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Kari Nadeau, MD, PhD
Allergist, Asthma specialist, Immunologist, Pediatrician
Naddisy Foundation Professor of Pediatric Food Allergy, Immunology and Asthma, Professor of Pediatrics, Senior Fellow at the Woods Institute and Professor, by courtesy, of Otolaryngology and of Epidemiology and Population Health at LPCH
Bio:
Dr. Kari Nadeau is the Naddisy Foundation Endowed Professor of Medicine and Pediatrics and, Director of the Sean N. Parker Center for Allergy and Asthma Research at Stanford University. She is Section Chief in Asthma and Allergy in the Pulmonary, Allergy and Critical Care Division at Stanford. She is the Sr. Director of Clinical Research for the Division of Hospital Medicine.
For more than 30 years, she has devoted herself to understanding how environmental and immune/genetic factors affect allergies, immune tolerance, and asthma. She and her team are focused in areas of global climate change and health by studying air pollution and wildfire exposures, particularly in underserved areas. As one of the globe’s foremost experts in adult and pediatric allergy, immunology, and asthma, her research is laying the groundwork for a variety of potential future therapies to prevent and cure allergies and asthma. Dr. Nadeau leads a team of specialists spanning allergy, asthma, and immunology across Stanford University. She has been a pioneer in the field of Translational Allergy and Immunology, both defining the mechanism of new therapies and then translating them clinically to make transformative changes for patients and their families. She has led research in oncology, transplant, infectious diseases, COVID, and autoimmune trials and is a member of the National Steering Committee for the intramural clinical research programs at the NIH Immune Tolerance Network. She and her team have been awarded many patents and have started 4 biotech companies in the Bay Area under Stanford patents and has worked in industry to shepherd two drugs through the FDA to approval. She also is an author of the Lancet Countdown in Global Climate Change 2020 and the book: The End of Food Allergy (published 2020).
Dr. Nadeau received her MD and PhD from Harvard Medical School through the NIH MSTP program. She completed a residency in pediatrics at Boston Children’s Hospital and a clinical fellowship in allergy, asthma and immunology at Stanford and at University of California, San Francisco.
Dr. Nadeau has served as a FDA consultant and a reviewer for NIH Study Sections. Also, she served on the environmental health policy committee for the American Thoracic Society, and serves on the Data and Safety Monitoring Board (DSMB) of the National Heart, Lung, and Blood Institute (NHLBI), and is a fellow in the American Academy of Allergy, Asthma, and Immunology (AAAAI). She started the Gordon Research Conference for Food Allergy and Chaired the first inaugural conference (2018). She is Chair of the Board of Scientific Counselors for the NIH Clinical Center (2018-2021). She is a member of the American Society for Clinical Investigation (ASCI), Association of American Physicians (AAP), the medical board of the American Lung Association in California, the Scientific Advisory Board of the EPA, and is currently working with the US Congress, the WHO, International Wildfire Policy Group, CUGH, and CA Governor’s office on Global Climate Change emergency preparedness plans.
In addition to her above involvements, Dr. Nadeau contributes on multiple editorial boards for high impact journals and to date published over 300 peer-reviewed publications, and is a reviewer for high impact journals in basic science and clinical medicine (Nature, Nature Medicine, Science, Science Translational Medicine, Lancet, NEJM, JAMA, Allergy, JACI).
She is also passionate about breaking down health barriers and creating meaningful change for children and adults in underserved areas and has developed outreach and educational programs with partners in East Palo Alto, Inner City Chicago, Harlem, and San Francisco.
Her work has been recognized with numerous grants and awards. She has collaborated with many organizations and institutions. Through FARE, CoFAR, WHO, the United Nations and other partnerships, she collaborates with colleagues from institutions around the globe.
For more than 30 years, she has devoted herself to understanding how environmental and immune/genetic factors affect allergies, immune tolerance, and asthma. She and her team are focused in areas of global climate change and health by studying air pollution and wildfire exposures, particularly in underserved areas. As one of the globe’s foremost experts in adult and pediatric allergy, immunology, and asthma, her research is laying the groundwork for a variety of potential future therapies to prevent and cure allergies and asthma. Dr. Nadeau leads a team of specialists spanning allergy, asthma, and immunology across Stanford University. She has been a pioneer in the field of Translational Allergy and Immunology, both defining the mechanism of new therapies and then translating them clinically to make transformative changes for patients and their families. She has led research in oncology, transplant, infectious diseases, COVID, and autoimmune trials and is a member of the National Steering Committee for the intramural clinical research programs at the NIH Immune Tolerance Network. She and her team have been awarded many patents and have started 4 biotech companies in the Bay Area under Stanford patents and has worked in industry to shepherd two drugs through the FDA to approval. She also is an author of the Lancet Countdown in Global Climate Change 2020 and the book: The End of Food Allergy (published 2020).
Dr. Nadeau received her MD and PhD from Harvard Medical School through the NIH MSTP program. She completed a residency in pediatrics at Boston Children’s Hospital and a clinical fellowship in allergy, asthma and immunology at Stanford and at University of California, San Francisco.
Dr. Nadeau has served as a FDA consultant and a reviewer for NIH Study Sections. Also, she served on the environmental health policy committee for the American Thoracic Society, and serves on the Data and Safety Monitoring Board (DSMB) of the National Heart, Lung, and Blood Institute (NHLBI), and is a fellow in the American Academy of Allergy, Asthma, and Immunology (AAAAI). She started the Gordon Research Conference for Food Allergy and Chaired the first inaugural conference (2018). She is Chair of the Board of Scientific Counselors for the NIH Clinical Center (2018-2021). She is a member of the American Society for Clinical Investigation (ASCI), Association of American Physicians (AAP), the medical board of the American Lung Association in California, the Scientific Advisory Board of the EPA, and is currently working with the US Congress, the WHO, International Wildfire Policy Group, CUGH, and CA Governor’s office on Global Climate Change emergency preparedness plans.
In addition to her above involvements, Dr. Nadeau contributes on multiple editorial boards for high impact journals and to date published over 300 peer-reviewed publications, and is a reviewer for high impact journals in basic science and clinical medicine (Nature, Nature Medicine, Science, Science Translational Medicine, Lancet, NEJM, JAMA, Allergy, JACI).
She is also passionate about breaking down health barriers and creating meaningful change for children and adults in underserved areas and has developed outreach and educational programs with partners in East Palo Alto, Inner City Chicago, Harlem, and San Francisco.
Her work has been recognized with numerous grants and awards. She has collaborated with many organizations and institutions. Through FARE, CoFAR, WHO, the United Nations and other partnerships, she collaborates with colleagues from institutions around the globe.
Practice Areas
- Allergen Immunotherapy
- Allergy Tests
- Anaphylaxis
- Angioedema
- Asthma
- Contact Dermatitis
- Eczema
- Food and Drug Allergies
- Hives (Urticaria)
- Infections in Immunocompromised Patients
- Seasonal Allergies
Professional Education
- Board Certification: American Board of Allergy and Immunology, Allergy and Immunology (2007)
- Fellowship, Stanford University Medical Center - University of California, San Francisco (UCSF), Asthma and Immunology (2006)
- Residency, Stanford University Medical Center in Stanford, California, Pediatric (2004)
- Internship and Residency, Children's Hospital of Boston, Pediatric (Special Alternative Pathway) (1997)
- MD, PhD, Harvard Medical School, Biochemistry and Immunology (1995)
- B.S., Haverford College, Biology (1988)
Honors & Awards
- "An Allergy Free World For Every Child" Annual Innovations Lecture, United Nations University (2015)
- American Society for Clinical Investigation, The American Society of Clinical Investigation (ASCI) (2014)
- Chair and Founder, GRC Food Allergy, Gordon Research Conference (GRC) (2018)
- Chair, Board of Scientific Counselors, National Institutes of Health (NIH) Clinical Center (2018-Current)
- CVI Seed Grant Award, “Single-cell Sequencing to Identify Air Pollution-Induced Cardiac Risks.”, Stanford Cardiovascular Institute (CVI) (2019)
- Distinguished Research Award, Food Allergy Research & Education (FARE) (2018)
- Elected into Association of American Physicians, Association of American Physicians (APA) (2020)
- EPA Star Grant Award, Environmental Protection Agency (EPA) (2011-2013)
- Grand Rounds and Pierson Lectureship, University of Washington (2015)
- Honor Your Doctor - California, Food Allergy Research & Education (FARE) (2020)
- National Distinguished Scientist Award, American Academy of Allergy, Asthma and Immunology (AAAAI) (2020)
- Nominee from Stanford Medical School for Warren Alpert Award, Warren Alpert Foundation (2020)
- Visiting Professorship Lecture, Texas Children’s Hospital (2015)
Administrative Appointments
- Director, Sean N. Parker Center for Allergy Research at Stanford University (2014 - Present)
- Medical Director, Precision Allergy, School of Medicine (2020 - Present)
- Professor, Affiliate appointment in Otolaryngology (2015 - Present)
- Professor, Pediatrics (2015 - Present)
- Professor, Medicine (2016 - Present)
- Professor, Affiliate appointment in Epidemiology and Population Health (2020 - Present)
- Section Chief, Allergy and Asthma at the Stanford School of Medicine (2016 - Present)
- Senior Director, Clinical Research in Hospital Medicine, Department of Medicine (2020 - Present)
Publications
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Renal allograft protection with losartan in Fisher -> Lewis rats: Hemodynamics, macrophages, and cytokines
Ziai, F., Nagano, H., Kusaka, M., Coito, A. J., Troy, J. L., Nadeau, K. C., … Mackenzie, H. S. (2000). Renal allograft protection with losartan in Fisher -> Lewis rats: Hemodynamics, macrophages, and cytokines. KIDNEY INTERNATIONAL, 57(6), 2618–2625. -
Inhibition of CD40 ligand (CD154) in the treatment of factor VIII inhibitors.
Ewenstein, B. M., Hoots, W. K., Lusher, J. M., DiMichele, D., White, G. C., Adelman, B., & Nadeau, K. (2000). Inhibition of CD40 ligand (CD154) in the treatment of factor VIII inhibitors. Haematologica, 85(10), 35–39. -
Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients
Cho, C. S., Burkly, L. C., Fechner, J. H., Kirk, A. D., Oberley, T. D., Dong, Y. C., … Knechtle, S. J. (2001). Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients. TRANSPLANTATION, 72(4), 587–597. -
PURIFICATION OF GLUTATHIONYLSPERMIDINE AND TRYPANOTHIONE SYNTHETASES FROM CRITHIDIA-FASCICULATA
Smith, K., Nadeau, K., Bradley, M., Walsh, C., & Fairlamb, A. H. (1992). PURIFICATION OF GLUTATHIONYLSPERMIDINE AND TRYPANOTHIONE SYNTHETASES FROM CRITHIDIA-FASCICULATA. PROTEIN SCIENCE, 1(7), 874–883.
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83-KILODALTON HEAT-SHOCK PROTEINS OF TRYPANOSOMES ARE POTENT PEPTIDE-STIMULATED ATPASES
Nadeau, K., Sullivan, M. A., Bradley, M., Engman, D. M., & Walsh, C. T. (1992). 83-KILODALTON HEAT-SHOCK PROTEINS OF TRYPANOSOMES ARE POTENT PEPTIDE-STIMULATED ATPASES. PROTEIN SCIENCE, 1(8), 970–979.
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MOLECULAR STUDIES ON TRYPANOTHIONE REDUCTASE - AN ANTIPARASITIC TARGET ENZYME
Walsh, C., Bradley, M., & Nadeau, K. (1992). MOLECULAR STUDIES ON TRYPANOTHIONE REDUCTASE - AN ANTIPARASITIC TARGET ENZYME. CURRENT TOPICS IN CELLULAR REGULATION, 33, 409–417.
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KINETIC ISOTOPE EFFECT ANALYSIS OF THE REACTION CATALYZED BY TRYPANOSOMA-CONGOLENSE TRYPANOTHIONE REDUCTASE
LEICHUS, B. N., Bradley, M., Nadeau, K., Walsh, C. T., & Blanchard, J. S. (1992). KINETIC ISOTOPE EFFECT ANALYSIS OF THE REACTION CATALYZED BY TRYPANOSOMA-CONGOLENSE TRYPANOTHIONE REDUCTASE. BIOCHEMISTRY, 31(28), 6414–6420.
