Biography
Dr. Sneha S. Jain is a Clinical Assistant Professor of Medicine in the Division of Cardiovascular Medicine and Director of the GUIDE-AI Lab. She specializes in general cardiovascular medicine and preventive cardiology.
Dr. Jain pursued her undergraduate degree in Economics at Duke University and graduated with distinction. She received her medical degree from the Johns Hopkins School of Medicine and her MBA from Harvard Business School. She completed internal medicine residency training at Columbia/NewYork-Presbyterian, and fellowship training in cardiovascular medicine at Stanford University.
Her research focuses on the development and responsible evaluation of AI tools to augment healthcare delivery and improve patient outcomes. She works with the Data Science Team at Stanford Healthcare and the Stanford Center for Clinical Research to deploy and prospectively evaluate AI solutions across the healthcare enterprise. She serves on the American College of Cardiology Healthcare Innovation Section leadership council, the American Heart Association Expert Panel for the AI Validation Lab, and as an Expert AI consultant for the Journal of the American College of Cardiology.
Dr. Jain pursued her undergraduate degree in Economics at Duke University and graduated with distinction. She received her medical degree from the Johns Hopkins School of Medicine and her MBA from Harvard Business School. She completed internal medicine residency training at Columbia/NewYork-Presbyterian, and fellowship training in cardiovascular medicine at Stanford University.
Her research focuses on the development and responsible evaluation of AI tools to augment healthcare delivery and improve patient outcomes. She works with the Data Science Team at Stanford Healthcare and the Stanford Center for Clinical Research to deploy and prospectively evaluate AI solutions across the healthcare enterprise. She serves on the American College of Cardiology Healthcare Innovation Section leadership council, the American Heart Association Expert Panel for the AI Validation Lab, and as an Expert AI consultant for the Journal of the American College of Cardiology.
View Full Biography
Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Cardiovascular Disease (2024)
- Fellowship: Stanford University Cardiovascular Medicine Fellowship Program (2024) CA
- Board Certification: American Board of Internal Medicine, Internal Medicine (2021)
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- Residency: Columbia University College of Physicians and Surgeons (2021) NY
- Medical Education: Johns Hopkins University School of Medicine (2018) MD
- MD, Johns Hopkins School of Medicine
- MBA, Harvard Business School
Honors & Awards
- Chief Fellow, Stanford University (2023)
- Edwin Alderman Award for Excellence in Clinical Research, Stanford University (2024)
- Fellow-in-Training Travel Award, American Heart Association (2023)
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- Joseph Muschel Resident Award, New York Presbyterian-Columbia (2020)
- Silverman Fellow in Healthcare Innovation, New York Presbyterian-Columbia (2020)
- Stanford Cardiovascular Institute Manuscript Award, Stanford University (2025)
- Stanford Clinical Trial Research Fellow, Stanford University (2021)
Memberships
- Member of the Expert Panel for the American Heart Association Artificial Intelligence Validation Lab, American Heart Association (2025 - Present)
- Healthcare Innovation Council Member, American College of Cardiology (2023 - Present)
- Co-Director of the Cross-Sectional Artificial Intelligence Working Group, American College of Cardiology (2024 - Present)
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- Consultant for Data Science/Artificial Intelligence, Journal of the American College of Cardiology (2025 - Present)
Publications
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Clinical and economic burden of obstructive hypertrophic cardiomyopathy in the United States
Jain, S. S., Li, S. S., Xie, J., Sutton, M. B., Fine, J. T., Edelberg, J. M., … Cohen, D. J. (2021). Clinical and economic burden of obstructive hypertrophic cardiomyopathy in the United States. JOURNAL OF MEDICAL ECONOMICS, 24(1), 1115–1123. -
The Effect of Chaplain Patient Navigators and Multidisciplinary Family Meetings on Patient Outcomes in the ICU: The Critical Care Collaboration and Communication Project.
