Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens.
Schwartz, N., Temkin, P., Jurado, S., Lim, B. K., Heifets, B. D., Polepalli, J. S., & Malenka, R. C. (2014). Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens. Science , 345(6196), 535–42.

MDMA as a Probe and Treatment for Social Behaviors.
Heifets, B. D., & Malenka, R. C. (2016). MDMA as a Probe and Treatment for Social Behaviors. Cell, 166(2), 269–72.

Endocannabinoid Signaling and Long-Term Synaptic Plasticity
Heifets, B. D., & Castillo, P. E. (2009). Endocannabinoid Signaling and Long-Term Synaptic Plasticity. ANNUAL REVIEW OF PHYSIOLOGY, 71, 283–306.

Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin
Heifets, B. D., Chevaleyre, V., & Castillo, P. E. (2008). Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(29), 10250–10255.

Rabies screen reveals GPe control of cocaine-triggered plasticity.
Beier, K. T., Kim, C. K., Hoerbelt, P., Hung, L. W., Heifets, B. D., DeLoach, K. E., … Malenka, R. C. (2017). Rabies screen reveals GPe control of cocaine-triggered plasticity. Nature.

Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures
Gold, S. J., Heifets, B. D., Pudiak, C. M., Potts, B. W., & Nestler, E. J. (2002). Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. JOURNAL OF NEUROCHEMISTRY, 82(4), 828–38.

The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure
Woodruff-Pak, D. S., Green, J. T., Pak, J. T., Heifets, B., & Pak, M. H. (2002). The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure. INTEGRATIVE PHYSIOLOGICAL AND BEHAVIORAL SCIENCE, 37(2), 103–13.

Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit.
Pak, J., Green, J., Heifets, B., Pak, M., & Woodruff-Pak, D. (2002). Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit. Medical Science Monitor , 8(4), BR105–12.

Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine
Witkin, J. M., Gasior, M., Heifets, B., & Tortella, F. C. (1999). Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 289(2), 703–11.

Case Report of an Awake Craniotomy in a Patient With Eisenmenger Syndrome.
Heifets, B. D., Crawford, E., Jackson, E., Brodt, J., Jaffe, R. A., & Burbridge, M. A. (2017). Case Report of an Awake Craniotomy in a Patient With Eisenmenger Syndrome. A & A Case Reports.

Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms.
Hoerbelt, P., & Heifets, B. D. (2018). Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms. Methods in Enzymology, 602, 301–38.

Fluid management concepts for severe neurological illness: an overview.
Heifets, B. D., Tanaka, P., & Burbridge, M. A. (2018). Fluid management concepts for severe neurological illness: an overview. Current Opinion in Anaesthesiology.

5-HT release in nucleus accumbens rescues social deficits in mouse autism model.
Walsh, J. J., Christoffel, D. J., Heifets, B. D., Ben-Dor, G. A., Selimbeyoglu, A., Hung, L. W., … Malenka, R. C. (2018). 5-HT release in nucleus accumbens rescues social deficits in mouse autism model. Nature.

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.
Williams, N. R., Heifets, B. D., Blasey, C., Sudheimer, K., Pannu, J., Pankow, H., … Schatzberg, A. F. (2018). Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism. The American Journal of Psychiatry, appiajp201818020138.

BEYOND KETAMINE FOR PSYCHIATRIC DISEASE: UNRAVELING THE MURINE NEURAL MECHANISMS OF THE EMPATHOGEN MDMA, A NOVEL, RAPID-ONSET SINGLE-SHOT CLINICAL THERAPY FOR POST-TRAUMATIC STRESS DISORDER
Heifets, B. D., Taylor, M., Hung, L. W., & Malenka, R. C. (2016). BEYOND KETAMINE FOR PSYCHIATRIC DISEASE: UNRAVELING THE MURINE NEURAL MECHANISMS OF THE EMPATHOGEN MDMA, A NOVEL, RAPID-ONSET SINGLE-SHOT CLINICAL THERAPY FOR POST-TRAUMATIC STRESS DISORDER. ANESTHESIA AND ANALGESIA, 122.

HIPPOCAMPAL GABAERGIC FIELD POTENTIALS: A NOVEL HIGH THROUGHPUT SCREEN FOR GENERAL ANESTHETICS IN RAT
Nie, J., Sharma, B., Maclver, B., & Heifets, B. D. (2014). HIPPOCAMPAL GABAERGIC FIELD POTENTIALS: A NOVEL HIGH THROUGHPUT SCREEN FOR GENERAL ANESTHETICS IN RAT. ANESTHESIA AND ANALGESIA, 118, S144.