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Lgl1 is suppressed in oxygen toxicity animal models of bronchopulmonary dysplasia and normalizes during recovery in air
Nadeau, K., Jankov, R. P., Tanswell, A. K., Sweezey, N. B., & Kaplan, F. (2006). Lgl1 is suppressed in oxygen toxicity animal models of bronchopulmonary dysplasia and normalizes during recovery in air. PEDIATRIC RESEARCH, 59(3), 389–395.
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Cutting edge: Decreased accumulation and regulatory function of CD4(+)CD25(high) T cells in human STAT 5b deficiency
Cohen, A. C., Nadeau, K. C., Tu, W., Hwa, V., Dionis, K., Bezrodnik, L., … Lewis, D. B. (2006). Cutting edge: Decreased accumulation and regulatory function of CD4(+)CD25(high) T cells in human STAT 5b deficiency. JOURNAL OF IMMUNOLOGY, 177(5), 2770–74.
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Altered phosphorylated signal transducer and activator of transcription profile of CD4(+)CD161(+) T cells in asthma: Modulation by allergic status and oral corticosteroids
Gernez, Y., Tirouvanziam, R., Nguyen, K. D., Herzenberg, L. A., Krensky, A. M., & Nadeau, K. C. (2007). Altered phosphorylated signal transducer and activator of transcription profile of CD4(+)CD161(+) T cells in asthma: Modulation by allergic status and oral corticosteroids. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 120(6), 1441–48.
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A novel mutation associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
Bhui, R. D., Lewis, D. B., & Nadeau, K. C. (2008). A novel mutation associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 100(2), 169–169.
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THE PROMOTER OF THE LATENCY-ASSOCIATED TRANSCRIPTS OF HERPES-SIMPLEX VIRUS TYPE-1 CONTAINS A FUNCTIONAL CAMP-RESPONSE ELEMENT - ROLE OF THE LATENCY-ASSOCIATED TRANSCRIPTS AND CAMP IN REACTIVATION OF VIRAL LATENCY
Leib, D. A., Nadeau, K. C., Rundle, S. A., & Schaffer, P. A. (1991). THE PROMOTER OF THE LATENCY-ASSOCIATED TRANSCRIPTS OF HERPES-SIMPLEX VIRUS TYPE-1 CONTAINS A FUNCTIONAL CAMP-RESPONSE ELEMENT - ROLE OF THE LATENCY-ASSOCIATED TRANSCRIPTS AND CAMP IN REACTIVATION OF VIRAL LATENCY. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 88(1), 48–52.
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Increased cytotoxicity of CD4(+) invariant NKT cells against CD4(+)CD25(hi)CD127(lo/-) regulatory T cells in allergic asthma
Nguyen, K. D., Vanichsarn, C., & Nadeau, K. C. (2008). Increased cytotoxicity of CD4(+) invariant NKT cells against CD4(+)CD25(hi)CD127(lo/-) regulatory T cells in allergic asthma. EUROPEAN JOURNAL OF IMMUNOLOGY, 38(7), 2034–45.
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A TEST FOR GENETIC EXCHANGE IN MIXED INFECTIONS OF LEISHMANIA-MAJOR IN THE SAND FLY PHLEBOTOMUS-PAPATASI
PANTON, L. J., Tesh, R. B., Nadeau, K. C., & Beverley, S. M. (1991). A TEST FOR GENETIC EXCHANGE IN MIXED INFECTIONS OF LEISHMANIA-MAJOR IN THE SAND FLY PHLEBOTOMUS-PAPATASI. JOURNAL OF PROTOZOOLOGY, 38(3), 224–228.
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Idiopathic neutropenia of childhood is associated with Fas/FasL expression
Nadeau, K. C., Callejas, A., Wong, W. B., Joh, J. W., Cohen, H. J., & Jeng, M. R. (2008). Idiopathic neutropenia of childhood is associated with Fas/FasL expression. CLINICAL IMMUNOLOGY, 129(3), 438–47.
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XCL1 enhances regulatory activities of CD4(+)CD25(high)CD127(low/-) T cells in human allergic asthma
Nguyen, K. D., Fohner, A., Booker, J. D., Dong, C., Krensky, A. M., & Nadeau, K. C. (2008). XCL1 enhances regulatory activities of CD4(+)CD25(high)CD127(low/-) T cells in human allergic asthma. JOURNAL OF IMMUNOLOGY, 181(8), 5386–95.
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Selective deregulation in chemokine signaling pathways of CD4(+)CD25(hi)CD127(lo/-) regulatory T cells in human allergic asthma
Nguyen, K. D., Vanichsarn, C., Fohner, A., & Nadeau, K. C. (2009). Selective deregulation in chemokine signaling pathways of CD4(+)CD25(hi)CD127(lo/-) regulatory T cells in human allergic asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 123(4), 933–39.
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Regulatory T cell dysfunction in subjects with common variable immunodeficiency complicated by autoimmune disease
Yu, G. P., Chiang, D., Song, S. J., Hoyte, E. G., Huang, J., Vanishsarn, C., & Nadeau, K. C. (2009). Regulatory T cell dysfunction in subjects with common variable immunodeficiency complicated by autoimmune disease. CLINICAL IMMUNOLOGY, 131(2), 240–53.
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Neonatal Alloimmune Thrombocytopenia and Neutropenia Associated With Maternal Human Leukocyte Antigen Antibodies
Gramatges, M. M., Fani, P., Nadeau, K., Pereira, S., & Jeng, M. R. (2009). Neonatal Alloimmune Thrombocytopenia and Neutropenia Associated With Maternal Human Leukocyte Antigen Antibodies. PEDIATRIC BLOOD & CANCER, 53(1), 97–99.
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MOLECULAR STUDIES ON TRYPANOTHIONE REDUCTASE, A TARGET FOR ANTIPARASITIC DRUGS
Walsh, C., Bradley, M., & Nadeau, K. (1991). MOLECULAR STUDIES ON TRYPANOTHIONE REDUCTASE, A TARGET FOR ANTIPARASITIC DRUGS. TRENDS IN BIOCHEMICAL SCIENCES, 16(8), 305–309.
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Impaired IL-10-dependent Induction of Tolerogenic Dendritic Cells by CD4(+)CD25(hi)CD127(lo/-) Natural Regulatory T Cells in Human Allergic Asthma
Nguyen, K. D., Vanichsarn, C., & Nadeau, K. C. (2009). Impaired IL-10-dependent Induction of Tolerogenic Dendritic Cells by CD4(+)CD25(hi)CD127(lo/-) Natural Regulatory T Cells in Human Allergic Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180(9), 823–33.
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Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing
Boyd, S. D., Marshall, E. L., Merker, J. D., Maniar, J. M., Zhang, L. N., Sahaf, B., … Fire, A. Z. (2009). Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing. SCIENCE TRANSLATIONAL MEDICINE, 1(12).
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TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway.
Nguyen, K. D., Vanichsarn, C., & Nadeau, K. C. (2010). TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 6(1), 4-?
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Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements
Boyd, S. D., Gaeta, B. A., Jackson, K. J., Fire, A. Z., Marshall, E. L., Merker, J. D., … Collins, A. M. (2010). Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements. JOURNAL OF IMMUNOLOGY, 184(12), 6986–92.
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Migration of regulatory T cells toward airway epithelial cells is impaired in chronic rhinosinusitis with nasal polyposis
Kim, Y. M., Munoz, A., Hwang, P. H., & Nadeau, K. C. (2010). Migration of regulatory T cells toward airway epithelial cells is impaired in chronic rhinosinusitis with nasal polyposis. CLINICAL IMMUNOLOGY, 137(1), 111–121.
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Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay.
Kudelko, K. T., Nadeau, K., Leung, A. N., Liu, J., Haddad, F., Zamanian, R. T., & de Jesus Perez, V. (2010). Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay. Journal of Heart and Lung Transplantation , 29(9), 1071–75.
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Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis
Patel, A. J., Fuentebella, J., Gernez, Y., Nguyen, T., Bass, D., Berquist, W., … Nadeau, K. (2010). Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 51(3), 290–94.
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Increased Number of Regulatory T Cells in Children With Eosinophilic Esophagitis
Fuentebella, J., Patel, A., Nguyen, T., Sanjanwala, B., Berquist, W., Kerner, J. A., … Nadeau, K. (2010). Increased Number of Regulatory T Cells in Children With Eosinophilic Esophagitis. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 51(3), 283–89.
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Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis.
Huang, J. J., Joh, J. W., Fuentebella, J., Patel, A., Nguyen, T., Seki, S., … Nadeau, K. C. (2010). Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 6(1), 25-?
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Basophil CD203c Levels Are Increased at Baseline and Can Be Used to Monitor Omalizumab Treatment in Subjects with Nut Allergy
Gernez, Y., Tirouvanziam, R., Yu, G., Ghosn, E. E. B., Reshamwala, N., Tammie Nguyen, T., … Nadeau, K. C. (2011). Basophil CD203c Levels Are Increased at Baseline and Can Be Used to Monitor Omalizumab Treatment in Subjects with Nut Allergy. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 154(4), 318–27.
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Serum amyloid A overrides T-reg anergy via monocyte-dependent and T-reg-intrinsic, SOCS3-associated pathways
Nguyen, K. D., Macaubas, C., Nadeau, K. C., Phi Truong, T., Yoon, T., Lee, T., … Mellins, E. D. (2011). Serum amyloid A overrides T-reg anergy via monocyte-dependent and T-reg-intrinsic, SOCS3-associated pathways. BLOOD, 117(14), 3793–98.
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Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy
Nadeau, K. C., Schneider, L. C., Hoyte, L., Borras, I., & Umetsu, D. T. (2011). Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(6), 1622–1624.
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Immunophenotyping of Peripheral Eosinophils Demonstrates Activation in Eosinophilic Esophagitis
Tammie Nguyen, T., Gernez, Y., Fuentebella, J., Patel, A., Tirouvanziam, R., Reshamwala, N., … Nadeau, K. C. (2011). Immunophenotyping of Peripheral Eosinophils Demonstrates Activation in Eosinophilic Esophagitis. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 53(1), 40–47.
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T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets
Alonso, M. N., Wong, M. T., Zhang, A. L., Winer, D., Suhoski, M. M., Tolentino, L. L., … Engleman, E. G. (2011). T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets. BLOOD, 118(12), 3311–20.
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Genotype, phenotype, and outcomes of nine patients with T-B plus NK plus SCID
Yu, G. P., Nadeau, K. C., Berk, D. R., de Saint Basile, G., Lambert, N., Knapnougel, P., … Cowan, M. J. (2011). Genotype, phenotype, and outcomes of nine patients with T-B plus NK plus SCID. PEDIATRIC TRANSPLANTATION, 15(7), 733–41.
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Oral Immunotherapy and Anti-IgE Antibody-Adjunctive Treatment for Food Allergy
Nadeau, K. C., Kohli, A., Iyengar, S., DeKruyff, R. H., & Umetsu, D. T. (2012). Oral Immunotherapy and Anti-IgE Antibody-Adjunctive Treatment for Food Allergy. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 32(1), 111-?
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Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction
Morgan, A. A., Pyrgos, V. J., Nadeau, K. C., Williamson, P. R., & Butte, A. J. (2012). Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 19(2), 284–88.
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Modulation of mTOR Effector Phosphoproteins in Blood Basophils from Allergic Patients
Gernez, Y., Tirouvanziam, R., Reshamwala, N., Yu, G., Weldon, B. C., Galli, S. J., … Nadeau, K. C. (2012). Modulation of mTOR Effector Phosphoproteins in Blood Basophils from Allergic Patients. JOURNAL OF CLINICAL IMMUNOLOGY, 32(3), 565–73.
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Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
Chen, R., Mias, G. I., Li-Pook-Than, J., Jiang, L., Lam, H. Y. K., Chen, R., … Snyder, M. (2012). Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes. CELL, 148(6), 1293–1307.
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Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy
Swamy, R. S., Reshamwala, N., Hunter, T., Vissamsetti, S., Santos, C. B., Baroody, F. M., … Nadeau, K. C. (2012). Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 130(1), 215-?
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The Safety of Peanut Oral Immunotherapy in Peanut-Allergic Subjects in a Single-Center Trial
Yu, G. P., Weldon, B., Neale-May, S., & Nadeau, K. C. (2012). The Safety of Peanut Oral Immunotherapy in Peanut-Allergic Subjects in a Single-Center Trial. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 159(2), 179–182.