Alghanim, F., Furqan, M., Prichett, L., Landon, J., Tao, X., Selvam, P., … Zakaria, S. (2021). The Effect of Chaplain Patient Navigators and Multidisciplinary Family Meetings on Patient Outcomes in the ICU: The Critical Care Collaboration and Communication Project. Critical Care Explorations, 3(11), e0574. -
Prognostic Importance of Health Status Versus Functional Status in Heart Failure and Secondary Mitral Regurgitation
Arnold, S. V., Stone, G. W., Jain, S. S., Mack, M. J., Saxon, J. T., Zhang, Z., … Cohen, D. J. (2021). Prognostic Importance of Health Status Versus Functional Status in Heart Failure and Secondary Mitral Regurgitation. JACC-HEART FAILURE, 9(9), 684–692. -
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Defining a Clinically Important Change in 6-Minute Walk Distance in Patients With Heart Failure and Mitral Valve Disease
Jain, S. S., Cohen, D. J., Zhang, Z., Uriel, N., Sayer, G., Lindenfeld, J. A., … Arnold, S. V. (2021). Defining a Clinically Important Change in 6-Minute Walk Distance in Patients With Heart Failure and Mitral Valve Disease. CIRCULATION-HEART FAILURE, 14(3), 405–407. -
Admission Cardiac Diagnostic Testing with Electrocardiography and Troponin Measurement Prognosticates Increased 30-Day Mortality in COVID-19
Poterucha, T. J., Elias, P., Jain, S. S., Sayer, G., Redfors, B., Burkhoff, D., … Wan, E. Y. (2021). Admission Cardiac Diagnostic Testing with Electrocardiography and Troponin Measurement Prognosticates Increased 30-Day Mortality in COVID-19. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(1), e018476. -
Prognostic Importance of Functional Status Versus Health Status in Patients With Heart Failure and Severe Secondary Mitral Regurgitation
Arnold, S., Stone, G., Jain, S., Mack, M., Saxon, J., Ambrosy, A., … Cohen, D. (2020). Prognostic Importance of Functional Status Versus Health Status in Patients With Heart Failure and Severe Secondary Mitral Regurgitation. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. ELSEVIER SCIENCE INC. -
The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19
Elias, P., Poterucha, T. J., Jain, S. S., Sayer, G., Raikhelkar, J., Fried, J., … Uriel, N. (2020). The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19. MAYO CLINIC PROCEEDINGS, 95(10), 2099–2109. -
An Evaluation of Biometric Monitoring Technologies for Vital Signs in the Era of COVID-19
Manta, C., Jain, S. S., Coravos, A., Mendelsohn, D., & Izmailova, E. S. (2020). An Evaluation of Biometric Monitoring Technologies for Vital Signs in the Era of COVID-19. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 13(6), 1034–1044. -
Indications for and Findings on Transthoracic Echocardiography in COVID-19
Jain, S. S., Liu, Q., Raikhelkar, J., Fried, J., Elias, P., Poterucha, T. J., … Anstey, D. E. (2020). Indications for and Findings on Transthoracic Echocardiography in COVID-19. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 33(10), 1278–1284. -
The Variety of Cardiovascular Presentations of COVID-19
Fried, J. A., Ramasubbu, K., Bhatt, R., Topkara, V. K., Clerkin, K. J., Horn, E., … Sayer, G. (2020). The Variety of Cardiovascular Presentations of COVID-19. CIRCULATION, 141(23), 1930–1936. -
COVID-19 and Cardiovascular Disease
Clerkin, K. J., Fried, J. A., Raikhelkar, J., Sayer, G., Griffin, J. M., Masoumi, A., … Uriel, N. (2020). COVID-19 and Cardiovascular Disease. CIRCULATION, 141(20), 1648–1655. -
Impact of Periprocedural Major Adverse Events After PCI and CABG on Long-Term Outcomes in Patients With Left Main Disease: The EXCEL Trial
Jain, S., Dressler, O., Serruys, P., Kappetein, A. P., Sabik, J., Leon, M., … Stone, G. (2019). Impact of Periprocedural Major Adverse Events After PCI and CABG on Long-Term Outcomes in Patients With Left Main Disease: The EXCEL Trial. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. ELSEVIER SCIENCE INC. -
Diagnostic Capability of Three-Dimensional Macular Parameters for Glaucoma Using Optical Coherence Tomography Volume Scans
Vercellin, A. C. V., Jassim, F., Poon, L. Y.-C., Tsikata, E., Braaf, B., Shah, S., … Chen, T. C. (2018). Diagnostic Capability of Three-Dimensional Macular Parameters for Glaucoma Using Optical Coherence Tomography Volume Scans. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(12), 4998–5010. -
Why are patients being readmitted after surgery for esophageal cancer?
Shah, S. P., Xu, T., Hooker, C. M., Hulbert, A., Battafarano, R. J., Brock, M. V., … Yang, S. C. (2015). Why are patients being readmitted after surgery for esophageal cancer? JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 149(5), 1384–1389. -
Outflow Graft Narrowing of the HeartMate 3 Left Ventricular Assist Device.
