Biography
Dr. Lim’s clinical interests include the treatment of benign and malignant brain tumors, with special interest in gliomas, meningiomas, metastatic tumors, and skull base tumors. Dr. Lim also specializes in surgical treatments for trigeminal neuralgia. During his time at Johns Hopkins, Dr. Lim built one of the largest brain tumor and trigeminal neuralgia practices and utilized the most advanced surgical technologies and techniques for his patients. As a passionate voice for patient experience, he has been recognized by his peers and patients for his integrity and compassionate care, including a Service Excellence Award from HealthNetwork Foundation.
As a mentor, he has garnered numerous teaching awards, including being honored as an outstanding teacher by Johns Hopkins University School of Medicine. He is actively involved in shaping education for neurosurgery and oncology across the United States and around the world. He is the recipient of the prestigious 2023 Abhijit Guha Award in Neuro-Oncology.
Dr. Lim’s research interests focus on harnessing the immune system to fight cancer. His laboratory focuses on understanding mechanisms of immune evasion by cancer cells. He has successfully translated his findings from the laboratory to the clinics and has conducted and led several large national immunotherapy clinical trials for brain tumors.
Dr. Lim’s bibliography contains well over 300 articles on topics such as immunotherapy for glioblastoma, long-term survival of glioma patients treated with stereotactic radiation, and treatment of neuropathic pain. His work has appeared in Science Translational Medicine, Clinical Cancer Research, Lancet Oncology, Nature Immunology, and many more publications. He also has written 20 book chapters and monographs.
Dr. Lim is a world leader in immunotherapy for brain tumors. In addition to being invited world-wide to give lectures and seminars, he has given platform presentations on the topics of immunotherapy for brain tumors, neurosurgical techniques and management of brain tumors at the American Society of Clinical Oncologists, American Academy of Neurological Surgeons, Radiological Society of North America, Annual Symposium on Brain and Spine Metastases, Congress of Neurological Surgeons, and other meetings. In addition, he has served as platform chairman of the CNS session at the American Society for Clinical Oncology conference.
Dr. Lim is a member of the American Society for Clinical Oncology, Congress of Neurological Surgeons, American Association of Neurological Surgeons, and Society for Neuro-Oncology. Dr. Lim served as the program co-chair of the Society for Neuro-Oncology and CNS section of the American Society for Clinical Oncology. He also served on many executive committees, including the Executive Committee for the Joint Tumor Section of the American Association of Neurological Surgeons and Congress of Neurological Surgeons.
Professional Summary
Education & Certifications
- Residency: Stanford University Dept of Neurosurgery (2007) CA
- Board Certification: American Board of Neurological Surgery, Neurosurgery (2012)
- Medical Education: Johns Hopkins University School of Medicine (2000) MD
Honors & Awards
- Abhijit Guha Award, AANS/CNS Section on Tumors and Society of Neuro-Oncology (September 2023)
Memberships
- Co-Chair, SNO Scientific Program Committee (2018 - 2020)
- Member, NCI Brain Malignancy Steering Committee (2021 - Present)
Publications
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The efficacy of linear accelerator stereotactic radiosurgery in treating glomus jugulare tumors
Lim, M., Gibbs, I. C., Adler, J. R., Martin, D. P., & Chang, S. D. (2003). The efficacy of linear accelerator stereotactic radiosurgery in treating glomus jugulare tumors. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2(3), 261–65. -
Efficacy and safety of stereotactic radiosurgery for glomus jugulare tumors.
Lim, M., Gibbs, I. C., Adler, J. R., & Chang, S. D. (2004). Efficacy and safety of stereotactic radiosurgery for glomus jugulare tumors. Neurosurgical Focus, 17(2), E11-? -
CyberKnife radiosurgery for idiopathic trigeminal neuralgia.
Lim, M., Villavicencio, A. T., Burneikiene, S., Chang, S. D., Romanelli, P., McNeely, L., … Adler, J. R. (2005). CyberKnife radiosurgery for idiopathic trigeminal neuralgia. Neurosurgical Focus, 18(5), E9-? -
Characterization of the integrin alpha v beta 3 in arteriovenous malformations and cavernous malformations
Lim, M., Haddix, T., Harsh, G. R., Vogel, H., Steinberg, G. K., & Guccione, S. (2005). Characterization of the integrin alpha v beta 3 in arteriovenous malformations and cavernous malformations. CEREBROVASCULAR DISEASES, 20(1), 23–27. -
alpha(v)beta(3) integrin in central nervous system tumors
Lim, M., Guccione, S., Haddix, T., Sims, L., Cheshier, S., Chu, P., … Harsh, G. (2005). alpha(v)beta(3) integrin in central nervous system tumors. HUMAN PATHOLOGY, 36(6), 665–69. -
Visual field preservation after curative multi-modality treatment of occipital lobe artemovenous malformations
Sinclair, J., Marks, M. P., Levy, R. P., Adler, J. R., Chang, S. D., Lopez, J. R., … Steinberg, G. K. (2005). Visual field preservation after curative multi-modality treatment of occipital lobe artemovenous malformations. NEUROSURGERY, 57(4), 655–66. -
Stereotactic radiosurgery using CT cisternography and non-isocentric planning for the treatment of trigeminal neuralgia.
Lim, M., Cotrutz, C., Romanelli, P., Schaal, D., Gibbs, I., Chang, S. D., & Adler, J. R. (2006). Stereotactic radiosurgery using CT cisternography and non-isocentric planning for the treatment of trigeminal neuralgia. Computer Aided Surgery , 11(1), 11–20. -
CyberKnife radiosurgery for extremity schwannomas: Technical note and case report
Lim, M., & Adler, J. R. (2006). CyberKnife radiosurgery for extremity schwannomas: Technical note and case report. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 84(2-3), 60–63. -
New vessel formation in the central nervous system during tumor growth, vascular malformations, and Moyamoya
Lim, M., Cheshier, S., & Steinberg, G. K. (2006). New vessel formation in the central nervous system during tumor growth, vascular malformations, and Moyamoya. CURRENT NEUROVASCULAR RESEARCH, 3(3), 237–45. -
Cerebral perfusion imaging in vasospasm.
Lad, S. P., Guzman, R., Kelly, M. E., Li, G., Lim, M., Lovbald, K., & Steinberg, G. K. (2006). Cerebral perfusion imaging in vasospasm. Neurosurgical Focus, 21(3), E7-? -
Radiosurgery for glomus Jugulare tumors
Lim, M., Bower, R., Nangiana, J. S., Adler, J. R., & Chang, S. D. (2007). Radiosurgery for glomus Jugulare tumors. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 6(5), 419–23. -
Irradiation of glomus jugulare tumors: a historical perspective.
Li, G., Chang, S., Adler, J. R., & Lim, M. (2007). Irradiation of glomus jugulare tumors: a historical perspective. Neurosurgical Focus, 23(6), E13-? -
CyberKnife radiosurgical rhizotomy for the treatment of atypical trigeminal nerve pain.
Patil, C. G., Veeravagu, A., Bower, R. S., Li, G., Chang, S. D., Lim, M., & Adler, J. R. (2007). CyberKnife radiosurgical rhizotomy for the treatment of atypical trigeminal nerve pain. Neurosurgical Focus, 23(6), E9-? -
Cyberknife radiosurgery for trigeminal neuralgia treatment: A preliminary multicenter experience
Villavicencio, A. T., Lim, M., Burneikiene, S., Romanelli, P., Adler, J. R., McNeely, L., … Thramann, J. J. (2008). Cyberknife radiosurgery for trigeminal neuralgia treatment: A preliminary multicenter experience. NEUROSURGERY, 62(3), 647–54. -
Suprasellar giant cell ependymoma: a rare neoplasm in a unique location
Sangoi, A. R., Lim, M., Dulai, M. S., Vogel, H., & Chang, S. D. (2008). Suprasellar giant cell ependymoma: a rare neoplasm in a unique location. HUMAN PATHOLOGY, 39(9), 1396–1401. -
A VIRTUAL FRAME SYSTEM FOR STEREOTACTIC RADIOSURGERY PLANNING
Ford, E., Purger, D., Tryggestad, E., McNutt, T., Christodouleas, J., Rigamonti, D., … Kleinberg, L. (2008). A VIRTUAL FRAME SYSTEM FOR STEREOTACTIC RADIOSURGERY PLANNING. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 72(4), 1244–49. -
NONISOCENTRIC RADIOSURGICAL RHIZOTOMY FOR TRIGEMINAL NEURALGIA
Adler, J. R., Bower, R., Gupta, G., Lim, M., Efron, A., Gibbs, I. C., … Soltys, S. G. (2009). NONISOCENTRIC RADIOSURGICAL RHIZOTOMY FOR TRIGEMINAL NEURALGIA. NEUROSURGERY, 64(2), A84–A90. -
A NEUROSURGEON'S GUIDE TO STEM CELLS, CANCER STEM CELLS, AND BRAIN TUMOR STEM CELLS
Cheshier, S. H., Kalani, M. Y. S., Lim, M., Ailles, L., Huhn, S. L., & Weissman, I. L. (2009). A NEUROSURGEON'S GUIDE TO STEM CELLS, CANCER STEM CELLS, AND BRAIN TUMOR STEM CELLS. NEUROSURGERY, 65(2), 237–49. -
Radiosurgery for glomus jugulare: history and recent progress
Guss, Z. D., Batra, S., Li, G., Chang, S. D., Parsa, A. T., Rigamont, D., … Lim, M. (2009). Radiosurgery for glomus jugulare: history and recent progress. NEUROSURGICAL FOCUS, 27(6). -
RADIOSURGERY OF GLOMUS JUGULARE TUMORS: A META-ANALYSIS
Guss, Z. D., Batra, S., Limb, C. J., Li, G., Sughrue, M. E., Redmond, K., … Lim, M. (2011). RADIOSURGERY OF GLOMUS JUGULARE TUMORS: A META-ANALYSIS. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(4), E497–E502. -
The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage
Lim, M., Bower, R. S., Wang, Y., Sims, L., Bower, M. R., Camara-Quintana, J., … Guccione, S. (2012). The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage. NEUROSURGICAL REVIEW, 35(3), 413–19. -
Perspectives on key articles in neurosurgery.
Lim, M., Sherman, J. H., Wang, V. Y., Smith, Z. A., Cho, J. M., Colen, C. B., … Yang, I. (2012). Perspectives on key articles in neurosurgery. Surgical Neurology International, 3, 58-? -
Anti-angiogenic targeted therapy in a rat model for glioblastoma multiforme tumor with temporal MRI and pet studies
Lim, M., Yang, Y.-S., Sims, L., Choi, S., Wang, Y., & Guccione, S. (2006). Anti-angiogenic targeted therapy in a rat model for glioblastoma multiforme tumor with temporal MRI and pet studies. NEURO-ONCOLOGY, 8(4), 415–15. -
Flow cytometric analysis of neural stem cell markers on pediatric brain tumors
Cheshier, S. H., Ailles, L. E., Lim, M., Laddis, P., Tse, V., Weissman, I. L., & Huhn, S. (2006). Flow cytometric analysis of neural stem cell markers on pediatric brain tumors. NEURO-ONCOLOGY, 8(4), 466–66. -
CD90 expression segregates tumor-sphere forming cells in human glioblastoma multiforme
Cheshier, S. H., Ailles, L., Higgins, D. M. O., Lim, M., Kalani, M. Y. S., Bababeygy, S., & Weissman, I. L. (2006). CD90 expression segregates tumor-sphere forming cells in human glioblastoma multiforme. NEURO-ONCOLOGY, 8(4), 471–71. -
LEVERAGING EXPRESSION OF A5/GABA-A RECEPTOR IN MEDULLOBLASTOMA AS A NOVEL THERAPEUTIC TARGET
Sengupta, S., Weeraratne, S. D., Phallen, J., Sun, H., Rallapalli, S., Amani, V., … Cho, Y.-J. (2012). LEVERAGING EXPRESSION OF A5/GABA-A RECEPTOR IN MEDULLOBLASTOMA AS A NOVEL THERAPEUTIC TARGET. Presented at the 15th International Symposium on Pediatric Neuro-Oncology (ISPNO), TORONTO,CANADA,CANADA,CANADA,CANADA: OXFORD UNIV PRESS INC. -
DEVELOPMENT AND VALIDATION OF A PRE-OPERATIVE PROGNOSTIC SCORING SYSTEM FOR PATIENTS WITH GLIOBLASTOMA
Chaichana, K., Pendleton, C., Chambless, L., Nathan, J., Camara-Quintana, J., Li, G., … Quinones-Hinojosa, A. (2011). DEVELOPMENT AND VALIDATION OF A PRE-OPERATIVE PROGNOSTIC SCORING SYSTEM FOR PATIENTS WITH GLIOBLASTOMA. Presented at the 16th Annual Scientific Meeting of the Society-for-Neuro-Oncology (SNO)/AANS/CNS Section on Tumors, CA: OXFORD UNIV PRESS INC. -
Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma.
Chaichana, K. L., Pendleton, C., Chambless, L., Camara-Quintana, J., Nathan, J. K., Hassam-Malani, L., … Quinones-Hinojosa, A. (2013). Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma. Journal of Clinical Neuroscience , 20(10), 1422–26. -
alpha 5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth
Sengupta, S., Weeraratne, S. D., Sun, H., Phallen, J., Rallapalli, S. K., Teider, N., … Cho, Y.-J. (2014). alpha 5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. ACTA NEUROPATHOLOGICA, 127(4), 593–603. -
Current Vaccine Trials in Glioblastoma: A Review
Xu, L. W., Chow, K. K., Lim, M., & Li, G. (2014). Current Vaccine Trials in Glioblastoma: A Review. JOURNAL OF IMMUNOLOGY RESEARCH. -
The future of glioblastoma therapy: synergism of standard of care and immunotherapy.
Patel, M. A., Kim, J. E., Ruzevick, J., Li, G., & Lim, M. (2014). The future of glioblastoma therapy: synergism of standard of care and immunotherapy. Cancers, 6(4), 1953–85. -
Neurosurgery concepts: Key perspectives on dendritic cell vaccines, metastatic tumor treatment, and radiosurgery.
Li, G., Sherman, J. H., Cho, J. M., Lim, M., Khalessi, A. A., Colen, C. B., … Yang, I. (2015). Neurosurgery concepts: Key perspectives on dendritic cell vaccines, metastatic tumor treatment, and radiosurgery. Surgical Neurology International, 6, 6. -
Combining immunotherapy with radiation for the treatment of glioblastoma.
Chow, K. K., Hara, W., Lim, M., & Li, G. (2015). Combining immunotherapy with radiation for the treatment of glioblastoma. Journal of Neuro-Oncology, 123(3), 459–64. -
Neurosurgery concepts: Key perspectives on imaging characteristics of spinal metastases, surgery for low back pain, anesthesia for disc surgery, and laminectomy versus laminectomy and fusion for lumbar spondylolisthesis.
Lagman, C., Chung, L. K., Macyszyn, L., Choy, W., Smith, Z. A., Dahdaleh, N. S., … Yang, I. (2017). Neurosurgery concepts: Key perspectives on imaging characteristics of spinal metastases, surgery for low back pain, anesthesia for disc surgery, and laminectomy versus laminectomy and fusion for lumbar spondylolisthesis. Surgical Neurology International, 8, 9. -
Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines
Binder, Z. A., Wilson, K. M., Salmasi, V., Orr, B. A., Eberhart, C. G., Siu, I.-M., … Gallia, G. L. (2016). Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines. PLOS ONE, 11(3). -
Neurosurgery concepts: Key perspectives on endoscopic versus microscopic resection for pituitary adenomas, surgical decision-making in tuberculum sellae meningiomas, optic nerve mobilization during resection of craniopharyngiomas, and evaluation of headache and quality of life after endoscopic transphenoidal surgery for pituitary adenomas.
Germanwala, A. V., Hofler, R., Lagman, C., Chung, L. K., Khalessi, A. A., Zada, G., … Yang, I. (2017). Neurosurgery concepts: Key perspectives on endoscopic versus microscopic resection for pituitary adenomas, surgical decision-making in tuberculum sellae meningiomas, optic nerve mobilization during resection of craniopharyngiomas, and evaluation of headache and quality of life after endoscopic transphenoidal surgery for pituitary adenomas. Surgical Neurology International, 8, 52. -
The Future of Glioblastoma Therapy: Synergism of Standard of Care and Immunotherapy
Patel, M. A., Kim, J. E., Ruzevick, J., Li, G., & Lim, M. (2014). The Future of Glioblastoma Therapy: Synergism of Standard of Care and Immunotherapy. CANCERS, 6(4), 1953–85. -
Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial
Weller, M., Butowski, N., Tran, D. D., Recht, L. D., Lim, M., Hirte, H., … Sampson, J. H. (2017). Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial. LANCET ONCOLOGY, 18(10), 1373–85. -
Go, no-go decision making for phase 3 clinical trials: ACT IV revisited Reply
Weller, M., Butowski, N., Tran, D. D., Recht, L. D., Lim, M., Hirte, H., … Sampson, J. H. (2017). Go, no-go decision making for phase 3 clinical trials: ACT IV revisited Reply. LANCET ONCOLOGY, 18(12), E709–E710. -
Growth of human glioblastoma multiforme and medulloblastoma tumors in RAG 2 and common cytokine receptor gamma chain double knockout mice: A new model for in vivo study of GBM
Cheshier, S. H., Ailles, L., Tse, V., Skirboll, S., Huhn, S., & Weissman, I. (2006). Growth of human glioblastoma multiforme and medulloblastoma tumors in RAG 2 and common cytokine receptor gamma chain double knockout mice: A new model for in vivo study of GBM. NEURO-ONCOLOGY, 8(4), 471. -
Immunotherapy for glioma: promises and challenges.
Han, S. J., Zygourakis, C., Lim, M., & Parsa, A. T. (2012). Immunotherapy for glioma: promises and challenges. Neurosurgery Clinics of North America, 23(3), 357–70. -
ACT IV: AN INTERNATIONAL, DOUBLE-BLIND, PHASE 3 TRIAL OF RINDOPEPIMUT IN NEWLY DIAGNOSED, EGFRvIII-EXPRESSING GLIOBLASTOMA
Weller, M., Butowski, N., Tran, D., Recht, L., Lim, M., Hirte, H., … Sampson, J. (2016). ACT IV: AN INTERNATIONAL, DOUBLE-BLIND, PHASE 3 TRIAL OF RINDOPEPIMUT IN NEWLY DIAGNOSED, EGFRvIII-EXPRESSING GLIOBLASTOMA. NEURO-ONCOLOGY, 18, 17–18. -
Go, no-go decision making for phase 3 clinical trials: ACT IV revisited - Authors' reply.
Weller, M., Butowski, N., Tran, D. D., Recht, L. D., Lim, M., Hirte, H., … Sampson, J. H. (2017). Go, no-go decision making for phase 3 clinical trials: ACT IV revisited - Authors' reply. The Lancet. Oncology, 18(12), e709–e710. -
Combination anti-CXCR4 and anti-PD-1 immunotherapy provides survival benefit in glioblastoma through immune cell modulation of tumor microenvironment.
Wu, A., Maxwell, R., Xia, Y., Cardarelli, P., Oyasu, M., Belcaid, Z., … Lim, M. (2019). Combination anti-CXCR4 and anti-PD-1 immunotherapy provides survival benefit in glioblastoma through immune cell modulation of tumor microenvironment. Journal of Neuro-Oncology. -
Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naive prostate cancer
Simons, J. W., Carducci, M. A., Mikhak, B., Lim, M., Biedrzycki, B., Borellini, F., … Nelson, W. G. (2006). Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naive prostate cancer. CLINICAL CANCER RESEARCH, 12(11), 3394–3401. -
Alternative Checkpoints as Targets for Immunotherapy.
Pant, A., Medikonda, R., & Lim, M. (2020). Alternative Checkpoints as Targets for Immunotherapy. Current Oncology Reports, 22(12), 126. -
A Dose-Response Model of Local Tumor Control Probability After Stereotactic Radiosurgery for Brain Metastases Resection Cavities.