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The STAT5b Pathway Defect and Autoimmunity.
Kanai, T., Jenks, J., & Nadeau, K. C. (2012). The STAT5b Pathway Defect and Autoimmunity. Frontiers in Immunology, 3, 234-?
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Immunomodulatory effect of vancomycin on Treg in pediatric inflammatory bowel disease and primary sclerosing cholangitis.
Abarbanel, D. N., Seki, S. M., Davies, Y., Marlen, N., Benavides, J. A., Cox, K., … Cox, K. L. (2013). Immunomodulatory effect of vancomycin on Treg in pediatric inflammatory bowel disease and primary sclerosing cholangitis. Journal of Clinical Immunology, 33(2), 397–406.
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Markers of Antigen Presentation and Activation on Eosinophils and T Cells in the Esophageal Tissue of Patients With Eosinophilic Esophagitis
Le-Carlson, M., Seki, S., Abarbanel, D., Quiros, A., Cox, K., & Nadeau, K. C. (2013). Markers of Antigen Presentation and Activation on Eosinophils and T Cells in the Esophageal Tissue of Patients With Eosinophilic Esophagitis. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 56(3), 257–62.
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Asthma Discordance in Twins Is Linked to Epigenetic Modifications of T Cells
Runyon, R. S., Cachola, L. M., Rajeshuni, N., Hunter, T., Garcia, M., Ahn, R., … Nadeau, K. C. (2012). Asthma Discordance in Twins Is Linked to Epigenetic Modifications of T Cells. PLOS ONE, 7(11).
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Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells.
Liu, J., Zhang, L., Winterroth, L. C., Garcia, M., Weiman, S., Wong, J. W., … Nadeau, K. C. (2013). Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells. Journal of Toxicology, 2013, 967029-?
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DASH for asthma: A pilot study of the DASH diet in not-well-controlled adult asthma
Ma, J., Strub, P., Lavori, P. W., Buist, S., Camargo, C. A., Nadeau, K. C., … Xiao, L. (2013). DASH for asthma: A pilot study of the DASH diet in not-well-controlled adult asthma. CONTEMPORARY CLINICAL TRIALS, 35(2), 55–67.
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SEQUENTIAL CYTOKINE DYNAMICS IN CHRONIC REJECTION OF RAT RENAL-ALLOGRAFTS - ROLES FOR CYTOKINES RANTES AND MCP-1
Nadeau, K. C., Azuma, H., & Tilney, N. L. (1995). SEQUENTIAL CYTOKINE DYNAMICS IN CHRONIC REJECTION OF RAT RENAL-ALLOGRAFTS - ROLES FOR CYTOKINES RANTES AND MCP-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 92(19), 8729–8733.
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MOLECULAR AND BIOCHEMICAL-COMPARISON OF THE 70-KDA HEAT-SHOCK PROTEINS OF TRYPANOSOMA-CRUZI
Olson, C. L., Nadeau, K. C., Sullivan, M. A., Winquist, A. G., Donelson, J. E., Walsh, C. T., & Engman, D. M. (1994). MOLECULAR AND BIOCHEMICAL-COMPARISON OF THE 70-KDA HEAT-SHOCK PROTEINS OF TRYPANOSOMA-CRUZI. JOURNAL OF BIOLOGICAL CHEMISTRY, 269(5), 3868–3874.
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STUDIES ON THE INTERACTION OF THE IMMUNOSUPPRESSANT 15-DEOXYSPERGUALIN WITH HEAT-SHOCK PROTEINS
Nadler, S. G., Cleaveland, J., Tepper, M. A., Walsh, C., & Nadeau, K. (1993). STUDIES ON THE INTERACTION OF THE IMMUNOSUPPRESSANT 15-DEOXYSPERGUALIN WITH HEAT-SHOCK PROTEINS. Presented at the Conference on Immunosuppressive and Antiinflammatory Drugs, ORLANDO,FL: NEW YORK ACAD SCIENCES.
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QUANTITATION OF THE INTERACTION OF THE IMMUNOSUPPRESSANT DEOXYSPERGUALIN AND ANALOGS WITH HSC70 AND HSP90
Nadeau, K., Nadler, S. G., Saulnier, M., Tepper, M. A., & Walsh, C. T. (1994). QUANTITATION OF THE INTERACTION OF THE IMMUNOSUPPRESSANT DEOXYSPERGUALIN AND ANALOGS WITH HSC70 AND HSP90. BIOCHEMISTRY, 33(9), 2561–2567.
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HSP90 CHAPERONINS POSSESS ATPASE ACTIVITY AND BIND HEAT-SHOCK TRANSCRIPTION FACTORS AND PEPTIDYL PROLYL ISOMERASES
Nadeau, K., Das, A., & Walsh, C. T. (1993). HSP90 CHAPERONINS POSSESS ATPASE ACTIVITY AND BIND HEAT-SHOCK TRANSCRIPTION FACTORS AND PEPTIDYL PROLYL ISOMERASES. JOURNAL OF BIOLOGICAL CHEMISTRY, 268(2), 1479–1487.
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Prevention of functional, structural, and molecular changes of chronic rejection of rat renal allografts by a specific macrophage inhibitor
Azuma, H., Nadeau, K. C., Ishibashi, M., & Tilney, N. L. (1995). Prevention of functional, structural, and molecular changes of chronic rejection of rat renal allografts by a specific macrophage inhibitor. TRANSPLANTATION, 60(12), 1577–1582.
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Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection
Azuma, H., Chandraker, A., Nadeau, K., Hancock, W. W., Carpenter, C. B., Tilney, N. L., & Sayegh, M. H. (1996). Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93(22), 12439–12444.
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Sequential cytokine expression in renal allografts in rats immunosuppressed with maintenance cyclosporine or mycophenolate mofetil
Nadeau, K. C., Azuma, H., & Tilney, N. L. (1996). Sequential cytokine expression in renal allografts in rats immunosuppressed with maintenance cyclosporine or mycophenolate mofetil. TRANSPLANTATION, 62(9), 1363–1366.
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Nephron mass modulates the hemodynamic, cellular, and molecular response of the rat renal allograft
Azuma, H., Nadeau, K., Mackenzie, H. S., BRENNER, B. M., & Tilney, N. L. (1997). Nephron mass modulates the hemodynamic, cellular, and molecular response of the rat renal allograft. TRANSPLANTATION, 63(4), 519–528.
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Unaccompanied children in detention in the US
Nadeau, K. C. (1997). Unaccompanied children in detention in the US. PEDIATRICS, 99(4), 653–653.
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Inhibition of CD28-B7 T-cell costimulatory activation pathway affects intragraft cytokine and growth factor expression in chronic renal allograft rejection
Nadeau, K., Azuma, H., Chandraker, A., Sayegh, M. H., & Tilney, N. L. (1997). Inhibition of CD28-B7 T-cell costimulatory activation pathway affects intragraft cytokine and growth factor expression in chronic renal allograft rejection. TRANSPLANTATION PROCEEDINGS, 29(1-2), 1038–1038.
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Early cellular and molecular changes in ischemia/reperfusion injury: Inhibition by a selectin antagonist, P-selectin glycoprotein ligand-1
Takada, M., Nadeau, K. C., SHAW, G. D., & Tilney, N. L. (1997). Early cellular and molecular changes in ischemia/reperfusion injury: Inhibition by a selectin antagonist, P-selectin glycoprotein ligand-1. TRANSPLANTATION PROCEEDINGS, 29(1-2), 1324–1325.
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Initial ischemia/reperfusion injury influences late functional and structural changes in the kidney
Azuma, H., Nadeau, K., Takada, M., & Tilney, N. L. (1997). Initial ischemia/reperfusion injury influences late functional and structural changes in the kidney. TRANSPLANTATION PROCEEDINGS, 29(1-2), 1528–1529.
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Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats
Nagano, H., Nadeau, K. C., Takada, M., Kusaka, M., & Tilney, N. L. (1997). Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats. TRANSPLANTATION, 63(8), 1101–1108.
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Immigrating unaccompanied miners - A neglected minority?
Nadeau, K., Hannibal, K., Sirkin, S., & Nightingale, E. O. (1997). Immigrating unaccompanied miners - A neglected minority? WESTERN JOURNAL OF MEDICINE, 166(3), 221–221.
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The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney - Inhibition by a soluble P-selectin ligand
Takada, M., Nadeau, K. C., SHAW, G. D., MARQUETTE, K. A., & Tilney, N. L. (1997). The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney - Inhibition by a soluble P-selectin ligand. JOURNAL OF CLINICAL INVESTIGATION, 99(11), 2682–2690.
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Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney
Azuma, H., Nadeau, K., Takada, M., Mackenzie, H. S., & Tilney, N. L. (1997). Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney. TRANSPLANTATION, 64(2), 190–197.
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The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury
Takada, M., Chandraker, A., Nadeau, K. C., Sayegh, M. H., & Tilney, N. L. (1997). The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury. JOURNAL OF CLINICAL INVESTIGATION, 100(5), 1199–1203.
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CD28-B7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury - Rapid Communication
Chandraker, A., Takada, M., Nadeau, K. C., Peach, R., Tilney, N. L., & Sayegh, M. H. (1997). CD28-B7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury - Rapid Communication. KIDNEY INTERNATIONAL, 52(6), 1678–1684.
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Prevention of late renal changes after initial ischemia/reperfusion injury by blocking early selectin binding
Takada, M., Nadeau, K. C., SHAW, G. D., & Tilney, N. L. (1997). Prevention of late renal changes after initial ischemia/reperfusion injury by blocking early selectin binding. TRANSPLANTATION, 64(11), 1520–1525.
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Infection-associated macrophage activation accelerates chronic renal allograft rejection in rats
Nagano, H., Nadeau, K. C., Kusaka, M., Heeman, U. W., & Tilney, N. L. (1997). Infection-associated macrophage activation accelerates chronic renal allograft rejection in rats. TRANSPLANTATION, 64(11), 1602–1605.
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Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection
Chandraker, A., Azuma, H., Nadeau, K., Carpenter, C. B., Tilney, N. L., Hancock, W. W., & Sayegh, M. H. (1998). Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection. JOURNAL OF CLINICAL INVESTIGATION, 101(11), 2309–2318.
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Influence of initial antigen-independent events on acute allograft rejection: Inhibition by a soluble P-selectin ligand and low-dose cyclosporine in combination
Kusaka, M., Nadeau, K. C., Takada, M., Nagano, H., SHAW, G. D., & Tilney, N. L. (1998). Influence of initial antigen-independent events on acute allograft rejection: Inhibition by a soluble P-selectin ligand and low-dose cyclosporine in combination. TRANSPLANTATION PROCEEDINGS, 30(4), 1027–1028.
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Effects of explosive brain death on cytokine activation of peripheral organs in the rat
Takada, M., Nadeau, K. C., Hancock, W. W., Mackenzie, H. S., SHAW, G. D., Waaga, A. M., … Tilney, N. L. (1998). Effects of explosive brain death on cytokine activation of peripheral organs in the rat. TRANSPLANTATION, 65(12), 1533–1542.
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Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata
Tetaud, E., Manai, F., Barrett, M. P., Nadeau, K., Walsh, C. T., & Fairlamb, A. H. (1998). Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata. JOURNAL OF BIOLOGICAL CHEMISTRY, 273(31), 19383–19390.
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Inflammatory mediators, cells and their products in acute host alloresponsiveness.
Tilney, N. L., & Nadeau, K. (1996). Inflammatory mediators, cells and their products in acute host alloresponsiveness. Annals of Transplantation , 1(3), 5–13.
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Ambient Air Pollution Impairs Regulatory T-Cell Function in Asthma.
Ambient Air Pollution Impairs Regulatory T-Cell Function in Asthma. (2010). J Allergy Clin Immunol, 126(4).
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Bradykinin Inhibitors in Hereditary Angioedema
Bradykinin Inhibitors in Hereditary Angioedema. (2010). J Angioedema, 1(1).
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STAT5b Deficiency: An Unsuspected Cause of Growth Failure, Immunodeficiency, and Severe Pulmonary Disease
STAT5b Deficiency: An Unsuspected Cause of Growth Failure, Immunodeficiency, and Severe Pulmonary Disease. (2011). J Pediatr, 158(5).
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Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis.
Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis. (2010). J Pediatr Gastroenterol Nutr, 51(3).
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Increased Number of Regulatory T Cells in Children with Eosinophilic Esophagitis.
Increased Number of Regulatory T Cells in Children with Eosinophilic Esophagitis. (2010). J Pediatr Gastroenterol Nutri, 51(3).
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T Lymphocytes and Its Subsets in Transplanted Small Bowel Treated with Alemtuzumab (Campath-1H)
T Lymphocytes and Its Subsets in Transplanted Small Bowel Treated with Alemtuzumab (Campath-1H). (2009). Proc XI Int Small Bowel Transplant Sym, Dec.
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Epoprostenol-Associated Pneumonitis: Diagnostic Use of a T Cell Proliferation Assay
Epoprostenol-Associated Pneumonitis: Diagnostic Use of a T Cell Proliferation Assay. (2010). J Heart Lung Transplant, 29(9).
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CHARACTERIZATION OF AUTOANTIBODY PROFILE AMONG PATIENTS WITH PRIMARY IMMUNODEFICIENCY SECONDARY TO RAG MUTATIONS
Walter, J. E., Matthew, D., Lee, Y. N., Recher, M., Patrizi, L., Al-Herz, W., … Notarangelo, L. D. (2012). CHARACTERIZATION OF AUTOANTIBODY PROFILE AMONG PATIENTS WITH PRIMARY IMMUNODEFICIENCY SECONDARY TO RAG MUTATIONS. Presented at the 15th Biennial Meeting of the European-Society-for-Immunodeficiency (ESID), FLORENCE,ITALY,ITALY,ITALY,ITALY,ITALY: SPRINGER/PLENUM PUBLISHERS.
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Mechanistic Studies of Tolerance in sublingual innmunotherapy (SLIT) patients with Dermatophagoides farinae and Timothy grass allergy
Reshamwala, N., Swamy, R., Berquist, S., Nguyen, T., Hoyte, E., Vissamsetti, S., … Nadeau, K. (2010). Mechanistic Studies of Tolerance in sublingual innmunotherapy (SLIT) patients with Dermatophagoides farinae and Timothy grass allergy. Presented at the 10th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, BOSTON,MA,MA,MA,MA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
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Correlation of Phenotypic Expression of Milk Sensitivity in Young Patients by the Simultaneous Determination of IgE to Whole Milk Extract and Milk Specific Allergenic Proteins
Saper, V., Innerst, D., Nadeau, K., Hoyte, E., Vanichsarn, C., & Zychlinsky, E. (2009). Correlation of Phenotypic Expression of Milk Sensitivity in Young Patients by the Simultaneous Determination of IgE to Whole Milk Extract and Milk Specific Allergenic Proteins. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 123(2), S30–S30.
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Identifying Eosinophilic Esophagitis through Evaluation of Plasma Biomarkers
Joh, J., Huang, J., Nguyen, T., Vishwaanath, N., Patel, A., Fuentebella, J., … Nadeau, K. (2009). Identifying Eosinophilic Esophagitis through Evaluation of Plasma Biomarkers. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 123(2), S169–S169.
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Transcription Factors as Disease Indicators in Eosinophilic Esophagitis
Nguyen, T., Gernez, Y., Fuentella, J., Patel, A., Tirouvanziam, R., Reshamwala, N., … Nadeau, K. (2010). Transcription Factors as Disease Indicators in Eosinophilic Esophagitis. Presented at the 10th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, BOSTON,MA,MA,MA,MA,MA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
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Role of Fas/FasL pathway in pediatric idiopathic neutropenia
Joh, J. W., Callejas, A., Wong, W., Cohen, H. J., Nadeau, K., & Jeng, M. (2007). Role of Fas/FasL pathway in pediatric idiopathic neutropenia. BLOOD, 110(11), 966A–967A.
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Identification of specific chemokines and apoptosis molecules in pediatric idiopathic neutropenia.
Callejas, A., Nadeau, K., Bakshi, K., Wong, W., Carroll, T., Lau, K., … Jeng, M. (2006). Identification of specific chemokines and apoptosis molecules in pediatric idiopathic neutropenia. BLOOD, 108(11), 40B–40B.
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Outcomes in twelve T-B+Nk+ SCID patients treated with HSCT.
Yu, G., Nadeau, K., Berk, D., Jun, I., Tsao, G., Lewis, D., … Mort, C. (2006). Outcomes in twelve T-B+Nk+ SCID patients treated with HSCT. Presented at the 6th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, SAN FRANCISCO,CA,CA,CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
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Multi-Allergen Oral Immunotherapy Improves Quality of Life in Subjects with Food Allergies
Otani, I., Dominguez, T. L. R., Sciancalepore, A., Mehrotra, A., Pineda, D., & Nadeau, K. (2013). Multi-Allergen Oral Immunotherapy Improves Quality of Life in Subjects with Food Allergies. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(2), AB58–AB58.
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Use of a Novel Protocol to Successfully Characterize and Treat Immune-Mediated Acute Hepatitis and Liver Failure in Children
McKenzie, R., Berquist, W., Nadeau, K., Chen, S., Sibley, R., & Cox, K. (2013). Use of a Novel Protocol to Successfully Characterize and Treat Immune-Mediated Acute Hepatitis and Liver Failure in Children. Presented at the 13th American Transplant Congress (ATC), SEATTLE,WA,WA: WILEY-BLACKWELL.
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Human Basophils: New Mechanisms Of Action And Role In Food Allergy
Gernez, Y., Tirouvanziam, R., Yu, G., Reshamwala, N., Tsai, M., GALLI, S. J., … Nadeau, K. C. (2010). Human Basophils: New Mechanisms Of Action And Role In Food Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(2), AB86–AB86.
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T lymphocytes and Its Subsets in Transplanted Small Bowel Treated with Alemtuzumab (Campath-1H)
Fuentebella, J., Seki, S., Nadeau, K., & Castillo, R. O. (2009). T lymphocytes and Its Subsets in Transplanted Small Bowel Treated with Alemtuzumab (Campath-1H). Presented at the 11th International Symposium on Small Bowel Transplant, BOLOGNA,ITALY,ITALY: MEDIMOND S R L.
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Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-alpha production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1
Pedroza, L. A., Kumar, V., Sanborn, K. B., Mace, E. M., Niinikoski, H., Nadeau, K., … Orange, J. S. (2012). Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-alpha production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(2), 464–U287.
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Safety of omalizumab treatment in children (> 4 years) with high serum IgE and severe atopic dermatitis and food allergy
Iyengar, S. R., Hoyte, E. G., Loza, A., Bonaccorso, S., Umetsu, D. T., & Nadeau, K. C. (2008). Safety of omalizumab treatment in children (> 4 years) with high serum IgE and severe atopic dermatitis and food allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 121(2), S32–S32.
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Natural Regulatory T Cell Dysfunction in Subjects with Common Variable Immunodeficiency Complicated by Autoimmune Disease is associated with activation of the AkT-mTOR pathway
Yu, G. P., Berquist, S. W., Huang, J. J., Martinez, J., Hoyte, E. G., Vanichsarn, C. T., & Nadeau, K. C. (2009). Natural Regulatory T Cell Dysfunction in Subjects with Common Variable Immunodeficiency Complicated by Autoimmune Disease is associated with activation of the AkT-mTOR pathway. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 123(2), S264–S264.
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Pretreatment With Omalizumab Permits Rapid Oral Desensitization For Cow's Milk Allergy
Nadeau, K. C., Schneider, L. C., Hoyte, E., Borras, I., & Umetsu, D. T. (2011). Pretreatment With Omalizumab Permits Rapid Oral Desensitization For Cow's Milk Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(2), AB2–AB2.
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Patient and Parent Perspectives on Quality of Life during Participation in a Study of Rapid Oral Desensitization with Omalizumab Therapy in Patients with Milk Allergy
LeBovidge, J. S., Haskell, S., Borras, I., Hoyte, E., Umetsu, D. T., Nadeau, K. C., & Schneider, L. C. (2012). Patient and Parent Perspectives on Quality of Life during Participation in a Study of Rapid Oral Desensitization with Omalizumab Therapy in Patients with Milk Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(2), AB30–AB30.
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Identification of CCR9+and CD103+Dendritic Cells in Tolerance Protocols for Food Allergy
Garcia, M. A., Yu, G., Singh, A. K., Longbottom, T., & Nadeau, K. C. (2011). Identification of CCR9+and CD103+Dendritic Cells in Tolerance Protocols for Food Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(2), AB30–AB30.
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The Effects of CCR9+and CD103+Dendritic Cells on Regulatory T-cells in Food Allergy
Garcia, M. A., & Nadeau, K. (2012). The Effects of CCR9+and CD103+Dendritic Cells on Regulatory T-cells in Food Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(2), AB24–AB24.
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Molecular Mechanisms Involved in Dendritic Cell-Dependent Regulatory T Cell Generation During Immunotherapy
Garcia, M. A., & Nadeau, K. (2013). Molecular Mechanisms Involved in Dendritic Cell-Dependent Regulatory T Cell Generation During Immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(2), AB127–AB127.
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Lymphotactin improves treg function in asthmatics via the STAT5 pathway
Fohner, A., Nguyen, K., Krensky, A. M., & Nadeau, K. C. (2007). Lymphotactin improves treg function in asthmatics via the STAT5 pathway. Presented at the 7th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, SAN DIEGO,CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
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Epigenetic Modifications of Foxp3 Locus are Associated with Asthma in Children exposed to High Levels of Ambient Air Pollution
McDonald-Hyman, C., Tager, I., & Nadeau, K. (2010). Epigenetic Modifications of Foxp3 Locus are Associated with Asthma in Children exposed to High Levels of Ambient Air Pollution. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(2), AB356–AB356.
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The Effect of Polycyclic Aromatic Hydrocarbons on Aryl Hydrocarbon Receptor and DNA Methyltransferase I Transcription
Cachola, L., Liu, J., McDonald-Hyman, C., & Nadeau, K. (2011). The Effect of Polycyclic Aromatic Hydrocarbons on Aryl Hydrocarbon Receptor and DNA Methyltransferase I Transcription. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(2), AB127–AB127.
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Exposure to Polycyclic Aromatic Hydrocarbons Is Associated with Higher Levels of Total IgE, Decreased Function of T Regulatory Cells and an Increase of Asthma Occurrence in Children
Walker, A. I., Kohli, A., Syed, A., Eisen, E. A., Noth, E. M., Pratt, B., … Nadeau, K. (2013). Exposure to Polycyclic Aromatic Hydrocarbons Is Associated with Higher Levels of Total IgE, Decreased Function of T Regulatory Cells and an Increase of Asthma Occurrence in Children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(2), AB54–AB54.
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Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab
Bedoret, D., Singh, A. K., Shaw, V., Hoyte, E. G., HAMILTON, R., DeKruyff, R. H., … Umetsu, D. T. (2012). Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. MUCOSAL IMMUNOLOGY, 5(3), 267–276.
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Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-? in T effector cells and Foxp3 in T regulatory cells in children.
Kohli, A., Garcia, M. A., Miller, R. L., Maher, C., Humblet, O., Hammond, S. K., & Nadeau, K. (2012). Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-? in T effector cells and Foxp3 in T regulatory cells in children. Clinical Epigenetics, 4(1), 17-?
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Differentiating the roles of STAT5B and STAT5A in human CD4(+) T cells
Jenks, J. A., Seki, S., Kanai, T., Huang, J., Morgan, A. A., Scalco, R. C., … Nadeau, K. C. (2013). Differentiating the roles of STAT5B and STAT5A in human CD4(+) T cells. CLINICAL IMMUNOLOGY, 148(2), 227–36.
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Efficacy of Oral Immunotherapy and Anti-IgE Antibody-Adjunctive Treatment in Patients with Multiple Food Allergies
Dominguez, T. L. R., Wilson, S. P., Sciancalepore, A., Pineda, D., Mehrotra, A., Rubinstein, S. W., … Nadeau, K. (2013). Efficacy of Oral Immunotherapy and Anti-IgE Antibody-Adjunctive Treatment in Patients with Multiple Food Allergies. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(2), AB93–AB93.
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Bystander Suppression in Food Allergy
Motosue, M. S., Dominquez, T., Sciancalepore, A., Pineda, D., Mehrotra, A., Hoyte, L., & Nadeau, K. (2013). Bystander Suppression in Food Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(2), AB92–AB92.
