

Biography
His research background is in molecular biology, genetics, and cancer pathogenesis, and combines the tools of molecular and anatomic imaging to improve patients' outcomes. His current research projects include: imaging markers of lung and heart diseases, aided by articial intelligence, early cancer detection, low radiation dose CT, PET-CT of the lungs, quantitative CT, and in 3D printing of thoracic structures to improve education and optimize pre-treatment planning.
He is a native of the South Bay and enjoys working in the dynamic environment at Stanford and the Silicon Valley.
Professional Summary
Professional Education
- Internship: Scripps Mercy Hospital San Diego (2007) CA
- Fellowship: Stanford University Radiology Fellowships (2012) CA
- Residency: Stanford University Radiology Residency (2011) CA
- Medical Education: University of Washington School of Medicine (2006) WA
- Board Certification: American Board of Nuclear Medicine, Nuclear Medicine (2012)
- Fellowship in Chest Radiology, Stanford Hospital and Clinics, CA USA (2012)
- Board Certification: American Board of Radiology, Diagnostic Radiology (2011)
- PhD, University of Washington, Pathology and Molecular Biology (2004)
- Bachelor of Science, Massachusetts Institute of Technology, Molecular Biology (1997)
Honors & Awards
- Alpha Omega Alpha, (AOA)
- ARCS Scholar, University of Washington
- Clinician of the Year, Stanford Department of Radiology (2019)
- Faculty Educator of the year (early career), Stanford Radiology Residency (2014)
- MSTP, University of Washington
- Sigma Xi, MIT
Publications
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Best Cases from the AFIP Fatal 2009 Influenza A (H1N1) Infection, Complicated by Acute Respiratory Distress Syndrome and Pulmonary Interstitial Emphysema
Guo, H. H., Sweeney, R. T., Regula, D., & Leung, A. N. (2010). Best Cases from the AFIP Fatal 2009 Influenza A (H1N1) Infection, Complicated by Acute Respiratory Distress Syndrome and Pulmonary Interstitial Emphysema. RADIOGRAPHICS, 30(2), 327–33. -
Demonstration of peripheral nerve root involvement by non-Hodgkin's lymphoma on F-18-FDG PET/CT
Guo, H., Mosci, C., & Iagaru, A. (2012). Demonstration of peripheral nerve root involvement by non-Hodgkin's lymphoma on F-18-FDG PET/CT. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 39(4), 729–30. -
Protein tolerance to random amino acid change
GUO, H. H., Choe, J., & Loeb, L. A. (2004). Protein tolerance to random amino acid change. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(25), 9205–10. -
Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase
Klapacz, J., Lingaraju, G. M., Guo, H. H., Shah, D., Moar-Shoshani, A., Loeb, L. A., & Samson, L. D. (2010). Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase. MOLECULAR CELL, 37(6), 843–53. -
Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival
Chen, C.-Y., Guo, H. H., Shah, D., Blank, A., Samson, L. D., & Loeb, L. A. (2008). Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival. DNA REPAIR, 7(10), 1731–45. -
Tumbling down a different pathway to genetic instability
GUO, H. H., & Loeb, L. A. (2003). Tumbling down a different pathway to genetic instability. JOURNAL OF CLINICAL INVESTIGATION, 112(12), 1793–95. -
Pre-treatment non-target lung FDG-PET uptake predicts symptomatic radiation pneumonitis following Stereotactic Ablative Radiotherapy (SABR).
Chaudhuri, A. A., Binkley, M. S., Rigdon, J., Carter, J. N., Aggarwal, S., Dudley, S. A., … Guo, H. H. (2016). Pre-treatment non-target lung FDG-PET uptake predicts symptomatic radiation pneumonitis following Stereotactic Ablative Radiotherapy (SABR). Radiotherapy and Oncology , 119(3), 454–60. -
Clinical significance of extraskeletal computed tomography findings on 18F-NaF PET/CT performed for osseous metastatic disease evaluation.
Guo, H. H., Moradi, F., & Iagaru, A. (2016). Clinical significance of extraskeletal computed tomography findings on 18F-NaF PET/CT performed for osseous metastatic disease evaluation. Nuclear Medicine Communications, 37(9), 975–82. -
A Wandering Pulmonary Nodule.
Van Wert, R., Gayer, G., Guo, H. H., & Nair, V. S. (2016). A Wandering Pulmonary Nodule. American Journal of Respiratory and Critical Care Medicine, -? -
Methyl Methacrylate Mimicking a Retained Guide Wire.
Moradzadeh, N., Hwang, G., Nair, V., & Guo, H. H. (2016). Methyl Methacrylate Mimicking a Retained Guide Wire. Journal of Vascular and Interventional Radiology : JVIR, 27(12), 1906. -
Coccidioidomycosis: Surgical Issues and Implications.