IMPROVING DEEP BRAIN STIMULATION THROUGH TARGETED SYNAPTIC MODIFICATION
Heifets, B. D., Deisseroth, K., Malenka, R., & MacIver, B. (2013). IMPROVING DEEP BRAIN STIMULATION THROUGH TARGETED SYNAPTIC MODIFICATION. ANESTHESIA AND ANALGESIA, 116, 159.

Interpreting Ketamine's Opioid Receptor Dependent Effect: Response to Sanacora.
Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., & Schatzberg, A. F. (2019). Interpreting Ketamine's Opioid Receptor Dependent Effect: Response to Sanacora. The American Journal of Psychiatry, 176(3), 249–50.

Target Population, Dose, and Timing Considerations for Understanding Naltrexone's Subjective Effect: Response to Amiaz.
Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., & Schatzberg, A. F. (2019). Target Population, Dose, and Timing Considerations for Understanding Naltrexone's Subjective Effect: Response to Amiaz. The American Journal of Psychiatry, 176(3), 251–52.

KETAMINE'S ANTIDEPRESSANT EFFECT IS BLOCKED BY A MU-OPIOID RECEPTOR ANTAGONIST IN HUMANS AND MICE
Heifets, B. D., Williams, N., Sudheimer, K., Pankow, H., Blasey, C., Lyons, D., & Schatzberg, A. F. (2018). KETAMINE'S ANTIDEPRESSANT EFFECT IS BLOCKED BY A MU-OPIOID RECEPTOR ANTAGONIST IN HUMANS AND MICE. ANESTHESIA AND ANALGESIA, 126(4), 343.

Case Report of an Awake Craniotomy in a Patient With Eisenmenger Syndrome.
Heifets, B. D., Crawford, E., Jackson, E., Brodt, J., Jaffe, R. A., & Burbridge, M. A. (2018). Case Report of an Awake Craniotomy in a Patient With Eisenmenger Syndrome. A&A Practice, 10(9), 219–222.

Rigorous Translational Models Are Key to Studying Ketamine's Antidepressant Mechanism: Response to Wang and Kaplin.
Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., & Schatzberg, A. F. (2019). Rigorous Translational Models Are Key to Studying Ketamine's Antidepressant Mechanism: Response to Wang and Kaplin. The American Journal of Psychiatry, 176(5), 412.

Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect.
Heifets, B. D., Williams, N. R., Bentzley, B. S., & Schatzberg, A. F. (2019). Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect. JAMA Psychiatry.

Interpreting Ketamine's Opioid Receptor Dependent Effect: Response to Sanacora
Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., & Schatzberg, A. F. (2019). Interpreting Ketamine's Opioid Receptor Dependent Effect: Response to Sanacora. AMERICAN JOURNAL OF PSYCHIATRY, 176(3), 249–50.

Target Population, Dose, and Timing Considerations for Understanding Naltrexone's Subjective Effect: Response to Amiaz
Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., & Schatzberg, A. F. (2019). Target Population, Dose, and Timing Considerations for Understanding Naltrexone's Subjective Effect: Response to Amiaz. AMERICAN JOURNAL OF PSYCHIATRY, 176(3), 251–52.

Rigorous Translational Models Are Key to Studying Ketamine's Antidepressant Mechanism: Response to Wang and Kaplin
Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., & Schatzberg, A. F. (2019). Rigorous Translational Models Are Key to Studying Ketamine's Antidepressant Mechanism: Response to Wang and Kaplin. AMERICAN JOURNAL OF PSYCHIATRY, 176(5), 412.

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism
Williams, N. R., Heifets, B. D., Blasey, C., Sudheimer, K., Pannu, J., Pankow, H., … Schatzberg, A. F. (2018). Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism. AMERICAN JOURNAL OF PSYCHIATRY. AMER PSYCHIATRIC PUBLISHING, INC.

Disruptive Psychopharmacology.
Heifets, B. D., & Malenka, R. C. (2019). Disruptive Psychopharmacology. JAMA Psychiatry.

Attenuation of Anti-Suicidal Effects of Ketamine by Opioid Receptor Antagonism
Williams, N., Heifets, B., Bentzley, B., Blasey, C., Sudheimer, K., Lyons, D., & Schatzberg, A. (2019). Attenuation of Anti-Suicidal Effects of Ketamine by Opioid Receptor Antagonism. BIOLOGICAL PSYCHIATRY, 85(10), S113.