Gui, C., Grimm, J., Kleinberg, L. R., Zaki, P., Spoleti, N., Mukherjee, D., … Redmond, K. J. (2020). A Dose-Response Model of Local Tumor Control Probability After Stereotactic Radiosurgery for Brain Metastases Resection Cavities. Advances in Radiation Oncology, 5(5), 840–49. -
Updated safety phase I trial of anti-LAG-3 alone and in combination with anti-PD-1 in patients with recurrent GBM.
Lim, M., Ye, X., Piotrowski, A. F., Desai, A. S., Ahluwalia, M. S., Walbert, T., … Grossman, S. A. (2020). Updated safety phase I trial of anti-LAG-3 alone and in combination with anti-PD-1 in patients with recurrent GBM. JOURNAL OF CLINICAL ONCOLOGY, 38(15). -
Scalp Invasion by Atypical or Anaplastic Meningioma Is a Risk Factor for Development of Systemic Metastasis
Garzon-Muvdi, T., Maxwell, R., Luksik, A., Kessler, R., Weingart, J., Olivi, A., … Lim, M. (2020). Scalp Invasion by Atypical or Anaplastic Meningioma Is a Risk Factor for Development of Systemic Metastasis. WORLD NEUROSURGERY, 142, E133–E139. -
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma
Sa, J. K., Chang, N., Lee, H. W., Cho, H. J., Ceccarelli, M., Cerulo, L., … Nam, D.-H. (2020). Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma. GENOME BIOLOGY, 21(1), 216. -
Investigating in vivo synergistic effect of checkpoint blockade and radiation therapy against chordomas in a humanized mouse model
Ishida, W., McCormick, K. L., Mahajan, A., Feldstein, E., Lim, M., Bruce, J. N., … Lo, S.-fu L. (2019). Investigating in vivo synergistic effect of checkpoint blockade and radiation therapy against chordomas in a humanized mouse model. CANCER IMMUNOLOGY RESEARCH, 7(2). -
The Effects of Postoperative Neurological Deficits on Survival in Patients With Single Brain Metastasis.
Medikonda, R., Jackson, C. M., Feghali, J., & Lim, M. (2020). The Effects of Postoperative Neurological Deficits on Survival in Patients With Single Brain Metastasis. Operative Neurosurgery (Hagerstown, Md.). -
Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy.
Belcaid, Z., Berrevoets, C., Choi, J., van Beelen, E., Stavrakaki, E., Pierson, T., … Lamfers, M. L. (2020). Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy. Neuro-Oncology Advances, 2(1), vdaa011. -
A systematic review and meta-analysis of supratotal versus gross total resection for glioblastoma
Jackson, C., Choi, J., Khalafallah, A. M., Price, C., Bettegowda, C., Lim, M., … Mukherjee, D. (2020). A systematic review and meta-analysis of supratotal versus gross total resection for glioblastoma. JOURNAL OF NEURO-ONCOLOGY, 148(3), 419–31. -
Hemophagocytic Lymphohistiocytosis Secondary to PD-1 and IDO Inhibition in a Patient with Refractory Glioblastoma
Thummalapalli, R., Heumann, T., Stein, J., Khan, S., Priemer, D. S., Duffield, A. S., … Holdhoff, M. (2020). Hemophagocytic Lymphohistiocytosis Secondary to PD-1 and IDO Inhibition in a Patient with Refractory Glioblastoma. CASE REPORTS IN ONCOLOGY, 13(2), 508–14. -
Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma The CheckMate 143 Phase 3 Randomized Clinical Trial
Reardon, D. A., Brandes, A. A., Omuro, A., Mulholland, P., Lim, M., Wick, A., … Weller, M. (2020). Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma The CheckMate 143 Phase 3 Randomized Clinical Trial. JAMA ONCOLOGY, 6(7), 1003–10. -
ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma
Tong, L., Li, J., Li, Q., Wang, X., Medikonda, R., Zhao, T., … Yang, X. (2020). ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma. THERANOSTICS, 10(13), 5943–56. -
Adult immuno-oncology: using past failures to inform the future.
Rahman, M., Sawyer, W. G., Lindhorst, S., Deleyrolle, L. P., Harrison, J. K., Karachi, A., … Reardon, D. A. (2020). Adult immuno-oncology: using past failures to inform the future. Neuro-Oncology, 22(9), 1249–61. -
Cottonoid Sliders: A Simple and Cost-Effective Tool for Retractorless Intracranial Surgery.
Shao, J., Borghei-Razavi, H., Kshettry, V. R., Lim, M., & Recinos, P. F. (2020). Cottonoid Sliders: A Simple and Cost-Effective Tool for Retractorless Intracranial Surgery. Operative Neurosurgery (Hagerstown, Md.), 19(4), E428–E431. -
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.
Wen, P. Y., Weller, M., Lee, E. Q., Alexander, B. M., Barnholtz-Sloan, J. S., Barthel, F. P., … van den Bent, M. J. (2020). Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro-Oncology, 22(8), 1073–1113. -
Understanding innate immune response in glioblastoma in search of a way forward
Pant, A., & Lim, M. (2020). Understanding innate immune response in glioblastoma in search of a way forward. NEURO-ONCOLOGY, 22(4), 444–45. -
A review of glioblastoma immunotherapy
Medikonda, R., Dunn, G., Rahman, M., Fecci, P., & Lim, M. (2020). A review of glioblastoma immunotherapy. JOURNAL OF NEURO-ONCOLOGY. -
Characterizing patterns of cytokine coexpression with immune checkpoint markers in CD4 and CD8 tumor-infiltrating lymphocytes.
Jackson, C. M., Dinalankara, W., Choi, J., Nirschl, T. R., Kochel, C. M., Pant, A., … Lim, M. (2020). Characterizing patterns of cytokine coexpression with immune checkpoint markers in CD4 and CD8 tumor-infiltrating lymphocytes. CANCER IMMUNOLOGY RESEARCH, 8(3), 47–48. -
New Prospects for Molecular Targets for Chordomas
Ozair, M. Z., Shah, P. P., Mathios, D., Lim, M., & Moss, N. S. (2020). New Prospects for Molecular Targets for Chordomas. NEUROSURGERY CLINICS OF NORTH AMERICA, 31(2), 289-+. -
Integrin alpha 6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells
Herrmann, A., Lahtz, C., Song, J., Aftabizadeh, M., Cherryholmes, G. A., Xin, H., … Yu, H. (2020). Integrin alpha 6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells. ONCOGENE, 39(10), 2156–69. -
PD-L1 EXPRESSION IS NEGATIVELY CORRELATED TO OUTCOMES IN PATIENTS WITH MGMT METHYLATED PROMOTERS IN GBM
Srivastava, S., Choi, J., & Lim, M. (2019). PD-L1 EXPRESSION IS NEGATIVELY CORRELATED TO OUTCOMES IN PATIENTS WITH MGMT METHYLATED PROMOTERS IN GBM. NEURO-ONCOLOGY, 21, 250. -
MULTI-TIME POINT EVALUATION OF PERIPHERAL BLOOD MYELOID-DERIVED SUPPRESSOR CELL AND LYMPHOCYTE POPULATIONS IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA RECEIVING ADJUVANT THERAPY
Sloan, L., Sen, R., Doucet, M., Blosser, L., Shpitser, I., Sherman, E., … Kleinberg, L. (2019). MULTI-TIME POINT EVALUATION OF PERIPHERAL BLOOD MYELOID-DERIVED SUPPRESSOR CELL AND LYMPHOCYTE POPULATIONS IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA RECEIVING ADJUVANT THERAPY. NEURO-ONCOLOGY, 21, 283. -
NIVOLUMAB VS BEVACIZUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA: EXPLORATORY ANALYSIS OF MGMT METHYLATION STATUS AND BASELINE CORTICOSTEROID USE
Weller, M., Reardon, D., Brandes, A., Sampson, J., Mulholland, P., Wick, A., … Lim, M. (2019). NIVOLUMAB VS BEVACIZUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA: EXPLORATORY ANALYSIS OF MGMT METHYLATION STATUS AND BASELINE CORTICOSTEROID USE. NEURO-ONCOLOGY, 21, 12. -
SUPRATOTAL VERSUS GROSS TOTAL RESECTION OF GLIOBLASTOMA: A SYSTEMATIC REVIEW
Jackson, C., Choi, J., Price, C., Bettegowda, C., Lim, M., Gallia, G., … Mukherjee, D. (2019). SUPRATOTAL VERSUS GROSS TOTAL RESECTION OF GLIOBLASTOMA: A SYSTEMATIC REVIEW. NEURO-ONCOLOGY, 21, 243. -
IMMUNOGENOMIC RESPONDER PHENOTYPE FROM A PHASE I TRIAL OF ANTI-LAG3 OR ANTI-CD137 ALONE AND IN COMBINATION WITH ANTI-PD-1 IN PATIENTS WITH RECURRENT GBM
Jackson, C., Choi, J., Zhang, J. J., Piotrowski, A., Walbert, T., Desai, A., … Lim, M. (2019). IMMUNOGENOMIC RESPONDER PHENOTYPE FROM A PHASE I TRIAL OF ANTI-LAG3 OR ANTI-CD137 ALONE AND IN COMBINATION WITH ANTI-PD-1 IN PATIENTS WITH RECURRENT GBM. NEURO-ONCOLOGY, 21, 122. -
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM
Hung, A. L., Maxwell, R., Theodros, D., Belcaid, Z., Mathios, D., Luksik, A. S., … Lim, M. (2018). TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM. ONCOIMMUNOLOGY, 7(8), e1466769. -
Tumor-Treating Field Arrays Do Not Reduce Target Volume Coverage for Glioblastoma Radiation Therapy
Stachelek, G. C., Grimm, J., Moore, J., Huang, E., Spoleti, N., Redmond, K. J., … Kleinberg, L. (2020). Tumor-Treating Field Arrays Do Not Reduce Target Volume Coverage for Glioblastoma Radiation Therapy. ADVANCES IN RADIATION ONCOLOGY, 5(1), 62–69. -
PD-L1, PD-1, LAG-3, and TIM-3 in Melanoma: Expression in Brain Metastases Compared to Corresponding Extracranial Tumors
Wang, J. J., Burger, P., Taube, J., Soni, A., Chaichana, K., Sheu, M., … Lim, M. (2019). PD-L1, PD-1, LAG-3, and TIM-3 in Melanoma: Expression in Brain Metastases Compared to Corresponding Extracranial Tumors. CUREUS, 11(12), e6352. -
Carboxylated branched poly(beta-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing
Rui, Y., Wilson, D. R., Choi, J., Varanasi, M., Sanders, K., Karlsson, J., … Green, J. J. (2019). Carboxylated branched poly(beta-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing. SCIENCE ADVANCES, 5(12), eaay3255. -
PD-L1 Expression in Pediatric Low-Grade Gliomas Is Independent of BRAF V600E Mutational Status
Martin, A. M., Bell, W. R., Yuan, M., Harris, L., Poore, B., Arnold, A., … Eberhart, C. G. (2020). PD-L1 Expression in Pediatric Low-Grade Gliomas Is Independent of BRAF V600E Mutational Status. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 79(1), 74–85. -
In Vivo Bioluminescence Tomography Center of Mass-Guided Conformal Irradiation
Deng, Z., Xu, X., Garzon-Muvdi, T., Xia, Y., Kim, E., Belcaid, Z., … Wang, K. K.-H. (2020). In Vivo Bioluminescence Tomography Center of Mass-Guided Conformal Irradiation. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 106(3), 612–20. -
A Phase 2 Study of Post-Operative Stereotactic Body Radiation Therapy (SBRT) for Solid Tumor Spine Metastases
Redmond, K. J., Sciubba, D., Khan, M., Gui, C., Lo, S.-fu L., Gokaslan, Z. L., … Lim, M. (2020). A Phase 2 Study of Post-Operative Stereotactic Body Radiation Therapy (SBRT) for Solid Tumor Spine Metastases. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 106(2), 261–68. -
CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma
Tong, L., Li, J., Choi, J., Pant, A., Xia, Y., Jackson, C., … Yang, X. (2020). CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. CANCER GENE THERAPY, 27(9), 669–79. -
Updated phase I trial of anti-LAG-3 or anti-CD137 alone and in combination with anti-PD-1 in patients with recurrent GBM.
Lim, M., Ye, X., Piotrowski, A. F., Desai, A. S., Ahluwalia, M. S., Walbert, T., … Grossman, S. A. (2019). Updated phase I trial of anti-LAG-3 or anti-CD137 alone and in combination with anti-PD-1 in patients with recurrent GBM. JOURNAL OF CLINICAL ONCOLOGY, 37(15). -
Phase II study to evaluate safety and efficacy of MEDI4736 (durvalumab) plus radiotherapy in patients with newly diagnosed unmethylated MGMT glioblastoma (new unmeth GBM).
Reardon, D. A., Kaley, T. J., Dietrich, J., Clarke, J. L., Dunn, G., Lim, M., … Venhaus, R. R. (2019). Phase II study to evaluate safety and efficacy of MEDI4736 (durvalumab) plus radiotherapy in patients with newly diagnosed unmethylated MGMT glioblastoma (new unmeth GBM). JOURNAL OF CLINICAL ONCOLOGY, 37(15). -
Updated risk models demonstrate low risk of symptomatic radionecrosis following stereotactic radiosurgery for brain metastases.
Peng, L., Grimm, J., Gui, C., Shen, C. J., Redmond, K. J., Sloan, L., … Kleinberg, L. R. (2019). Updated risk models demonstrate low risk of symptomatic radionecrosis following stereotactic radiosurgery for brain metastases. Surgical Neurology International, 10, 32. -
Targeting Myeloid Cells in Combination Treatments for Glioma and Other Tumors
Ding, A. S., Routkevitch, D., Jackson, C., & Lim, M. (2019). Targeting Myeloid Cells in Combination Treatments for Glioma and Other Tumors. FRONTIERS IN IMMUNOLOGY, 10, 1715. -
Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types
Mathios, D., Hwang, T., Xia, Y., Phallen, J., Rui, Y., See, A. P., … Lim, M. (2019). Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types. INTERNATIONAL JOURNAL OF CANCER, 145(12), 3425–35. -
Mechanisms of immunotherapy resistance: lessons from glioblastoma
Jackson, C. M., Choi, J., & Lim, M. (2019). Mechanisms of immunotherapy resistance: lessons from glioblastoma. NATURE IMMUNOLOGY, 20(9), 1100–1109. -
Radiotherapy, Lymphopenia, and Host Immune Capacity in Glioblastoma: A Potentially Actionable Toxicity Associated With Reduced Efficacy of Radiotherapy
Kleinberg, L., Sloan, L., Grossman, S., & Lim, M. (2019). Radiotherapy, Lymphopenia, and Host Immune Capacity in Glioblastoma: A Potentially Actionable Toxicity Associated With Reduced Efficacy of Radiotherapy. NEUROSURGERY, 85(4), 441–53. -
Absence of Ischemic Injury after Sacrificing the Superior Petrosal Vein during Microvascular Decompression.
Xia, Y., Kim, T. Y., Mashouf, L. A., Patel, K. K., Xu, R., Casaos, J., … Lim, M. (2020). Absence of Ischemic Injury after Sacrificing the Superior Petrosal Vein during Microvascular Decompression. Operative Neurosurgery (Hagerstown, Md.), 18(3), 316–20. -
Targeting DDX3 in medulloblastoma by RK-33
Tantravedi, S., Vesuna, F., Martin, A., Lim, M., Eberhart, C. G. E. G., van Diest, P. J., & Raman, V. (2018). Targeting DDX3 in medulloblastoma by RK-33. CANCER RESEARCH, 78(13). -
Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma
Hwang, T., Mathios, D., McDonald, K. L., Daris, I., Park, S.-H., Burger, P. C., … Park, C.-K. (2019). Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 7, 88. -
Assessing the Effectiveness of Systemic Therapy after Stereotactic Radiosurgery on Cancer Recurrence and All-Cause Mortality
Al-Khindi, T., Shen, C. J., Peng, L., Redmond, K. J., Lim, M., Kleinberg, L. R., & Bettegowda, C. (2019). Assessing the Effectiveness of Systemic Therapy after Stereotactic Radiosurgery on Cancer Recurrence and All-Cause Mortality. WORLD NEUROSURGERY, 129, E572–E581. -
The combination of CXCR4 and checkpoint receptor inhibition improves survival in an orthotopic murine glioma model
Wu, A., Cardarelli, P., Oyasu, M., Menezes, D., Ponath, P., Cogswell, J., … Lim, M. (2018). The combination of CXCR4 and checkpoint receptor inhibition improves survival in an orthotopic murine glioma model. CANCER RESEARCH, 78(13). -
Association Between Radiofrequency Rhizotomy Parameters and Duration of Pain Relief in Trigeminal Neuralgia Patients with Recurrent Pain
Xie, E., Garzon-Muvdi, T., Bender, M., Doshi, T., Carson, B., Lim, M., & Bettegowda, C. (2019). Association Between Radiofrequency Rhizotomy Parameters and Duration of Pain Relief in Trigeminal Neuralgia Patients with Recurrent Pain. WORLD NEUROSURGERY, 129, E128–E133. -
Utilization of the Nasoseptal Flap for Repair of Cerebrospinal Fluid Leak after Endoscopic Endonasal Approach for Resection of Pituitary Tumors.
Kessler, R. A., Garzon-Muvdi, T., Kim, E., Ramanathan, M., & Lim, M. (2019). Utilization of the Nasoseptal Flap for Repair of Cerebrospinal Fluid Leak after Endoscopic Endonasal Approach for Resection of Pituitary Tumors. Brain Tumor Research and Treatment, 7(1), 10–15. -
A Characterization of Dendritic Cells and Their Role in Immunotherapy in Glioblastoma: From Preclinical Studies to Clinical Trials
Srivastava, S., Jackson, C., Kim, T., Choi, J., & Lim, M. (2019). A Characterization of Dendritic Cells and Their Role in Immunotherapy in Glioblastoma: From Preclinical Studies to Clinical Trials. CANCERS, 11(4). -
Extracranial Abscopal Responses after Radiation Therapy for Intracranial Metastases: A Review of the Clinical Literature and Commentary on Mechanism
Gui, C., Kleinberg, L. R., Lim, M., & Redmond, K. J. (2019). Extracranial Abscopal Responses after Radiation Therapy for Intracranial Metastases: A Review of the Clinical Literature and Commentary on Mechanism. CUREUS, 11(3), e4207. -
Bespoke immunotherapy: how close are we?
