Biography
I am a translational physician-scientist committed to understanding the pathophysiology of schizophrenia to identify disease-modifying therapeutic interventions. I examined the role of C4 protein activation in clinical samples from individuals with schizophrenia compared to controls, its relationship to C4 CNV and effect on blood brain barrier permeability using in vitro model systems. I contributed to identifying LINE-1 insertions in postmortem brain samples of individuals with schizophrenia and C4 copy number variation (CNV) in pediatric patients with neuropsychiatric symptoms. Since accumulating evidence points to the synapses as the locus of pathology in schizophrenia, I am focusing my current research effort to defining the underlying abnormality in synapses in schizophrenia using a combination of in vitro iPS based model systems and postmortem brain samples, and applying cutting-edge techniques like spatial transcriptomics and array tomography.
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Professional Summary
Education & Certifications
- Residency: Stanford University Psychiatry Residency (2017) CA
- Board Certification: American Board of Psychiatry and Neurology, Psychiatry (2018)
- Medical Education: University of Pittsburgh School of Medicine (2013) PA
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- PhD, Carnegie Mellon University, Biomedical Engineering (2011)
Honors & Awards
- 2022 Young Investigator Grant, Brain and Behavior Research Foundation (2023-2025)
- Advanced Fellow in Mental Illness Research, Sierra Pacific Mental Illness Research Education and Clinical Center (MIRECC), VA Palo Alto (2019-present)
- CDI Fellow, Career Development Institute for Psychiatry (2025-2026)
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- Early Career Award Program, Veterans Association Palo Alto VISN21 (2022-2024)
- K08 Career Development Award, National Institute of Mental Health (2024-2029)
- Outstanding Resident Award- Honorable Mention, National Institutes of Health (2017)
- Ruth L. Kirschstein National Research Service Award F30, National Institutes of Health (2008-2013)
- T32 Postdoctoral Research Training in Psychiatric Research, National Institutes of Health (2017-2019)
- Translational Research and Applied Medicine Scholar, Stanford University School of Medicine (2018-2020)
Memberships
- NIMH Study Section Reviewer, Training in Neurobiology of Disease, Psychopathology & Molecular Processes Special Emphasis Panel (2025 - Present)
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Publications
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Stabilization of the spectrin-like domains of nesprin-1a by the evolutionarily conserved "adaptive" domain.
Zhong, Z., Chang, S. A., Kalinowski, A., Wilson, K. L., & Dahl, K. N. (2010). Stabilization of the spectrin-like domains of nesprin-1a by the evolutionarily conserved "adaptive" domain. Cellular and Molecular Bioengineering, 3(2), 139–150. -
Governmental standard drink definitions and low-risk alcohol consumption guidelines in 37 countries
Kalinowski, A., & Humphreys, K. (2016). Governmental standard drink definitions and low-risk alcohol consumption guidelines in 37 countries. ADDICTION, 111(7), 1293–98. -
MACHINE LEARNING REVEALS BILATERAL DISTRIBUTION OF SOMATIC L1 INSERTIONS IN HUMAN NEURONS AND GLIA
Zhu, X., Zhou, B., Pattni, R., Gleason, K., Tan, C., Kalinowski, A., … Urban, A. (2019). MACHINE LEARNING REVEALS BILATERAL DISTRIBUTION OF SOMATIC L1 INSERTIONS IN HUMAN NEURONS AND GLIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. ELSEVIER. -
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Teaching Practice-Based Learning on Inpatient Psychiatric Services.
Kalinowski, A., Raj, K. S., & Bandstra, B. S. (2019). Teaching Practice-Based Learning on Inpatient Psychiatric Services. Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry. -
Low C4 Copy Number of Total C4 Gene, C4B Gene and C4BL Gene in Children with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
Kalinowski, A., Lee, J., Hedlin, H., Pattini, R., Ollila, H., Mignot, E., … Frankovich, J. (2020). Low C4 Copy Number of Total C4 Gene, C4B Gene and C4BL Gene in Children with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). ARTHRITIS & RHEUMATOLOGY. WILEY. -
Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics.
Dahl, K. N., Kalinowski, A., & Pekkan, K. (2010). Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics. Microcirculation (New York, N.Y. : 1994), 17(3), 179–91. -
Nucleoskeleton mechanics at a glance.
Dahl, K. N., & Kalinowski, A. (2011). Nucleoskeleton mechanics at a glance. Journal of Cell Science, 124(Pt 5), 675–8. -
The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A.