Forrester, J. D., Guo, H. H., & Weiser, T. G. (2016). Coccidioidomycosis: Surgical Issues and Implications. Surgical Infections, -? -
Left Atrium Maximal Axial Cross-Sectional Area is a Specific Computed Tomographic Imaging Biomarker of World Health Organization Group 2 Pulmonary Hypertension.
Jivraj, K., Bedayat, A., Sung, Y. K., Zamanian, R. T., Haddad, F., Leung, A. N. C., … Guo, H. H. (2017). Left Atrium Maximal Axial Cross-Sectional Area is a Specific Computed Tomographic Imaging Biomarker of World Health Organization Group 2 Pulmonary Hypertension. Journal of Thoracic Imaging, 32(2), 121–26. -
Pulmonary function after lung tumor stereotactic ablative radiotherapy depends on regional ventilation within irradiated lung.
Binkley, M. S., King, M. T., Shrager, J. B., Bush, K., Chaudhuri, A. A., Popat, R., … Loo, B. W. (2017). Pulmonary function after lung tumor stereotactic ablative radiotherapy depends on regional ventilation within irradiated lung. Radiotherapy and Oncology , 123(2), 270–75. -
Predictive radiogenomics modeling of EGFR mutation status in lung cancer
Gevaert, O., Echegaray, S., Khuong, A., Hoang, C. D., Shrager, J. B., Jensen, K. C., … Leung, A. N. (2017). Predictive radiogenomics modeling of EGFR mutation status in lung cancer. SCIENTIFIC REPORTS, 7. -
Identification of Pulmonary Hypertension Caused by Left Heart Disease (World Health Organization Group 2) Based on Cardiac Chamber Volumes Derived from Chest CT.
Aviram, G., Rozenbaum, Z., Ziv-Baran, T., Berliner, S., Topilsky, Y., Fleischmann, D., … Guo, H. H. (2017). Identification of Pulmonary Hypertension Caused by Left Heart Disease (World Health Organization Group 2) Based on Cardiac Chamber Volumes Derived from Chest CT. Chest. -
Initial Experience With Simultaneous 18F-FDG PET/MRI in the Evaluation of Cardiac Sarcoidosis and Myocarditis.
Hanneman, K., Kadoch, M., Guo, H. H., Jamali, M., Quon, A., Iagaru, A., & Herfkens, R. (2017). Initial Experience With Simultaneous 18F-FDG PET/MRI in the Evaluation of Cardiac Sarcoidosis and Myocarditis. Clinical Nuclear Medicine, 42(7), e328–e334. -
Improving Quality of Dynamic Airway Computed Tomography Using an Expiratory Airflow Indicator Device.
Hahn, L. D., Sung, A. W., Shafiq, M., & Guo, H. H. (2018). Improving Quality of Dynamic Airway Computed Tomography Using an Expiratory Airflow Indicator Device. Journal of Thoracic Imaging. -
Prognostic Value of Pretreatment FDG-PET Parameters in High-dose Image-guided Radiotherapy for Oligometastatic Non-Small-cell Lung Cancer.
Chin, A. L., Kumar, K. A., Guo, H. H., Maxim, P. G., Wakelee, H., Neal, J. W., … Gensheimer, M. F. (2018). Prognostic Value of Pretreatment FDG-PET Parameters in High-dose Image-guided Radiotherapy for Oligometastatic Non-Small-cell Lung Cancer. Clinical Lung Cancer. -
SERIAL CARDIAC FDG-PET IN THE DIAGNOSIS AND THERAPEUTIC GUIDANCE OF PATIENTS WITH CARDIAC SARCOIDOSIS: A STANFORD EXPERIENCE
Ning, N., Guo, H. H., Jagaru, A., Mittra, E., Fowler, M., & Witteles, R. (2018). SERIAL CARDIAC FDG-PET IN THE DIAGNOSIS AND THERAPEUTIC GUIDANCE OF PATIENTS WITH CARDIAC SARCOIDOSIS: A STANFORD EXPERIENCE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 71(11), 1690. -
Synchronous primary lung adenocarcinomas harboring distinct MET Exon 14 splice site mutations.
Wang, S. X., Lei, L., Guo, H. H., Shrager, J., Kunder, C. A., & Neal, J. W. (2018). Synchronous primary lung adenocarcinomas harboring distinct MET Exon 14 splice site mutations. Lung Cancer (Amsterdam, Netherlands), 122, 187–91. -
From Ocean Deep to Mountain High: Similar Computed Tomography Findings in Immersion and High-Altitude Pulmonary Edema.
