Professional Summary
Education & Certifications
- Residency: Stanford University Internal Medicine Residency (1985) CA
- Internship: Stanford University Internal Medicine Residency (1983) CA
- Medical Education: Brown University School of Medicine (1982) RI
- Board Certification: American Board of Internal Medicine, Internal Medicine (1985)
- MA, Santa Clara University, Pastoral Ministries (2007)
- MD, Brown University, School of Medicine (1982)
- MBA, Stanford University-GSB, Health Management (1993)
- BS, Brown University, Biological Sciences (1979)
Administrative Appointments
- Assistant Professor of Medicine, Stanford University (1985 - 1993)
- Co-Director, SPARK Program (2008 - Present)
- Director of Medical Affairs, Heartport - Redwood City, CA (1995 - 1999)
- Healthcare Consultant, . (1999 - 2004)
- Senior Consultant, The Advisory Board, Washington DC (1994 - 1995)
- Senior Director, Clinical Research, KAI Pharmaceuticals, Inc (2004 - 2007)
- White House Fellow, Washington, DC (1993 - 1994)
Publications
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Recognition, diagnosis, and treatment of primary focal hyperhidrosis
Hornberger, J., Grimes, K., NAUMANN, M., Glaser, D. A., Lowe, N. J., Naver, H., … Stolman, L. R. (2004). Recognition, diagnosis, and treatment of primary focal hyperhidrosis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 51(2), 274–86. -
Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
Roe, M. T., Hartmann, F., LINS, J., Batchelor, W., Ruzyllo, W., Kochman, J., … Zago, A. (2008). Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. CIRCULATION, 117(7), 886–96. -
Myocardial salvage in acute myocardial infarction - Challenges in clinical translation
Mochly-Rosen, D., & Grimes, K. V. (2011). Myocardial salvage in acute myocardial infarction - Challenges in clinical translation. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 51(4), 451–53. -
Protein kinase C, an elusive therapeutic target?
Mochly-Rosen, D., Das, K., & Grimes, K. V. (2012). Protein kinase C, an elusive therapeutic target? NATURE REVIEWS DRUG DISCOVERY, 11(12), 937–57. -
GRANULOCYTE COLONY-STIMULATING FACTOR MOBILIZED PERIPHERAL-BLOOD PROGENITOR CELLS ACCELERATE GRANULOCYTE AND PLATELET RECOVERY AFTER HIGH-DOSE CHEMOTHERAPY
Chao, N. J., Schriber, J. R., Grimes, K., Long, G. D., Negrin, R. S., RAIMONDI, C. M., … Blume, K. G. (1993). GRANULOCYTE COLONY-STIMULATING FACTOR MOBILIZED PERIPHERAL-BLOOD PROGENITOR CELLS ACCELERATE GRANULOCYTE AND PLATELET RECOVERY AFTER HIGH-DOSE CHEMOTHERAPY. BLOOD, 81(8), 2031–35. -
Human Chitotriosidase Does Not Catabolize Hyaluronan.
Danielson, B., Chen, C.-H. H., Kaber, G., Mochly-Rosen, D., Grimes, K., Stern, R., & Bollyky, P. L. (2017). Human Chitotriosidase Does Not Catabolize Hyaluronan. International Journal of Biological Macromolecules. -
Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries.
Parrish, M. C., Tan, Y. J., Grimes, K. V., & Mochly-Rosen, D. (2018). Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries. Annual Review of Pharmacology and Toxicology. -
Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer.
Knox, S. J., Jayachandran, P., Keeling, C. A., Stevens, K. J., Sandhu, N., Stamps-DeAnda, S. L., … Grimes, K. (2019). Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer. Translational Oncology, 12(11), 1525–31. -
A Qualitative Study on the Differences Between Trial Populations and the Approved Therapeutic Indications of Antineoplastic Agents by 3 Regulatory Agencies From 2010 to 2018.
Sumi, E., Asada, R., Lu, Y., Ito-Ihara, T., & Grimes, K. V. (2020). A Qualitative Study on the Differences Between Trial Populations and the Approved Therapeutic Indications of Antineoplastic Agents by 3 Regulatory Agencies From 2010 to 2018. Clinical Therapeutics. -
p38 MAPK inhibition: A promising therapeutic approach for COVID-19.
Grimes, J. M., & Grimes, K. V. (2020). p38 MAPK inhibition: A promising therapeutic approach for COVID-19. Journal of Molecular and Cellular Cardiology. -
Mechanisms of Azetidine-2-carboxylic Acid (Aze)-Induced Oligodendrogliopathy In Vivo and In Vitro
Sobel, R., Albertelli, M., Hinojoza, J., Eaton, M., Grimes, K., & Rubenstein, E. (2020). Mechanisms of Azetidine-2-carboxylic Acid (Aze)-Induced Oligodendrogliopathy In Vivo and In Vitro. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. OXFORD UNIV PRESS INC. -
Treatment-refractory ulcerative colitis responsive to indigo naturalis.