Ganesh, S., Qin, Z., Spagnol, S. T., Biegler, M. T., Coffey, K. A., Kalinowski, A., … Dahl, K. N. (2015). The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A. Nucleus (Austin, Tex.), 6(3), 203–11. -
Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson-Gilford progeria syndrome.
Kalinowski, A., Yaron, P. N., Qin, Z., Shenoy, S., Buehler, M. J., Lösche, M., & Dahl, K. N. (2014). Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson-Gilford progeria syndrome. Biophysical Chemistry, 195, 43–8. -
Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association.
Kalinowski, A., Qin, Z., Coffey, K., Kodali, R., Buehler, M. J., Lösche, M., & Dahl, K. N. (2013). Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association. Biophysical Journal, 104(10), 2246–53. -
Structure and stability of the lamin A tail domain and HGPS mutant.
Qin, Z., Kalinowski, A., Dahl, K. N., & Buehler, M. J. (2011). Structure and stability of the lamin A tail domain and HGPS mutant. Journal of Structural Biology, 175(3), 425–33. -
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
Choi, S., Wang, W., Ribeiro, A. J., Kalinowski, A., Gregg, S. Q., Opresko, P. L., … Dahl, K. N. (2011). Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. Nucleus (Austin, Tex.), 2(6), 570–9. -
Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition.
Dorignac, J., Kalinowski, A., Erramilli, S., & Mohanty, P. (2006). Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition. Physical Review Letters, 96(18), 186105. -
Medical Workup for First-Episode Psychosis
Kalinowski, A., & Ballon, J. S. (2019). Medical Workup for First-Episode Psychosis. Intervening Early in Psychosis (pp. 133–150). American Psychiatric Association Publishing. -
Neuroscience in Clinical Supervision: Toward a Neurobiopsychosocial Approach
Raj, K., Kalinowski, A., & Bandstra, B. (2019). Neuroscience in Clinical Supervision: Toward a Neurobiopsychosocial Approach. Supervision in Psychiatric Practice Practical Approaches Across Venues and Providers. American Psychiatric Association Publishing. -
Medical Workup for First-Episode Psychosis
Kalinowski, A., & Ballon, J. S. (2019). Medical Workup for First-Episode Psychosis. INTERVENING EARLY IN PSYCHOSIS: A TEAM APPROACH, 133–49. -
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia.
Zhu, X., Zhou, B., Pattni, R., Gleason, K., Tan, C., Kalinowski, A., … Urban, A. E. (2021). Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia. Nature Neuroscience. -
Increased activation product of complement 4 protein in plasma of individuals with schizophrenia.
Kalinowski, A., Liliental, J., Anker, L. A., Linkovski, O., Culbertson, C., Hall, J. N., … Urban, A. E. (2021). Increased activation product of complement 4 protein in plasma of individuals with schizophrenia. Translational Psychiatry, 11(1), 486. -
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic.
Bonilla, H., Quach, T. C., Tiwari, A., Bonilla, A. E., Miglis, M., Yang, P. C., … Geng, L. C. (2023). Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic. Frontiers in Neurology, 14, 1090747. -
Reductions in synaptic marker SV2A in early-course Schizophrenia.
Yoon, J. H., Zhang, Z., Mormino, E., Davidzon, G., Minzenberg, M. J., Ballon, J., … Chin, F. T. (2023). Reductions in synaptic marker SV2A in early-course Schizophrenia. Journal of Psychiatric Research, 161, 213–217. -
Evaluation of C4 gene copy number in Pediatric Acute Neuropsychiatric Syndrome
Kalinowski, A., Tian, L., Pattni, R., Ollila, H., Khan, M., Manko, C., … Frankovich, J. (2023). Evaluation of C4 gene copy number in Pediatric Acute Neuropsychiatric Syndrome. DEVELOPMENTAL NEUROSCIENCE. -
Inspire self report scale (ISRS): A feasibility study of a Novel self report scale for people with schizophrenia spectrum disorders.
Chawla, V., Bansal, N., Spelber, D., Desai, A., Frehlich, L., Ballon, J. S., … Noordsy, D. L. (2023). Inspire self report scale (ISRS): A feasibility study of a Novel self report scale for people with schizophrenia spectrum disorders. Journal of Psychiatric Research, 165, 248–253. -
Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia.
Zhu, X., Zhou, B., Pattni, R., Gleason, K., Tan, C., Kalinowski, A., … Urban, A. E. (2023). Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia. Nature Neuroscience. -
Synaptic pruning in schizophrenia is not classical.
Kalinowski, A., & Urban, A. E. (2024). Synaptic pruning in schizophrenia is not classical. Brain, Behavior, and Immunity.
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Teaching Practice-Based Learning on Inpatient Psychiatric Services.
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