Unresponsive to Hypomethylating Agents with ON 01910.Na. BLOOD, 116(21), 1635–35. -
A c-Myc Activation Sensor-Based High-Throughput Drug Screening Identifies an Antineoplastic Effect of Nitazoxanide.
Fan-Minogue, H., Bodapati, S., Solow-Cordero, D., Fan, A., Paulmurugan, R., Massoud, T. F., … Gambhir, S. S. (2013). A c-Myc Activation Sensor-Based High-Throughput Drug Screening Identifies an Antineoplastic Effect of Nitazoxanide. Molecular Cancer Therapeutics, 12(9), 1896–1905. -
BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells.
Beurlet, S., Omidvar, N., Gorombei, P., Krief, P., Le Pogam, C., Setterblad, N., … Padua, R. A. (2013). BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells. Blood, 122(16), 2864–76. -
Oncogene withdrawal engages the immune system to induce sustained cancer regression.
Casey, S. C., Li, Y., Fan, A. C., & Felsher, D. W. (2014). Oncogene withdrawal engages the immune system to induce sustained cancer regression. Journal for Immunotherapy of Cancer, 2, 24-? -
Alteration of the lipid profile in lymphomas induced by MYC overexpression.
Eberlin, L. S., Gabay, M., Fan, A. C., Gouw, A. M., Tibshirani, R. J., Felsher, D. W., & Zare, R. N. (2014). Alteration of the lipid profile in lymphomas induced by MYC overexpression. Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10450–55. -
Real-time nanoscale proteomic analysis of the novel multi-kinase pathway inhibitor rigosertib to measure the response to treatment of cancer.
Fan, A. C., O'Rourke, J. J., Praharaj, D. R., & Felsher, D. W. (2013). Real-time nanoscale proteomic analysis of the novel multi-kinase pathway inhibitor rigosertib to measure the response to treatment of cancer. Expert Opinion on Investigational Drugs, 22(11), 1495–1509. -
BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia.
Li, Y., Deutzmann, A., Choi, P. S., Fan, A. C., & Felsher, D. W. (2016). BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia. Oncotarget. -
BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia
Li, Y., Deutzmann, A., Choi, P. S., Fan, A. C., & Felsher, D. W. (2016). BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia. ONCOTARGET, 7(19), 26926–34. -
KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study.
Swords, R. T., Greenberg, P. L., Wei, A. H., Durrant, S., Advani, A. S., Hertzberg, M. S., … Lancet, J. E. (2016). KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study. Leukemia Research, 50, 123–31. -
Phase II Study of Pazopanib and Paclitaxel in Patients With Refractory Urothelial Cancer.
Narayanan, S., Lam, A., Vaishampayan, U., Harshman, L., Fan, A., Pachynski, R., … Srinivas, S. (2016). Phase II Study of Pazopanib and Paclitaxel in Patients With Refractory Urothelial Cancer. Clinical Genitourinary Cancer, 14(5), 432–37. -
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.
Sharma, A., Burridge, P. W., McKeithan, W. L., Serrano, R., Shukla, P., Sayed, N., … Wu, J. C. (2017). High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Science Translational Medicine, 9(377). -
Consolidative Radiotherapy in Metastatic Urothelial Cancer.
Shah, S., Zhang, C. A., Hancock, S., Fan, A., Skinner, E., & Srinivas, S. (2017). Consolidative Radiotherapy in Metastatic Urothelial Cancer. Clinical Genitourinary Cancer. -
Monitoring Neutropenia for Cancer Patients at the Point of Care
Inan, H. (2017). Monitoring Neutropenia for Cancer Patients at the Point of Care. Small Methods. -
Consolidative radiotherapy in metastatic urothelial cancer (MUC)
Srinivas, S., Narayanan, S., Fan, A. C., Hancock, S. L., & Skinner, E. C. (2016). Consolidative radiotherapy in metastatic urothelial cancer (MUC). JOURNAL OF CLINICAL ONCOLOGY, 34(2). -
Use of nano-immuno assay to generate rapid, quantitative nanoscale proteomic profiling of the hypoxia pathway in renal cell carcinoma clinical specimens.