Saiki, J. P., Andreasson, J. O., Grimes, K. V., Frumkin, L. R., Sanjines, E., Davidson, M. G., … Limketkai, B. (1800). Treatment-refractory ulcerative colitis responsive to indigo naturalis. BMJ Open Gastroenterology, 8(1). -
From random to predictive: a context-specific interaction framework improves selection of drug protein-protein interactions for unknown drug pathways.
Wilson, J. L., Gravina, A., & Grimes, K. (2022). From random to predictive: a context-specific interaction framework improves selection of drug protein-protein interactions for unknown drug pathways. Integrative Biology : Quantitative Biosciences from Nano to Macro. -
Preventive drugs for Huntington's disease: A choice-based conjoint survey of patient preferences.
Parrish, M. C., Hanson-Kahn, A., Srinivasan, V., & Grimes, K. V. (2022). Preventive drugs for Huntington's disease: A choice-based conjoint survey of patient preferences. Journal of Clinical and Translational Science, 6(1), e35. -
Controlling astrocyte-mediated synaptic pruning signals for schizophrenia drug repurposing with deep graph networks.
Gravina, A., Wilson, J. L., Bacciu, D., Grimes, K. J., & Priami, C. (2022). Controlling astrocyte-mediated synaptic pruning signals for schizophrenia drug repurposing with deep graph networks. PLoS Computational Biology, 18(5), e1009531. -
Azetidine-2-Carboxylic Acid-Induced Oligodendrogliopathy: Relevance to the Pathogenesis of Multiple Sclerosis.
Sobel, R. A., Albertelli, M., Hinojoza, J. R., Eaton, M. J., Grimes, K. V., & Rubenstein, E. (2022). Azetidine-2-Carboxylic Acid-Induced Oligodendrogliopathy: Relevance to the Pathogenesis of Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology. -
A US clinical trial network is needed for the next pandemic.
Yajima, R., More, A. F., Garvan, C., Harper, C., & Grimes, K. V. (2022). A US clinical trial network is needed for the next pandemic. Nature Medicine. -
A network paradigm predicts drug synergistic effects using downstream protein-protein interactions.
Wilson, J. L., Steinberg, E., Racz, R., Altman, R. B., Shah, N., & Grimes, K. (2022). A network paradigm predicts drug synergistic effects using downstream protein-protein interactions. CPT: Pharmacometrics & Systems Pharmacology. -
Existing and Developing Preclinical Models for Neurofibromatosis Type 1-Related Cutaneous Neurofibromas.
Staedtke, V., Topilko, P., Le, L. Q., Grimes, K., Largaespada, D. A., Cagan, R. L., … Serra, E. (2023). Existing and Developing Preclinical Models for Neurofibromatosis Type 1-Related Cutaneous Neurofibromas. The Journal of Investigative Dermatology. -
A Call for Discovery and Therapeutic Development for Cutaneous Neurofibromas.
Blakeley, J. O., Le, L. Q., Lee, S. Y., Ly, I., Rhodes, S. D., Romo, C. G., … Wolkenstein, P. (2023). A Call for Discovery and Therapeutic Development for Cutaneous Neurofibromas. The Journal of Investigative Dermatology. -
An electronic health record cohort of Veterans with amyotrophic lateral sclerosis.
Reimer, R. J., Goncalves, A., Soper, B., Cadena, J., Wilson, J. L., Gryshuk, A. L., … Ray, P. (2023). An electronic health record cohort of Veterans with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 1–7. -
Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease.
Bowen, E. R., DiGiacomo, P., Fraser, H. P., Guttenplan, K., Smith, B. A., Heberling, M. L., … Grimes, K. V. (2023). Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease. Discover Mental Health, 3(1), 27. -
SPARKing academic technologies across the valley of death.
Kim, J. S., Kargotich, S., Lee, S. H., Yajima, R., Garcia, A. A., Ehrenkaufer, G., … Mochly-Rosen, D. (2024). SPARKing academic technologies across the valley of death. Nature Biotechnology, 42(2), 339–342.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Practice Locations
SHC- Hospital Medicine Stanford, CA
Stanford, CAImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Referring Physicians
PHYSICIAN HELPLINE
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Stanford Health Care provides comprehensive services to refer and track patients, as well as the latest information and news for physicians and office staff. For help with all referral needs and questions, visit Referral Information.
You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
- Send referrals online
- Place radiology and lab orders
- View referral status
- Access medical records