A newly developed anesthetic based on a unique chemical core.
Cayla, N. S., Dagne, B. A., Wu, Y., Lu, Y., Rodriguez, L., Davies, D. L., … Bertaccini, E. J. (2019). A newly developed anesthetic based on a unique chemical core. Proceedings of the National Academy of Sciences of the United States of America.

Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect
Heifets, B. D., Williams, N. R., Bentzley, B. S., & Schatzberg, A. F. (2019). Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect. JAMA PSYCHIATRY, 76(6), 657–58.

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism.
Williams, N. R., Heifets, B. D., Bentzley, B. S., Blasey, C., Sudheimer, K. D., Hawkins, J., … Schatzberg, A. F. (2019). Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism. Molecular Psychiatry.

Distinct neural mechanisms for the prosocial and rewarding properties of MDMA.
Heifets, B. D., Salgado, J. S., Taylor, M. D., Hoerbelt, P., Cardozo Pinto, D. F., Steinberg, E. E., … Malenka, R. C. (2019). Distinct neural mechanisms for the prosocial and rewarding properties of MDMA. Science Translational Medicine, 11(522).

Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning.
Steinberg, E. E., Gore, F., Heifets, B. D., Taylor, M. D., Norville, Z. C., Beier, K. T., … Malenka, R. C. (2020). Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning. Neuron.

Better living through chemistry: MDMA's prosocial mechanism as a starting point for improved therapeutics.
Heifets, B. D., & Malenka, R. C. (2020). Better living through chemistry: MDMA's prosocial mechanism as a starting point for improved therapeutics. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology.

Piercing the Ketamine Cloud
Heifets, B. D. (2020). Piercing the Ketamine Cloud. ANESTHESIOLOGY, 133(5), 970–72.

Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine.
De Gregorio, D., Aguilar-Valles, A., Preller, K. H., Heifets, B. D., Hibicke, M., Mitchell, J., & Gobbi, G. (2020). Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience.

Brain-wide unbiased mapping of neuronal activity pinpoints ketamine's interaction with the opioid system in mice
Ryskamp, D., Salgado, J., Barbosa, D. A., & Heifets, B. D. (2020). Brain-wide unbiased mapping of neuronal activity pinpoints ketamine's interaction with the opioid system in mice. ANESTHESIA AND ANALGESIA, 130, 415.

Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding.
Christoffel, D. J., Walsh, J. J., Heifets, B. D., Hoerbelt, P., Neuner, S., Sun, G., … Malenka, R. C. (2021). Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nature Communications, 12(1), 2135.

Unraveling the opioid actions of S-ketamine and R-ketamine: comment on Bonaventura et al.
Heifets, B. D., Bentzley, B. S., Williams, N., & Schatzberg, A. F. (2021). Unraveling the opioid actions of S-ketamine and R-ketamine: comment on Bonaventura et al. Molecular Psychiatry.

Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin.
Christoffel, D. J., Walsh, J. J., Hoerbelt, P., Heifets, B. D., Llorach, P., Lopez, R. C., … Malenka, R. C. (2021). Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin. Proceedings of the National Academy of Sciences of the United States of America, 118(24).

Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD.
Walsh, J. J., Llorach, P., Cardozo Pinto, D. F., Wenderski, W., Christoffel, D. J., Salgado, J. S., … Malenka, R. C. (2021). Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology.

5-HT modulation of a medial septal circuit tunes social memory stability.
Wu, X., Morishita, W., Beier, K. T., Heifets, B. D., & Malenka, R. C. (2021). 5-HT modulation of a medial septal circuit tunes social memory stability. Nature.

Local accumbens invivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding.
Wu, H., Kakusa, B., Neuner, S., Christoffel, D. J., Heifets, B. D., Malenka, R. C., & Halpern, C. H. (1800). Local accumbens invivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding. Proceedings of the National Academy of Sciences of the United States of America, 119(1).

A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings.
McInnes, L. A., Qian, J. J., Gargeya, R. S., DeBattista, C., & Heifets, B. D. (1800). A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings. Journal of Affective Disorders.

Brain wide mapping of neuronal activity evoked by MDMA, a rapid-acting therapy for post-traumatic stress disorder
Ryskamp, D., Llorach, P., Schlozman, S., Rastegar, Z., Salgado, J. S., Hietamies, T., … Heifets, B. D. (2021). Brain wide mapping of neuronal activity evoked by MDMA, a rapid-acting therapy for post-traumatic stress disorder. ANESTHESIA AND ANALGESIA. LIPPINCOTT WILLIAMS & WILKINS.