Jackson, C., & Lim, M. (2019). Bespoke immunotherapy: how close are we? NEURO-ONCOLOGY, 21(3), 289–90. -
Surgical Resection for Primary Central Nervous System Lymphoma: A Systematic Review
Labak, C. M., Holdhoff, M., Bettegowda, C., Gallia, G. L., Lim, M., Weingart, J. D., & Mukherjee, D. (2019). Surgical Resection for Primary Central Nervous System Lymphoma: A Systematic Review. WORLD NEUROSURGERY, 126, E1436–E1448. -
TUMOR-TREATING FIELDS THERAPY IS COMPATIBLE WITH STANDARD CHEMORADIOTHERAPY FOR GLIOBLASTOMA
Stachelek, G., Grimm, J., Lim, M., Bettegowda, C., Redmond, K., & Kleinberg, L. (2018). TUMOR-TREATING FIELDS THERAPY IS COMPATIBLE WITH STANDARD CHEMORADIOTHERAPY FOR GLIOBLASTOMA. NEURO-ONCOLOGY, 20, 228. -
UPDATED RESULTS OF A PHASE I TRIAL OF ANTI-LAG-3 OR ANTI-CD137 ALONE AND IN COMBINATION WITH ANTI-PD-1 IN PATIENTS WITH RECURRENT GBM
Lim, M., Ye, X., Nabors, L. B., Piotrowski, A., Ahluwalia, M., Desai, A., … Grossman, S. (2018). UPDATED RESULTS OF A PHASE I TRIAL OF ANTI-LAG-3 OR ANTI-CD137 ALONE AND IN COMBINATION WITH ANTI-PD-1 IN PATIENTS WITH RECURRENT GBM. NEURO-ONCOLOGY, 20, 5. -
PHASE 2 STUDY TO EVALUATE THE CLINICAL EFFICACY AND SAFETY OF MEDI4736 (DURVALUMAB, DURVA) plus BEVACIZUMAB (BEV) IN BEV-NAIVE PATIENTS WITH RECURRENT GLIOBLASTOMA (GBM)
Reardon, D., Kaley, T., Dietrich, J., Clarke, J., Dunn, G., Lim, M., … Venhaus, R. (2018). PHASE 2 STUDY TO EVALUATE THE CLINICAL EFFICACY AND SAFETY OF MEDI4736 (DURVALUMAB, DURVA) plus BEVACIZUMAB (BEV) IN BEV-NAIVE PATIENTS WITH RECURRENT GLIOBLASTOMA (GBM). NEURO-ONCOLOGY, 20, 10. -
LOCAL ONCOLYTIC ADENOVIRUS TREATMENT AFFECTS BOTH THE INNATE AND ADAPTIVE ARMS OF THE IMMUNE SYSTEM AND PROVIDES AN AVENUE FOR ENHANCING IMMUNOTHERAPIES FOR GBM
Lamfers, M., Belcaid, Z., van den Bossche, W., Kleijn, A., Berrevoets, C., Lamers, C., … Dirven, C. (2018). LOCAL ONCOLYTIC ADENOVIRUS TREATMENT AFFECTS BOTH THE INNATE AND ADAPTIVE ARMS OF THE IMMUNE SYSTEM AND PROVIDES AN AVENUE FOR ENHANCING IMMUNOTHERAPIES FOR GBM. NEURO-ONCOLOGY, 20, 85. -
IN VIVO SYNERGISTIC EFFECT OF CHECKPOINT BLOCKADE AND RADIATION THERAPY AGAINST CHORDOMAS IN A HUMANIZED MOUSE MODEL
Ishida, W., McCormick, K., Mahajan, A., Feldstein, E., Lim, M., Bruce, J., … Lo, S.-fu. (2018). IN VIVO SYNERGISTIC EFFECT OF CHECKPOINT BLOCKADE AND RADIATION THERAPY AGAINST CHORDOMAS IN A HUMANIZED MOUSE MODEL. NEURO-ONCOLOGY, 20, 276. -
Retrosigmoid approach for glycerin rhizotomy in the treatment of trigeminal neuralgia without overt arterial compression: updated case series
Kim, T. Y., Jackson, C. M., Xia, Y., Mashouf, L. A., Patel, K. K., Kim, E. S., … Lim, M. (2020). Retrosigmoid approach for glycerin rhizotomy in the treatment of trigeminal neuralgia without overt arterial compression: updated case series. JOURNAL OF NEUROSURGERY, 132(4), 1227–33. -
Why is immunotherapy for glioblastoma "Lag"-ging.
Mathios, D., & Lim, M. (2019). Why is immunotherapy for glioblastoma "Lag"-ging. Oncotarget, 10(12), 1228–29. -
Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma
Ehresman, J. S., Garzon-Muvdi, T., Rogers, D., Lim, M., Gallia, G. L., Weingart, J., … Chaichana, K. L. (2019). Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma. JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 80(1), 59–66. -
Deferred Radiotherapy After Debulking of Non-functioning Pituitary Macroadenomas: Clinical Outcomes
Nicholas, S. E., Salvatori, R., Quinones-Hinojosa, A., Redmond, K., Gallia, G., Lim, M., … Kleinberg, L. (2019). Deferred Radiotherapy After Debulking of Non-functioning Pituitary Macroadenomas: Clinical Outcomes. FRONTIERS IN ONCOLOGY, 8, 660. -
Current State of Immune-Based Therapies for Glioblastoma.
Lim, M., Weller, M., & Chiocca, E. A. (2016). Current State of Immune-Based Therapies for Glioblastoma. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting, (36), e132–e139. -
Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system
Maxwell, R., Luksik, A. S., Garzon-Muvdi, T., Hung, A. L., Kim, E. S., Wu, A., … Lim, M. (2018). Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system. ONCOIMMUNOLOGY, 7(12), e1500108. -
Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy
Jiang, S., Eberhart, C. G., Lim, M., Heo, H.-Y., Zhang, Y., Blair, L., … Zhou, J. (2019). Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy. CLINICAL CANCER RESEARCH, 25(2), 552–61. -
Distinguishing True Progression From Radionecrosis After Stereotactic Radiation Therapy for Brain Metastases With Machine Learning and Radiomics
Peng, L., Parekh, V., Huang, P., Lin, D. D., Sheikh, K., Baker, B., … Kleinberg, L. (2018). Distinguishing True Progression From Radionecrosis After Stereotactic Radiation Therapy for Brain Metastases With Machine Learning and Radiomics. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 102(4), 1236–43. -
Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33
Tantravedi, S., Vesuna, F., Winnard, P. T., Martin, A., Lim, M., Eberhart, C. G., … Raman, V. (2019). Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33. TRANSLATIONAL ONCOLOGY, 12(1), 96–105. -
Outcomes of Metastatic Brain Lesions Treated with Radioactive Cs-131 Seeds after Surgery: Experience from One Institution
Xia, Y., Mashouf, L. A., Baker, B. R., Maxwell, R., Bettegowda, C., Redmond, K. J., … Lim, M. (2018). Outcomes of Metastatic Brain Lesions Treated with Radioactive Cs-131 Seeds after Surgery: Experience from One Institution. CUREUS, 10(7), e3075. -
Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma
Harris-Bookman, S., Mathios, D., Martin, A. M., Xia, Y., Kim, E., Xu, H., … Lim, M. (2018). Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma. INTERNATIONAL JOURNAL OF CANCER, 143(12), 3201–8. -
REPLY TO HAFFNER ET AL.: DNA hypomethylation renders tumors more immunogenic
Stone, M. L., Chiappinelli, K. B., Li, H., Murphy, L. M., Travers, M. E., Topper, M. J., … Zahnow, C. A. (2018). REPLY TO HAFFNER ET AL.: DNA hypomethylation renders tumors more immunogenic. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(37), E8583–E8584. -
Prior ablative procedure: a prognostic factor for poor outcome of microvascular decompression? Response
Theodros, D., & Lim, M. (2018). Prior ablative procedure: a prognostic factor for poor outcome of microvascular decompression? Response. JOURNAL OF NEUROSURGERY, 128(6), 1905. -
Adjuvant radiotherapy and outcomes of presumed hemorrhagic melanoma brain metastases without malignant cells.
Xia, Y., Mashouf, L. A., Maxwell, R., Peng, L. C., Lipson, E. J., Sharfman, W. H., … Lim, M. (2018). Adjuvant radiotherapy and outcomes of presumed hemorrhagic melanoma brain metastases without malignant cells. Surgical Neurology International, 9, 146. -
Local recurrence patterns after postoperative stereotactic radiation surgery to resected brain metastases: A quantitative analysis to guide target delineation
Gui, C., Moore, J., Grimm, J., Kleinberg, L., McNutt, T., Shen, C., … Redmond, K. J. (2018). Local recurrence patterns after postoperative stereotactic radiation surgery to resected brain metastases: A quantitative analysis to guide target delineation. PRACTICAL RADIATION ONCOLOGY, 8(6), 388–96. -
Absence of host NF-kappa B p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization
Barberi, T., Martin, A., Suresh, R., Barakat, D. J., Harris-Bookman, S., Drake, C. G., … Friedman, A. D. (2018). Absence of host NF-kappa B p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization. CANCER IMMUNOLOGY IMMUNOTHERAPY, 67(10), 1491–1503. -
Commentary: Does Stereotactic Radiosurgery Have a Role in the Management of Patients Presenting With 4 or More Brain Metastases?
Kleinberg, L., & Lim, M. (2019). Commentary: Does Stereotactic Radiosurgery Have a Role in the Management of Patients Presenting With 4 or More Brain Metastases? NEUROSURGERY, 84(3), 567–68. -
Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas
Kim, J. E., Patel, M. A., Mangraviti, A., Kim, E. S., Theodros, D., Velarde, E., … Lim, M. (2017). Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas. CLINICAL CANCER RESEARCH, 23(1), 124–36. -
Concurrent Immune Checkpoint Inhibitors and Radiation Therapy Reply
Chen, L., Redmond, K., & Lim, M. (2018). Concurrent Immune Checkpoint Inhibitors and Radiation Therapy Reply. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 101(4), 998–99. -
Immediate and Long-Term Outcomes of Microvascular Decompression for Mixed Trigeminal Neuralgia
Wu, A., Doshi, T., Hung, A., Garzon-Muvdi, T., Bender, M. T., Bettegowda, C., & Lim, M. (2018). Immediate and Long-Term Outcomes of Microvascular Decompression for Mixed Trigeminal Neuralgia. WORLD NEUROSURGERY, 117, E300–E307. -
Adult Cranioplasty Reconstruction With Customized Cranial Implants: Preferred Technique, Timing, and Biomaterials
Wolff, A., Santiago, G. F., Belzberg, M., Huggins, C., Lim, M., Weingart, J., … Gordon, C. (2018). Adult Cranioplasty Reconstruction With Customized Cranial Implants: Preferred Technique, Timing, and Biomaterials. JOURNAL OF CRANIOFACIAL SURGERY, 29(4), 887–94. -
Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.
Garzon-Muvdi, T., Theodros, D., Luksik, A. S., Maxwell, R., Kim, E., Jackson, C. M., … Lim, M. (2018). Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma. Oncotarget, 9(29), 20681–97. -
PD-L1 expression in medulloblastoma: an evaluation by subgroup.
Martin, A. M., Nirschl, C. J., Polanczyk, M. J., Bell, W. R., Nirschl, T. R., Harris-Bookman, S., … Lim, M. (2018). PD-L1 expression in medulloblastoma: an evaluation by subgroup. Oncotarget, 9(27), 19177–91. -
Immunotherapy for Glioblastoma: Playing Chess, Not Checkers
Jackson, C. M., & Lim, M. (2018). Immunotherapy for Glioblastoma: Playing Chess, Not Checkers. CLINICAL CANCER RESEARCH, 24(17), 4059–61. -
Current state of immunotherapy for glioblastoma
Lim, M., Xia, Y., Bettegowda, C., & Weller, M. (2018). Current state of immunotherapy for glioblastoma. NATURE REVIEWS CLINICAL ONCOLOGY, 15(7), 422–42. -
Nivolumab with or without ipilimumab in patients with recurrent glioblastoma: results from exploratory phase I cohorts of CheckMate 143
Omuro, A., Vlahovic, G., Lim, M., Sahebjam, S., Baehring, J., Cloughesy, T., … Sampson, J. H. (2018). Nivolumab with or without ipilimumab in patients with recurrent glioblastoma: results from exploratory phase I cohorts of CheckMate 143. NEURO-ONCOLOGY, 20(5), 674–86. -
Concurrent Immune Checkpoint Inhibitors and Stereotactic Radiosurgery for Brain Metastases in Non-Small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma
Chen, L., Douglass, J., Kleinberg, L., Ye, X., Marciscano, A. E., Forde, P. M., … Redmond, K. J. (2018). Concurrent Immune Checkpoint Inhibitors and Stereotactic Radiosurgery for Brain Metastases in Non-Small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 100(4), 916–25. -
A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain
Ruzevick, J., Nicholas, S., Redmond, K., Kleinberg, L., Lipson, E. J., & Lim, M. (2013). A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain. CASE REPORTS IN ONCOLOGICAL MEDICINE, 946392. -
The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas
Ehresman, J. S., Garzon-Muvdi, T., Rogers, D., Lim, M., Gallia, G. L., Weingart, J., … Chaichana, K. L. (2018). The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas. WORLD NEUROSURGERY, 109, E588–E593. -
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden
Stone, M. L., Chiappinelli, K. B., Li, H., Murphy, L. M., Travers, M. E., Topper, M. J., … Zahnow, C. A. (2017). Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(51), E10981–E10990. -
Targeting cytokines for treatment of neuropathic pain
Hung, A. L., Lim, M., & Doshi, T. L. (2017). Targeting cytokines for treatment of neuropathic pain. SCANDINAVIAN JOURNAL OF PAIN, 17, 287–93. -
Postoperative sinonasal morbidity in sellar reconstruction: mucosal autograft versus acellular dermal allograft
Roxbury, C. R., Magruder, J. T., Ramanathan, M., Lim, M., Gallia, G. L., Ishii, M., & Reh, D. D. (2017). Postoperative sinonasal morbidity in sellar reconstruction: mucosal autograft versus acellular dermal allograft. INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 7(12), 1178–85. -
PHASE I TRIAL OF ANTI-LAG-3 OR ANTI-CD137 ALONE AND IN COMBINATION WITH ANTI-PD-1 IN PATIENTS WITH RECURRENT GBM
Lim, M., Ye, X., Nabors, B., Piotrowski, A. F., Fisher, J., Desideri, S., … Grossman, S. A. (2017). PHASE I TRIAL OF ANTI-LAG-3 OR ANTI-CD137 ALONE AND IN COMBINATION WITH ANTI-PD-1 IN PATIENTS WITH RECURRENT GBM. NEURO-ONCOLOGY, 19, 31. -
A PILOT STUDY OF STEREOTACTIC RADIOSURGERY (SRS) COMBINED WITH IPILIMUMAB PROLONGED SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED MELANOMA BRAIN METASTASES
Lim, M., Kleinberg, L., Ye, X., Nicholas, S., Lin, D., Redmond, K., … Lipson, E. (2017). A PILOT STUDY OF STEREOTACTIC RADIOSURGERY (SRS) COMBINED WITH IPILIMUMAB PROLONGED SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED MELANOMA BRAIN METASTASES. NEURO-ONCOLOGY, 19, 27. -
PHASE 2 STUDY TO EVALUATE THE CLINICAL EFFICACY AND SAFETY OF MEDI4736 (DURVALUMAB [DUR]) IN PATIENTS WITH BEVACIZUMAB (BEV)-REFRACTORY RECURRENT GLIOBLASTOMA (GBM)
Reardon, D., Kaley, T., Dietrich, J., Clarke, J. L., Dunn, G. P., Lim, M., … Venhaus, R. (2017). PHASE 2 STUDY TO EVALUATE THE CLINICAL EFFICACY AND SAFETY OF MEDI4736 (DURVALUMAB [DUR]) IN PATIENTS WITH BEVACIZUMAB (BEV)-REFRACTORY RECURRENT GLIOBLASTOMA (GBM). NEURO-ONCOLOGY, 19, 28. -
POPULATION PHARMACOKINETIC (PPK) ANALYSIS OF NIVOLUMAB FLAT AND WEIGHT-BASED DOSING REGIMENS AND ASSOCIATIONS WITH SAFETY IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM) TREATED IN CHECKMATE 143
Shen, J., Hruska, M., Zwirtes, R., Potter, V., Paliwal, P., Roy, A., … Lim, M. (2017). POPULATION PHARMACOKINETIC (PPK) ANALYSIS OF NIVOLUMAB FLAT AND WEIGHT-BASED DOSING REGIMENS AND ASSOCIATIONS WITH SAFETY IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM) TREATED IN CHECKMATE 143. NEURO-ONCOLOGY, 19, 30. -
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors
Luksik, A. S., Maxwell, R., Garzon-Muvdi, T., & Lim, M. (2017). The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors. NEUROTHERAPEUTICS, 14(4), 1049–65. -
Histopathologic review of suspected disease progression in patients with recurrent glioblastoma (GBM) receiving nivolumab +/- ipilimumab: CheckMate 143.
Sahebjam, S., Ramkissoon, S., Baehring, J. M., Mulholland, P. J., Grauer, O. M., Cloughesy, T. F., … Ligon, K. L. (2017). Histopathologic review of suspected disease progression in patients with recurrent glioblastoma (GBM) receiving nivolumab +/- ipilimumab: CheckMate 143. JOURNAL OF CLINICAL ONCOLOGY, 35. -
Immunotherapy and radiation in glioblastoma
Sahebjam, S., Sharabi, A., Lim, M., Kesarwani, P., & Chinnaiyan, P. (2017). Immunotherapy and radiation in glioblastoma. JOURNAL OF NEURO-ONCOLOGY, 134(3), 531–39. -
Management of Cerebral Brain Metastasis
Patel, M. A., Ruzevick, J., & Lim, M. (2014). Management of Cerebral Brain Metastasis. CURRENT SURGERY REPORTS, 2(12). -
Long-term Treatment Response and Patient Outcomes for Vestibular Schwannoma Patients Treated with Hypofractionated Stereotactic Radiotherapy
Patel, M. A., Marciscano, A. E., Hu, C., Jusue-Torres, I., Garg, R., Rashid, A., … Kleinberg, L. R. (2017). Long-term Treatment Response and Patient Outcomes for Vestibular Schwannoma Patients Treated with Hypofractionated Stereotactic Radiotherapy. FRONTIERS IN ONCOLOGY, 7, 200. -
Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma
Maxwell, R., Jackson, C. M., & Lim, M. (2017). Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 18(8), 51. -
Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors
Wu, A., Weingart, J. D., Gallia, G. L., Lim, M., Brem, H., Bettegowda, C., & Chaichana, K. L. (2017). Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors. WORLD NEUROSURGERY, 104, 120–28. -
Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas
Jiang, S., Eberhart, C. G., Zhang, Y., Heo, H.-Y., Wen, Z., Blair, L., … Zhou, J. (2017). Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas. EUROPEAN JOURNAL OF CANCER, 83, 9–18. -
Induction of immunity to prostate cancer antigens: Results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer
Simons, J. W., Mikhak, B., Chang, J. F., DeMarzo, A. M., Carducci, M. A., Lim, M., … Nelson, W. G. (1999). Induction of immunity to prostate cancer antigens: Results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer. CANCER RESEARCH, 59(20), 5160–68. -
Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy
Bloch, O., Lim, M., Sughrue, M. E., Komotar, R. J., Abrahams, J. M., O'Rourke, D. M., … Parsa, A. T. (2017). Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy. CLINICAL CANCER RESEARCH, 23(14), 3575–84. -
Phase 2 study to evaluate the clinical efficacy and safety of MEDI4736 (durvalumab) in patients with glioblastoma (GBM).
Reardon, D. A., Kaley, T. J., Dietrich, J., Lim, M., Dunn, G. P., Gan, H. K., … Venhaus, R. R. (2016). Phase 2 study to evaluate the clinical efficacy and safety of MEDI4736 (durvalumab) in patients with glioblastoma (GBM). JOURNAL OF CLINICAL ONCOLOGY, 34(15). -
A randomized, phase 3, open-label study of nivolumab versus temozolomide (TMZ) in combination with radiotherapy (RT) in adult patients (pts) with newly diagnosed, O-6-methylguanine DNA methyltransferase (MGMT)-unmethylated glioblastoma (GBM): CheckMate-498.