Jain, S. S., Clerkin, K. J., Anstey, D. E., Liu, Q., Fried, J. A., Raikhelkar, J., … Leb, J. (2022). Outflow Graft Narrowing of the HeartMate 3 Left Ventricular Assist Device. The Annals of Thoracic Surgery. -
Leading Change – A National Survey of Chief Innovation Officers in Health Systems
Shah, S. P., McCourt, L., Jakobson, K., Saddington, A., Harvey, K., & Schulman, K. A. (2018). Leading Change – A National Survey of Chief Innovation Officers in Health Systems. Health Management, Policy & Innovation, 3(1). -
Committing To Transformation: Chief Innovation Officers And The Role Of Organizational Redesign
Jain, S. S., & Schulman, K. A. (2018). Committing To Transformation: Chief Innovation Officers And The Role Of Organizational Redesign. Health Affairs Forefront. -
The Evolving Roles of Digital Health, Big Data and AI: "Tech-celeration" in CV Care
Jain, S. S. (2021). The Evolving Roles of Digital Health, Big Data and AI: "Tech-celeration" in CV Care. Cardiology Magazine. -
Impact of Periprocedural AdverseEventsAfter PCI and CABGon5-Year Mortality: The EXCEL Trial.
Jain, S. S., Li, D., Dressler, O., Kotinkaduwa, L., Serruys, P. W., Kappetein, A. P., … Stone, G. W. (2023). Impact of Periprocedural AdverseEventsAfter PCI and CABGon5-Year Mortality: The EXCEL Trial. JACC. Cardiovascular Interventions, 16(3), 303–313. -
Notch-1 and Notch-4 Receptors as Prognostic Markers in Breast Cancer
Yao, K., Rizzo, P., Rajan, P., Albain, K., Rychlik, K., Shah, S., & Miele, L. (2011). Notch-1 and Notch-4 Receptors as Prognostic Markers in Breast Cancer. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 19(5), 607–613. -
The 2.5 angstrom Structure of CD1c in Complex with a Mycobacterial Lipid Reveals an Open Groove Ideally Suited for Diverse Antigen Presentation
Scharf, L., Li, N.-S., Hawk, A. J., Garzon, D., Zhang, T., Fox, L. M., … Adams, E. J. (2010). The 2.5 angstrom Structure of CD1c in Complex with a Mycobacterial Lipid Reveals an Open Groove Ideally Suited for Diverse Antigen Presentation. IMMUNITY, 33(6), 853–862. -
Association of Coronary Artery Calcium Detected by Routine Ungated CT Imaging With Cardiovascular Outcomes.
Peng, A. W., Dudum, R., Jain, S. S., Maron, D. J., Patel, B. N., Khandwala, N., … Rodriguez, F. (2023). Association of Coronary Artery Calcium Detected by Routine Ungated CT Imaging With Cardiovascular Outcomes. Journal of the American College of Cardiology, 82(12), 1192–1202. -
Aortic Root Thrombosis in Patients with HeartMate 3 Left Ventricular Assist Device Support.
Carey, M. R., Marshall, D., Clerkin, K., Laracuente, R., Sanchez, J., Jain, S. S., … Fried, J. A. (2023). Aortic Root Thrombosis in Patients with HeartMate 3 Left Ventricular Assist Device Support. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. -
Treatment effect of canagliflozin for patients on therapy for heart failure: Pooled analysis of the CANVAS program and CREDENCE trial.
Jain, S. S., Yu, J., Arnott, C., Neal, B., Perkovic, V., Neuen, B. L., … Mahaffey, K. W. (2023). Treatment effect of canagliflozin for patients on therapy for heart failure: Pooled analysis of the CANVAS program and CREDENCE trial. International Journal of Cardiology, 131444. -
Contemporary attitudes and beliefs on coronary artery calcium from social media using artificial intelligence.
Somani, S., Balla, S., Peng, A. W., Dudum, R., Jain, S., Nasir, K., … Rodriguez, F. (2024). Contemporary attitudes and beliefs on coronary artery calcium from social media using artificial intelligence. NPJ Digital Medicine, 7(1), 83. -
Artificial Intelligence for Cardiovascular Care - Part 1: Advances: JACC Review Topic of the Week.
Elias, P., Jain, S., Poterucha, T., Randazzo, M., Lopez Jimenez, F., Khera, R., … Maddox, T. M. (2024). Artificial Intelligence for Cardiovascular Care - Part 1: Advances: JACC Review Topic of the Week. Journal of the American College of Cardiology. -
Artificial Intelligence in Cardiovascular Care - Part 2: Applications: JACC Review Topic of the Week.
Jain, S., Elias, P., Poterucha, T., Randazzo, M., Lopez Jimenez, F., Khera, R., … Maddox, T. M. (2024). Artificial Intelligence in Cardiovascular Care - Part 2: Applications: JACC Review Topic of the Week. Journal of the American College of Cardiology. -
Artificial Intelligence in Cardiovascular Disease Prevention: Is it Ready for Prime Time?