Morphine Tolerance and Reward is Regulated by Aldehyde Dehydrogenase-2 in Mice
Zambelli, V., Salgado, J. S., Heifets, B. D., Tawfik, V., & Gross, E. R. (2021). Morphine Tolerance and Reward is Regulated by Aldehyde Dehydrogenase-2 in Mice. ANESTHESIA AND ANALGESIA. LIPPINCOTT WILLIAMS & WILKINS.

Antidepressant Effect of Intraoperative Ketamine in Patients with Major Depression Undergoing Surgery: An Open-Label Pilot Study
Lii, T., Okada, R., Pfaff, K., Thordstein, R., Cianfichi, L., & Heifets, B. D. (2021). Antidepressant Effect of Intraoperative Ketamine in Patients with Major Depression Undergoing Surgery: An Open-Label Pilot Study. ANESTHESIA AND ANALGESIA. LIPPINCOTT WILLIAMS & WILKINS.

Brain-wide unbiased mapping of neuronal activity pinpoints ketamine's interaction with the opioid system in mice
Ryskamp, D., Hietamies, T., Schlozman, S., Llorach, P., Salgado, J. S., Barbosa, D. A., & Heifets, B. D. (2021). Brain-wide unbiased mapping of neuronal activity pinpoints ketamine's interaction with the opioid system in mice. ANESTHESIA AND ANALGESIA. LIPPINCOTT WILLIAMS & WILKINS.

Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials.
Aday, J. S., Heifets, B. D., Pratscher, S. D., Bradley, E., Rosen, R., & Woolley, J. D. (2022). Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials. Psychopharmacology.

Deconstructing Ketamine-Induced Changes in Cortisol and Dissociative and Affective States in a Controlled Mechanistic Study
Hack, L. M., Zhang, X., Brawer, J., Gray, N., Heifets, B., Suppes, T., … Williams, L. (2022). Deconstructing Ketamine-Induced Changes in Cortisol and Dissociative and Affective States in a Controlled Mechanistic Study. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Acute Ketamine Modulates Cognitive Control Network Activity During Cognitive Inhibition: Evidence From a Mechanistic Trial
Zhang, X., Hack, L., Brawer, J., Gray, N., Heifets, B., Suppes, T., … Williams, L. (2022). Acute Ketamine Modulates Cognitive Control Network Activity During Cognitive Inhibition: Evidence From a Mechanistic Trial. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Anesthetic-Induced Intraoperative Dream Associated With Remission of a Psychiatric Disorder: A Case Report.
Chow, H. S., Hack, L. M., Kawai, M., & Heifets, B. D. (2022). Anesthetic-Induced Intraoperative Dream Associated With Remission of a Psychiatric Disorder: A Case Report. A&A Practice, 16(8), e01613.

Intraoperative Anesthetic Probes of Brain Health: Ketamine as a Canary in the Coal Mine?
Reese, M., Heifets, B. D., & Berger, M. (2022). Intraoperative Anesthetic Probes of Brain Health: Ketamine as a Canary in the Coal Mine? Anesthesia and Analgesia, 135(4), 679–682.

An immune signature of postoperative cognitive dysfunction (POCD)
Verdonk, F., Tsai, A. S., Hedou, J., Heifets, B. D., Gaudilliere, D., Bellan, G., … Gaudilliere, B. (2022). An immune signature of postoperative cognitive dysfunction (POCD). ANESTHESIA AND ANALGESIA. LIPPINCOTT WILLIAMS & WILKINS.

Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal.
Pomrenze, M. B., Cardozo Pinto, D. F., Neumann, P. A., Llorach, P., Tucciarone, J. M., Morishita, W., … Malenka, R. C. (2022). Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal. Neuron.

Cervical sympathectomy to treat cerebral vasospasm: a scoping review.
Bombardieri, A. M., Heifets, B. D., Treggiari, M., Albers, G. W., Steinberg, G. K., & Heit, J. J. (2022). Cervical sympathectomy to treat cerebral vasospasm: a scoping review. Regional Anesthesia and Pain Medicine.

A Protocol for Reducing Intensive Care Utilization After Craniotomy: A 3-Year Assessment.
Ruiz Colón, G. D., Ohkuma, R., Pendharkar, A. V., Heifets, B. D., Li, G., Lu, A., … Ratliff, J. K. (2023). A Protocol for Reducing Intensive Care Utilization After Craniotomy: A 3-Year Assessment. Neurosurgery.