Sampson, J. H., Omuro, A. M. P., Preusser, M., Lim, M., Butowski, N. A., Cloughesy, T. F., … Reardon, D. A. (2016). A randomized, phase 3, open-label study of nivolumab versus temozolomide (TMZ) in combination with radiotherapy (RT) in adult patients (pts) with newly diagnosed, O-6-methylguanine DNA methyltransferase (MGMT)-unmethylated glioblastoma (GBM): CheckMate-498. JOURNAL OF CLINICAL ONCOLOGY, 34(15). -
Spontaneous Intracranial Hypotension after Vestibular Schwannoma Resection Due to an Unexpected Pathology: Tarlov Cysts
Pross, S. E., Sharon, J. D., Lim, M., Moghekar, A., Rao, A., & Carey, J. P. (2017). Spontaneous Intracranial Hypotension after Vestibular Schwannoma Resection Due to an Unexpected Pathology: Tarlov Cysts. CUREUS, 9(5), e1261. -
Long-term Outcomes With Planned Multistage Reduced Dose Repeat Stereotactic Radiosurgery for Treatment of Inoperable High-Grade Arteriovenous Malformations: An Observational Retrospective Cohort Study
Marciscano, A. E., Huang, J., Tamargo, R. J., Hu, C., Khattab, M. H., Aggarwal, S., … Kleinberg, L. R. (2017). Long-term Outcomes With Planned Multistage Reduced Dose Repeat Stereotactic Radiosurgery for Treatment of Inoperable High-Grade Arteriovenous Malformations: An Observational Retrospective Cohort Study. NEUROSURGERY, 81(1), 136–46. -
Use of Stereotactic Radiosurgery in Elderly and Very Elderly Patients With Brain Metastases to Limit Toxicity Associated With Whole Brain Radiation Therapy
Chen, L., Shen, C., Redmond, K. J., Page, B. R., Kummerlowe, M., Mcnutt, T., … Kleinberg, L. (2017). Use of Stereotactic Radiosurgery in Elderly and Very Elderly Patients With Brain Metastases to Limit Toxicity Associated With Whole Brain Radiation Therapy. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 98(4), 939–47. -
Biomarkers and Immunotherapeutic Targets in Glioblastoma
Hung, A. L., Garzon-Muvdi, T., & Lim, M. (2017). Biomarkers and Immunotherapeutic Targets in Glioblastoma. WORLD NEUROSURGERY, 102, 494–506. -
Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature
Kessler, R. A., Garzon-Muvdi, T., Yang, W., Weingart, J., Olivi, A., Huang, J., … Lim, M. (2017). Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature. WORLD NEUROSURGERY, 101, 47–56. -
The Potential of Cellular- and Viral-Based Immunotherapies for Malignant Glioma-Dendritic Cell Vaccines, Adoptive Cell Transfer, and Oncolytic Viruses
Maxwell, R., Luksik, A. S., Garzon-Muvdi, T., & Lim, M. (2017). The Potential of Cellular- and Viral-Based Immunotherapies for Malignant Glioma-Dendritic Cell Vaccines, Adoptive Cell Transfer, and Oncolytic Viruses. CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 17(6), 50. -
Efficacy of primary microvascular decompression versus subsequent microvascular decompression for trigeminal neuralgia
Theodros, D., Goodwin, C. R., Bender, M. T., Zhou, X., Garzon-Muvdi, T., De la Garza-Ramos, R., … Lim, M. (2017). Efficacy of primary microvascular decompression versus subsequent microvascular decompression for trigeminal neuralgia. JOURNAL OF NEUROSURGERY, 126(5), 1691–97. -
BRAF-V600 mutational status affects recurrence patterns of melanoma brain metastasis
Maxwell, R., Garzon-Muvdi, T., Lipson, E. J., Sharfman, W. H., Bettegowda, C., Redmond, K. J., … Lim, M. (2017). BRAF-V600 mutational status affects recurrence patterns of melanoma brain metastasis. INTERNATIONAL JOURNAL OF CANCER, 140(12), 2716–27. -
MODULATING THE MYELOID COMPARTMENT TO POTENTIATE ANTI-PD1 MEDIATED IMMUNOTHERAPY AGAINST GLIOBLASTOMA
Muvdi, T. G., Theodros, D., Carrera-Haro, M., Kim, E., Jackson, C., Luksik, A., … Lim, M. (2016). MODULATING THE MYELOID COMPARTMENT TO POTENTIATE ANTI-PD1 MEDIATED IMMUNOTHERAPY AGAINST GLIOBLASTOMA. NEURO-ONCOLOGY, 18, 99. -
PHASE 2 STUDY TO EVALUATE THE CLINICAL EFFICACY AND SAFETY OF MEDI4736 (DURVALUMAB [DUR]) IN PATIENTS WITH GLIOBLASTOMA (GBM): RESULTS FOR COHORT B (DUR MONOTHERAPY), BEVACIZUMAB (BEV) NAIVE PATIENTS WITH RECURRENT GBM
Reardon, D., Kaley, T., Dietrich, J., Lim, M., Dunn, G., Gan, H., … Venhaus, R. (2016). PHASE 2 STUDY TO EVALUATE THE CLINICAL EFFICACY AND SAFETY OF MEDI4736 (DURVALUMAB [DUR]) IN PATIENTS WITH GLIOBLASTOMA (GBM): RESULTS FOR COHORT B (DUR MONOTHERAPY), BEVACIZUMAB (BEV) NAIVE PATIENTS WITH RECURRENT GBM. NEURO-ONCOLOGY, 18, 18. -
NIVOLUMAB COMBINED WITH RADIOTHERAPY WITH OR WITHOUT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA: RESULTS FROM PHASE 1 SAFETY COHORTS IN CHECKMATE 143
Omuro, A., Vlahovic, G., Baehring, J., Butowski, N. A., Reardon, D. A., Cloughesy, T., … Sampson, J. (2016). NIVOLUMAB COMBINED WITH RADIOTHERAPY WITH OR WITHOUT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA: RESULTS FROM PHASE 1 SAFETY COHORTS IN CHECKMATE 143. NEURO-ONCOLOGY, 18, 21. -
Progressive Low-Grade Glioma: Assessment of Prognostic Importance of Histologic Reassessment and MRI Findings
Narang, A. K., Chaichana, K. L., Weingart, J. D., Redmond, K. J., Lim, M., Olivi, A., … Kleinberg, L. R. (2017). Progressive Low-Grade Glioma: Assessment of Prognostic Importance of Histologic Reassessment and MRI Findings. WORLD NEUROSURGERY, 99, 751–57. -
Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM
Mathios, D., Kim, J. E., Mangraviti, A., Phallen, J., Park, C.-K., Jackson, C. M., … Lim, M. (2016). Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM. SCIENCE TRANSLATIONAL MEDICINE, 8(370), 370ra180. -
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma (vol 4, 28, 2016)
Patel, M. A., Kim, J. E., Theodros, D., Tam, A., Velarde, E., Kochel, C. M., … Lim, M. (2016). Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma (vol 4, 28, 2016). JOURNAL FOR IMMUNOTHERAPY OF CANCER, 4, 74. -
Influence of Insurance Status on Survival of Adults With Glioblastoma Multiforme: A Population-Based Study
Rong, X., Yang, W., Garzon-Muvdi, T., Caplan, J. M., Hui, X., Lim, M., & Huang, J. (2016). Influence of Insurance Status on Survival of Adults With Glioblastoma Multiforme: A Population-Based Study. CANCER, 122(20), 3157–65. -
Layered sellar reconstruction with avascular free grafts: Acceptable alternative to the nasoseptal flap for repair of low-volume intraoperative cerebrospinal fluid leak
Roxbury, C. R., Saavedra, T., Ramanathan, M., Lim, M., Ishii, M., Gallia, G. L., & Reh, D. D. (2016). Layered sellar reconstruction with avascular free grafts: Acceptable alternative to the nasoseptal flap for repair of low-volume intraoperative cerebrospinal fluid leak. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 30(5), 367–71. -
Discussion on: Usefulness of an Osteotomy Template for Skull Tumorectomy and Simultaneous Skull Reconstruction
Gordon, C. R., Murphy, R. J., Armand, M., Liacouras, P., Weingart, J., Huang, J., … Lim, M. (2016). Discussion on: Usefulness of an Osteotomy Template for Skull Tumorectomy and Simultaneous Skull Reconstruction. JOURNAL OF CRANIOFACIAL SURGERY, 27(6), 1568–70. -
The strategy of repeat stereotactic radiosurgery without whole brain radiation treatment for new brain metastases: Outcomes and implications for follow-up monitoring
Shen, C. J., Rigamonti, D., Redmond, K. J., Kummerlowe, M. N., Lim, M., & Kleinberg, L. R. (2016). The strategy of repeat stereotactic radiosurgery without whole brain radiation treatment for new brain metastases: Outcomes and implications for follow-up monitoring. PRACTICAL RADIATION ONCOLOGY, 6(6), 409–16. -
Timely stereotactic body radiotherapy (SBRT) for spine metastases using a rapidly deployable automated planning algorithm
Mian, O. Y., Thomas, O., Lee, J. J. Y., Le, Y., McNutt, T., Lim, M., … Kleinberg, L. (2016). Timely stereotactic body radiotherapy (SBRT) for spine metastases using a rapidly deployable automated planning algorithm. SPRINGERPLUS, 5, 1337. -
Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors.
Nicholas, S., Mathios, D., Ruzevick, J., Jackson, C., Yang, I., & Lim, M. (2013). Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors. Brain Tumor Research and Treatment, 1(1), 2–8. -
Controversies in the Therapy of Brain Metastases: Shifting Paradigms in an Era of Effective Systemic Therapy and Longer-Term Survivorship
Shen, C. J., Lim, M., & Kleinberg, L. R. (2016). Controversies in the Therapy of Brain Metastases: Shifting Paradigms in an Era of Effective Systemic Therapy and Longer-Term Survivorship. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 17(9), 46. -
A Systematic Analysis of the Reliability of Diffusion Tensor Imaging Tractography for Facial Nerve Imaging in Patients with Vestibular Schwannoma
Ung, N., Mathur, M., Chung, L. K., Cremer, N., Pelargos, P., Frew, A., … Yang, I. (2016). A Systematic Analysis of the Reliability of Diffusion Tensor Imaging Tractography for Facial Nerve Imaging in Patients with Vestibular Schwannoma. JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 77(4), 314–18. -
Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system
Salzberg, S. L., Breitwieser, F. P., Kumar, A., Hao, H., Burger, P., Rodriguez, F. J., … Pardo, C. A. (2016). Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system. NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 3(4), e251. -
Preface
Lee, J. Y. K., & Lim, M. (2016). Preface. NEUROSURGERY CLINICS OF NORTH AMERICA, 27(3), IX. -
Current State of Immune-Based Therapies for Glioblastoma.
Lim, M., Weller, M., & Chiocca, E. A. (2016). Current State of Immune-Based Therapies for Glioblastoma. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting, 35, e132–9. -
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma
Patel, M. A., Kim, J. E., Theodros, D., Tam, A., Velarde, E., Kochel, C. M., … Lim, M. (2016). Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 4, 28. -
PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment (vol 121, pg 251, 2015)
Mathios, D., Ruzevick, J., Jackson, C. M., Xu, H., Shah, S. R., Taube, J. M., … Lim, M. (2016). PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment (vol 121, pg 251, 2015). JOURNAL OF NEURO-ONCOLOGY, 128(1), 183. -
Ganetespib radiosensitization for liver cancer therapy
Chettiar, S. T., Malek, R., Annadanam, A., Nugent, K. M., Kato, Y., Wang, H., … Tran, P. T. (2016). Ganetespib radiosensitization for liver cancer therapy. CANCER BIOLOGY & THERAPY, 17(4), 457–66. -
Phase 2 study to evaluate the clinical efficacy and safety of MEDI4736 in patients with glioblastoma (GBM)
Reardon, D. A., Dietrich, J., Kaley, T., Gan, H., Dunn, G. P., Cloughesy, T., … Venhaus, R. (2016). Phase 2 study to evaluate the clinical efficacy and safety of MEDI4736 in patients with glioblastoma (GBM). CANCER IMMUNOLOGY RESEARCH, 4(1). -
Stereotactic Radiosurgery: Treatment of Brain Metastasis Without Interruption of Systemic Therapy
Shen, C. J., Kummerlowe, M. N., Redmond, K. J., Rigamonti, D., Lim, M. K., & Kleinberg, L. R. (2016). Stereotactic Radiosurgery: Treatment of Brain Metastasis Without Interruption of Systemic Therapy. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 95(2), 735–42. -
Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination
Jackson, C. M., Kochel, C. M., Nirschl, C. J., Durham, N. M., Ruzevick, J., Alme, A., … Drake, C. G. (2016). Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination. CLINICAL CANCER RESEARCH, 22(5), 1161–72. -
Oligometastatic Adenocarcinoma of the Lung: A Therapeutic Opportunity for Long-Term Survival
Yarchoan, M., Lim, M., Brahmer, J. R., & Ettinger, D. (2015). Oligometastatic Adenocarcinoma of the Lung: A Therapeutic Opportunity for Long-Term Survival. CUREUS, 7(12), e409. -
Laser speckle imaging to improve clinical outcomes for patients with trigeminal neuralgia undergoing radiofrequency thermocoagulation
Ringkamp, M., Wooten, M., Carson, B. S., Lim, M., Hartke, T., & Guarnieri, M. (2016). Laser speckle imaging to improve clinical outcomes for patients with trigeminal neuralgia undergoing radiofrequency thermocoagulation. JOURNAL OF NEUROSURGERY, 124(2), 422–28. -
Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium
Kim, E. S., Kim, J. E., Patel, M. A., Mangraviti, A., Ruzevick, J., & Lim, M. (2016). Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium. JOURNAL OF IMMUNOLOGY RESEARCH, 2016, 4683607. -
Technical Nuances of Microvascular Decompression of the Posterior Fossa Cranial Nerves: 3-Dimensional Operative Video
Binning, M. J., & Veznedaroglu, E. (2014). Technical Nuances of Microvascular Decompression of the Posterior Fossa Cranial Nerves: 3-Dimensional Operative Video. OPERATIVE NEUROSURGERY, 10(3), 487. -
Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature
Khattab, M. H., Marciscano, A. E., Lo, S. S., Lim, M., Laterra, J. J., Kleinberg, L. R., & Redmond, K. J. (2015). Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature. CASE REPORTS IN ONCOLOGICAL MEDICINE, 431819. -
Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature
Theodros, D., Goodwin, C. R., Crane, G. M., Liauw, J., Kleinberg, L., & Lim, M. (2015). Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature. CASE REPORTS IN ONCOLOGICAL MEDICINE, 847058. -
Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement
Eseonu, C. I., Goodwin, C. R., Zhou, X., Theodros, D., Bender, M. T., Mathios, D., … Lim, M. (2015). Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement. JOURNAL OF NEUROSURGERY, 123(6), 1476–79. -
Pituitary adenomas: historical perspective, surgical management and future directions.
Theodros, D., Patel, M., Ruzevick, J., Lim, M., & Bettegowda, C. (2015). Pituitary adenomas: historical perspective, surgical management and future directions. CNS Oncology, 4(6), 411–29. -
Prognostic factors associated with pain palliation after spine stereotactic body radiation therapy
Puvanesarajah, V., Lo, S.-fu L., Aygun, N., Liauw, J. A., Jusue-Torres, I., Lina, I. A., … Lim, M. (2015). Prognostic factors associated with pain palliation after spine stereotactic body radiation therapy. JOURNAL OF NEUROSURGERY-SPINE, 23(5), 620–29. -
Immunomodulation: checkpoint blockade etc.
Curry, W. T., & Lim, M. (2015). Immunomodulation: checkpoint blockade etc. NEURO-ONCOLOGY, 17, 26–31. -
Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model
Mathios, D., Park, C.-K., Marcus, W. D., Alter, S., Rhode, P. R., Jeng, E. K., … Lim, M. (2016). Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model. INTERNATIONAL JOURNAL OF CANCER, 138(1), 187–94. -
Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy
Sharabi, A. B., Lim, M., DeWeese, T. L., & Drake, C. G. (2015). Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy. LANCET ONCOLOGY, 16(13), E498–E509. -
Prospects of immune checkpoint modulators in the treatment of glioblastoma
Preusser, M., Lim, M., Hafler, D. A., Reardon, D. A., & Sampson, J. H. (2015). Prospects of immune checkpoint modulators in the treatment of glioblastoma. NATURE REVIEWS NEUROLOGY, 11(9), 504–14. -
Phase II study to evaluate the clinical efficacy and safety of MEDI4736 in patients with glioblastoma (GBM).
Reardon, D. A., Dietrich, J., Kaley, T. J., Gan, H. K., Dunn, G. P., Cloughesy, T. F., … Venhaus, R. R. (2015). Phase II study to evaluate the clinical efficacy and safety of MEDI4736 in patients with glioblastoma (GBM). JOURNAL OF CLINICAL ONCOLOGY, 33(15). -
Preliminary safety and activity of nivolumab and its combination with ipilimumab in recurrent glioblastoma (GBM): CHECKMATE-143.
Sampson, J. H., Vlahovic, G., Sahebjam, S., Omuro, A. M. P., Baehring, J. M., Hafler, D. A., … Reardon, D. A. (2015). Preliminary safety and activity of nivolumab and its combination with ipilimumab in recurrent glioblastoma (GBM): CHECKMATE-143. JOURNAL OF CLINICAL ONCOLOGY, 33(15). -
Newly diagnosed glioblastoma patients treated with an autologous heat shock protein peptide vaccine: PD-L1 expression and response to therapy
Bloch, O., Raizer, J. J., Lim, M., Sughrue, M., Komotar, R., Abrahams, J., … Parsa, A. (2015). Newly diagnosed glioblastoma patients treated with an autologous heat shock protein peptide vaccine: PD-L1 expression and response to therapy. JOURNAL OF CLINICAL ONCOLOGY, 33(15). -
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord
Wang, Y., Springer, S., Zhang, M., McMahon, K. W., Kinde, I., Dobbyn, L., … Bettegowda, C. (2015). Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(31), 9704–9. -
Immunosuppressive mechanisms of malignant gliomas: parallels at non-CNS sites
Perng, P., & Lim, M. (2015). Immunosuppressive mechanisms of malignant gliomas: parallels at non-CNS sites. FRONTIERS IN ONCOLOGY, 5, 153. -
Immediate Single-Stage Cranioplasty Following Calvarial Resection for Benign and Malignant Skull Neoplasms Using Customized Craniofacial Implants
Berli, J. U., Thomaier, L., Zhong, S., Huang, J., Quinones, A., Lim, M., … Gordon, C. R. (2015). Immediate Single-Stage Cranioplasty Following Calvarial Resection for Benign and Malignant Skull Neoplasms Using Customized Craniofacial Implants. JOURNAL OF CRANIOFACIAL SURGERY, 26(5), 1456–62. -
Introduction: brain tumor immunotherapy
Lim, M., & Liau, L. M. (2015). Introduction: brain tumor immunotherapy. JOURNAL OF NEURO-ONCOLOGY, 123(3), 321–22. -
The role of checkpoints in the treatment of GBM
Kim, J. E., & Lim, M. (2015). The role of checkpoints in the treatment of GBM. JOURNAL OF NEURO-ONCOLOGY, 123(3), 413–23. -
Risk of surgical site infection in 401 consecutive patients with glioblastoma with and without carmustine wafer implantation
Chaichana, K. L., Kone, L., Bettegowda, C., Weingart, J. D., Olivi, A., Lim, M., … Brem, H. (2015). Risk of surgical site infection in 401 consecutive patients with glioblastoma with and without carmustine wafer implantation. NEUROLOGICAL RESEARCH, 37(8), 717–26. -
Technical note: Orbitozygomatic craniotomy using an ultrasonic osteotome for precise osteotomies
Ruzevick, J., Raza, S. M., Recinos, P. F., Chaichana, K., Pradilla, G., Kim, J. E., … Lim, M. (2015). Technical note: Orbitozygomatic craniotomy using an ultrasonic osteotome for precise osteotomies. CLINICAL NEUROLOGY AND NEUROSURGERY, 134, 24–27. -
Stereotactic Radiation Therapy Combined With Immunotherapy: Augmenting the Role of Radiation in Local and Systemic Treatment
Sharabi, A. B., Tran, P. T., Lim, M., Drake, C. G., & DeWeese, T. L. (2015). Stereotactic Radiation Therapy Combined With Immunotherapy: Augmenting the Role of Radiation in Local and Systemic Treatment. ONCOLOGY-NEW YORK, 29(5), 331–40. -
Immunotherapy for glioblastoma: are we finally getting closer?