Fan, A. C., Banerjee, P., Leppert, J., Harshman, L. C., Sabatti, C., Brooks, J. D., & Felsher, D. W. (2012). Use of nano-immuno assay to generate rapid, quantitative nanoscale proteomic profiling of the hypoxia pathway in renal cell carcinoma clinical specimens. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
NANO-SCALE PROTEOMIC PROFILING TO DEFINE DIAGNOSTIC SIGNATURES AND BIOMARKERS OF THERAPEUTIC ACTIVITY IN RCC
Leppert, J., Fan, A., Liliental, J., Xu, L., Thong, A., Yost, C., … Felsher, D. (2013). NANO-SCALE PROTEOMIC PROFILING TO DEFINE DIAGNOSTIC SIGNATURES AND BIOMARKERS OF THERAPEUTIC ACTIVITY IN RCC. JOURNAL OF UROLOGY. ELSEVIER SCIENCE INC. -
INTRA-TUMOR HETEROGENEITY IN RENAL CELL CARCINOMA: IMPLICATIONS FOR PROTEOMIC ANALYSIS OF RENAL MASS BIOPSIES
Massoudi, R., Hoerner, C., Metzner, T., O'Rourke, J., Curtis, R., Stell, L., … Leppert, J. (2017). INTRA-TUMOR HETEROGENEITY IN RENAL CELL CARCINOMA: IMPLICATIONS FOR PROTEOMIC ANALYSIS OF RENAL MASS BIOPSIES. JOURNAL OF UROLOGY. ELSEVIER SCIENCE INC. -
Clinicopathologic Characteristics of Fumarate Hydratase-Deficient and Hereditary Leiomyomatosis and Renal Cell Carcinoma-Associated Renal Cell Carcinoma: A Series of 10 Cases
Lau, H., Williamson, S. R., Kunder, C., Fan, A. C., & Kao, C.-S. (2018). Clinicopathologic Characteristics of Fumarate Hydratase-Deficient and Hereditary Leiomyomatosis and Renal Cell Carcinoma-Associated Renal Cell Carcinoma: A Series of 10 Cases. MODERN PATHOLOGY. NATURE PUBLISHING GROUP. -
KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study (vol 50, pg 123, 2016)
Swords, R. T., Greenberg, P. L., Wei, A. H., Durrant, S., Advani, A. S., Hertzberg, M. S., … Lancet, J. E. (2017). KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study (vol 50, pg 123, 2016). LEUKEMIA RESEARCH, 59, 65. -
Serum miR371a Quantitation for Assessing Tumor Burden in Testicular Germ Cell Tumors
Kunder, C., Imae, Y., Srinivas, S., & Fan, A. C. (2018). Serum miR371a Quantitation for Assessing Tumor Burden in Testicular Germ Cell Tumors. MODERN PATHOLOGY, 31, 703. -
Nano-scale phospho-proteomic analysis to define diagnostic signatures and biomarkers of therapeutic activity in cancer
Fan, A. C., Banerjee, P., Xu, L., Kong, C., Sabatti, C., Wilheim, F., … Felsher, D. W. (2012). Nano-scale phospho-proteomic analysis to define diagnostic signatures and biomarkers of therapeutic activity in cancer. CANCER RESEARCH, 72. -
Clinicopathologic Characteristics of Fumarate Hydratase-Deficient and Hereditary Leiomyomatosis and Renal Cell Carcinoma-Associated Renal Cell Carcinoma: A Series of 10 Cases
Lau, H., Williamson, S. R., Kunder, C., Fan, A. C., & Kao, C.-S. (2018). Clinicopathologic Characteristics of Fumarate Hydratase-Deficient and Hereditary Leiomyomatosis and Renal Cell Carcinoma-Associated Renal Cell Carcinoma: A Series of 10 Cases. LABORATORY INVESTIGATION. NATURE PUBLISHING GROUP. -
The 'Achilles Heel' of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy.
Hoerner, C. R., Chen, V. J., & Fan, A. C. (2019). The 'Achilles Heel' of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy. Kidney Cancer, 3(1), 15–29. -
18F-FPPRGD2 PET/CT in patients with metastatic renal cell cancer.