The effects of ketamine on symptoms of depression and anxiety in real-world care settings: A retrospective controlled analysis.
Hietamies, T. M., McInnes, L. A., Klise, A. J., Worley, M. J., Qian, J. J., Williams, L. M., … Levine, S. P. (2023). The effects of ketamine on symptoms of depression and anxiety in real-world care settings: A retrospective controlled analysis. Journal of Affective Disorders.

Trial of Ketamine Masked by Surgical Anesthesia in Depressed Patients.
Lii, T. R., Smith, A. E., Flohr, J. R., Okada, R. L., Nyongesa, C. A., Cianfichi, L. J., … Heifets, B. D. (2023). Trial of Ketamine Masked by Surgical Anesthesia in Depressed Patients. MedRxiv : the Preprint Server for Health Sciences.

UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice.
Rijsketic, D. R., Casey, A. B., Barbosa, D. A., Zhang, X., Hietamies, T. M., Ramirez-Ovalle, G., … Heifets, B. D. (2023). UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology.

UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice.
Rijsketic, D. R., Casey, A. B., Barbosa, D. A., Zhang, X., Hietamies, T. M., Ramirez-Ovalle, G., … Heifets, B. D. (2023). UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice. BioRxiv : the Preprint Server for Biology.

Therapeutic mechanisms of psychedelics and entactogens.
Heifets, B. D., & Olson, D. E. (2023). Therapeutic mechanisms of psychedelics and entactogens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology.

Acute Effects of MDMA on Intrinsic Functional Connectomes Associated With Altered States of Consciousness and Defensiveness
Zhang, X., Hack, L., Heifets, B., Suppes, T., van Roessel, P., Yesavage, J., … Williams, L. (2023). Acute Effects of MDMA on Intrinsic Functional Connectomes Associated With Altered States of Consciousness and Defensiveness. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Acute Effects of MDMA on Negative Affective Brain Circuit Function: A Randomized Controlled Mechanistic Trial
Hack, L., Zhang, X., Heifets, B., Suppes, T., van Roessel, P., Yesavage, J., … Williams, L. (2023). Acute Effects of MDMA on Negative Affective Brain Circuit Function: A Randomized Controlled Mechanistic Trial. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Ketamine's Acute Effects on Negative Brain States are Mediated Through Distinct Altered States in Humans
Zhang, X., Hack, L., Heifets, B., Suppes, T., Van Roessel, P., Yesavage, J., … Williams, L. (2023). Ketamine's Acute Effects on Negative Brain States are Mediated Through Distinct Altered States in Humans. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Brain-Wide Activity Mapping Reveals a Required Role for the Dorsal Endopiriform Nucleus in MDMA-Evoked Prosocial Behavior
Heifets, B., Rijsketic, D., Salgado, J., Wall, N., Ramirez-Ovalle, G., Llorach, P., … Malenka, R. (2023). Brain-Wide Activity Mapping Reveals a Required Role for the Dorsal Endopiriform Nucleus in MDMA-Evoked Prosocial Behavior. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

An orexigenic subnetwork within the human hippocampus.
Barbosa, D. A., Gattas, S., Salgado, J. S., Kuijper, F. M., Wang, A. R., Huang, Y., … Halpern, C. H. (2023). An orexigenic subnetwork within the human hippocampus. Nature.

Ketamine's acute effects on negative brain states are mediated through distinct altered states of consciousness in humans.
Hack, L. M., Zhang, X., Heifets, B. D., Suppes, T., van Roessel, P. J., Yesavage, J. A., … Williams, L. M. (2023). Ketamine's acute effects on negative brain states are mediated through distinct altered states of consciousness in humans. Nature Communications, 14(1), 6631.

An orexigenic subnetwork within the human hippocampus
Barbosa, D. A. N., Gattas, S., Salgado, J. S., Kuijper, F. M., Wang, A. R., Huang, Y., … Halpern, C. H. (2023). An orexigenic subnetwork within the human hippocampus. NATURE.

Randomized trial of ketamine masked by surgical anesthesia in patients with depression.
Lii, T. R., Smith, A. E., Flohr, J. R., Okada, R. L., Nyongesa, C. A., Cianfichi, L. J., … Heifets, B. D. (2023). Randomized trial of ketamine masked by surgical anesthesia in patients with depression. Nature Mental Health, 1(11), 876–886.

Expectancy effects in psychedelic trials.
Szigeti, B., & Heifets, B. (2024). Expectancy effects in psychedelic trials. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging.