Lim, M. (2015). Immunotherapy for glioblastoma: are we finally getting closer? NEURO-ONCOLOGY, 17(6), 771–72. -
PD-1 BLOCKADE SHOWS SYNERGISTIC SURVIVAL, ANTI-TUMOR IMMUNE RESPONSE AND LONG-TERM MEMORY WITH INTERSTITIAL BUT NOT SYSTEMIC CHEMOTHERAPY: STUDY IN A MURINE GLIOBLASTOMA MODEL
Mathios, D., Phallen, J., Park, C.-K., Jackson, C., Nicholas, S., Tyler, B., … Lim, M. (2014). PD-1 BLOCKADE SHOWS SYNERGISTIC SURVIVAL, ANTI-TUMOR IMMUNE RESPONSE AND LONG-TERM MEMORY WITH INTERSTITIAL BUT NOT SYSTEMIC CHEMOTHERAPY: STUDY IN A MURINE GLIOBLASTOMA MODEL. NEURO-ONCOLOGY, 16. -
PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment
Mathios, D., Ruzevick, J., Jackson, C. M., Xu, H., Shah, S., Taube, J. M., … Lim, M. (2015). PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment. JOURNAL OF NEURO-ONCOLOGY, 121(2), 251–59. -
Neurocytoma of the Spinal Cord
Kim, J. E., & Lim, M. (2015). Neurocytoma of the Spinal Cord. NEUROSURGERY CLINICS OF NORTH AMERICA, 26(1), 109-+. -
Identifying Better Surgical Candidates Among Recursive Partitioning Analysis Class 2 Patients who Underwent Surgery for Intracranial Metastases
Chaichana, K. L., Acharya, S., Flores, M., Wijesekera, O., Rigamonti, D., Weingart, J. D., … Quinones-Hinojosa, A. (2014). Identifying Better Surgical Candidates Among Recursive Partitioning Analysis Class 2 Patients who Underwent Surgery for Intracranial Metastases. WORLD NEUROSURGERY, 82(1-2), E267–E275. -
Planning Evaluation of C-Arm Cone Beam CT Angiography for Target Delineation in Stereotactic Radiation Surgery of Brain Arteriovenous Malformations
Kang, J., Huang, J., Gailloud, P., Rigamonti, D., Lim, M., Bernard, V., … Ford, E. C. (2014). Planning Evaluation of C-Arm Cone Beam CT Angiography for Target Delineation in Stereotactic Radiation Surgery of Brain Arteriovenous Malformations. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 90(2), 430–37. -
TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting
Herrmann, A., Cherryholmes, G., Schroeder, A., Phallen, J., Alizadeh, D., Xin, H., … Yu, H. (2014). TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting. CANCER RESEARCH, 74(18), 5218–28. -
Selective cerebral hypothermia induced via hypothermic retrograde jugular vein saline flush in a porcine model
Chen, C.-W., Puvanesarajah, V., Lo, S.-F. L., Cheng, T.-J., Cheng, C.-Y., Lim, M., & Lin, H.-J. (2014). Selective cerebral hypothermia induced via hypothermic retrograde jugular vein saline flush in a porcine model. NEUROLOGICAL RESEARCH, 36(10), 897–902. -
Immunotherapy for Brain Cancer: Recent Progress and Future Promise
Jackson, C. M., Lim, M., & Drake, C. G. (2014). Immunotherapy for Brain Cancer: Recent Progress and Future Promise. CLINICAL CANCER RESEARCH, 20(14), 3651–59. -
Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model
Belcaid, Z., Phallen, J. A., Zeng, J., See, A. P., Mathios, D., Gottschalk, C., … Lim, M. (2014). Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model. PLOS ONE, 9(7), e101764. -
DIFFERENTIAL EXPRESSION OF PD-L1 ON HEMATOPOIETIC VERSUS TUMOR CELLS IN MEDULLOBLASTOMA
Martin, A. M., Nirschl, C., Polanczyk, M., Bell, R., Martinez, D., Sullivan, L. M., … Lim, M. (2014). DIFFERENTIAL EXPRESSION OF PD-L1 ON HEMATOPOIETIC VERSUS TUMOR CELLS IN MEDULLOBLASTOMA. NEURO-ONCOLOGY, 16, 89. -
Postradiation imaging changes in the CNS: how can we differentiate between treatment effect and disease progression?
Walker, A. J., Ruzevick, J., Malayeri, A. A., Rigamonti, D., Lim, M., Redmond, K. J., & Kleinberg, L. (2014). Postradiation imaging changes in the CNS: how can we differentiate between treatment effect and disease progression? FUTURE ONCOLOGY, 10(7), 1277–97. -
Multidisciplinary Approach for Improved Outcomes in Secondary Cranial Reconstruction: Introducing the Pericranial-Onlay Cranioplasty Technique
Gordon, C. R., Fisher, M., Liauw, J., Lina, I., Puvanesarajah, V., Susarla, S., … Huang, J. (2014). Multidisciplinary Approach for Improved Outcomes in Secondary Cranial Reconstruction: Introducing the Pericranial-Onlay Cranioplasty Technique. OPERATIVE NEUROSURGERY, 10(2), 179–89. -
The role of regulatory T-cells in glioma immunology
Ooi, Y. C., Tran, P., Ung, N., Thill, K., Trang, A., Fong, B. M., … Yang, I. (2014). The role of regulatory T-cells in glioma immunology. CLINICAL NEUROLOGY AND NEUROSURGERY, 119, 125–32. -
Invasive adenoma and pituitary carcinoma: a SEER database analysis
Hansen, T. M., Batra, S., Lim, M., Gallia, G. L., Burger, P. C., Salvatori, R., … Redmond, K. J. (2014). Invasive adenoma and pituitary carcinoma: a SEER database analysis. NEUROSURGICAL REVIEW, 37(2), 279–85. -
STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications
Kim, J. E., Patel, M., Ruzevick, J., Jackson, C. M., & Lim, M. (2014). STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications. CANCERS, 6(1), 376–95. -
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Bettegowda, C., Sausen, M., Leary, R. J., Kinde, I., Wang, Y., Agrawal, N., … Diaz, L. A. (2014). Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies. SCIENCE TRANSLATIONAL MEDICINE, 6(224), 224ra24. -
AMIDE PROTON TRANSFER MRI OF MALIGNANT GLIOMAS FOR DETECTING ACTIVE VERSUS INACTIVE TUMOR
Wolf, D., Ye, X., Lim, M., Zhu, H., Wang, M., Quinones-Hinojosa, A., … Blakeley, J. (2013). AMIDE PROTON TRANSFER MRI OF MALIGNANT GLIOMAS FOR DETECTING ACTIVE VERSUS INACTIVE TUMOR. NEURO-ONCOLOGY, 15, 204. -
DEFERRED RADIATION IS AN APPROPRIATE OPTION FOR PATIENTS PRESENTING FOR TREATMENT OF NON-FUNCTIONING PITUITARY MACROADENOMAS WITH RESIDUAL POST SURGICAL TUMOR
Nicholas, S., Salvatori, R., Lim, M., Redmond, K., Quinones, A., Gallia, G., … Kleinberg, L. (2013). DEFERRED RADIATION IS AN APPROPRIATE OPTION FOR PATIENTS PRESENTING FOR TREATMENT OF NON-FUNCTIONING PITUITARY MACROADENOMAS WITH RESIDUAL POST SURGICAL TUMOR. NEURO-ONCOLOGY, 15, 185. -
THE ROLE OF PD-1 PATHWAY IN CHORDOMAS
Mathios, D., Lim, M., Ruzevick, J., Nicholas, S., Polanczyk, M., Jackson, C., … Xu, H. (2013). THE ROLE OF PD-1 PATHWAY IN CHORDOMAS. NEURO-ONCOLOGY, 15, 64–65. -
Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma
Chaichana, K. L., Jusue-Torres, I., Navarro-Ramirez, R., Raza, S. M., Pascual-Gallego, M., Ibrahim, A., … Quinones-Hinojosa, A. (2014). Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma. NEURO-ONCOLOGY, 16(1), 113–22. -
The Transconjunctival Transorbital Approach: A Keyhole Approach to the Midline Anterior Skull Base
Raza, S. M., Quinones-Hinojosa, A., Lim, M., & Boahene, K. D. O. (2013). The Transconjunctival Transorbital Approach: A Keyhole Approach to the Midline Anterior Skull Base. WORLD NEUROSURGERY, 80(6), 864–71. -
Glycerol rhizotomy via a retrosigmoid approach as an alternative treatment for trigeminal neuralgia
Goodwin, C. R., Yang, J. X., Bettegowda, C., Hwang, B., James, C., Biser, A., … Lim, M. (2013). Glycerol rhizotomy via a retrosigmoid approach as an alternative treatment for trigeminal neuralgia. CLINICAL NEUROLOGY AND NEUROSURGERY, 115(12), 2454–56. -
Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses
Zeng, J., Harris, T. J., Lim, M., Drake, C. G., & Tran, P. T. (2013). Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses. BIOMED RESEARCH INTERNATIONAL, 2013, 658126. -
Patients undergoing surgery of intracranial metastases have different outcomes based on their primary pathology
Chaichana, K. L., Gadkaree, S., Rao, K., Link, T., Rigamonti, D., Purtell, M., … Quinones-Hinojosa, A. (2013). Patients undergoing surgery of intracranial metastases have different outcomes based on their primary pathology. NEUROLOGICAL RESEARCH, 35(10), 1059–69. -
Three-Dimensional Amide Proton Transfer MR Imaging of Gliomas: Initial Experience and Comparison With Gadolinium Enhancement
Zhou, J., Zhu, H., Lim, M., Blair, L., Quinones-Hinojosa, A., Messina, S. A., … Blakeley, J. O. (2013). Three-Dimensional Amide Proton Transfer MR Imaging of Gliomas: Initial Experience and Comparison With Gadolinium Enhancement. JOURNAL OF MAGNETIC RESONANCE IMAGING, 38(5), 1119–28. -
Survival and Recurrence for Patients Undergoing Surgery of Skull Base Intracranial Metastases
Chaichana, K. L., Flores, M., Acharya, S., Sampognaro, P., Bettegowda, C., Rigamonti, D., … Quinones-Hinojosa, A. (2013). Survival and Recurrence for Patients Undergoing Surgery of Skull Base Intracranial Metastases. JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 74(4), 228–35. -
Postoperative Anticoagulation in Patients with Mechanical Heart Valves Following Surgical Treatment of Subdural Hematomas
Amin, A. G., Ng, J., Hsu, W., Pradilla, G., Raza, S., Quinones-Hinojosa, A., & Lim, M. (2013). Postoperative Anticoagulation in Patients with Mechanical Heart Valves Following Surgical Treatment of Subdural Hematomas. NEUROCRITICAL CARE, 19(1), 90–94. -
Predictors of Visual Outcome Following Surgical Resection of Medial Sphenoid Wing Meningiomas
Chaichana, K. L., Jackson, C., Patel, A., Miller, N. R., Subramanian, P., Lim, M., … Quinones-Hinojosa, A. (2012). Predictors of Visual Outcome Following Surgical Resection of Medial Sphenoid Wing Meningiomas. JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 73(5), 321–26. -
Real-Time Imaging with the O-Arm for Skull Base Applications: A Cadaveric Feasibility Study
Raza, S. M., See, A. P., & Lim, M. (2012). Real-Time Imaging with the O-Arm for Skull Base Applications: A Cadaveric Feasibility Study. JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 73(5), 293–301. -
Radiosurgery for Arteriovenous Malformations
Ruzevick, J., Batra, S., Lim, M., & Rigamonti, D. (2013). Radiosurgery for Arteriovenous Malformations. HANDBOOK OF RADIOSURGERY IN CNS DISEASE, 123–35. -
Skull-Base Tumors D. Radiosurgery for Vestibular Schwannomas
Ruzevick, J., Lim, M., & Rigamonti, D. (2013). Skull-Base Tumors D. Radiosurgery for Vestibular Schwannomas. HANDBOOK OF RADIOSURGERY IN CNS DISEASE, 83–91. -
Skull-Base Tumors C. Stereotactic Radiosurgery for Glomus Jugulare Tumors
Guss, Z. D., Amin, A. G., & Lim, M. (2013). Skull-Base Tumors C. Stereotactic Radiosurgery for Glomus Jugulare Tumors. HANDBOOK OF RADIOSURGERY IN CNS DISEASE, 77–81. -
Technology and Techniques of Cranial Radiosurgery
Ruzevick, J., & Lim, M. (2013). Technology and Techniques of Cranial Radiosurgery. HANDBOOK OF RADIOSURGERY IN CNS DISEASE, 13–25. -
Handbook of Radiosurgery in CNS Disease Preface
Lim, M., Hsu, W., Rigamonti, D., & Kleinberg, L. R. (2013). Handbook of Radiosurgery in CNS Disease Preface. HANDBOOK OF RADIOSURGERY IN CNS DISEASE, IX-X. -
Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection
Chen, L., Guerrero-Cazares, H., Ye, X., Ford, E., McNutt, T., Kleinberg, L., … Redmond, K. (2013). Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 86(4), 616–22. -
MYC AMPLIFICATION STATUS INFLUENCES TUMOR IMMUNE EVASION IN MEDULLOBLASTOMA
Martin, A., Nirschl, C., Polanczyk, M., Cohen, K., Pardoll, D., Drake, C., & Lim, M. (2013). MYC AMPLIFICATION STATUS INFLUENCES TUMOR IMMUNE EVASION IN MEDULLOBLASTOMA. NEURO-ONCOLOGY, 15, 15–16. -
Factors associated with survival for patients with glioblastoma with poor pre-operative functional status
Chaichana, K. L., Martinez-Gutierrez, J. C., De la Garza-Ramos, R., Weingart, J. D., Olivi, A., Gallia, G. L., … Quinones-Hinojosa, A. (2013). Factors associated with survival for patients with glioblastoma with poor pre-operative functional status. JOURNAL OF CLINICAL NEUROSCIENCE, 20(6), 818–23. -
Metastatic Melanoma to the Brain: Surgery and Radiation Is Still the Standard of Care
Nicholas, S., Mathios, D., Jackson, C., & Lim, M. (2013). Metastatic Melanoma to the Brain: Surgery and Radiation Is Still the Standard of Care. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 14(2), 264–79. -
Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas
Zeng, J., See, A. P., Phallen, J., Jackson, C. M., Belcaid, Z., Ruzevick, J., … Lim, M. (2013). Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 86(2), 343–49. -
Seizure Control for Patients Undergoing Meningioma Surgery
Chaichana, K. L., Pendleton, C., Zaidi, H., Olivi, A., Weingart, J. D., Gallia, G. L., … Quinones-Hinojosa, A. (2013). Seizure Control for Patients Undergoing Meningioma Surgery. WORLD NEUROSURGERY, 79(3-4), 515–24. -
Multiple resections for patients with glioblastoma: prolonging survival Clinical article
Chaichana, K. L., Zadnik, P., Weingart, J. D., Olivi, A., Gallia, G. L., Blakeley, J., … Quistones-Hinojosa, A. (2013). Multiple resections for patients with glioblastoma: prolonging survival Clinical article. JOURNAL OF NEUROSURGERY, 118(4), 812–20. -
Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors
Chaichana, K. L., Pendleton, C., Jackson, C., Martinez-Gutierrez, J. C., Diaz-Stransky, A., Aguayo, J., … Quinones-Hinojosa, A. (2013). Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors. NEUROLOGICAL RESEARCH, 35(2), 206–11. -
Vaccine strategies for glioblastoma: progress and future directions
Jackson, C., Ruzevick, J., Brem, H., & Lim, M. (2013). Vaccine strategies for glioblastoma: progress and future directions. IMMUNOTHERAPY, 5(2), 155–67. -
Glycerol rhizotomy and radiofrequency thermocoagulation for trigeminal neuralgia in multiple sclerosis
Bender, M. T., Pradilla, G., Batra, S., See, A. P., James, C., Pardo, C. A., … Lim, M. (2013). Glycerol rhizotomy and radiofrequency thermocoagulation for trigeminal neuralgia in multiple sclerosis. JOURNAL OF NEUROSURGERY, 118(2), 329–36. -
INCREASED RADIATION DOSE TO THE SVZ IMPROVES PROGRESSION FREE SURVIVAL IN GBM PATIENTS
Chen, L., Guerrero-Cazares, H., Ford, E., McNutt, T., Kleinberg, L., Lim, M., … Redmond, K. (2012). INCREASED RADIATION DOSE TO THE SVZ IMPROVES PROGRESSION FREE SURVIVAL IN GBM PATIENTS. NEURO-ONCOLOGY, 14, 139. -
A PROSPECTIVE STUDY OF MOTOR DYSFUNCTION FOLLOWING CRANIAL IRRADIATION FOR PEDIATRIC BRAIN TUMORS
Redmond, K. J., Mahone, E. M., Kleinberg, L., Terezakis, S., McNutt, T., Agbahiwe, H., … Horska, A. (2012). A PROSPECTIVE STUDY OF MOTOR DYSFUNCTION FOLLOWING CRANIAL IRRADIATION FOR PEDIATRIC BRAIN TUMORS. NEURO-ONCOLOGY, 14, 137. -
ONCOGENIC DRIVERS OF MEDULLOBLASTOMA MAY DETERMINE A NOVEL IMMUNE PHENOTYPE
Martin, A. M., Nirschl, C., Polanczyk, M., Cohen, K. J., Pardoll, D. M., Drake, C. G., & Lim, M. (2012). ONCOGENIC DRIVERS OF MEDULLOBLASTOMA MAY DETERMINE A NOVEL IMMUNE PHENOTYPE. NEURO-ONCOLOGY, 14, 41. -
The role of STAT3 activation in modulating the immune microenvironment of GBM
See, A. P., Han, J. E., Phallen, J., Binder, Z., Gallia, G., Pan, F., … Lim, M. (2012). The role of STAT3 activation in modulating the immune microenvironment of GBM. JOURNAL OF NEURO-ONCOLOGY, 110(3), 359–68. -
NOVEL IMMUNE CHARACTERISTICS OF MEDULLOBLASTOMA CORRELATE WITH MYC AMPLIFICATION STATUS
Martin, A., Nirschl, C., Polanczyk, M., Cohen, K. J., Pardoll, D. M., Drake, C. G., & Lim, M. (2012). NOVEL IMMUNE CHARACTERISTICS OF MEDULLOBLASTOMA CORRELATE WITH MYC AMPLIFICATION STATUS. NEURO-ONCOLOGY, 14, 93. -
Subependymoma: clinical features and surgical outcomes
Jain, A., Amin, A. G., Jain, P., Burger, P., Jallo, G. I., Lim, M., & Bettegowda, C. (2012). Subependymoma: clinical features and surgical outcomes. NEUROLOGICAL RESEARCH, 34(7), 677–84. -
Clinical Trials with Immunotherapy for High-Grade Glioma
Ruzevick, J., Jackson, C., Phallen, J., & Lim, M. (2012). Clinical Trials with Immunotherapy for High-Grade Glioma. NEUROSURGERY CLINICS OF NORTH AMERICA, 23(3), 459-+. -
Potential Role for STAT3 Inhibitors in Glioblastoma
Jackson, C., Ruzevick, J., Amin, A. G., & Lim, M. (2012). Potential Role for STAT3 Inhibitors in Glioblastoma. NEUROSURGERY CLINICS OF NORTH AMERICA, 23(3), 379-+. -
Overall Survival and Prognostic Factors for Overall Survival Vary by Histology and Performance Status for Patients with Newly Diagnosed Brain Metastases Treated with Gamma Knife
Todd, A., Lawrence, K., Aizik, W., Sachin, B., Borletto, P., Chettan, B., … Rigamonti, D. (2012). Overall Survival and Prognostic Factors for Overall Survival Vary by Histology and Performance Status for Patients with Newly Diagnosed Brain Metastases Treated with Gamma Knife. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 35(2), 201–2. -