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Immunologic Effects of Omalizumab in Children with Severe Refractory Atopic Dermatitis: A Randomized, Placebo-Controlled Clinical Trial
Iyengar, S. R., Hoyte, E. G., Loza, A., Bonaccorso, S., Chiang, D., Umetsu, D. T., & Nadeau, K. C. (2013). Immunologic Effects of Omalizumab in Children with Severe Refractory Atopic Dermatitis: A Randomized, Placebo-Controlled Clinical Trial. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 162(1), 89–93.
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The Impact of Food Allergies on Quality of Life
Bacal, L. R., & Nadeau, K. C. (2013). The Impact of Food Allergies on Quality of Life. PEDIATRIC ANNALS, 42(7), 141–45.
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Food allergy diagnosis and therapy: where are we now?
Syed, A., Kohli, A., & Nadeau, K. C. (2013). Food allergy diagnosis and therapy: where are we now? IMMUNOTHERAPY, 5(9), 931–944.
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Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-gamma in T effector cells and Foxp3 in T regulatory cells in children
Kohli, A., Garcia, M. A., Miller, R. L., Maher, C., Humblet, O., Hammond, S. K., & Nadeau, K. (2012). Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-gamma in T effector cells and Foxp3 in T regulatory cells in children. CLINICAL EPIGENETICS, 4.
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Identification of STAT5A and STAT5B target genes in human T cells.
Kanai, T., Seki, S., Jenks, J. A., Kohli, A., Kawli, T., Martin, D. P., … Nadeau, K. C. (2014). Identification of STAT5A and STAT5B target genes in human T cells. PloS One, 9(1).
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Safety and feasibility of oral immunotherapy to multiple allergens for food allergy.
Bégin, P., Winterroth, L. C., Dominguez, T., Wilson, S. P., Bacal, L., Mehrotra, A., … Nadeau, K. C. (2014). Safety and feasibility of oral immunotherapy to multiple allergens for food allergy. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 10(1), 1-?
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Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab.
Bégin, P., Dominguez, T., Wilson, S. P., Bacal, L., Mehrotra, A., Kausch, B., … Nadeau, K. C. (2014). Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 10(1), 7-?
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Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).
Syed, A., Garcia, M. A., Lyu, S.-C., Bucayu, R., Kohli, A., Ishida, S., … Nadeau, K. C. (2014). Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). Journal of Allergy and Clinical Immunology, 133(2), 500–510.
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Introduction to the special issue on Stanford Immunology.
Jones, P. P., & Nadeau, K. C. (2014). Introduction to the special issue on Stanford Immunology. Immunologic Research, 58(2-3), 161–63.
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Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects.
Otani, I. M., Bégin, P., Kearney, C., Dominguez, T. L. R., Mehrotra, A., Bacal, L. R., … Nadeau, K. (2014). Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 10(1), 25-?
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Regulatory T cells and their roles in immune dysregulation and allergy.
Pellerin, L., Jenks, J. A., Bégin, P., Bacchetta, R., & Nadeau, K. C. (2014). Regulatory T cells and their roles in immune dysregulation and allergy. Immunologic Research, 58(2-3), 358–68.
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Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma.
Klingbeil, E. C., Hew, K. M., Nygaard, U. C., & Nadeau, K. C. (2014). Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma. Immunologic Research, 58(2-3), 369–373.
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Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias
Chen, R., Giliani, S., Lanzi, G., Mias, G. I., Lonardi, S., Dobbs, K., … Notarangelo, L. D. (2013). Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(3), 656-?
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Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice.
Reber, L. L., Marichal, T., Mukai, K., Kita, Y., Tokuoka, S. M., Roers, A., … Galli, S. J. (2013). Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. Journal of Allergy and Clinical Immunology, 132(4), 881–88 e11.
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Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab.
Bégin, P., Dominguez, T., Wilson, S. P., Bacal, L., Mehrotra, A., Kausch, B., … Nadeau, K. C. (2014). Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 10(1), 7-?
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Safety and feasibility of oral immunotherapy to multiple allergens for food allergy.
Bégin, P., Winterroth, L. C., Dominguez, T., Wilson, S. P., Bacal, L., Mehrotra, A., … Nadeau, K. C. (2014). Safety and feasibility of oral immunotherapy to multiple allergens for food allergy. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 10(1), 1-?
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Identification of STAT5A and STAT5B Target Genes in Human T Cells.
Kanai, T., Seki, S., Jenks, J. A., Kohli, A., Kawli, T., Martin, D. P., … Nadeau, K. C. (2014). Identification of STAT5A and STAT5B Target Genes in Human T Cells. PloS One, 9(1).
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Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects.
Otani, I. M., Bégin, P., Kearney, C., Dominguez, T. L. R., Mehrotra, A., Bacal, L. R., … Nadeau, K. (2014). Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 10(1), 25-?
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Novel protocol including liver biopsy to identify and treat CD8+ T-cell predominant acute hepatitis and liver failure.
McKenzie, R. B., Berquist, W. E., Nadeau, K. C., Louie, C. Y., Chen, S. F., Sibley, R. K., … Cox, K. L. (2014). Novel protocol including liver biopsy to identify and treat CD8+ T-cell predominant acute hepatitis and liver failure. Pediatric Transplantation, 18(5), 503–9.
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Ambient polycyclic aromatic hydrocarbons and pulmonary function in children
Padula, A. M., Balmes, J. R., Eisen, E. A., Mann, J., Noth, E. M., Lurmann, F. W., … Hammond, S. K. (2015). Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 25(3), 295–302.
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Long-term Sinonasal Outcomes of Aspirin Desensitization in Aspirin Exacerbated Respiratory Disease
Cho, K.-S., Soudry, E., Psaltis, A. J., Nadeau, K. C., McGhee, S. A., Nayak, J. V., & Hwang, P. H. (2014). Long-term Sinonasal Outcomes of Aspirin Desensitization in Aspirin Exacerbated Respiratory Disease. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 151(4), 575–81.
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Lessons learned from mice and man: Mimicking human allergy through mouse models
Graham, M. T., & Nadeau, K. C. (2014). Lessons learned from mice and man: Mimicking human allergy through mouse models. CLINICAL IMMUNOLOGY, 155(1), 1–16.
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Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis
Alexander, E. S., Martin, L. J., Collins, M. H., Kottyan, L. C., Sucharew, H., He, H., … Rothenberg, M. E. (2014). Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 134(5), 1084-?
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Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss.
Haraksingh, R. R., Jahanbani, F., Rodriguez-Paris, J., Gelernter, J., Nadeau, K. C., Oghalai, J. S., … Snyder, M. P. (2014). Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss. BMC Genomics, 15, 1155-?
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Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
Arasi, S., Otani, I. M., Klingbeil, E., Begin, P., Kearney, C., Dominguez, T. L. R., … Nadeau, K. C. (2014). Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 10.
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Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells.
Hew, K. M., WALKER, A. I., Kohli, A., Garcia, M., Syed, A., McDonald-Hyman, C., … Nadeau, K. C. (2015). Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clinical and Experimental Allergy , 45(1), 238–248.
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Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis.
Rothenberg, M. E., Wen, T., Greenberg, A., Alpan, O., Enav, B., Hirano, I., … Gunawardena, K. A. (2015). Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. Journal of Allergy and Clinical Immunology, 135(2), 500–507.
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The future of biologics: Applications for food allergy
Bauer, R. N., Manohar, M., Singh, A. M., Jay, D. C., & Nadeau, K. C. (2015). The future of biologics: Applications for food allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(2), 312–23.
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Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.
Hong, X., Hao, K., Ladd-Acosta, C., Hansen, K. D., Tsai, H.-J., Liu, X., … Wang, X. (2015). Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nature Communications, 6, 6304-?
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In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort
Nadeau, K. C., Li, Z., Farzan, S., Koestler, D., Robbins, D., Fei, D. L., … Karagas, M. R. (2014). In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. CLINICAL IMMUNOLOGY, 155(2), 188–97.
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Immune Mechanisms of Sublingual Immunotherapy
Jay, D. C., & Nadeau, K. C. (2014). Immune Mechanisms of Sublingual Immunotherapy. CURRENT ALLERGY AND ASTHMA REPORTS, 14(11).
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The Use of Epinephrine in Acute Allergic Reaction to Food
Dominguez, T. L. R., Begin, P., & Nadeau, K. C. (2013). The Use of Epinephrine in Acute Allergic Reaction to Food. PEDIATRIC ANNALS, 42(7), 293–295.
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Diagnosis of Food Allergy
Begin, P., & Nadeau, K. C. (2013). Diagnosis of Food Allergy. PEDIATRIC ANNALS, 42(6), 102–109.
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Epigenetic regulation of asthma and allergic disease
Begin, P., & Nadeau, K. C. (2014). Epigenetic regulation of asthma and allergic disease. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 10.
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Ambient air pollution impairs regulatory T-cell function in asthma
Nadeau, K., McDonald-Hyman, C., Noth, E. M., Pratt, B., Hammond, S. K., Balmes, J., & Tager, I. (2010). Ambient air pollution impairs regulatory T-cell function in asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 126(4), 845–U280.
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B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
Recher, M., Burns, S. O., de la Fuente, M. A., Volpi, S., Dahlberg, C., Walter, J. E., … Notarangelo, L. D. (2012). B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. BLOOD, 119(12), 2819–28.
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STAT5b deficiency: Lessons from STAT5b gene mutations
Hwa, V., Nadeau, K., Wit, J. M., & Rosenfeld, R. G. (2011). STAT5b deficiency: Lessons from STAT5b gene mutations. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 25(1), 61–75.
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STAT5b Deficiency: An Unsuspected Cause of Growth Failure, Immunodeficiency, and Severe Pulmonary Disease
Nadeau, K., Hwa, V., & Rosenfeld, R. G. (2011). STAT5b Deficiency: An Unsuspected Cause of Growth Failure, Immunodeficiency, and Severe Pulmonary Disease. JOURNAL OF PEDIATRICS, 158(5), 701–708.
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Food allergy: A practice parameter update-2014
Sampson, H. A., Aceves, S., Bock, S. A., James, J., Jones, S., Lang, D., … Wood, R. (2014). Food allergy: A practice parameter update-2014. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 134(5), 1016-?
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Monozygotic Twin Pair Showing Discordant Phenotype for X-linked Thrombocytopenia and Wiskott-Aldrich Syndrome: a Role for Epigenetics?
Buchbinder, D., Nadeau, K., & Nugent, D. (2011). Monozygotic Twin Pair Showing Discordant Phenotype for X-linked Thrombocytopenia and Wiskott-Aldrich Syndrome: a Role for Epigenetics? JOURNAL OF CLINICAL IMMUNOLOGY, 31(5), 773–777.
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The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook
Pajno, G. B., Nadeau, K. C., Passalacqua, G., Caminiti, L., Hobson, B., Jay, D. C., … Salzano, G. (2015). The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 11(1), 141–154.
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Oral immunotherapy for the treatment of food allergy
Begin, P., Chinthrajah, R. S., & Nadeau, K. C. (2014). Oral immunotherapy for the treatment of food allergy. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 10(8), 2295–2302.
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PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.
Mathieu, A.-L., Verronese, E., Rice, G. I., Fouyssac, F., Bertrand, Y., Picard, C., … Belot, A. (2015). PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. Journal of Allergy and Clinical Immunology, 135(6), 1578–88 e5.
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In utero arsenic exposure and infant infection in a United States cohort: A prospective study
Farzan, S. F., Korrick, S., Li, Z., Enelow, R., Gandolfi, A. J., Madan, J., … Karagas, M. R. (2013). In utero arsenic exposure and infant infection in a United States cohort: A prospective study. ENVIRONMENTAL RESEARCH, 126, 24–30.
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Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases.
Sabounchi, S., Bollyky, J., & Nadeau, K. (2015). Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases. Current Allergy and Asthma Reports, 15(6), 33-?
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Single B-cell deconvolution of peanut-specific antibody responses in allergic patients
Hoh, R. A., Joshi, S. A., Liu, Y., Wang, C., Roskin, K. M., Lee, J.-Y., … Boyd, S. D. (2016). Single B-cell deconvolution of peanut-specific antibody responses in allergic patients. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(1), 157–67.
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GWAS identifies four novel eosinophilic esophagitis loci
Sleiman, P. M. A., Wang, M.-L., Cianferoni, A., Aceves, S., Gonsalves, N., Nadeau, K., … Hakonarson, H. (2014). GWAS identifies four novel eosinophilic esophagitis loci. NATURE COMMUNICATIONS, 5.