Lindholm, P., Swenson, E. R., Martínez-Jiménez, S., & Guo, H. H. (2018). From Ocean Deep to Mountain High: Similar Computed Tomography Findings in Immersion and High-Altitude Pulmonary Edema. American Journal of Respiratory and Critical Care Medicine, 198(8), 1088–1089. -
3D Printing and the Cystic Fibrosis Lung.
Mirza, A. A., Robinson, T. E., Gifford, K., & Guo, H. H. (2018). 3D Printing and the Cystic Fibrosis Lung. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. -
Endogenous mutagenesis and cancer.
Davidson, J. F., Guo, H. H., & Loeb, L. A. (2002). Endogenous mutagenesis and cancer. Mutation Research, 509(1-2), 17–21. -
Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis
Ning, N., Guo, H. H., Iagaru, A., Mittra, E., Fowler, M., & Witteles, R. (2019). Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis. JOURNAL OF CARDIAC FAILURE, 25(4), 307–11. -
A Young Woman With a Rapidly GrowingThoracic Tumor.
Lai, Y. K., Holmes, B., & Guo, H. H. (2019). A Young Woman With a Rapidly GrowingThoracic Tumor. Chest, 155(5), e145–e148. -
Single-Lumen Endotracheal Tube and Bronchial Blocker for Airway Management During Tracheobronchoplasty for Tracheobronchomalacia: A Case Report.
Lui, N. S., Guo, H. H., Sung, A. W., Peterson, A., & Kulkarni, V. N. (2019). Single-Lumen Endotracheal Tube and Bronchial Blocker for Airway Management During Tracheobronchoplasty for Tracheobronchomalacia: A Case Report. A&A Practice. -
Evaluation of integrin alphavbeta6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis.
Kimura, R. H., Wang, L., Shen, B., Huo, L., Tummers, W., Filipp, F. V., … Gambhir, S. S. (2019). Evaluation of integrin alphavbeta6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis. Nature Communications, 10(1), 4673. -
Thoracic Radiologists' Versus Computer Scientists' Perspectives on the Future of Artificial Intelligence in Radiology.
Eltorai, A. E., Bratt, A. K., & Guo, H. H. (2019). Thoracic Radiologists' Versus Computer Scientists' Perspectives on the Future of Artificial Intelligence in Radiology. Journal of Thoracic Imaging. -
Left Atrial Volume as a Biomarker of Atrial Fibrillation at Routine Chest CT: Deep Learning Approach
Bratt, A., Guenther, Z., Lewis, H., Kadoch, M., Adams, P. L., Leung, A. N. C., & Guo, H. H. (2019). Left Atrial Volume as a Biomarker of Atrial Fibrillation at Routine Chest CT: Deep Learning Approach. Radiology: Cardiothoracic Imaging, 1(5). -
The Intralobular Gradient as Seen in Re-Expansion Pulmonary Edema
Lai, Y. K., Lindholm, P., & Guo, H. H. (2019). The Intralobular Gradient as Seen in Re-Expansion Pulmonary Edema. Radiology: Cardiothoracic Imaging, 1(5). -
Tracheobronchial Tumors: Radiologic-Pathologic Correlation of Tumors and Mimics
Bedayat, A., Yang, E., Ghandili, S., Galera, P., Chalian, H., Ansari-Gilani, K., & Guo, H. H. (2020). Tracheobronchial Tumors: Radiologic-Pathologic Correlation of Tumors and Mimics. CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY, 49(4), 275–84. -
Radiology-pathology Correlation in Recovered COVID-19, Demonstrating Organizing Pneumonia.
Pogatchnik, B. P., Swenson, K. E., Sharifi, H., Bedi, H., Berry, G. J., & Guo, H. H. (2020). Radiology-pathology Correlation in Recovered COVID-19, Demonstrating Organizing Pneumonia. American Journal of Respiratory and Critical Care Medicine. -
Using Online Survey Software to Enhance Radiology Learning.
Kelahan, L., Cheng, S. N., Kagoma, Y. K., Horowitz, J. M., Miller, F. H., Guo, H. H., & Chow, L. (2020). Using Online Survey Software to Enhance Radiology Learning. Academic Radiology. -
Prognostic values of quantitative and morphological parameters of dbPET in patients with luminal-type breast cancer: A pilot study
Miyake, K., Nakamoto, Y., Ikeda, D., Iagaru, A., Daniel, B., Lipson, J., … Togashi, K. (2020). Prognostic values of quantitative and morphological parameters of dbPET in patients with luminal-type breast cancer: A pilot study. JOURNAL OF NUCLEAR MEDICINE. SOC NUCLEAR MEDICINE INC. -
Anatomical variability in the upper tracheobronchial tree: sex-based differences and implications for personalized inhalation therapies.