Effectiveness of Repeat Glycerol Rhizotomy in Treating Recurrent Trigeminal Neuralgia
Bender, M., Pradilla, G., Batra, S., See, A., Bhutiani, N., James, C., … Lim, M. (2012). Effectiveness of Repeat Glycerol Rhizotomy in Treating Recurrent Trigeminal Neuralgia. NEUROSURGERY, 70(5), 1125–33. -
Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment
Jackson, C., Ruzevick, J., Phallen, J., Belcaid, Z., & Lim, M. (2011). Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 732413. -
GENOME-WIDE ANALYSIS OF CLINICALLY SIGNIFICANT CPG METHYLATION SITES IN GLIOBLASTOMA MULTIFORME
See, A. P., Hwang, T., Shin, D., Shin, J. H., Gao, Y., & Lim, M. (2011). GENOME-WIDE ANALYSIS OF CLINICALLY SIGNIFICANT CPG METHYLATION SITES IN GLIOBLASTOMA MULTIFORME. NEURO-ONCOLOGY, 13, 79. -
COMBINING ANTI-PD-1 (B7-H1) IMMUNOTHERAPY WITH STEREOTACTIC RADIOSURGERY IN A MOUSE ORTHOTOPIC GLIOBLASTOMA MODEL
Zeng, J., See, A. P., Phallen, J., Belcaid, Z., Durham, N., Meyer, C., … Lim, M. (2011). COMBINING ANTI-PD-1 (B7-H1) IMMUNOTHERAPY WITH STEREOTACTIC RADIOSURGERY IN A MOUSE ORTHOTOPIC GLIOBLASTOMA MODEL. NEURO-ONCOLOGY, 13, 37–38. -
STEREOTACTIC RADIOSURGERY COMBINED WITH DOUBLE IMMUNOTHERAPY WITH ANTI-CTLA-4 AND ANTI-4-1BB YIELDS LONG-TERM SURVIVAL AND PROTECTIVE ANTITUMOR RESPONSE IN A MOUSE ORTHOTOPIC GLIOBLASTOMA MODEL
Belcaid, Z., Phallen, J. A., Zeng, J., See, A. P., Albesiano, E., Durham, N. M., … Lim, M. (2011). STEREOTACTIC RADIOSURGERY COMBINED WITH DOUBLE IMMUNOTHERAPY WITH ANTI-CTLA-4 AND ANTI-4-1BB YIELDS LONG-TERM SURVIVAL AND PROTECTIVE ANTITUMOR RESPONSE IN A MOUSE ORTHOTOPIC GLIOBLASTOMA MODEL. NEURO-ONCOLOGY, 13, 32. -
MEDULLOBLASTOMA: A COMPARISON OF PEDIATRIC AND ADULT PATIENTS TREATED AT THE JOHNS HOPKINS HOSPITAL
Ishaq, O., Montgomery, J., Terezakis, S., Wharam, M., Lim, M., Holdhoff, M., … Redmond, K. (2011). MEDULLOBLASTOMA: A COMPARISON OF PEDIATRIC AND ADULT PATIENTS TREATED AT THE JOHNS HOPKINS HOSPITAL. NEURO-ONCOLOGY, 13, 29. -
Stereotactic Radiosurgery of Cranial Arteriovenous Malformations and Dural Arteriovenous Fistulas
See, A. P., Raza, S., Tamargo, R. J., & Lim, M. (2012). Stereotactic Radiosurgery of Cranial Arteriovenous Malformations and Dural Arteriovenous Fistulas. NEUROSURGERY CLINICS OF NORTH AMERICA, 23(1), 133-+. -
Surgical treatment of pediatric trigeminal neuralgia: case series and review of the literature
Bender, M. T., Pradilla, G., James, C., Raza, S., Lim, M., & Carson, B. S. (2011). Surgical treatment of pediatric trigeminal neuralgia: case series and review of the literature. CHILDS NERVOUS SYSTEM, 27(12), 2123–29. -
Delivery of stereotactic radiosurgery: a cross-platform comparison
Trang Nguyen, Hsu, W., Lim, M., & Naff, N. (2011). Delivery of stereotactic radiosurgery: a cross-platform comparison. NEUROLOGICAL RESEARCH, 33(8), 787–91. -
Nelfinavir induces radiation sensitization in pituitary adenoma cells
Zeng, J., See, A. P., Aziz, K., Thiyagarajan, S., Salih, T., Gajula, R. P., … Lim, M. (2011). Nelfinavir induces radiation sensitization in pituitary adenoma cells. CANCER BIOLOGY & THERAPY, 12(7), 657–63. -
Endoscopic Transvestibular Paramandibular Exploration of the Infratemporal Fossa and Parapharyngeal Space: A Minimally Invasive Approach to the Middle Cranial Base
Chan, J. Y. K., Li, R. J., Lim, M., Hinojosa, A. Q., & Boahene, K. D. (2011). Endoscopic Transvestibular Paramandibular Exploration of the Infratemporal Fossa and Parapharyngeal Space: A Minimally Invasive Approach to the Middle Cranial Base. LARYNGOSCOPE, 121(10), 2075–80. -
Clinical Outcomes after Treatment of Germ Cell Tumors
Jackson, C., Jallo, G., & Lim, M. (2011). Clinical Outcomes after Treatment of Germ Cell Tumors. NEUROSURGERY CLINICS OF NORTH AMERICA, 22(3), 385-+. -
Heat shock protein-peptide complex in the treatment of glioblastoma
See, A. P., Pradilla, G., Yang, I., Han, S., Parsa, A. T., & Lim, M. (2011). Heat shock protein-peptide complex in the treatment of glioblastoma. EXPERT REVIEW OF VACCINES, 10(6), 721–31. -
THE RADIOSURGICAL TREATMENT OF ARTERIOVENOUS MALFORMATIONS: OBLITERATION, MORBIDITIES, AND PERFORMANCE STATUS
Sun, D. Q., Carson, K. A., Raza, S. M., Batra, S., Kleinberg, L. R., Lim, M., … Rigamonti, D. (2011). THE RADIOSURGICAL TREATMENT OF ARTERIOVENOUS MALFORMATIONS: OBLITERATION, MORBIDITIES, AND PERFORMANCE STATUS. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 80(2), 354–61. -
Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series
See, A. P., Zeng, J., Tran, P. T., & Lim, M. (2011). Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series. RADIATION ONCOLOGY, 6, 25. -
Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literature
Sun, D. Q., Cheng, J. J., Frazier, J. L., Batra, S., Wand, G., Kleinberg, L. R., … Lim, M. (2011). Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literature. NEUROSURGICAL REVIEW, 34(2), 181–89. -
ESTABLISHMENT OF GBM SUSPENSION CELL LINES
Binder, Z. A., Salmasi, V., Lim, M., Weingart, J., Brem, H., Olivi, A., … Gallia, G. L. (2010). ESTABLISHMENT OF GBM SUSPENSION CELL LINES. NEURO-ONCOLOGY, 12, 134. -
PODOCALYXIN EXPRESSION CORRELATES WITH ASTROCYTOMA TUMOR GRADE
Binder, Z. A., Orr, B., Lim, M., Weingart, J. D., Brem, H., Olivi, A., … Gallia, G. L. (2010). PODOCALYXIN EXPRESSION CORRELATES WITH ASTROCYTOMA TUMOR GRADE. NEURO-ONCOLOGY, 12, 119–20. -
ADJUVANT STEREOTACTIC RADIOSURGERY INCREASES TUMOR CONTROL RATES IN PATIENTS WITH CEREBRAL METASTASES AFTER SURGICAL RESECTION
Jackson, C. M., Amin, A., See, P., Pradilla, G., Tryggestad, E., & Lim, M. (2010). ADJUVANT STEREOTACTIC RADIOSURGERY INCREASES TUMOR CONTROL RATES IN PATIENTS WITH CEREBRAL METASTASES AFTER SURGICAL RESECTION. NEURO-ONCOLOGY, 12, 112. -
STAT3 INHIBITION ALTERS THE IMMUNE PROFILE IN MURINE GLIOMAS
Han, J. E., Albesiano, E., Pradilla, G., & Lim, M. (2010). STAT3 INHIBITION ALTERS THE IMMUNE PROFILE IN MURINE GLIOMAS. NEURO-ONCOLOGY, 12, 16–17. -
THE ROLE OF STAT3 ACTIVATION IN MODULATING THE IMMUNE MICROENVIRONMENT OF GLIOMAS
Albesiano, E., Han, J. E., See, A., Jackson, C., & Lim, M. (2010). THE ROLE OF STAT3 ACTIVATION IN MODULATING THE IMMUNE MICROENVIRONMENT OF GLIOMAS. NEURO-ONCOLOGY, 12, 31. -
Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors
Grossman, R., Mukherjee, D., Chang, D. C., Purtell, M., Lim, M., Brem, H., & Quinones-Hinojosa, A. (2011). Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. ANNALS OF SURGICAL ONCOLOGY, 18(2), 521–28. -
Stereotactic Radiosurgery for Spine Tumors: Review of Current Literature
Hsu, W., Nguyen, T., Kleinberg, L., Ford, E. C., Rigamonti, D., Gokaslan, Z. L., & Lim, M. (2010). Stereotactic Radiosurgery for Spine Tumors: Review of Current Literature. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 88(5), 315–21. -
Immunologic Consequences of Signal Transducers and Activators of Transcription 3 Activation in Human Squamous Cell Carcinoma
Albesiano, E., Davis, M., See, A. P., Han, J. E., Lim, M., Pardoll, D. M., & Kim, Y. (2010). Immunologic Consequences of Signal Transducers and Activators of Transcription 3 Activation in Human Squamous Cell Carcinoma. CANCER RESEARCH, 70(16), 6467–76. -
Transpalpebral Orbitofrontal Craniotomy: A Minimally Invasive Approach to Anterior Cranial Vault Lesions
Boahene, K. D. O., Lim, M., Chu, E., & Quinones-Hinojosa, A. (2010). Transpalpebral Orbitofrontal Craniotomy: A Minimally Invasive Approach to Anterior Cranial Vault Lesions. SKULL BASE-AN INTERDISCIPLINARY APPROACH, 20(4), 237–44. -
Immunotherapy Combined with Chemotherapy in the Treatment of Tumors
Frazier, J. L., Han, J. E., Lim, M., & Olivi, A. (2010). Immunotherapy Combined with Chemotherapy in the Treatment of Tumors. NEUROSURGERY CLINICS OF NORTH AMERICA, 21(1), 187-+. -
Mechanisms of Local Immunoresistance in Glioma
Albesiano, E., Han, J. E., & Lim, M. (2010). Mechanisms of Local Immunoresistance in Glioma. NEUROSURGERY CLINICS OF NORTH AMERICA, 21(1), 17-+. -
Immunotherapy Preface
Yang, I., & Lim, M. (2010). Immunotherapy Preface. NEUROSURGERY CLINICS OF NORTH AMERICA, 21(1), XV. -
Biologic Principles of Immunotherapy for Malignant Gliomas
Han, S. J., Kaur, G., Yang, I., & Lim, M. (2010). Biologic Principles of Immunotherapy for Malignant Gliomas. NEUROSURGERY CLINICS OF NORTH AMERICA, 21(1), 1-+. -
STEREOTACTIC RADIOSURGERY IN THE MANAGEMENT OF BRAIN METASTASES: AN INSTITUTIONAL RETROSPECTIVE ANALYSIS OF SURVIVAL
Frazier, J. L., Batra, S., Kapor, S., Vellimana, A., Gandhi, R., Carson, K. A., … Rigamonti, D. (2010). STEREOTACTIC RADIOSURGERY IN THE MANAGEMENT OF BRAIN METASTASES: AN INSTITUTIONAL RETROSPECTIVE ANALYSIS OF SURVIVAL. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 76(5), 1486–92. -
Reversible posterior leukoencephalopathy occurring during resection of a posterior fossa tumor: Case report and review of the literature
Moriarity, J. L., Lim, M., Storm, P. B., Beauchamp, N. J., & Olivi, A. (2001). Reversible posterior leukoencephalopathy occurring during resection of a posterior fossa tumor: Case report and review of the literature. NEUROSURGERY, 49(5), 1237–39. -
Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases
Zhong, H., De Marzo, A. M., Laughner, E., Lim, M., Hilton, D. A., Zagzag, D., … Simons, J. W. (1999). Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. CANCER RESEARCH, 59(22), 5830–35. -
Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee.
Gastman, B., Agarwal, P. K., Berger, A., Boland, G., Broderick, S., Butterfield, L. H., … Kaufman, H. L. (2020). Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee. Journal for Immunotherapy of Cancer, 8(2). -
THE STATE OF NEURO-ONCOLOGY DURING THE COVID-19 PANDEMIC: A WORLDWIDE ASSESSMENT
Mrugala, M., Ostrom, Q., Pressley, S., Thomas, A., Wefel, J. S., Coven, S., … Chheda, M. (2020). THE STATE OF NEURO-ONCOLOGY DURING THE COVID-19 PANDEMIC: A WORLDWIDE ASSESSMENT. NEURO-ONCOLOGY, 22, 27. -
EFFICACY OF CXCR6 BLOCKADE AS A POTENTIATOR OF ANTI-PD-1 THERAPY FOR THE TREATMENT OF GLIOBLASTOMA
Pant, A., Saleh, L., Patel, K., Medikonda, R., & Lim, M. (2020). EFFICACY OF CXCR6 BLOCKADE AS A POTENTIATOR OF ANTI-PD-1 THERAPY FOR THE TREATMENT OF GLIOBLASTOMA. NEURO-ONCOLOGY, 22, 107. -
SINGLE CELL RNA-SEQUENCING IDENTIFIES NOVEL BONE MARROW DERIVED MYELOID CELLS IN GLIOBLASTOMA ASSOCIATED WITH TUMOR AGGRESSION
Jackson, C., Cherry, C., Bom, S., Zhang, H., Choi, J., Yegnasubramanian, V., … Pardoll, D. (2020). SINGLE CELL RNA-SEQUENCING IDENTIFIES NOVEL BONE MARROW DERIVED MYELOID CELLS IN GLIOBLASTOMA ASSOCIATED WITH TUMOR AGGRESSION. NEURO-ONCOLOGY, 22, 110. -
A CROWDSOURCED CONSENSUS ON SUPRATOTAL RESECTION VERSUS GROSS TOTAL RESECTION FOR ANATOMICALLY DISTINCT PRIMARY GLIOBLASTOMA
Mukherjee, D., Rakovec, M., Bettegowda, C., Jackson, C., Gallia, G., Lim, M., … Khalafallah, A. (2020). A CROWDSOURCED CONSENSUS ON SUPRATOTAL RESECTION VERSUS GROSS TOTAL RESECTION FOR ANATOMICALLY DISTINCT PRIMARY GLIOBLASTOMA. NEURO-ONCOLOGY, 22, 208. -
GBM AGILE: A GLOBAL, PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA
Buxton, M., Alexander, B., Berry, D., Cavenee, W., Colman, H., de Groot, J., … Cloughesy, T. (2020). GBM AGILE: A GLOBAL, PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA. NEURO-ONCOLOGY, 22, 195–96. -
MANAGEMENT OF BRAIN METASTASIS IN TRIPLE NEGATIVE BREAST CANCER
Medikonda, R., Srivastava, S., Kim, T., Xia, Y., Patel, M., Jackson, C., … Lim, M. (2020). MANAGEMENT OF BRAIN METASTASIS IN TRIPLE NEGATIVE BREAST CANCER. NEURO-ONCOLOGY, 22, 130. -
EFFICACY OF ANTICONVULSANT THERAPY IN GLIOMA PATIENTS
Medikonda, R., Patel, K., Saleh, L., Srivastava, S., Jackson, C., Mohan, A., … Lim, M. (2020). EFFICACY OF ANTICONVULSANT THERAPY IN GLIOMA PATIENTS. NEURO-ONCOLOGY, 22, 134. -
THE SAFETY AND EFFICACY OF DEXAMETHASONE IN THE MANAGEMENT OF GLIOMA PATIENTS
Medikonda, R., Patel, K., Saleh, L., Srivastava, S., Jackson, C., Mohan, A., … Lim, M. (2020). THE SAFETY AND EFFICACY OF DEXAMETHASONE IN THE MANAGEMENT OF GLIOMA PATIENTS. NEURO-ONCOLOGY, 22, 136. -
Unique challenges for glioblastoma immunotherapy - Discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology.
Chuntova, P., Chow, F., Watchmaker, P., Galvez, M., Heimberger, A. B., Newell, E. W., … Okada, H. (2020). Unique challenges for glioblastoma immunotherapy - Discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Neuro-Oncology. -
PD-1+ Monocytes Mediate Cerebral Vasospasm Following Subarachnoid Hemorrhage.
Jackson, C. M., Choi, J., Routkevitch, D., Pant, A., Saleh, L., Ye, X., … Lim, M. (2020). PD-1+ Monocytes Mediate Cerebral Vasospasm Following Subarachnoid Hemorrhage. Neurosurgery. -
Improved survival and disease control following pembrolizumab-induced immune-related adverse events in high PD-L1 expressing non-small cell lung cancer with brain metastases.
Zhang, M., Rodrigues, A. J., Pollom, E. L., Gibbs, I. C., Soltys, S. G., Hancock, S. L., … Li, G. (2021). Improved survival and disease control following pembrolizumab-induced immune-related adverse events in high PD-L1 expressing non-small cell lung cancer with brain metastases. Journal of Neuro-Oncology. -
In Reply: Absence of Ischemic Injury After Sacrificing the Superior Petrosal Vein During Microvascular Decompression.
Xia, Y., & Lim, M. (2021). In Reply: Absence of Ischemic Injury After Sacrificing the Superior Petrosal Vein During Microvascular Decompression. Operative Neurosurgery (Hagerstown, Md.). -
Role of surgery for glioblastoma: response to letters from Dr. Gerritsen and his colleagues and Dr. Vargas Lopez.
Wen, P. Y., Weller, M., Chiocca, E. A., Lim, M., Tonn, J.-C. C., Zadeh, G., … van den Bent, M. (2021). Role of surgery for glioblastoma: response to letters from Dr. Gerritsen and his colleagues and Dr. Vargas Lopez. Neuro-Oncology. -
Development of new brain metastases in triple negative breast cancer.
Medikonda, R., Srivastava, S., Kim, T., Xia, Y., Kim, J., Jackson, C., … Lim, M. (2021). Development of new brain metastases in triple negative breast cancer. Journal of Neuro-Oncology. -
Reprogramming transcription factors Oct4 and Sox2 induces a BRD-dependent immunosuppressive transcriptome in GBM-propagating cells.
Laterra, J., Ma, T., Hu, C., Lal, B., Zhou, W., Ma, Y., … Li, Y. (2021). Reprogramming transcription factors Oct4 and Sox2 induces a BRD-dependent immunosuppressive transcriptome in GBM-propagating cells. Cancer Research. -
Combination immunotherapy strategies for glioblastoma.
Chan, H. Y., Choi, J., Jackson, C., & Lim, M. (2021). Combination immunotherapy strategies for glioblastoma. Journal of Neuro-Oncology, 151(3), 375–91. -
Characterizing long non-coding RNA expression of tumor-infiltrating lymphocytes across solid cancers
Dinalankara, W., Imada, E.-L., Jackson, C. M., Nirschl, T. R., Lim, M., Drake, C. G., & Marchionni, L. (2020). Characterizing long non-coding RNA expression of tumor-infiltrating lymphocytes across solid cancers. CANCER RESEARCH, 80(16). -
GBM AGILE: A global, phase II/III adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma.
Buxton, M. B., Alexander, B. M., Berry, D. A., Cavenee, W. K., Colman, H., De Groot, J. F., … Cloughesy, T. F. (2020). GBM AGILE: A global, phase II/III adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma. JOURNAL OF CLINICAL ONCOLOGY, 38(15). -
Thalamic gliomas: Advances in the surgical management
Hung, A., Wu, A., Jackson, C., & Lim, M. (2019). Thalamic gliomas: Advances in the surgical management. NEW TECHNIQUES FOR MANAGEMENT OF INOPERABLE GLIOMAS, 117–135. -
The state of neuro-oncology during the COVID-19 pandemic: a worldwide assessment.
Mrugala, M. M., Ostrom, Q. T., Pressley, S. M., Taylor, J. W., Thomas, A. A., Wefel, J. S., … Chheda, M. G. (2021). The state of neuro-oncology during the COVID-19 pandemic: a worldwide assessment. Neuro-Oncology Advances, 3(1), vdab035. -
Immunotherapy for Chordoma and Chondrosarcoma: Current Evidence.