Toriihara, A., Duan, H., Thompson, H. M., Park, S., Hatami, N., Baratto, L., … Iagaru, A. (2019). 18F-FPPRGD2 PET/CT in patients with metastatic renal cell cancer. European Journal of Nuclear Medicine and Molecular Imaging. -
Serum miR371a Quantitation for Assessing Tumor Burden in Testicular Germ Cell Tumors
Kunder, C., Imae, Y., Srinivas, S., & Fan, A. C. (2018). Serum miR371a Quantitation for Assessing Tumor Burden in Testicular Germ Cell Tumors. LABORATORY INVESTIGATION. NATURE PUBLISHING GROUP. -
Phase II study of pazopanib with weekly paclitaxel in refractory urothelial cancer.
Srinivas, S., Narayanan, S., Harshman, L. C., Pachynski, R. K., Lam, A. P., Fan, A. C., … Vaishampayan, U. N. (2015). Phase II study of pazopanib with weekly paclitaxel in refractory urothelial cancer. JOURNAL OF CLINICAL ONCOLOGY, 33(7). -
Nanoscale proteomic profiling to define diagnostic signatures and biomarkers of therapeutic activity in patients with RCC
Fan, A. C., Leppert, J., Liliental, J. E., Xu, L., Thong, A. E., Yost, C., … Felsher, D. W. (2013). Nanoscale proteomic profiling to define diagnostic signatures and biomarkers of therapeutic activity in patients with RCC. JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
Pilot study of F-18-FSPG vs F-18-FDG PET imaging for response assessment in cancer
Park, S., Hatami, N., Rutledge, O., Koglin, N., Loo, B., Fan, A., & Mittra, E. (2017). Pilot study of F-18-FSPG vs F-18-FDG PET imaging for response assessment in cancer. JOURNAL OF NUCLEAR MEDICINE, 58. -
A nano-immunoassay system for monitoring changes in signaling upon oncogene inactivation in hematopoietic tumors
Fan, A. C., Deb-Basu, D., Gotlib, J., Voehringer, D. W., & Felsher, D. W. (2007). A nano-immunoassay system for monitoring changes in signaling upon oncogene inactivation in hematopoietic tumors. MOLECULAR CANCER THERAPEUTICS, 6(12), 3610S. -
Nano-fluidic detection of oncoprotein signaling in preclinical and patient lymphoma samples.
Fan, A. C., Deb-Basu, D., Horoschak, M., Shirer, A., Voehringer, D., O'Neill, R., & Felsher, D. W. (2006). Nano-fluidic detection of oncoprotein signaling in preclinical and patient lymphoma samples. BLOOD, 108(11), 715A. -
Two oncogenic hits are required to initiate lymphomagenesis in adult, but not neonatal hosts.
Fan, A. C., Giuriato, S., Karlsson, A., Padua, R. A., & Felsher, D. W. (2005). Two oncogenic hits are required to initiate lymphomagenesis in adult, but not neonatal hosts. BLOOD, 106(11), 732A. -
Cooperation between MYC and BCL2 to induce lymphoma is uncovered in an adult context
Fan, A. C., Giuriato, S., Feng, C., Padua, R. A., & Felsher, D. (2004). Cooperation between MYC and BCL2 to induce lymphoma is uncovered in an adult context. BLOOD, 104(11), 429A. -
MYC or RAS, but not BCL2 expression induces reversible lymphomagenesis
Fan, A. C., Giuriato, S., Karlsson, A., Bachireddy, P., Bendapudi, P., Rakhra, K., … Felsher, D. (2006). MYC or RAS, but not BCL2 expression induces reversible lymphomagenesis. CANCER RESEARCH, 66(8). -
Nanoliter-scale Western-blot-like BCL-2 analysis of lymphoma fine needle aspirates
Fan, A. C., Voehringer, D., Deb-Basu, D., Gossett, J., O-Neill, R., & Felsher, D. W. (2006). Nanoliter-scale Western-blot-like BCL-2 analysis of lymphoma fine needle aspirates. CANCER RESEARCH, 66(8). -
MYC quantification in lymphoma fine needle aspirates using "Firefly," a novel nanofluidic protein analysis system
Fan, A. C., Voehringer, D., Deb-Basu, D., Gossett, J., O'Neill, R., & Felsher, D. (2006). MYC quantification in lymphoma fine needle aspirates using "Firefly," a novel nanofluidic protein analysis system. CANCER RESEARCH, 66(8). -
Phase 1 study of glutaminase (GLS) inhibitor CB-839 combined with either everolimus (E) or cabozantinib (Cabo) in patients (pts) with clear cell (cc) and papillary (pap) metastatic renal cell cancer (mRCC).