Parsa, S., Somani, S., Dudum, R., Jain, S. S., & Rodriguez, F. (2024). Artificial Intelligence in Cardiovascular Disease Prevention: Is it Ready for Prime Time? Current Atherosclerosis Reports. -
Sociodemographic Differences Among Patients Receiving Coronary Artery Calcium Scoring vs. Non-Gated Chest CT Imaging
Peng, A. W., Skye, M., Jain, S. S., Dudum, R., Maron, D. J., Sandhu, A. T., & Rodriguez, F. (2023). Sociodemographic Differences Among Patients Receiving Coronary Artery Calcium Scoring vs. Non-Gated Chest CT Imaging. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. -
Introduction to Wearable Technology in Arrhythmia Management.
Perez-Guerrero, E. J., Mehrotra, I., Jain, S. S., & Perez, M. V. (2024). Introduction to Wearable Technology in Arrhythmia Management. Heart Rhythm. -
Large Language Models as Partners in Medical Literature.
Perez-Guerrero, E. J., Mehrotra, I., Jain, S. S., & Perez, M. V. (2024). Large Language Models as Partners in Medical Literature. Heart Rhythm. -
When Two Isn't Better Than One: Single Versus Multiple Angiographic Views for Quantitative Flow Ratio.
Jain, S. S., & Fearon, W. F. (2022). When Two Isn't Better Than One: Single Versus Multiple Angiographic Views for Quantitative Flow Ratio. Journal of the Society for Cardiovascular Angiography & Interventions, 1(5), 100411. -
Milvexian: An Oral, Bioavailable Factor XIa Inhibitor.
Parsa, S., Jain, S. S., Akinrimisi, O., Lam, C. S., & Mahaffey, K. W. (2024). Milvexian: An Oral, Bioavailable Factor XIa Inhibitor. Cardiology and Therapy. -
Democratizing Congenital Heart Disease Management: The Potential for AI-Enabled Care and Necessary Future Directions.
Jain, S. S., Elias, P., & Clark, D. E. (2024). Democratizing Congenital Heart Disease Management: The Potential for AI-Enabled Care and Necessary Future Directions. Journal of the American College of Cardiology, 84(9), 829–831. -
Milvexian vs apixaban for stroke prevention in atrial fibrillation: The LIBREXIA atrial fibrillation trial rationale and design.
Jain, S. S., Mahaffey, K. W., Pieper, K. S., Shimizu, W., Potpara, T., Ruff, C. T., … Lam, C. S. (2024). Milvexian vs apixaban for stroke prevention in atrial fibrillation: The LIBREXIA atrial fibrillation trial rationale and design. American Heart Journal. -
Novel Digital Strategy for Improving Diversity in Cardiovascular Clinical Trials
Jain, S. S., Perez, M. V., Nguyen, K. T., Hernandez, A. F., Turakhia, M., & Mahaffey, K. W. (2023). Novel Digital Strategy for Improving Diversity in Cardiovascular Clinical Trials. CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. -
Low-Density Lipoprotein Cholesterol Control as a Performance Measure: A National Analysis of the VHA.
Jain, S. S., Skye, M., Din, N., Furst, A., Maron, D. J., Heidenreich, P., … Rodriguez, F. (2024). Low-Density Lipoprotein Cholesterol Control as a Performance Measure: A National Analysis of the VHA. Journal of the American College of Cardiology, 84(13), 1272–1275. -
Avoiding Financial Toxicity for Patients from Clinicians' Use of AI.
Jain, S. S., Mello, M. M., & Shah, N. H. (2024). Avoiding Financial Toxicity for Patients from Clinicians' Use of AI. The New England Journal of Medicine. -
Artificial Intelligence in Cardiovascular Clinical Trials.
Cunningham, J. W., Abraham, W. T., Bhatt, A. S., Dunn, J., Felker, G. M., Jain, S. S., … Solomon, S. D. (2024). Artificial Intelligence in Cardiovascular Clinical Trials. Journal of the American College of Cardiology, 84(20), 2051–2062. -
The Coming AI Revolution in ClinicalTrials.
Jain, S. S., Sarraju, A., Shah, N. H., Schulman, K. A., Ashley, E. A., Harrington, R. A., & Mahaffey, K. W. (2024). The Coming AI Revolution in ClinicalTrials. Journal of the American College of Cardiology. -
From Better Models to Better Care.