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Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).
Syed, A., Garcia, M. A., Lyu, S.-C., Bucayu, R., Kohli, A., Ishida, S., … Nadeau, K. C. (2014). Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). Journal of Allergy and Clinical Immunology, 133(2), 500–510 e11.
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PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity
Mathieu, A.-L., Verronese, E., Rice, G. I., Fouyssac, F., Bertrand, Y., Picard, C., … Belot, A. (2015). PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(6), 1578–U294.
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Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children
Hong, X., Hao, K., Ladd-Acosta, C., Hansen, K. D., Tsai, H.-J., Liu, X., … Wang, X. (2015). Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. NATURE COMMUNICATIONS, 6.
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IgH sequences in common variable immune deficiency reveal altered B cell development and selection.
Roskin, K. M., Simchoni, N., Liu, Y., Lee, J.-Y., Seo, K., Hoh, R. A., … Boyd, S. D. (2015). IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Science Translational Medicine, 7(302), 302ra135-?
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Long-term sinonasal outcomes of aspirin desensitization in aspirin exacerbated respiratory disease.
Cho, K.-S., Soudry, E., Psaltis, A. J., Nadeau, K. C., McGhee, S. A., Nayak, J. V., & Hwang, P. H. (2014). Long-term sinonasal outcomes of aspirin desensitization in aspirin exacerbated respiratory disease. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 151(4), 575–81.
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The future of biologics: applications for food allergy.
Bauer, R. N., Manohar, M., Singh, A. M., Jay, D. C., & Nadeau, K. C. (2015). The future of biologics: applications for food allergy. Journal of Allergy and Clinical Immunology, 135(2), 312–23.
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Abdominal and general adiposity and level of asthma control in adults with uncontrolled asthma.
Lv, N., Xiao, L., Camargo, C. A., Wilson, S. R., Buist, A. S., Strub, P., … Ma, J. (2014). Abdominal and general adiposity and level of asthma control in adults with uncontrolled asthma. Annals of the American Thoracic Society, 11(8), 1218–1224.
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Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency
Walter, J. E., Rosen, L. B., Csomos, K., Rosenberg, J. M., Mathew, D., Keszei, M., … Notarangelo, L. D. (2015). Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. JOURNAL OF CLINICAL INVESTIGATION, 125(11), 4135–48.
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The Potential of Anti-IgE in Food Allergy Therapy.
Manohar, M., & Nadeau, K. C. (2014). The Potential of Anti-IgE in Food Allergy Therapy. Current Treatment Options in Allergy, 1(2), 145–56.
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The STAT5b pathway defect and autoimmunity
Kanai, T., Jenks, J., & Nadeau, K. C. (2012). The STAT5b pathway defect and autoimmunity. FRONTIERS IN IMMUNOLOGY, 3.
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Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma
Ma, J., Strub, P., Lv, N., Xiao, L., Camargo, C. A., Buist, A. S., … Rosas, L. G. (2016). Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma. EUROPEAN RESPIRATORY JOURNAL, 47(1), 122–32.
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IgH sequences in common variable immune deficiency reveal altered B cell development and selection.
Roskin, K. M., Simchoni, N., Liu, Y., Lee, J.-Y., Seo, K., Hoh, R. A., … Boyd, S. D. (2015). IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Science Translational Medicine, 7(302), 302ra135-?
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Future Research Directions in Asthma An NHLBI Working Group Report
Levy, B. D., Noel, P. J., Freemer, M. M., Cloutier, M. M., Georas, S. N., Jarjour, N. N., … Erzurum, S. C. (2015). Future Research Directions in Asthma An NHLBI Working Group Report. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 192(11), 1366–72.
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Gut Microbiome and the Development of Food Allergy and Allergic Disease
Prince, B. T., Mandel, M. J., Nadeau, K., & Singh, A. M. (2015). Gut Microbiome and the Development of Food Allergy and Allergic Disease. PEDIATRIC CLINICS OF NORTH AMERICA, 62(6), 1479-?
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The role of epigenetic mediation and the future of food allergy research
Quake, C., & Nadeau, K. C. (2015). The role of epigenetic mediation and the future of food allergy research. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 43, 125–30.
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Diagnosis of Food Allergy
Chinthrajah, R. S., Tupa, D., Prince, B. T., Block, W. M., Rosa, J. S., Singh, A. M., & Nadeau, K. (2015). Diagnosis of Food Allergy. PEDIATRIC CLINICS OF NORTH AMERICA, 62(6), 1393-?
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Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases
Sabounchi, S., Bollyky, J., & Nadeau, K. (2015). Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases. CURRENT ALLERGY AND ASTHMA REPORTS, 15(6).
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Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets.
Ryan, J. F., Hovde, R., Glanville, J., Lyu, S.-C., Ji, X., Gupta, S., … Nadeau, K. C. (2016). Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets. Proceedings of the National Academy of Sciences of the United States of America, 113(9), E1286–95.
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Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss
Haraksingh, R. R., Jahanbani, F., Rodriguez-Paris, J., Gelernter, J., Nadeau, K. C., Oghalai, J. S., … Snyder, M. P. (2014). Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss. BMC GENOMICS, 15.
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Personal exposure to airborne particulate matter due to residential dryer lint cleaning
Cheng, K.-C., Zheng, D., Tetteh, A. O., Park, H.-K., Nadeau, K. C., & Hildemann, L. M. (2016). Personal exposure to airborne particulate matter due to residential dryer lint cleaning. BUILDING AND ENVIRONMENT, 98, 145–149.
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Molecular and cellular mechanisms of food allergy and food tolerance.
Chinthrajah, R. S., Hernandez, J. D., Boyd, S. D., Galli, S. J., & Nadeau, K. C. (2016). Molecular and cellular mechanisms of food allergy and food tolerance. Journal of Allergy and Clinical Immunology, 137(4), 984–97.
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Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
Pennington, L. F., Tarchevskaya, S., Brigger, D., Sathiyamoorthy, K., Graham, M. T., Nadeau, K. C., … Jardetzky, T. S. (2016). Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. NATURE COMMUNICATIONS, 7.
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Giant magnetoresistive sensor array for sensitive and specific multiplexed food allergen detection
Ng, E., Nadeau, K. C., & Wang, S. X. (2016). Giant magnetoresistive sensor array for sensitive and specific multiplexed food allergen detection. BIOSENSORS & BIOELECTRONICS, 80, 359–65.
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T-Cell Immunophenotyping of Second-Hand Smoke-related Asthma.
Bauer, R. N., Chinthrajah, R. S., Andorf, S., Hobson, B., Miller, R. L., & Nadeau, K. C. (2016). T-Cell Immunophenotyping of Second-Hand Smoke-related Asthma. Annals of the American Thoracic Society, 13, S95-?
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Giant magnetoresistive sensor array for sensitive and specific multiplexed food allergen detection.
Ng, E., Nadeau, K. C., & Wang, S. X. (2016). Giant magnetoresistive sensor array for sensitive and specific multiplexed food allergen detection. Biosensors & Bioelectronics, 80, 359–65.
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Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region.
Bégin, P., Schulze, J., Baron, U., Olek, S., Bauer, R. N., Passerini, L., … Nadeau, K. C. (2015). Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region. Clinical and Translational Allergy, 5, 35-?
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Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance.
Gebe, J. A., Yadava, K., Ruppert, S. M., Marshall, P., Hill, P., Falk, B. A., … Bollyky, P. L. (2016). Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. American Journal of Respiratory Cell and Molecular Biology, -?
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Mixing and sink effects of air purifiers on indoor PM2.5 concentrations: A pilot study of eight residential homes in Fresno, California
Cheng, K.-C., Park, H.-K., Tetteh, A. O., Zheng, D., Ouellette, N. T., Nadeau, K. C., & Hildemann, L. M. (2016). Mixing and sink effects of air purifiers on indoor PM2.5 concentrations: A pilot study of eight residential homes in Fresno, California. AEROSOL SCIENCE AND TECHNOLOGY, 50(8), 835–45.
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Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a US Cohort
Farzan, S. F., Li, Z., Korrick, S. A., Spiegelman, D., Enelow, R., Nadeau, K., … Karagas, M. R. (2016). Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a US Cohort. ENVIRONMENTAL HEALTH PERSPECTIVES, 124(6), 840–847.
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Identification and Characterization of a New Pecan [Carya illinoinensis (Wangenh.) K. Koch] Allergen, Car i 2
Zhang, Y., Lee, B., Du, W.-X., Lyu, S.-C., Nadeau, K. C., Grauke, L. J., … McHugh, T. H. (2016). Identification and Characterization of a New Pecan [Carya illinoinensis (Wangenh.) K. Koch] Allergen, Car i 2. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64(20), 4146–51.
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A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy
Wood, R. A., Kim, J. S., Lindblad, R., Nadeau, K., Henning, A. K., Dawson, P., … Sampson, H. A. (2016). A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(4), 1103-?
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Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis.
Mukai, K., Gaudenzio, N., Gupta, S., Vivanco, N., Bendall, S. C., Maecker, H. T., … Galli, S. J. (2016). Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis. Journal of Allergy and Clinical Immunology.
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Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review.
Dhami, S., Nurmatov, U., Pajno, G. B., Fernandez-Rivas, M., Muraro, A., Roberts, G., … Sheikh, A. (2016). Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review. Clinical and Translational Allergy, 6, 24-?
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Epoprostenol-associated pneumonitis: Diagnostic use of a T-cell proliferation assay
Kudelko, K. T., Nadeau, K., Leung, A. N., Liu, J., Haddad, F., Zamanian, R. T., & Perez, V. D. J. (2010). Epoprostenol-associated pneumonitis: Diagnostic use of a T-cell proliferation assay. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 29(9), 1071–75.
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Advances in food allergy oral immunotherapy: toward tolerance.
Hussey Freeland, D. M., Fan-Minogue, H., Spergel, J. M., Chatila, T. A., & Nadeau, K. C. (2016). Advances in food allergy oral immunotherapy: toward tolerance. Current Opinion in Immunology, 42, 119–23.
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Temporal Regulation by Innate Type 2 Cytokines in Food Allergies.
Graham, M. T., Andorf, S., Spergel, J. M., Chatila, T. A., & Nadeau, K. C. (2016). Temporal Regulation by Innate Type 2 Cytokines in Food Allergies. Current Allergy and Asthma Reports, 16(10), 75-?
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Food allergy: immune mechanisms, diagnosis and immunotherapy
Yu, W., Freeland, D. M. H., & Nadeau, K. C. (2016). Food allergy: immune mechanisms, diagnosis and immunotherapy. NATURE REVIEWS IMMUNOLOGY, 16(12), 751–65.
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Omalizumab facilitates rapid oral desensitization for peanut allergy.
MacGinnitie, A. J., Rachid, R., Gragg, H., Little, S. V., Lakin, P., Cianferoni, A., … Schneider, L. C. (2017). Omalizumab facilitates rapid oral desensitization for peanut allergy. Journal of Allergy and Clinical Immunology, 139(3), 873–881 e8.
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Effectiveness of air purifier on health outcomes and indoor particles in homes of children with allergic diseases in Fresno, California: A pilot study.
Park, H.-K., Cheng, K.-C., Tetteh, A. O., Hildemann, L. M., & Nadeau, K. C. (2016). Effectiveness of air purifier on health outcomes and indoor particles in homes of children with allergic diseases in Fresno, California: A pilot study. Journal of Asthma , 1–6.
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Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.
Walter, J. E., Rosen, L. B., Csomos, K., Rosenberg, J. M., Mathew, D., Keszei, M., … Notarangelo, L. D. (2016). Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. Journal of Clinical Investigation, 126(11), 4389-?
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Epigenetic Changes During Food-Specific Immunotherapy.
Bunning, B. J., DeKruyff, R. H., & Nadeau, K. C. (2016). Epigenetic Changes During Food-Specific Immunotherapy. Current Allergy and Asthma Reports, 16(12), 87-?
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Purification and Characterization of a Black Walnut (Juglans nigra) Allergen, Jug n 4
Zhang, Y.-Z., Du, W.-X., Fan, Y., Yi, J., Lyu, S.-C., Nadeau, K. C., … McHugh, T. (2017). Purification and Characterization of a Black Walnut (Juglans nigra) Allergen, Jug n 4. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65(2), 454–62.