Traylor, J. I., Pernik, M. N., Plitt, A. R., Lim, M., & Garzon-Muvdi, T. (2021). Immunotherapy for Chordoma and Chondrosarcoma: Current Evidence. Cancers, 13(10). -
Mutation status and postresection survival of patients with non-small cell lung cancer brain metastasis: implications of biomarker-driven therapy.
Shah, P. P., Franke, J. L., Medikonda, R., Jackson, C. M., Srivastava, S., Choi, J., … Lim, M. (2021). Mutation status and postresection survival of patients with non-small cell lung cancer brain metastasis: implications of biomarker-driven therapy. Journal of Neurosurgery, 1–11. -
Bone Cement Internal Auditory Canal Reconstruction to Reduce CSF Leak After Vestibular Schwannoma Retrosigmoid Approach.
Zhang, L., Galaiya, D., Jackson, C. M., Tamargo, R. J., Lim, M., Carey, J., & Creighton, F. X. (2021). Bone Cement Internal Auditory Canal Reconstruction to Reduce CSF Leak After Vestibular Schwannoma Retrosigmoid Approach. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. -
Enhancing proteasomal processing improves survival for a peptide vaccine used to treat glioblastoma.
Fidanza, M., Gupta, P., Sayana, A., Shanker, V., Pahlke, S.-M., Vu, B., … Wong, A. J. (2021). Enhancing proteasomal processing improves survival for a peptide vaccine used to treat glioblastoma. Science Translational Medicine, 13(598). -
Systematic review of combinations of targeted or immunotherapy in advanced solid tumors.
Tan, A. C., Bagley, S. J., Wen, P. Y., Lim, M., Platten, M., Colman, H., … Khasraw, M. (2021). Systematic review of combinations of targeted or immunotherapy in advanced solid tumors. Journal for Immunotherapy of Cancer, 9(7). -
Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma
Choi, J., Pant, A., Medikonda, R., Kim, Y.-H., Routkevitch, D., Saleh, L., … Lim, M. (2021). Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma. ONCOIMMUNOLOGY, 10(1). -
Emerging Technologies for Non-invasive Monitoring of Treatment Response to Immunotherapy for Brain Tumors.
Mathios, D., Srivastava, S., Kim, T., Bettegowda, C., & Lim, M. (2021). Emerging Technologies for Non-invasive Monitoring of Treatment Response to Immunotherapy for Brain Tumors. Neuromolecular Medicine. -
Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma.
Choi, J., Pant, A., Medikonda, R., Kim, Y.-H. H., Routkevitch, D., Saleh, L., … Lim, M. (2021). Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma. Oncoimmunology, 10(1), 1940673. -
A Crowdsourced Consensus on Supratotal Resection Versus Gross Total Resection for Anatomically Distinct Primary Glioblastoma.
Khalafallah, A. M., Rakovec, M., Bettegowda, C., Jackson, C. M., Gallia, G. L., Weingart, J. D., … Mukherjee, D. (2021). A Crowdsourced Consensus on Supratotal Resection Versus Gross Total Resection for Anatomically Distinct Primary Glioblastoma. Neurosurgery. -
Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma.
Medikonda, R., Choi, J., Pant, A., Saleh, L., Routkevitch, D., Tong, L., … Lim, M. (2021). Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma. Journal of Neurosurgery, 1–10. -
Quantitative Bioluminescence Tomography-guided Conformal Irradiation for Pre-clinical Radiation Research.
Xu, X., Deng, Z., Dehghani, H., Iordachita, I., Lim, M., Wong, J. W., & Wang, K. K.-H. (2021). Quantitative Bioluminescence Tomography-guided Conformal Irradiation for Pre-clinical Radiation Research. International Journal of Radiation Oncology, Biology, Physics. -
Roles of Neutrophils in Glioma and Brain Metastases.
Lin, Y.-J., Wei, K.-C., Chen, P.-Y., Lim, M., & Hwang, T.-L. (2021). Roles of Neutrophils in Glioma and Brain Metastases. Frontiers in Immunology, 12, 701383. -
Combination checkpoint therapy with anti-PD-1 and anti-BTLA results in a synergistic therapeutic effect against murine glioblastoma
Choi, J., Medikonda, R., Saleh, L., Kim, T., Pant, A., Srivastava, S., … Lim, M. (2021). Combination checkpoint therapy with anti-PD-1 and anti-BTLA results in a synergistic therapeutic effect against murine glioblastoma. ONCOIMMUNOLOGY, 10(1), 1956142. -
The safety and efficacy of dexamethasone in the perioperative management of glioma patients.
Medikonda, R., Patel, K., Jackson, C., Saleh, L., Srivastava, S., Feghali, J., … Lim, M. (2021). The safety and efficacy of dexamethasone in the perioperative management of glioma patients. Journal of Neurosurgery, 1–8. -
Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma.
Singh, K., Batich, K. A., Wen, P. Y., Tan, A. C., Bagley, S. J., Lim, M., … Khasraw, M. (2021). Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
The Challenges and Future of Immunotherapy for Gliomas.
Wu, A., & Lim, M. (2021). The Challenges and Future of Immunotherapy for Gliomas. Cancer Journal (Sudbury, Mass.), 27(5), 371–378. -
Checkpoint blockade in recurrent meningiomas: Lessons for future management.
Pant, A., & Lim, M. (2021). Checkpoint blockade in recurrent meningiomas: Lessons for future management. Neuro-Oncology. -
Is There a Role for Immunotherapy in Central Nervous System Cancers?
Flores, C., Dunn, G., Fecci, P., Lim, M., Mitchell, D., & Reardon, D. A. (2022). Is There a Role for Immunotherapy in Central Nervous System Cancers? Hematology/Oncology Clinics of North America, 36(1), 237–252. -
Quantitative Bioluminescence Tomography for In Vivo Volumetric-Guided Radiotherapy.
Deng, Z., Xu, X., Dehghani, H., Sforza, D. M., Iordachita, I., Lim, M., … Wang, K. K.-H. (2022). Quantitative Bioluminescence Tomography for In Vivo Volumetric-Guided Radiotherapy. Methods in Molecular Biology (Clifton, N.J.), 2393, 701–731. -
GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma.
Wen, P. Y., Mellinghoff, I. K., Buxton, M. B., Cavenee, W. K., Colman, H., De Groot, J. F., … Cloughesy, T. F. (2021). GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
In Vivo Evaluation of Near-Infrared Fluorescent Probe for TIM3 Targeting in Mouse Glioma.
Zhang, M., Zhou, Q., Huang, C., Chan, C. T., Wu, W., Li, G., … Daldrup-Link, H. E. (2021). In Vivo Evaluation of Near-Infrared Fluorescent Probe for TIM3 Targeting in Mouse Glioma. Molecular Imaging and Biology. -
ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma.
Hu, C., Wang, K., Damon, C., Fu, Y., Ma, T., Kratz, L., … Li, Y. (1800). ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma. Neuro-Oncology. -
Advances in Immunotherapies for Gliomas.
Zhang, M., Choi, J., & Lim, M. (1800). Advances in Immunotherapies for Gliomas. Current Neurology and Neuroscience Reports. -
Introduction. Immunology of neurosurgical diseases.
Quinones-Hinojosa, A., Rahman, M., Lim, M., Suarez-Meade, P., & Marenco-Hillembrand, L. (1800). Introduction. Immunology of neurosurgical diseases. Neurosurgical Focus, 52(2), E1. -
Clinical features and surgical outcomes of intracranial and spinal cord subependymomas.
Rincon-Torroella, J., Rakovec, M., Khalafallah, A. M., Liu, A., Bettegowda, A., Kut, C., … Bettegowda, C. (2022). Clinical features and surgical outcomes of intracranial and spinal cord subependymomas. Journal of Neurosurgery, 1–12. -
Impact of international research fellows in neurosurgery: results from a single academic center
Yang, W., Rincon-Torroella, J., Feghali, J., Khalafallah, A. M., Ishida, W., Perdomo-Pantoja, A., … Huang, J. (2022). Impact of international research fellows in neurosurgery: results from a single academic center. JOURNAL OF NEUROSURGERY, 136(1), 295–305. -
Quality of Life and Role of Palliative and Supportive Care for Patients With Brain Metastases and Caregivers: A Review
Wu, A., Ruiz Colon, G. D., & Lim, M. (2022). Quality of Life and Role of Palliative and Supportive Care for Patients With Brain Metastases and Caregivers: A Review. Frontiers in Neurology, 13. -
A RANDOMIZED PHASE 3 STUDY OF NIVOLUMAB OR PLACEBO COMBINED WITH RADIOTHERAPY PLUS TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA WITH METHYLATED MGMT PROMOTER: CHECKMATE 548
Weller, M., Lim, M., Idbaih, A., Steinbach, J., Finocchiaro, G., Raval, R., … Omuro, A. (2021). A RANDOMIZED PHASE 3 STUDY OF NIVOLUMAB OR PLACEBO COMBINED WITH RADIOTHERAPY PLUS TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA WITH METHYLATED MGMT PROMOTER: CHECKMATE 548. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
The roles of thermal and mechanical stress in focused ultrasound-mediated immunomodulation and immunotherapy for central nervous system tumors.
Kim, C., Lim, M., Woodworth, G. F., & Arvanitis, C. D. (2022). The roles of thermal and mechanical stress in focused ultrasound-mediated immunomodulation and immunotherapy for central nervous system tumors. Journal of Neuro-Oncology. -
CAR T Cell Therapy in Primary Brain Tumors: Current Investigations and the Future.
Lin, Y.-J., Mashouf, L. A., & Lim, M. (2022). CAR T Cell Therapy in Primary Brain Tumors: Current Investigations and the Future. Frontiers in Immunology, 13, 817296. -
Cranioplasty With Customized Craniofacial Implants and Intraoperative Resizing for Single-Stage Reconstruction Following Oncologic Resection of Skull Neoplasms.
Ben-Shalom, N., Asemota, A. O., Belzberg, M., Harnof, S., Huang, J., Lim, M., … Gordon, C. (2022). Cranioplasty With Customized Craniofacial Implants and Intraoperative Resizing for Single-Stage Reconstruction Following Oncologic Resection of Skull Neoplasms. The Journal of Craniofacial Surgery. -
Case Series in the Utility of Invasive Blood Pressure Monitoring in Microvascular Decompression.
Xu, R., Nair, S. K., Materi, J., Raj, D., Medikonda, R., Shah, P. P., … Lim, M. (2022). Case Series in the Utility of Invasive Blood Pressure Monitoring in Microvascular Decompression. Operative Neurosurgery (Hagerstown, Md.). -
Circulating Immune Cell and Outcome Analysis from the Phase 2 Study of PD-L1 Blockade with Durvalumab for Newly Diagnosed and Recurrent Glioblastoma.
Nayak, L., Standifer, N., Dietrich, J., Clarke, J. L., Dunn, G. P., Lim, M., … Reardon, D. A. (2022). Circulating Immune Cell and Outcome Analysis from the Phase 2 Study of PD-L1 Blockade with Durvalumab for Newly Diagnosed and Recurrent Glioblastoma. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. -
The Molecular Basis and Pathophysiology of Trigeminal Neuralgia.
Chen, Q. L., Yi, D. I., Perez, J. N., Liu, M., Chang, S. D., Barad, M. J., … Qian, X. (2022). The Molecular Basis and Pathophysiology of Trigeminal Neuralgia. International Journal of Molecular Sciences, 23(7). -
Nivolumab plus radiotherapy with or without temozolomide in newly diagnosed glioblastoma: Results from exploratory phase I cohorts of CheckMate 143.
Omuro, A., Reardon, D. A., Sampson, J. H., Baehring, J., Sahebjam, S., Cloughesy, T. F., … Lim, M. (2022). Nivolumab plus radiotherapy with or without temozolomide in newly diagnosed glioblastoma: Results from exploratory phase I cohorts of CheckMate 143. Neuro-Oncology Advances, 4(1), vdac025. -
Radiotherapy Combined With Nivolumab or Temozolomide for Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter: An International Randomized Phase 3 Trial.
Omuro, A., Brandes, A. A., Carpentier, A. F., Idbaih, A., Reardon, D. A., Cloughesy, T., … Weller, M. (2022). Radiotherapy Combined With Nivolumab or Temozolomide for Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter: An International Randomized Phase 3 Trial. Neuro-Oncology. -
Internal neurolysis versus intraoperative glycerin rhizotomy for trigeminal neuralgia.
Xu, R., Materi, J., Raj, D., Alomari, S., Xia, Y., Nair, S. K., … Lim, M. (2022). Internal neurolysis versus intraoperative glycerin rhizotomy for trigeminal neuralgia. Journal of Neurosurgery, 1–6. -
Phase 3 Trial of Chemoradiotherapy With Temozolomide Plus Nivolumab or Placebo for Newly Diagnosed Glioblastoma With Methylated MGMT Promoter.
Lim, M., Weller, M., Idbaih, A., Steinbach, J., Finocchiaro, G., Raval, R. R., … Omuro, A. (2022). Phase 3 Trial of Chemoradiotherapy With Temozolomide Plus Nivolumab or Placebo for Newly Diagnosed Glioblastoma With Methylated MGMT Promoter. Neuro-Oncology. -
The future of cancer immunotherapy for brain tumors: a collaborative workshop.
Brown, C. E., Bucktrout, S., Butterfield, L. H., Futer, O., Galanis, E., Hormigo, A., … Tanner, K. (2022). The future of cancer immunotherapy for brain tumors: a collaborative workshop. Journal of Translational Medicine, 20(1), 236. -
Calcium-Related Gene Signatures May Predict Prognosis and Level of Immunosuppression in Gliomas.
Liu, P., Li, Y., Zhang, Y., Choi, J., Zhang, J., Shang, G., … Yang, X. (2022). Calcium-Related Gene Signatures May Predict Prognosis and Level of Immunosuppression in Gliomas. Frontiers in Oncology, 12, 708272. -
Diversity within the Neurosurgical Oncology Workforce in the United States: A Cross-Sectional Study with Proposed Strategies to Pave the Path Forward.
Asfaw, Z. K., Rodriguez, A., Hodges, T. R., Mazumdar, M., Zhan, S., Lim, M., & Germano, I. M. (2022). Diversity within the Neurosurgical Oncology Workforce in the United States: A Cross-Sectional Study with Proposed Strategies to Pave the Path Forward. Neuro-Oncology. -
The Role of Myeloid Cells in GBM Immunosuppression.
Lin, Y.-J., Wu, C. Y.-J., Wu, J. Y., & Lim, M. (2022). The Role of Myeloid Cells in GBM Immunosuppression. Frontiers in Immunology, 13, 887781. -
Safety and cost savings associated with reduced inpatient hospitalization for microvascular decompression.
Xu, R., Nair, S. K., Materi, J., Raj, D., Park, G., Medikonda, R., … Bettegowda, C. (2022). Safety and cost savings associated with reduced inpatient hospitalization for microvascular decompression. World Neurosurgery. -
Predictors and Impact of Postoperative 30-Day Readmission in Glioblastoma.
Botros, D., Khalafallah, A. M., Huq, S., Dux, H., Oliveira, L. A., Pellegrino, R., … Mukherjee, D. (2022). Predictors and Impact of Postoperative 30-Day Readmission in Glioblastoma. Neurosurgery. -
Learning-based analysis of amide proton transfer-weighted MRI to identify true progression in glioma patients.
Guo, P., Unberath, M., Heo, H.-Y., Eberhart, C. G., Lim, M., Blakeley, J. O., & Jiang, S. (2022). Learning-based analysis of amide proton transfer-weighted MRI to identify true progression in glioma patients. NeuroImage. Clinical, 35, 103121. -
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain.
Vasavda, C., Xu, R., Liew, J., Kothari, R., Dhindsa, R. S., Semenza, E. R., … Snyder, S. H. (2022). Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Science Advances, 8(31), eabo5633. -
Radiomics analysis of amide proton transfer-weighted and structural MR images for treatment response assessment in malignant gliomas.
Jiang, S., Guo, P., Heo, H.-Y. Y., Zhang, Y., Wu, J., Jin, Y., … Blakeley, J. O. (2022). Radiomics analysis of amide proton transfer-weighted and structural MR images for treatment response assessment in malignant gliomas. NMR in Biomedicine, e4824. -
Immunometabolism, a new therapeutic development for immunotherapies of high-grade gliomas: a narrative review.
Wu, J. Y., Ren, A. L., & Lim, M. (2022). Immunometabolism, a new therapeutic development for immunotherapies of high-grade gliomas: a narrative review. Chinese Clinical Oncology, 11(4), 26. -
A potential role for steroids in acute pain management in patients with trigeminal neuralgia.
Xu, R., Nair, S. K., Shah, P. P., Kannapadi, N., Materi, J., Alomari, S., … Bettegowda, C. (2022). A potential role for steroids in acute pain management in patients with trigeminal neuralgia. World Neurosurgery. -
The role of preoperative MRI imaging in assessing neurovascular compression prior to microvascular decompression in trigeminal neuralgia.
Xu, R., Nair, S. K., Raj, D., Materi, J., So, R. J., Gujar, S. K., … Bettegowda, C. (2022). The role of preoperative MRI imaging in assessing neurovascular compression prior to microvascular decompression in trigeminal neuralgia. World Neurosurgery. -
Can tumor treating fields induce DNA damage and reduce cell motility in medulloblastoma cell lines?
Nitta, R. T., Luo, E. J., Lim, M., & Li, G. (2022). Can tumor treating fields induce DNA damage and reduce cell motility in medulloblastoma cell lines? Journal of Neurosurgery. Pediatrics, 1–12. -
GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma
Cloughesy, T. F., Alexander, B. M., Berry, D. A., Colman, H., De Groot, J. F., Ellingson, B. M., … Yung, W. K. A. (2022). GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
Updates in intraoperative strategies for enhancing intra-axial brain tumor control.
Wu, A., Wu, J. Y., & Lim, M. (2022). Updates in intraoperative strategies for enhancing intra-axial brain tumor control. Neuro-Oncology, 24(Supplement_6), S33–S41. -
PROTEASOME REARRANGED PEPTIDES ARE A NOVEL SOURCE OF ANTIGENS FOR THE PEPTIDE VACCINE IMMUNOTHERAPY OF GLIOBLASTOMAS
Fidanza, M., Gupta, P., Shanker, V., Wong, N., Skirboll, S., Lim, M., & Wong, A. (2022). PROTEASOME REARRANGED PEPTIDES ARE A NOVEL SOURCE OF ANTIGENS FOR THE PEPTIDE VACCINE IMMUNOTHERAPY OF GLIOBLASTOMAS. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
SINGLE-STAGE RECONSTRUCTION FOLLOWING ONCOLOGIC RESECTION OF BRAIN TUMORS WITH SKULL INVASION
Ben-Shalom, N., Anthony, A., Micah, B., Harnof, S., Huang, J., Lim, M., … Gordon, C. (2022). SINGLE-STAGE RECONSTRUCTION FOLLOWING ONCOLOGIC RESECTION OF BRAIN TUMORS WITH SKULL INVASION. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
UPDATE ON GBM AGILE: A GLOBAL, PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA.
Buxton, M., Alexander, B., Berry, D., Cavenee, W., Colman, H., de Groot, J., … Cloughesy, T. (2022). UPDATE ON GBM AGILE: A GLOBAL, PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
Advances in co-opting anti-depressant drugs in glioma therapy.
Pant, A., & Lim, M. (2022). Advances in co-opting anti-depressant drugs in glioma therapy. Cell Reports. Medicine, 3(12), 100837. -
Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors.
Medikonda, R., Pant, A., & Lim, M. (2023). Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors. Advances in Experimental Medicine and Biology, 1394, 73–84. -
A Case Series of Trigeminal Neuralgia With Pure Venous Compression: Postoperative Outcomes Associated With Intraoperative Venous Transposition Versus Coagulation.