Tannir, N. M., Fan, A. C., Lee, R. J., Carthon, B. C., Iliopoulos, O., Mier, J. W., … Bauer, T. M. (2018). Phase 1 study of glutaminase (GLS) inhibitor CB-839 combined with either everolimus (E) or cabozantinib (Cabo) in patients (pts) with clear cell (cc) and papillary (pap) metastatic renal cell cancer (mRCC). JOURNAL OF CLINICAL ONCOLOGY. AMER SOC CLINICAL ONCOLOGY. -
A rapid screening method for monitoring signaling changes in the monocyte cell line U937
Huang, Y.-W., Shahijanian, F., Deb-Basu, D., Fan, A., Voehringer, D., & Hirschberg, D. (2009). A rapid screening method for monitoring signaling changes in the monocyte cell line U937. CANCER RESEARCH, 69. -
The Simple Western rapidly generates quantitative profiles of MAPK and PI3K proteins in clinical specimens
Fan, A. C., Banerjee, P., & Felsher, D. W. (2012). The Simple Western rapidly generates quantitative profiles of MAPK and PI3K proteins in clinical specimens. CANCER RESEARCH, 72. -
Defining the genetic contexts when MYC inactivation induces sustained regression of hematopoietic tumors.
Giuriato, S., Passegue, E., Fan, A., Tang, F., & Felsher, D. W. (2003). Defining the genetic contexts when MYC inactivation induces sustained regression of hematopoietic tumors. BLOOD, 102(11), 586A. -
Acquired Resistance to Poly (ADP-ribose) Polymerase Inhibitor Olaparib in BRCA2-Associated Prostate Cancer Resulting From Biallelic BRCA2 Reversion Mutations Restores Both Germline and Somatic Loss-of-Function Mutations
Carneiro, B. A., Collier, K. A., Nagy, R. J., Pamarthy, S., Sagar, V., Fairclough, S., … Giles, F. J. (2018). Acquired Resistance to Poly (ADP-ribose) Polymerase Inhibitor Olaparib in BRCA2-Associated Prostate Cancer Resulting From Biallelic BRCA2 Reversion Mutations Restores Both Germline and Somatic Loss-of-Function Mutations. JCO PRECISION ONCOLOGY, 2. -
Monitoring Neutropenia for Cancer Patients at the Point of Care.
Inan, H., Kingsley, J. L., Ozen, M. O., Tekin, H. C., Hoerner, C. R., Imae, Y., … Demirci, U. (2017). Monitoring Neutropenia for Cancer Patients at the Point of Care. Small Methods, 1(9). -
A phase 1/2 study of CB-839, a first-in-class glutaminase inhibitor, combined with nivolumab in patients with advanced melanoma (MEL), renal cell carcinoma (RCC), or non-small cell lung cancer (NSCLC)
Meric-Bernstam, F., Gordon, M., Tykodi, S., Lam, E., Vaishampayan, U., Chaves, J., … Voss, M. (2017). A phase 1/2 study of CB-839, a first-in-class glutaminase inhibitor, combined with nivolumab in patients with advanced melanoma (MEL), renal cell carcinoma (RCC), or non-small cell lung cancer (NSCLC). JOURNAL FOR IMMUNOTHERAPY OF CANCER. BMC. -
F-18-FPPRGD(2) PET/CT in patients with metastatic renal cell cancer
Toriihara, A., Duan, H., Park, S., Hatami, N., Baratto, L., Fan, A., & Iagaru, A. (2018). F-18-FPPRGD(2) PET/CT in patients with metastatic renal cell cancer. JOURNAL OF NUCLEAR MEDICINE, 59. -
Economic burden of empiric drug utilization in metastatic renal cell carcinoma emphasizes the need for early biomarkers of response.