Shah, N. H., & Jain, S. S. (2025). From Better Models to Better Care. JACC. Heart Failure, 13(1), 88–90. -
Standing on FURM Ground: A Framework for Evaluating Fair, Useful, and Reliable AI Models in Health Care Systems
Callahan, A., McElfresh, D., Banda, J. M., Bunney, G., Char, D., Chen, J., … Shah, N. H. (2024). Standing on FURM Ground: A Framework for Evaluating Fair, Useful, and Reliable AI Models in Health Care Systems. NEJM CATALYST INNOVATIONS IN CARE DELIVERY, 5(10). -
South Asians and cardiometabolic health: A framework for comprehensive care for the individual, community, and population - An American society for preventive cardiology clinical practice statement.
Rohatgi, A., Anand, S. S., Gadgil, M., Gujral, U. P., Jain, S. S., Javed, Z., … Patel, J. (2025). South Asians and cardiometabolic health: A framework for comprehensive care for the individual, community, and population - An American society for preventive cardiology clinical practice statement. American Journal of Preventive Cardiology, 22, 101000. -
Racial and Ethnic Representation and Study Engagement in a Siteless Digital Clinical Trial Using a Smartwatch: Findings From the Apple Heart Study.
Nguyen, K. T., Yu, J., Hedlin, H., Phillips, A. T., Desai, S., Cheung, L., … Perez, M. V. (2025). Racial and Ethnic Representation and Study Engagement in a Siteless Digital Clinical Trial Using a Smartwatch: Findings From the Apple Heart Study. Mayo Clinic Proceedings. Digital Health, 3(3), 100232. -
A deep learning phenome wide association study of the electrocardiogram.
Hughes, J. W., Theurer, J., Vukadinovic, M., Rogers, A. J., Somani, S., Kang, G., … Ouyang, D. (2025). A deep learning phenome wide association study of the electrocardiogram. European Heart Journal. Digital Health, 6(4), 595–607. -
Successful Rituximab Treatment of GPIHBP1 Autoantibody-Associated Hypertriglyceridemia.
Hussain, T., Horomanski, A., Jain, S., Lamendola, C., Abbasi, F., Murakami, M., & Knowles, J. W. (2025). Successful Rituximab Treatment of GPIHBP1 Autoantibody-Associated Hypertriglyceridemia. JACC. Case Reports, 30(23), 104647. -
Moving Beyond the Model: Our Perspective on Meaningful AI Research in Cardiovascular Care.
Jain, S. S., Mortazavi, B. J., Chan You, S., Yao, X., Lam, C. S., Elias, P., … Krumholz, H. M. (2025). Moving Beyond the Model: Our Perspective on Meaningful AI Research in Cardiovascular Care. Journal of the American College of Cardiology, 86(10), 691–695. -
Digital Strategies for Recruitment to Improve Diversity and Inclusion in Prospective Cardiovascular Clinical Research.
Jain, S. S., Rodriguez, F., Perez, M. V., Yu, J., Shashidhar, S., Swope, S., … Mahaffey, K. W. (2025). Digital Strategies for Recruitment to Improve Diversity and Inclusion in Prospective Cardiovascular Clinical Research. Cardiology and Therapy. -
Detecting Transthyretin Cardiac Amyloidosis With Artificial Intelligence: A Nonrandomized Clinical Trial.
Jain, S. S., Sun, T., Pierson, E., Roedan Oliver, F., Malta, P., Castillo, M., … Poterucha, T. J. (2025). Detecting Transthyretin Cardiac Amyloidosis With Artificial Intelligence: A Nonrandomized Clinical Trial. JAMA Cardiology. -
Effects of Real-Time Notification of AI-Detected Incidental Coronary Artery Calcium on Statin Prescription: the NOTIFY-PICTURE Trial.
Dudum, R., Jain, S. S., Mastrodicasa, D., Furst, A., Xu, S., Ngo, S., … Rodriguez, F. (2025). Effects of Real-Time Notification of AI-Detected Incidental Coronary Artery Calcium on Statin Prescription: the NOTIFY-PICTURE Trial. Circulation. -
Pragmatic Approaches to the Evaluation and Monitoring of Artificial Intelligence in Health Care: A Science Advisory From the American Heart Association.
Jain, S. S., Goto, S., Hall, J. L., Khan, S. S., MacRae, C. A., Ofori, C., … Schwamm, L. H. (2025). Pragmatic Approaches to the Evaluation and Monitoring of Artificial Intelligence in Health Care: A Science Advisory From the American Heart Association. Circulation.
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Defining a Clinically Important Change in 6-Minute Walk Distance in Patients With Heart Failure and Mitral Valve Disease
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