Christou, S., Chatziathanasiou, T., Angeli, S., Koullapis, P., Stylianou, F., Sznitman, J., … Kassinos, S. C. (2020). Anatomical variability in the upper tracheobronchial tree: sex-based differences and implications for personalized inhalation therapies. Journal of Applied Physiology (Bethesda, Md. : 1985). -
Rituximab Versus Mycophenolate in the Treatment of Recalcitrant Connective Tissue Disease-Associated Interstitial Lung Disease.
Zhu, L., Chung, M. P., Gagne, L., Guo, H. H., Guenther, Z., Li, S., … Chung, L. (2020). Rituximab Versus Mycophenolate in the Treatment of Recalcitrant Connective Tissue Disease-Associated Interstitial Lung Disease. ACR Open Rheumatology. -
A calibration CT mini-lung-phantom created by 3-D printing and subtractive manufacturing.
Guo, H. H., Persson, M., Weinheimer, O., Rosenberg, J., Robinson, T. E., & Wang, J. (2021). A calibration CT mini-lung-phantom created by 3-D printing and subtractive manufacturing. Journal of Applied Clinical Medical Physics. -
Radiopaque Recreations of Lung Pathologies From Clinical Computed Tomography Images Using Potassium Iodide Inkjet 3-dimensional Printing: Proof of Concept.
Wang, J., Falkson, S. R., & Guo, H. H. (2021). Radiopaque Recreations of Lung Pathologies From Clinical Computed Tomography Images Using Potassium Iodide Inkjet 3-dimensional Printing: Proof of Concept. Journal of Thoracic Imaging. -
Prevalence and significance of pulmonary disease on lung ultrasonography in outpatients with SARS-CoV-2 infection.
Fairchild, R. M., Horomanski, A., Mar, D. A., Triant, G. R., Lu, R., Lu, D., … Baker, M. C. (2021). Prevalence and significance of pulmonary disease on lung ultrasonography in outpatients with SARS-CoV-2 infection. BMJ Open Respiratory Research, 8(1). -
An Opportunity to Reduce Disparities in Lung Cancer Screening
Song, J., & Guo, H. H. (2021). An Opportunity to Reduce Disparities in Lung Cancer Screening. JAMA NETWORK OPEN, 4(10), e2129126. -
Three-dimensional-printed model of surgically resectable angioinvasive pulmonary mucormycosis.
Byrd, C. T., Vyas, D., Guo, H. H., & Lui, N. S. (2022). Three-dimensional-printed model of surgically resectable angioinvasive pulmonary mucormycosis. JTCVS Techniques, 13, 244–246. -
Applications of Three-Dimensional Printing in Surgical Oncology.
Byrd, C. T., Lui, N. S., & Guo, H. H. (2022). Applications of Three-Dimensional Printing in Surgical Oncology. Surgical Oncology Clinics of North America, 31(4), 673–684. -
Induction EGFR tyrosine kinase inhibitors prior to definitive chemoradiotherapy in unresectable stage III EGFR-mutated non-small cell lung cancer.
Aredo, J. V., Wakelee, H. A., Hui, A. B.-Y., Padda, S. K., Joshi, N. D., Guo, H. H., … Neal, J. W. (2022). Induction EGFR tyrosine kinase inhibitors prior to definitive chemoradiotherapy in unresectable stage III EGFR-mutated non-small cell lung cancer. Cancer Treatment and Research Communications, 33, 100659. -
64Cu-DOTATATE Uptake in a Pulmonary Hamartoma.
Song, H., Guja, K. E., Yang, E. J., & Guo, H. H. (2023). 64Cu-DOTATATE Uptake in a Pulmonary Hamartoma. Clinical Nuclear Medicine, 48(1), 58–60. -
Pulmonary Vein Sign on Computed Tomography Pulmonary Angiography in Proximal and Distal Chronic Thromboembolic Pulmonary Hypertension With Hemodynamic Correlation.
Gopalan, D., Riley, J. Y., Leong, K., Guo, H. H., Zamanian, R. T., Hsi, A., … Lindholm, P. (2023). Pulmonary Vein Sign on Computed Tomography Pulmonary Angiography in Proximal and Distal Chronic Thromboembolic Pulmonary Hypertension With Hemodynamic Correlation. Journal of Thoracic Imaging. -
Opportunistic Screening for Atrial Fibrillation on Routine Chest Computed Tomography.
Parker, W. A., Vigneault, D. M., Yang, I., Bratt, A., Marquardt, A. C., Sharifi, H., & Guo, H. H. (2023). Opportunistic Screening for Atrial Fibrillation on Routine Chest Computed Tomography. Journal of Thoracic Imaging.
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