Chen, V., Gong, C., Zhang, C. A., Srinivas, S., Lee, H. E., & Fan, A. C. (2017). Economic burden of empiric drug utilization in metastatic renal cell carcinoma emphasizes the need for early biomarkers of response. JOURNAL OF CLINICAL ONCOLOGY, 35. -
Early Changes in CT Perfusion Parameters: Primary Renal Carcinoma Versus Metastases After Treatment with Targeted Therapy
Fan, A. C., Sundaram, V., Kino, A., Schmiedeskamp, H., Metzner, T. J., & Kamaya, A. (2019). Early Changes in CT Perfusion Parameters: Primary Renal Carcinoma Versus Metastases After Treatment with Targeted Therapy. CANCERS, 11(5). -
Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma.
Chen, V. J., Hernandez-Meza, G., Agrawal, P., Zhang, C. A., Xie, L., Gong, C. L., … Fan, A. C. (2019). Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma. Cancers, 11(7). -
Phase 1 study of CB-839, a small molecule inhibitor of glutaminase (GLS), alone and in combination with everolimus (E) in patients (pts) with renal cell cancer (RCC)
Meric-Bernstam, F., Tannir, N. M., Mier, J. W., DeMichele, A., Telli, M. L., Fan, A. C., … Harding, J. J. (2016). Phase 1 study of CB-839, a small molecule inhibitor of glutaminase (GLS), alone and in combination with everolimus (E) in patients (pts) with renal cell cancer (RCC). JOURNAL OF CLINICAL ONCOLOGY, 34(15). -
Multiregion Quantification of Extracellular Signal-regulated Kinase Activity in Renal Cell Carcinoma.
Hoerner, C. R., Massoudi, R., Metzner, T. J., Stell, L., O'Rourke, J. J., Kong, C. S., … Fan, A. C. (2018). Multiregion Quantification of Extracellular Signal-regulated Kinase Activity in Renal Cell Carcinoma. European Urology Oncology. -
Postmarketing Analysis of Sipuleucel-T-The Importance of Real-World Data.
Fan, A. C., & Leppert, J. T. (2019). Postmarketing Analysis of Sipuleucel-T-The Importance of Real-World Data. JAMA Network Open, 2(8), e199233. -
Prognostic factors for pancreatic metastases in renal cell cancer.
Chung, A., Li, S., Shah, S., Fan, A. C., & Srinivas, S. (2016). Prognostic factors for pancreatic metastases in renal cell cancer. JOURNAL OF CLINICAL ONCOLOGY, 34(15). -
A Clinicopathologic and Molecular Analysis of Fumarate Hydratase-Deficient Renal Cell Carcinoma in 32 Patients.
Lau, H. D., Chan, E., Fan, A. C., Kunder, C. A., Williamson, S. R., Zhou, M., … Kao, C.-S. (2019). A Clinicopathologic and Molecular Analysis of Fumarate Hydratase-Deficient Renal Cell Carcinoma in 32 Patients. The American Journal of Surgical Pathology. -
Routine plasma-based genotyping to comprehensively detect germline, somatic, and reversion BRCA mutations among patients with advanced solid tumors.
Vidula, N., Rich, T. A., Sartor, O., Yen, J., Hardin, A., Nance, T., … Cristofanilli, M. (2020). Routine plasma-based genotyping to comprehensively detect germline, somatic, and reversion BRCA mutations among patients with advanced solid tumors. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
Feasibility and design of a cloud-based digital platform in patients with advanced cancer.
Roy, M., Hall, E. T., Velazquez, B., Shah, S., Fardeen, T., Cunanan, K., … Ramchandran, K. (2019). Feasibility and design of a cloud-based digital platform in patients with advanced cancer. JOURNAL OF CLINICAL ONCOLOGY, 37(27). -
Landscape of BRCA1 and BRCA2 germline, somatic, and reversion alterations detectable by cell-free DNA testing among patients with metastatic breast, ovarian, pancreatic, or prostate cancer
Bardia, A., Rich, T. A., Raymond, V. M., Fairclough, S. R., Sartor, A. O., Lilly, M. B., … Cristofanilli, M. (2018). Landscape of BRCA1 and BRCA2 germline, somatic, and reversion alterations detectable by cell-free DNA testing among patients with metastatic breast, ovarian, pancreatic, or prostate cancer. JOURNAL OF CLINICAL ONCOLOGY, 36(15). -
Therapeutic benefit of empiric drug sequencing in metastatic renal cell carcinoma
Chen, V., Gong, C., Hoerner, C. R., Zhang, C. A., Srinivas, S., & Fan, A. C. (2018). Therapeutic benefit of empiric drug sequencing in metastatic renal cell carcinoma. JOURNAL OF CLINICAL ONCOLOGY, 36(15). -
Targeting Metabolic Pathways in Kidney Cancer: Rationale and Therapeutic Opportunities.