Reduction in Trauma-Related Symptoms After Anesthetic-Induced Intra-Operative Dreaming.
Hack, L. M., Sikka, P., Zhou, K., Kawai, M., Chow, H. S., & Heifets, B. (2024). Reduction in Trauma-Related Symptoms After Anesthetic-Induced Intra-Operative Dreaming. The American Journal of Psychiatry, appiajp20230698.

Opioid receptor expressing neurons of the central amygdala gate behavioral effects of ketamine in mice.
Pomrenze, M. B., Vaillancourt, S., Llorach, P., Rijsketic, D. R., Casey, A. B., Gregory, N., … Heifets, B. D. (2024). Opioid receptor expressing neurons of the central amygdala gate behavioral effects of ketamine in mice. BioRxiv : the Preprint Server for Biology.

Brain-Wide Activity Mapping Reveals a Required Role for the Dorsal Endopiriform Nucleus in MDMA-Evoked Prosocial Behavior
Heifets, B. (2023). Brain-Wide Activity Mapping Reveals a Required Role for the Dorsal Endopiriform Nucleus in MDMA-Evoked Prosocial Behavior. NEUROPSYCHOPHARMACOLOGY. SPRINGERNATURE.

MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens.
Rein, B., Raymond, K., Boustani, C., Tuy, S., Zhang, J., St Laurent, R., … Malenka, R. C. (2024). MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens. Science Advances, 10(17), eadl6554.

Prevalence and characteristics of preoperative patients with depression.
Hietamies, T. M., Smith, A. E., Lii, T. R., Muzzall, E., Flohr, J., Okada, R. L., … Heifets, B. D. (2024). Prevalence and characteristics of preoperative patients with depression. British Journal of Anaesthesia.

DREAMING UNDER ANESTHESIA OCCURS DURING PRE-EMERGENCE STATE
Ishii, T., Kawai, M., Heifets, B., & Chow, H. (2024). DREAMING UNDER ANESTHESIA OCCURS DURING PRE-EMERGENCE STATE. SLEEP. OXFORD UNIV PRESS INC.

Ketamine, the First Associative Anesthetic? Some Considerations on Classifying Psychedelics, Entactogens, and Dissociatives.
Denomme, N., & Heifets, B. D. (2024). Ketamine, the First Associative Anesthetic? Some Considerations on Classifying Psychedelics, Entactogens, and Dissociatives. The American Journal of Psychiatry, 181(9), 784–786.

Neural Circuit Delineation of (±)-3,4-methylenedioxymethamphetamine (MDMA)-evoked Sociability and Fear Memory Deficits
Casey, A., Rijsketic, D. R., Zhao, W., Palmer, A., Salgado, J., Llorach, P., … Heifets, B. (2024). Neural Circuit Delineation of (±)-3,4-methylenedioxymethamphetamine (MDMA)-evoked Sociability and Fear Memory Deficits. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Comparing the Antisuicidal and Antidepressant Effects of Intravenous Ketamine in Major Depressive Episodes With Suicidal Ideation
Bandeira, I. D., Tucciarone, J., Kratter, I. H., Heifets, B. D., Pankow, H., Chang, M., … Schatzberg, A. F. (2024). Comparing the Antisuicidal and Antidepressant Effects of Intravenous Ketamine in Major Depressive Episodes With Suicidal Ideation. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Opioid Use Diminishes Placebo Antidepressant Response Independently of Pain in a Ketamine Depression Trial: A Post Hoc Analysis
Lii, T., Smith, A., Flohr, J., Okada, R., Nyongesa, C., Cianfichi, L., … Heifets, B. (2024). Opioid Use Diminishes Placebo Antidepressant Response Independently of Pain in a Ketamine Depression Trial: A Post Hoc Analysis. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Clinical Outcomes and Biomarkers From a Randomized Trial of Ketamine Masked by Surgical Anesthesia in Depressed Patients
Heifets, B., Lii, T., Smith, A., Flohr, J., Nyongesa, C., Cianfichi, L., … Schatzberg, A. (2024). Clinical Outcomes and Biomarkers From a Randomized Trial of Ketamine Masked by Surgical Anesthesia in Depressed Patients. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.

Anesthesia as a Control for Blinding in Psychedelic Therapy
Hietamies, T., Casey, A., Zhao, W., Rijsketic, D., Deverett, B., Restagar, Z., & Heifets, B. (2024). Anesthesia as a Control for Blinding in Psychedelic Therapy. BIOLOGICAL PSYCHIATRY. ELSEVIER SCIENCE INC.