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Use of Specific IgE and Skin Prick Test to Determine Clinical Reaction Severity.
Ta, V., Weldon, B., Yu, G., Humblet, O., Neale-May, S., & Nadeau, K. (2011). Use of Specific IgE and Skin Prick Test to Determine Clinical Reaction Severity. British Journal of Medicine and Medical Research, 1(4), 410–429.
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Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance
Gebe, J. A., Yadava, K., Ruppert, S. M., Marshall, P., Hill, P., Falk, B. A., … Bollyky, P. L. (2017). Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 56(1), 109–20.
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Advances in food allergy oral immunotherapy: toward tolerance
Freeland, D. M. H., Fan-Minogue, H., Spergel, J. M., Chatila, T. A., & Nadeau, K. C. (2016). Advances in food allergy oral immunotherapy: toward tolerance. CURRENT OPINION IN IMMUNOLOGY, 42, 119–23.
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Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2
Zhang, Y., Du, W.-X., Fan, Y., Yi, J., Lyu, S.-C., Nadeau, K. C., & McHugh, T. H. (2016). Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2. FOOD RESEARCH INTERNATIONAL, 90, 268–274.
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Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region
Begin, P., Schulze, J., Baron, U., Olek, S., Bauer, R. N., Passerini, L., … Nadeau, K. C. (2015). Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region. CLINICAL AND TRANSLATIONAL ALLERGY, 5.
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Deciphering the black box of food allergy mechanisms.
Sampath, V., Tupa, D., Graham, M. T., Chatila, T. A., Spergel, J. M., & Nadeau, K. C. (2017). Deciphering the black box of food allergy mechanisms. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 118(1), 21–27.
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Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis.
Nurmatov, U., Dhami, S., Arasi, S., Pajno, G. B., Fernandez-Rivas, M., Muraro, A., … Sheikh, A. (2017). Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy.
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Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis
Mukai, K., Gaudenzio, N., Gupta, S., Vivanco, N., Bendall, S. C., Maecker, H. T., … Galli, S. J. (2017). Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(3), 889-?
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Omalizumab facilitates rapid oral desensitization for peanut allergy
MacGinnitie, A. J., Rachid, R., Gragg, H., Little, S. V., Lakin, P., Cianferoni, A., … Schneider, L. C. (2017). Omalizumab facilitates rapid oral desensitization for peanut allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(3), 873-?
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Effectiveness of air purifier on health outcomes and indoor particles in homes of children with allergic diseases in Fresno, California: A pilot study
Park, H.-K., Cheng, K.-C., Tetteh, A. O., Hildemann, L. M., & Nadeau, K. C. (2017). Effectiveness of air purifier on health outcomes and indoor particles in homes of children with allergic diseases in Fresno, California: A pilot study. JOURNAL OF ASTHMA, 54(4), 341–46.
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Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study.
Lee, E. Y., Lin, J., Noth, E. M., Hammond, S. K., Nadeau, K. C., Eisen, E. A., & Balmes, J. R. (2017). Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study. Journal of Occupational and Environmental Medicine, 59(5), 446–52.
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Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis
Otani, I. M., & Nadeau, K. C. (2017). Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 37(2), 369-?
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Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group
Breton, C. V., Marsit, C. J., Faustman, E., Nadeau, K., Goodrich, J. M., Dolinoy, D. C., … Murphy, S. K. (2017). Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. ENVIRONMENTAL HEALTH PERSPECTIVES, 125(4), 511–26.
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Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge
Ahuja, S. K., Manoharan, M. S., Harper, N. L., Jimenez, F., Hobson, B. D., Martinez, H., … He, W. (2017). Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(3), 844–54.
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Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children.
Andorf, S., Borres, M. P., Block, W., Tupa, D., Bollyky, J. B., Sampath, V., … Nadeau, K. C. (2017). Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children. Journal of Allergy and Clinical Immunology. In Practice.
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Food allergy and omics.
Dhondalay, G. K., Rael, E., Acharya, S., Zhang, W., Sampath, V., Galli, S. J., … Andorf, S. (2018). Food allergy and omics. The Journal of Allergy and Clinical Immunology, 141(1), 20–29.
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Immune monitoring for precision medicine in allergy and asthma.
Boyd, S. D., Hoh, R. A., Nadeau, K. C., & Galli, S. J. (2017). Immune monitoring for precision medicine in allergy and asthma. Current Opinion in Immunology, 48, 82–91.
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Stat5b (Signal Transducer and Activator of Transcription 5b), Not Stat5a, Is a Critical Modulator of Human Treg Development and Function
Jenks, J., Seki, S., Huang, J., Nath, R., Madmedov, M., Hwa, V., … Nadeau, K. C. (2012). Stat5b (Signal Transducer and Activator of Transcription 5b), Not Stat5a, Is a Critical Modulator of Human Treg Development and Function. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(2), AB10–AB10.
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USE OF A NOVEL PROTOCOL TO SUCCESSFULLY CHARACTERIZE AND TREAT IMMUNE-MEDIATED ACUTE HEPATITIS AND LIVER FAILURE IN CHILDREN
McKenzie, R. B., Berquist, W., Esquivel, C., Nadeau, K., Chen, S., Sibley, R., & Cox, K. (2013). USE OF A NOVEL PROTOCOL TO SUCCESSFULLY CHARACTERIZE AND TREAT IMMUNE-MEDIATED ACUTE HEPATITIS AND LIVER FAILURE IN CHILDREN. PEDIATRIC TRANSPLANTATION, 17, 52.
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Decreased generation and function of CD4+CD25(hi) T regulatory cells in human STAT5b deficiency.
Cleary, A., Nadeau, K., Tu, W. W., Hwa, Dionis, K. Y., Bezrodnik, L., … Lewis, D. B. (2005). Decreased generation and function of CD4+CD25(hi) T regulatory cells in human STAT5b deficiency. BLOOD, 106(11), 227A.
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Decreased generation and function of CD4+CD25(hi) T regulatory cells in human STAT5b deficiency.
Cohen, A., Nadeau, K., Tu, W., Hwa, V., Dionis, K., Bezrodnik, L., … Lewis, D. (2006). Decreased generation and function of CD4+CD25(hi) T regulatory cells in human STAT5b deficiency. CLINICAL IMMUNOLOGY, 119, S135.
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Enhanced Expression of CD66b on Peripheral Blood Granulocytes in Eosinophilic Esophagitis
Nguyen, T., Gernez, Y., Fuentebella, J., Patel, A., Herzenberg, L., Tirouvanziam, R., & Nadeau, K. (2009). Enhanced Expression of CD66b on Peripheral Blood Granulocytes in Eosinophilic Esophagitis. CLINICAL IMMUNOLOGY, 131, S120–S121.
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Safety and feasibility of oral immunotherapy to multiple allergens for food allergy (vol 10, 1, 2014)
Begin, P., Winterroth, L. C., Dominguez, T., Wilson, S. P., Bacal, L., Mehrotra, A., … Nadeau, K. C. (2016). Safety and feasibility of oral immunotherapy to multiple allergens for food allergy (vol 10, 1, 2014). ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 12, 28.
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Combining anti-IgE with oral immunotherapy
Lin, C., Lee, I. T., Sampath, V., Dinakar, C., DeKruyff, R. H., Schneider, L. C., & Nadeau, K. C. (2017). Combining anti-IgE with oral immunotherapy. PEDIATRIC ALLERGY AND IMMUNOLOGY, 28(7), 619–27.
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Isotype-specific agglutination-PCR (ISAP): Asensitive and multiplex method for measuring allergen-specific IgE.
Tsai, C.-T., Mukai, K., Robinson, P. V., Gray, M. A., Waschmann, M. B., Lyu, S.-C., … Galli, S. J. (2018). Isotype-specific agglutination-PCR (ISAP): Asensitive and multiplex method for measuring allergen-specific IgE. The Journal of Allergy and Clinical Immunology, 141(5), 1901.
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High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma.
Chinthrajah, R. S., Purington, N., Sampath, V., Andorf, S., Manohar, M., Prunicki, M., … Nadeau, K. C. (2018). High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology.
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Development of a tool predicting severity of allergic reaction during peanut challenge.
Chinthrajah, R. S., Purington, N., Andorf, S., Rosa, J. S., Mukai, K., Hamilton, R., … Nadeau, K. C. (2018). Development of a tool predicting severity of allergic reaction during peanut challenge. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology.
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Impact of allergen immunotherapy in allergic asthma.
Zhang, W., Lin, C., Sampath, V., & Nadeau, K. (2018). Impact of allergen immunotherapy in allergic asthma. Immunotherapy.
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The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses.
Sindher, S. B., Long, A., Acharya, S., Sampath, V., & Nadeau, K. C. (2018). The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses. Clinical Reviews in Allergy & Immunology.
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Socioeconomic Variables Associated with Immune Biomarkers in Asthmatic Children
Nyarko-Odoom, A. O., Prunicki, M., Zhang, W., Zhou, X., & Nadeau, K. C. (2018). Socioeconomic Variables Associated with Immune Biomarkers in Asthmatic Children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(2), AB74.
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Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial
Andorf, S., Purington, N., Block, W. M., Long, A. J., Tupa, D., Brittain, E., … Chinthrajah, R. S. (2018). Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial. LANCET GASTROENTEROLOGY & HEPATOLOGY, 3(2), 85–94.
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Basophil surface expressions of CD203c and CD63 following peanut allergen ex vivo stimulation correlate with severity of allergic reactions during food challenge
Rosa, J., Chinthrajah, R., Dominguez, T., Brock, E., & Nadeau, K. (2015). Basophil surface expressions of CD203c and CD63 following peanut allergen ex vivo stimulation correlate with severity of allergic reactions during food challenge. JOURNAL OF IMMUNOLOGY, 194.
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Single-Cell Signatures Link Ambient Air Pollution to Remodeling of the Immune System in Asthmatics
Fan-Minogue, H., Hew, K., Lyu, S.-C., Nygaard, U., Lurmann, F., Noth, E., … Nadeau, K. (2017). Single-Cell Signatures Link Ambient Air Pollution to Remodeling of the Immune System in Asthmatics. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB184.
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Changes in peanut-specific T-cell clonotype with oral immunotherapy
Begin, P., & Nadeau, K. C. (2015). Changes in peanut-specific T-cell clonotype with oral immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(6), 1636–38.
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A Randomized, Double-Blind, Placebo-Controlled Trial of Omalizumab Combined with Oral Immunotherapy (OIT) in the Treatment of Cow's Milk Allergy (CMA): Safety of Dosing
Kim, J. S., Wood, R. A., Lindblad, R., Noone, S. A., Paterakis, M. N., Henning, A., … Sampson, H. A. (2014). A Randomized, Double-Blind, Placebo-Controlled Trial of Omalizumab Combined with Oral Immunotherapy (OIT) in the Treatment of Cow's Milk Allergy (CMA): Safety of Dosing. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133(2), AB403.
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Epigenetic Changes in Immune Cells Following Successful Desensitization with Multi-Food Allergen Oral Immunotherapy
Chinthrajah, S., Andorf, S., Manohar, M., Maecker, H., Tsai, M., Galli, S., & Nadeau, K. (2018). Epigenetic Changes in Immune Cells Following Successful Desensitization with Multi-Food Allergen Oral Immunotherapy. JOURNAL OF CLINICAL IMMUNOLOGY, 38(3), 358–59.
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Efficacy and Safety of Long-Term Epicutaneous Immunotherapy (EPIT) Treatment of Peanut Allergy with Viaskin (R) peanut: Results of the Two-Year Extension of the Vipes Phase IIb Clinical Trial
Shreffler, W. G., Nadeau, K. C., Leonard, S. A., Sussman, G. L., & Sampson, H. A. (2017). Efficacy and Safety of Long-Term Epicutaneous Immunotherapy (EPIT) Treatment of Peanut Allergy with Viaskin (R) peanut: Results of the Two-Year Extension of the Vipes Phase IIb Clinical Trial. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB377.
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Trends in Adverse Reactions Requiring Epinephrine in the Build-up Phase of Oral Immunotherapy
Noshirvan, A., Petroni, D. H., Tsai, M., Galli, S. J., Chinthrajah, R. S., & Nadeau, K. C. (2016). Trends in Adverse Reactions Requiring Epinephrine in the Build-up Phase of Oral Immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB131.