Hoerner, C. R., Miao, S. Y., Hsieh, J. J., & Fan, A. C. Targeting Metabolic Pathways in Kidney Cancer: Rationale and Therapeutic Opportunities. Cancer Journal (Sudbury, Mass.), 26(5), 407–18. -
Clinicopathologic characterization of enfortumab vedotin-associated cutaneous toxicity in patients with urothelial carcinoma.
Hirotsu, K. E., Rana, J., Wang, J. Y., Raghavan, S. S., Rieger, K. E., Srinivas, S., … Zaba, L. (2020). Clinicopathologic characterization of enfortumab vedotin-associated cutaneous toxicity in patients with urothelial carcinoma. Journal of the American Academy of Dermatology. -
Giant Magnetoresistive Nanosensor Analysis of Circulating Tumor DNA Epidermal Growth Factor Receptor Mutations for Diagnosis and Therapy Response Monitoring.
Nesvet, J. C., Antilla, K. A., Pancirer, D. S., Lozano, A. X., Preiss, J. S., Ma, W., … Wang, S. X. (2021). Giant Magnetoresistive Nanosensor Analysis of Circulating Tumor DNA Epidermal Growth Factor Receptor Mutations for Diagnosis and Therapy Response Monitoring. Clinical Chemistry. -
In Search of Clinical Biomarkers of Response to Checkpoint Inhibitor Therapy in Renal Cell Carcinoma.
Fan, A. C., & Leppert, J. T. (2021). In Search of Clinical Biomarkers of Response to Checkpoint Inhibitor Therapy in Renal Cell Carcinoma. JAMA Network Open, 4(1), e2035120. -
Myocarditis Surveillance with High-Sensitivity Troponin I During Cancer Treatment with Immune Checkpoint Inhibitors.
Waliany, S., Neal, J. W., Reddy, S., Wakelee, H., Shah, S. A., Srinivas, S., … Zhu, H. (2021). Myocarditis Surveillance with High-Sensitivity Troponin I During Cancer Treatment with Immune Checkpoint Inhibitors. JACC. CardioOncology, 3(1), 137–39. -
Return of individual research results: What do participants prefer and expect?
Sayeed, S., Califf, R., Green, R., Wong, C., Mahaffey, K., Gambhir, S. S., … Wong, C. A. (2021). Return of individual research results: What do participants prefer and expect? PloS One, 16(7), e0254153. -
Implementation of a cloud-based electronic patient-reported outcome (ePRO) platform in patients with advanced cancer.
Generalova, O., Roy, M., Hall, E., Shah, S. A., Cunanan, K., Fardeen, T., … Ramchandran, K. (2021). Implementation of a cloud-based electronic patient-reported outcome (ePRO) platform in patients with advanced cancer. Journal of Patient-Reported Outcomes, 5(1), 91. -
The 'Achilles Heel' of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy
Hoerner, C. R., Chen, V. J., & Fan, A. C. (2019). The 'Achilles Heel' of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy. KIDNEY CANCER, 3(1), 15–29. -
Clinical laboratory tests associated with survival in patients with metastatic renal cell carcinoma: A Laboratory Wide Association Study (LWAS).
Velaer, K., Thomas, I.-C. C., Yang, J., Kapphahn, K., Metzner, T. J., Golla, A., … Leppert, J. T. (2021). Clinical laboratory tests associated with survival in patients with metastatic renal cell carcinoma: A Laboratory Wide Association Study (LWAS). Urologic Oncology. -
Use of a computer model and care coaches to increase advance care planning conversations for patients with metastatic cancer
Gupta, D., Fardeen, T., Teuteberg, W., Seevaratnam, B., Asuncion, M. K., Alves, N., … Ramchandran, K. (2021). Use of a computer model and care coaches to increase advance care planning conversations for patients with metastatic cancer. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Telaglenastat Plus Cabozantinib or Everolimus For Advanced or Metastatic Renal Cell Carcinoma: an Open-Label Phase 1 Trial.