So, R. J., Kalluri, A. L., Materi, J., Nair, S. K., Lim, M., Huang, J., … Xu, R. (2022). A Case Series of Trigeminal Neuralgia With Pure Venous Compression: Postoperative Outcomes Associated With Intraoperative Venous Transposition Versus Coagulation. Operative Neurosurgery (Hagerstown, Md.). -
Factors Predicting Cerebrospinal Fluid Leaks in Microvascular Decompressions: A Case Series of 1011 Patients.
Xu, R., So, R. J., Materi, J., Nair, S. K., Alomari, S. O., Huang, J., … Bettegowda, C. (2022). Factors Predicting Cerebrospinal Fluid Leaks in Microvascular Decompressions: A Case Series of 1011 Patients. Operative Neurosurgery (Hagerstown, Md.). -
Multiple Vessel Compression of the Trigeminal Nerve Is Associated With Worse Outcomes in Trigeminal Neuralgia After Microvascular Decompression.
So, R. J., Kalluri, A. L., Zhu, S., Materi, J., Nair, S. K., Lim, M., … Xu, R. (2022). Multiple Vessel Compression of the Trigeminal Nerve Is Associated With Worse Outcomes in Trigeminal Neuralgia After Microvascular Decompression. Neurosurgery. -
A racial analysis of pain outcomes following microvascular decompression for trigeminal neuralgia.
So, R. J., Kalluri, A. L., Storm, K., Nair, S. K., Budihal, B. R., Huang, J., … Xu, R. (2023). A racial analysis of pain outcomes following microvascular decompression for trigeminal neuralgia. Journal of Neurosurgery, 1–7. -
PP2Ac/STRN4 negatively regulates STING-Type I interferon signaling in tumor associated macrophages.
Ho, W. S., Mondal, I., Xu, B., Das, O., Sun, R. C., Chiou, P., … Lu, R. O. (2023). PP2Ac/STRN4 negatively regulates STING-Type I interferon signaling in tumor associated macrophages. The Journal of Clinical Investigation. -
The Tumor Immune Microenvironment in Primary CNS Neoplasms: A Review of Current Knowledge and Therapeutic Approaches.
Kalluri, A. L., Shah, P. P., & Lim, M. (2023). The Tumor Immune Microenvironment in Primary CNS Neoplasms: A Review of Current Knowledge and Therapeutic Approaches. International Journal of Molecular Sciences, 24(3). -
Sex-specific pain outcomes following microvascular decompression for trigeminal neuralgia.
Kilgore, C. B., So, R. J., Storm, K., Nair, S. K., Ran, K. R., Kalluri, A. L., … Xu, R. (2023). Sex-specific pain outcomes following microvascular decompression for trigeminal neuralgia. World Neurosurgery. -
CAR-T Therapy in GBM: Current Challenges and Avenues for Improvement.
Pant, A., & Lim, M. (2023). CAR-T Therapy in GBM: Current Challenges and Avenues for Improvement. Cancers, 15(4). -
Outcomes after microvascular decompression for sole arterial versus venous compression in trigeminal neuralgia.
Nair, S. K., Xie, M. E., Ran, K., Kalluri, A., Kilgore, C., Huang, J., … Xu, R. (2023). Outcomes after microvascular decompression for sole arterial versus venous compression in trigeminal neuralgia. World Neurosurgery. -
Response
Xu, R., Nair, S. K., Bettegowda, C., & Lim, M. (2023). Response. JOURNAL OF NEUROSURGERY, 138(1), 295. -
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb, D., Wanna, G. B., Ahmad, M., Lussey-Lepoutre, C., Perrier, N. D., Nölting, S., … Pacak, K. (2023). Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants. The Lancet. Diabetes & Endocrinology. -
Tumor inflammation-associated neurotoxicity.
Mahdi, J., Dietrich, J., Straathof, K., Roddie, C., Scott, B. J., Davidson, T. B., … Monje, M. (2023). Tumor inflammation-associated neurotoxicity. Nature Medicine. -
Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators.
Obradovic, A., Ager, C., Turunen, M., Nirschl, T., Khosravi-Maharlooei, M., Iuga, A., … Califano, A. (2023). Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators. Cancer Cell. -
Sequential onset of bilateral trigeminal neuralgia: clinical presentation and outcomes.
Xu, R., So, R. J., Lee, K. K., Kalluri, A. L., Materi, J., Nair, S. K., … Bettegowda, C. (2023). Sequential onset of bilateral trigeminal neuralgia: clinical presentation and outcomes. Clinical Neurology and Neurosurgery, 229, 107745. -
Advancing combination therapy for recurrent glioblastoma.
Wu, A., & Lim, M. (2023). Advancing combination therapy for recurrent glioblastoma. Nature Medicine. -
Use of tubular retractors to access deep brain lesions: A case series.
Rakovec, M., Camp, S., Day, D., Chakravarti, S., Parker, M., Porras, J. L., … Mukherjee, D. (2023). Use of tubular retractors to access deep brain lesions: A case series. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 114, 64–69. -
Translational Models in Glioma Immunotherapy Research.
Ren, A. L., Wu, J. Y., Lee, S. Y., & Lim, M. (2023). Translational Models in Glioma Immunotherapy Research. Current Oncology (Toronto, Ont.), 30(6), 5704–5718. -
A Case Series of Stereotactic Radiosurgery First for Trigeminal Neuralgia: A History of Stereotactic Radiosurgery Does Not Complicate Microvascular Decompression.
Nair, S. K., Xie, M. E., Ran, K., Kalluri, A., Kilgore, C., Halbert-Elliott, K., … Xu, R. (2023). A Case Series of Stereotactic Radiosurgery First for Trigeminal Neuralgia: A History of Stereotactic Radiosurgery Does Not Complicate Microvascular Decompression. Operative Neurosurgery (Hagerstown, Md.). -
Management outcomes of peripontine arteriovenous malformation patients presenting with trigeminal neuralgia.
Yang, W., Sattari, S. A., Feghali, J., Hung, A., Chen, Y., Xu, R., … Huang, J. (2023). Management outcomes of peripontine arteriovenous malformation patients presenting with trigeminal neuralgia. Journal of Neurosurgery, 1–7. -
Correcting the drug development paradigm for glioblastoma requires serial tissue sampling.
Singh, K., Hotchkiss, K. M., Parney, I. F., De Groot, J., Sahebjam, S., Sanai, N., … Khasraw, M. (2023). Correcting the drug development paradigm for glioblastoma requires serial tissue sampling. Nature Medicine. -
Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid.
Douville, C., Curtis, S., Summers, M., Azad, T. D., Rincon-Torroella, J., Wang, Y., … Bettegowda, C. (2023). Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid. Cell Reports. Medicine, 101148. -
TUMOR INFLAMMATION-ASSOCIATED NEUROTOXICITY (TIAN): A TOXICITY SYNDROME IN PATIENTS TREATED WITH IMMUNOTHERAPY FOR CENTRAL NERVOUS SYSTEM TUMORS
Mahdi, J., Dietrich, J., Straathof, K., Roddie, C., Scott, B., Davidson, T. B., … Monje, M. (2023). TUMOR INFLAMMATION-ASSOCIATED NEUROTOXICITY (TIAN): A TOXICITY SYNDROME IN PATIENTS TREATED WITH IMMUNOTHERAPY FOR CENTRAL NERVOUS SYSTEM TUMORS. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
Stereotactic Radiosurgery for Medically Refractory Trigeminal Neuralgia Secondary to Stroke: A Systematic Review and Clinical Case Presentation.
Zamarud, A., Park, D. J., Ung, T. H., McCleary, T.-L. L., Yoo, K. H., Soltys, S. G., … Meola, A. (2023). Stereotactic Radiosurgery for Medically Refractory Trigeminal Neuralgia Secondary to Stroke: A Systematic Review and Clinical Case Presentation. World Neurosurgery. -
Optimizing the synergy between stereotactic radiosurgery and immunotherapy for brain metastases.
Yoo, K. H., Park, D. J., Choi, J. H., Marianayagam, N. J., Lim, M., Meola, A., & Chang, S. D. (2023). Optimizing the synergy between stereotactic radiosurgery and immunotherapy for brain metastases. Frontiers in Oncology, 13, 1223599. -
Overcoming EGFR inhibitor resistance in Glioblastoma by targeting co-amplified genes.
Pant, A., & Lim, M. (2023). Overcoming EGFR inhibitor resistance in Glioblastoma by targeting co-amplified genes. Proceedings of the National Academy of Sciences of the United States of America, 120(38), e2312277120. -
The role of multiple sclerosis subtype in microvascular decompression outcomes for patients with trigeminal neuralgia.
Kalluri, A. L., So, R. J., Nair, S. K., Materi, J., Wang, D., Behera, N., … Xu, R. (2023). The role of multiple sclerosis subtype in microvascular decompression outcomes for patients with trigeminal neuralgia. Clinical Neurology and Neurosurgery, 233, 107967. -
Frailty predicts worse pain outcomes for older TN patients treated with microvascular decompression.
Kilgore, C. B., Kalluri, A. L., Nair, S. K., Halbert-Elliot, K. M., Ejimogu, E., Dong, B., … Xu, R. (2023). Frailty predicts worse pain outcomes for older TN patients treated with microvascular decompression. World Neurosurgery. -
Proteomic Analysis to Identify Prospective Biomarkers of Treatment Outcome After Microvascular Decompression for Trigeminal Neuralgia: A Preliminary Study.
Doshi, T. L., Dorsey, S. G., Huang, W., Kane, M. A., & Lim, M. (2023). Proteomic Analysis to Identify Prospective Biomarkers of Treatment Outcome After Microvascular Decompression for Trigeminal Neuralgia: A Preliminary Study. The Journal of Pain. -
The influence of prior percutaneous rhizotomy on outcomes following microvascular decompression for trigeminal neuralgia.
Nair, S. K., Xie, M. E., Kalluri, A., Ran, K., Kilgore, C., Halbert-Elliott, K., … Xu, R. (2023). The influence of prior percutaneous rhizotomy on outcomes following microvascular decompression for trigeminal neuralgia. Journal of Neurosurgery, 1–5. -
The pathophysiology of trigeminal neuralgia: a molecular review.
Dong, B., Xu, R., & Lim, M. (2023). The pathophysiology of trigeminal neuralgia: a molecular review. Journal of Neurosurgery, 139(5), 1471–1479. -
Neurovascular Compression in Patients With Trigeminal Neuralgia May Be Associated With Worse Outcomes After Primary Percutaneous Rhizotomy.
Nair, S. K., Al-Khars, H., Kalluri, A., Ran, K., Kilgore, C., Budihal, B. R., … Xu, R. (2023). Neurovascular Compression in Patients With Trigeminal Neuralgia May Be Associated With Worse Outcomes After Primary Percutaneous Rhizotomy. Neurosurgery. -
Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke.
Kim, J. E., Lee, R. P., Yazigi, E., Atta, L., Feghali, J., Pant, A., … Jackson, C. M. (2023). Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke. Brain, Behavior, and Immunity. -
Stanford University School of Medicine: Our Neurosurgical Heritage.
Veeravagu, A., Kim, L. H., Rao, V. L., Lim, M., Shuer, L. M., Harris, O. A., & Steinberg, G. K. (2023). Stanford University School of Medicine: Our Neurosurgical Heritage. Neurosurgery. -
Adult neuro-oncology trials in the United States over 5 decades: Analysis of trials completion rate to guide the path forward.
Smith, E. J., Naik, A., Goel, M., Wen, P. Y., Lim, M., Chang, S. M., & Germano, I. M. (2024). Adult neuro-oncology trials in the United States over 5 decades: Analysis of trials completion rate to guide the path forward. Neuro-Oncology Advances, 6(1), vdad169. -
ADULT NEURO-ONCOLOGY TRIAL LANDSCAPE IN THE UNITED STATES OVER FIVE DECADES
Smith, E., Naik, A., Goel, M., Wen, P., Lim, M., Chang, S., & Germano, I. (2023). ADULT NEURO-ONCOLOGY TRIAL LANDSCAPE IN THE UNITED STATES OVER FIVE DECADES. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
MITOCHONDRIAL ATP BIOGENESIS REGULATED BY VDAC1 IN TMEM119+TUMOR-ASSOCIATED MICROGLIA AND MACROPHAGES MEDIATES HIGH-GRADE GLIOMA GROWTH
Wu, C., Chen, Y., Lin, Y.-J., Wei, K.-C., Chang, K.-Y., Feng, L.-Y., … Lim, M. (2023). MITOCHONDRIAL ATP BIOGENESIS REGULATED BY VDAC1 IN TMEM119+TUMOR-ASSOCIATED MICROGLIA AND MACROPHAGES MEDIATES HIGH-GRADE GLIOMA GROWTH. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
A RANDOMIZED WINDOW OF OPPORTUNITY TRIAL WITH DOSE ESCALATION TO EVALUATE FLUOXETINE AND TEMOZOLOMIDE IN GLIOMA
Singh, K., Railton, C., Hotchkiss, K., Herndon, J., Peters, K., Friedman, H., … Khasraw, M. (2023). A RANDOMIZED WINDOW OF OPPORTUNITY TRIAL WITH DOSE ESCALATION TO EVALUATE FLUOXETINE AND TEMOZOLOMIDE IN GLIOMA. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
GBM AGILE PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GBM: RESULTS OF FIRST EXPERIMENTAL ARM, REGORAFENIB
Wen, P., Alexander, B., Berry, D., Buxton, M., Cavenee, W., Colman, H., … Lassman, A. (2023). GBM AGILE PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GBM: RESULTS OF FIRST EXPERIMENTAL ARM, REGORAFENIB. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
LONG TERM FOLLOW-UP OF A PROSPECTIVE SAFETY AND TOXICITY STUDY OF IMMUNE CHECKPOINT INHIBITOR THERAPY INITIATED 8 DAYS PRIOR TO RADIOSURGERY FOR MELANOMA BRAIN OR SPINE METASTASIS
Kleinberg, L., Ye, X., Sharfman, W., Jackson, C., Redmond, K., Bettegowda, C., … Lim, M. (2023). LONG TERM FOLLOW-UP OF A PROSPECTIVE SAFETY AND TOXICITY STUDY OF IMMUNE CHECKPOINT INHIBITOR THERAPY INITIATED 8 DAYS PRIOR TO RADIOSURGERY FOR MELANOMA BRAIN OR SPINE METASTASIS. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
Preoperative Opioid Use and Postoperative Outcomes in Patients Undergoing Microvascular Decompression for Trigeminal Neuralgia.
Kalluri, A. L., Ejimogu, E., Kilgore, C., Nair, S. K., Ran, K. R., Abdulrahim, M., … Xu, R. (2024). Preoperative Opioid Use and Postoperative Outcomes in Patients Undergoing Microvascular Decompression for Trigeminal Neuralgia. Neurosurgery. -
Intra- and post-pandemic impact of the COVID-19 outbreak on Stanford Health Care.
Phongpreecha, T., Berson, E., Xue, L., Shome, S., Saarunya, G., Fralick, J., … Kerr, A. (2024). Intra- and post-pandemic impact of the COVID-19 outbreak on Stanford Health Care. Academic Pathology, 11(2), 100113. -
CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy.
Pant, A., Hwa-Lin Bergsneider, B., Srivastava, S., Kim, T., Jain, A., Bom, S., … Lim, M. (2024). CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy. Oncoimmunology, 13(1), 2338965. -
External assessment of preoperative scores for predicting outcome after microvascular decompression for trigeminal neuralgia.
Xie, M. E., Halbert-Elliott, K., Nair, S. K., Jun, J., Dong, B. C., Ran, K. R., … Xu, R. (2024). External assessment of preoperative scores for predicting outcome after microvascular decompression for trigeminal neuralgia. Journal of Neurosurgery, 1–7. -
Glioma.
Weller, M., Wen, P. Y., Chang, S. M., Dirven, L., Lim, M., Monje, M., & Reifenberger, G. (2024). Glioma. Nature Reviews. Disease Primers, 10(1), 33. -
A history of stereotactic radiosurgery may predict failure of procedure following percutaneous glycerol rhizotomy for trigeminal neuralgia.
Nair, S. K., Oh, H. J., Kalluri, A., Ejimogu, N.-E. E., Al-Khars, H., Abdulrahim, M., … Xu, R. (2024). A history of stereotactic radiosurgery may predict failure of procedure following percutaneous glycerol rhizotomy for trigeminal neuralgia. Neurosurgical Review, 47(1), 289. -
Repeat percutaneous rhizotomy for trigeminal neuralgia is not associated with an increased risk of postoperative complications.
Nair, S. K., Kalluri, A., Ejimogu, N.-E. E., Reddy, S. C., Tantry, D., Wang, X., … Xu, R. (2024). Repeat percutaneous rhizotomy for trigeminal neuralgia is not associated with an increased risk of postoperative complications. Clinical Neurology and Neurosurgery, 245, 108466. -
The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function.
Jackson, C. M., Pant, A., Dinalankara, W., Choi, J., Jain, A., Nitta, R., … Lim, M. (2024). The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function. Immunity. -
The CCR6-CCL20 axis promotes regulatory T cell glycolysis and immunosuppression in tumors.
Pant, A., Jain, A., Chen, Y., Patel, K., Saleh, L., Tzeng, S., … Jackson, C. M. (2024). The CCR6-CCL20 axis promotes regulatory T cell glycolysis and immunosuppression in tumors. Cancer Immunology Research. -
Evaluation of VAL-083 in GBM AGILE, a phase 3 registration platform trial for newly diagnosed and recurrent glioblastoma.
De Groot, J. F., Cloughesy, T. F., Berry, D. A., Buxton, M. B., Colman, H., Ellingson, B. M., … Perry, J. R. (2024). Evaluation of VAL-083 in GBM AGILE, a phase 3 registration platform trial for newly diagnosed and recurrent glioblastoma. JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS. -
TUMOR INFLAMMATION-ASSOCIATED NEUROTOXICITY (TIAN): A TOXICITY SYNDROME IN PATIENTS TREATED WITH IMMUNOTHERAPY FOR CENTRAL NERVOUS SYSTEM TUMORS
Mahdi, J., Dietrich, J., Straathof, K., Roddie, C., Scott, B. J., Davidson, T. B., … Monje, M. (2024). TUMOR INFLAMMATION-ASSOCIATED NEUROTOXICITY (TIAN): A TOXICITY SYNDROME IN PATIENTS TREATED WITH IMMUNOTHERAPY FOR CENTRAL NERVOUS SYSTEM TUMORS. NEURO-ONCOLOGY. OXFORD UNIV PRESS INC. -
Radiation immunodynamics in patients with glioblastoma receiving chemoradiation.
Sloan, L., Sen, R., Liu, C., Doucet, M., Blosser, L., Katulis, L., … Kleinberg, L. R. (2024). Radiation immunodynamics in patients with glioblastoma receiving chemoradiation. Frontiers in Immunology, 15, 1438044.
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
- Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations
- Surgical Nivolumab And Ipilimumab For Recurrent GBM
- Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM
Practice Locations
Facial Pain Program at the Neuroscience Health Center Palo Alto, CA
Palo Alto, CAFacial Pain Program at the Neuroscience Health Center
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereBrain and Spine Tumor Center at Stanford Neuroscience Health Center Palo Alto, CA
Palo Alto, CABrain and Spine Tumor Center at Stanford Neuroscience Health Center
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereSkull Base Surgery at the Neuroscience Health Center Palo Alto, CA
Palo Alto, CASkull Base Surgery at the Neuroscience Health Center
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereCyberKnife Program at the Neuroscience Health Center Palo Alto, CA
Palo Alto, CACyberKnife Program at the Neuroscience Health Center
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereStanford Neuroscience Health Center Palo Alto, CA
Palo Alto, CAStanford Neuroscience Health Center
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereNeurosurgery Program Palo Alto, CA
Palo Alto, CANeurosurgery Program
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HerePituitary Center Palo Alto, CA
Palo Alto, CAPituitary Center
213 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information Getting HereImportant Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
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Referring Physicians
PHYSICIAN HELPLINE
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Stanford Health Care provides comprehensive services to refer and track patients, as well as the latest information and news for physicians and office staff. For help with all referral needs and questions, visit Referral Information.
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- Place radiology and lab orders
- View referral status
- Access medical records