Meric-Bernstam, F., Tannir, N. M., Lliopoulos, O., Lee, R. J., Telli, M. L., Fan, A. C., … Bauer, T. M. (2022). Telaglenastat Plus Cabozantinib or Everolimus For Advanced or Metastatic Renal Cell Carcinoma: an Open-Label Phase 1 Trial. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
Association of renal cell carcinoma (RCC) metastatic to pancreas with a distinct molecular profile and immune cell population.
Chiang, R. S., Ashok, A., Mauer, E., Barrett, A., Hoerner, C. R., Khan, O. A., … Khaki, A. R. (2022). Association of renal cell carcinoma (RCC) metastatic to pancreas with a distinct molecular profile and immune cell population. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Utilizing the autoantibody immune response to tumor antigens for kidney cancer early detection.
Hoerner, C. R., Jhatro, M., Waitz, R., Kamath, K., Zhang, M., Dhal, A., … Fan, A. C. (2022). Utilizing the autoantibody immune response to tumor antigens for kidney cancer early detection. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Telaglenastat Plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 ENTRATA Trial.
Lee, C.-H. H., Motzer, R., Emamekhoo, H., Matrana, M., Percent, I., Hsieh, J. J., … Tannir, N. M. (2022). Telaglenastat Plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 ENTRATA Trial. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
Personalised Risk Prediction in Hereditary Breast and Ovarian Cancer: A Protocol for a Multi-Centre Randomised Controlled Trial.
Archer, S., Fennell, N., Colvin, E., Laquindanum, R., Mills, M., Dennis, R., … Tischkowitz, M. (2022). Personalised Risk Prediction in Hereditary Breast and Ovarian Cancer: A Protocol for a Multi-Centre Randomised Controlled Trial. Cancers, 14(11). -
Personalised risk prediction in hereditary breast and ovarian cancer: A protocol for a multi-centre randomised controlled trial
Fennell, N., Colvin, E., Laquindanum, R., Mills, M., Dennis, R., Donoso, F. S., … Archer, S. (2022). Personalised risk prediction in hereditary breast and ovarian cancer: A protocol for a multi-centre randomised controlled trial. PSYCHO-ONCOLOGY. WILEY. -
Use of Machine Learning and Lay Care Coaches to Increase Advance Care Planning Conversations for Patients With Metastatic Cancer.
Gensheimer, M. F., Gupta, D., Patel, M. I., Fardeen, T., Hildebrand, R., Teuteberg, W., … Ramchandran, K. (2022). Use of Machine Learning and Lay Care Coaches to Increase Advance Care Planning Conversations for Patients With Metastatic Cancer. JCO Oncology Practice, OP2200128. -
The Role of Single-Cell Profiling and Deep Immunophenotyping in Understanding Immune Therapy Cardiotoxicity
Huang, Y. V., Waliany, S., Lee, D., Galdos, F. X., Witteles, R. M., Neal, J. W., … Zhu, H. (2022). The Role of Single-Cell Profiling and Deep Immunophenotyping in Understanding Immune Therapy Cardiotoxicity. JACC: CardioOncology, 4(5).
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts
- Safety Study of ABT-263 in Combination With Rituximab in Lymphoid Cancers
- Safety and Pharmacology of SNX-5422 Plus Everolimus in Subjects With Neuroendocrine Tumors
- Study of the Glutaminase Inhibitor CB-839 in Solid Tumors
- Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
- Phase 2 Study of Atorvastatin Safety and Antitumor Effects in Non-Hodgkin's Lymphoma
- A Phase II Trial to Evaluate the Efficacy of AZD6094 (HMPL-504) in Patients With Papillary Renal Cell Carcinoma (PRCC)
- Perfusion CT Monitoring to Predict Treatment Efficacy in Renal Cell Carcinoma
Practice Locations
Urologic Cancer Program in Palo Alto Palo Alto, CA
Palo Alto, CAUrologic Cancer Program in Palo Alto
875 Blake Wilbur Drive
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereNeurogenetic Cancer Palo Alto, CA
Palo Alto, CANeurogenetic Cancer
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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Referring Physicians
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