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Immunotolerance Mechanisms Depend On High Vs Low Dose of Sublingual Immunotherapy
Nadeau, K., & Vissamsetti, S. (2013). Immunotolerance Mechanisms Depend On High Vs Low Dose of Sublingual Immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(2), AB196.
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Selective Deregulation in Chemokine Signaling Pathways of CD4+CD25hiCD127lo/-Regulatory T Cells in Human Allergic Asthma
Nguyen, K., & Nadeau, K. (2009). Selective Deregulation in Chemokine Signaling Pathways of CD4+CD25hiCD127lo/-Regulatory T Cells in Human Allergic Asthma. CLINICAL IMMUNOLOGY, 131, S7.
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Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures
Nygaard, U. C., Li, Z., Palys, T., Jackson, B., Subbiah, M., Malipatlolla, M., … Nadeau, K. C. (2017). Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures. PLOS ONE, 12(6), e0179606.
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Long-Term Follow-up of Oral Immunotherapy for Multiple Food Allergies
Singh, S., Kshirsagar, R. A., Dominguez, T. L. R., Tupa, D., Block, W., Chinthrajah, R. S., & Nadeau, K. C. (2016). Long-Term Follow-up of Oral Immunotherapy for Multiple Food Allergies. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB132.
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Epicutaneous Immunotherapy (EPIT) Is Effective and Safe to Treat Peanut Allergy: A Multi-National Double-Blind PlaceboControlled Randomized Phase IIb Trial
Sampson, H. A., Agbotounou, W., Thebault, C., Charles, R., Martin, L., Yang, W. H., … Dupont, C. (2015). Epicutaneous Immunotherapy (EPIT) Is Effective and Safe to Treat Peanut Allergy: A Multi-National Double-Blind PlaceboControlled Randomized Phase IIb Trial. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(2), AB390.
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Regulatory T Cell Regulation by STAT5B
Kanai, T., Seki, S., Jenks, J., & Nadeau, K. C. (2012). Regulatory T Cell Regulation by STAT5B. JOURNAL OF CLINICAL IMMUNOLOGY, 32(2), 357.
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Changes in Binding Patterns of Cashew-Specific IgE and IgG4 Over the Course of Oral Immunotherapy with Omalizumab
Stankey, C. T., Andorf, S., Tetteh, A., Chinthrajah, S., & Nadeau, K. C. (2018). Changes in Binding Patterns of Cashew-Specific IgE and IgG4 Over the Course of Oral Immunotherapy with Omalizumab. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(2), AB246.
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Exploring Correlations Between Cross-Reactive Tree Nuts in Multiple Food Allergic Patients
Chang, A., Block, W., Bollyky, J. B., Chinthrajah, R. S., Nadeau, K. C., & Elizur, A. (2016). Exploring Correlations Between Cross-Reactive Tree Nuts in Multiple Food Allergic Patients. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB200.
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Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired
Pellerin, L., Jenks, J. A., Chinthrajah, S., Dominguez, T., Block, W., Zhou, X., … Bacchetta, R. (2018). Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(1), 202-+.
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Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma
Prunicki, M., Stell, L., Dinakarpandian, D., de Planell-Saguer, M., Lucas, R. W., Hammond, S. K., … Nadeau, K. C. (2018). Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma. CLINICAL EPIGENETICS, 10, 2.
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Peanut Specific-CD4+T Cells Responses in Peanut Allergic and Peanut Sensitized but Tolerant Subjects
Kwok, W. W., Farrington, M. L., Whalen, E., Wambre, E. R., Nadeau, K., & Renand, A. (2017). Peanut Specific-CD4+T Cells Responses in Peanut Allergic and Peanut Sensitized but Tolerant Subjects. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB71.
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IL-4R alpha Inhibitor for Atopic Disease
Chang, H. Y., & Nadeau, K. C. (2017). IL-4R alpha Inhibitor for Atopic Disease. CELL, 170(2), 222.
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Quality of Life, Risk Perception, and Treatment Burden with Peanut Oral Immunotherapy
LeBovidge, J. S., Rachid, R. A., MacGinnitie, A., Secor, W., Burke-Roberts, E. S., Pongracic, J. A., … Schneider, L. C. (2017). Quality of Life, Risk Perception, and Treatment Burden with Peanut Oral Immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB133.
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START: Susceptibility to Food Allergies in a Registry of Twins
De Schryver, S., Dery, A., Clarke, A. E., Nadeau, K. C., Harada, L., Greenwood, C., … Ben-Shoshan, M. (2016). START: Susceptibility to Food Allergies in a Registry of Twins. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB152.
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Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity A Randomized Clinical Trial
Sampson, H. A., Shreffler, W. G., Yang, W. H., Sussman, G. L., Brown-Whitehorn, T. F., Nadeau, K. C., … Dupont, C. (2017). Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 318(18), 1798–1809.
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Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab
Andorf, S., Manohar, M., Dominguez, T., Block, W., Tupa, D., Kshirsagar, R. A., … Nadeau, K. C. (2017). Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 13, 51.
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Characterization of multifood allergic children based on clinical and serological data
Andorf, S., Borres, M., Block, W., Lidholm, J., Jones, J. E., Galli, S. J., … Nadeau, K. C. (2017). Characterization of multifood allergic children based on clinical and serological data. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB140.
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Fraction of Exhaled Nitric Oxide (FeNO) As A Predictor Of GI Symptoms During Food Allergen Updosing
Chollet, M. B., Nadeau, K. C., Purington, N., Desai, M., & Chinthrajah, R. S. (2017). Fraction of Exhaled Nitric Oxide (FeNO) As A Predictor Of GI Symptoms During Food Allergen Updosing. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB258.
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Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review (vol 6, 24, 2016)
Dhami, S., Nurmatov, U., Pajno, G. B., Fernandez-Rivas, M., Muraro, A., Roberts, G., … Sheikh, A. (2017). Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review (vol 6, 24, 2016). CLINICAL AND TRANSLATIONAL ALLERGY, 7, 31.
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Prediction and Identification of Korean Pine (Pinus koraiensis) Vicilin As a Food
Zhang, Y., Du, W.-X., Fan, Y., Nadeau, K. C., & McHugh, T. H. (2016). Prediction and Identification of Korean Pine (Pinus koraiensis) Vicilin As a Food. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB267.
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In Vitro Induction of Peanut-Specific Tr1 Cells
Pellerin, L., Jenks, J. A., Chinthrajah, R. S., Noshirvan, A., Nadeau, K. C., Roncarolo, M. G., & Bacchetta, R. (2016). In Vitro Induction of Peanut-Specific Tr1 Cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB407.
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Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Th2 Immunity In Children
Hew, K. M., Walker, A. I., Kohli, A., Syed, A., McDonald-Hyman, C., Li, Z., … Nadeau, K. C. (2014). Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Th2 Immunity In Children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133(2), AB232.
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FOXP3 Epigenetic Signature To Distinguish Between Thymic- and Peripherally-Derived Regulatory T Cells During In Vivo Induction Of Immune Tolerance
Begin, P., Baron, U., Olek, S., Bacchetta, R., & Nadeau, K. C. (2014). FOXP3 Epigenetic Signature To Distinguish Between Thymic- and Peripherally-Derived Regulatory T Cells During In Vivo Induction Of Immune Tolerance. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133(2), AB137.
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Randomized Placebo-Controlled Multicenter Clinical Trial of Wheat Oral Immunotherapy
Nowak-Wegrzyn, A. H., Wood, R. A., Nadeau, K. C., Pongracic, J. A., Henning, A., Beyer, K., … Sampson, H. A. (2017). Randomized Placebo-Controlled Multicenter Clinical Trial of Wheat Oral Immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB378.
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Different Triggers for the Diagnosis of Individual Food Allergies in Multiple Food Allergic Patients
Elizur, A., Bollyky, J. B., Block, W., & Nadeau, K. C. (2016). Different Triggers for the Diagnosis of Individual Food Allergies in Multiple Food Allergic Patients. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB156.
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Immune Differences in Asthmatic Children Using Mass Cytometry
Paglino, T., Prunicki, M., Zhou, X., & Nadeau, K. C. (2017). Immune Differences in Asthmatic Children Using Mass Cytometry. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB375.
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New treatment directions in food allergy
Sampath, V., Sindher, S. B., Zhang, W., & Nadeau, K. C. (2018). New treatment directions in food allergy. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 120(3), 254–62.
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Assessing basophil activation by flow cytometry and mass cytometry in blood stored 24 hours before analysis
Mukai, K., Gaudenzio, N., Gupta, S., Vivanco, N., Bendall, S. C., Maecker, H. T., … Galli, S. J. (2017). Assessing basophil activation by flow cytometry and mass cytometry in blood stored 24 hours before analysis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB124.
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Distinct Anti-Cytokine Autoantibody Profile is Likely Driven by Innate Hyperinflammation Among Patients with Primary Immunodeficiency Secondary To Rag Mutations
Walter, J. E., Rosen, L. B., Chen, K., Lee, Y. N., Tirosh, I., Csomos, K., … Notarangelo, L. D. (2014). Distinct Anti-Cytokine Autoantibody Profile is Likely Driven by Innate Hyperinflammation Among Patients with Primary Immunodeficiency Secondary To Rag Mutations. JOURNAL OF CLINICAL IMMUNOLOGY, 34(3), 353–54.
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A new fluorescent-avidin-based method for quantifying basophil activation in whole blood
Mukai, K., Chinthrajah, R. S., Nadeau, K. C., Tsai, M., Gaudenzio, N., & Galli, S. J. (2017). A new fluorescent-avidin-based method for quantifying basophil activation in whole blood. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(4), 1202-+.
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Oral immunotherapy for food allergy
Freeland, D. M. H., Manohar, M., Andorf, S., Hobson, B. D., Zhang, W., & Nadeau, K. C. (2017). Oral immunotherapy for food allergy. SEMINARS IN IMMUNOLOGY, 30, 36–44.
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Identification of Tr1 Cells and Other CD4+T Cell Subsets in Humans Using Mass Cytometry: A Tool for Understanding Asthma
Prunicki, M., Zhou, X., Saguer, M. de P., Miller, R., & Nadeau, K. C. (2016). Identification of Tr1 Cells and Other CD4+T Cell Subsets in Humans Using Mass Cytometry: A Tool for Understanding Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB410.
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Omalizumab Facilitates Rapid Oral Desensitization for Peanut Allergy
Macginnitie, A. J., Rachid, R. A., Cianferoni, A., Dominguez, T. L. R., Heimall, J., Makhija, M. M., … Schneider, L. C. (2016). Omalizumab Facilitates Rapid Oral Desensitization for Peanut Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB194.
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Feasibility of sustained response through long-term dosing in food allergy immunotherapy
Andorf, S., Manohar, M., Dominguez, T., Block, W., Tupa, D., Kshirsagar, R. A., … Nadeau, K. C. (2017). Feasibility of sustained response through long-term dosing in food allergy immunotherapy. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 13, 52.
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Analysis of Peanut-specific T Cells as a Tool to Monitor State of Disease
Schulten, V., Oseroff, C., Tripple, V., Nadeau, K. C., Manohar, M., Sette, A., & Peters, B. (2017). Analysis of Peanut-specific T Cells as a Tool to Monitor State of Disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), AB72.
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Severity of Reactions to Oral Peanut Challenges in Children and Adults
Chinthrajah, R. S., Rosa, J. S., Tupa, D., Smith, B., Gupta, R. S., Galli, S. J., & Nadeau, K. C. (2016). Severity of Reactions to Oral Peanut Challenges in Children and Adults. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB134.
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Fraction of Exhaled Nitric Oxide (FeNO) and Abdominal Pain and/or Vomiting in Reaction to Oral Food Challenge
Slatkin, S. C., Tupa, D., Nadeau, K. C., & Chinthrajah, R. S. (2016). Fraction of Exhaled Nitric Oxide (FeNO) and Abdominal Pain and/or Vomiting in Reaction to Oral Food Challenge. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB135.
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Deep profiling of single T cell receptor repertoire and phenotype with targeted RNA-seq
Ji, X., Lyu, S.-C., Spindler, M., Bacchetta, R., Goncharov, I., Han, A., … Maecker, H. (2015). Deep profiling of single T cell receptor repertoire and phenotype with targeted RNA-seq. JOURNAL OF IMMUNOLOGY, 194.
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Mechanisms of Th2 to Treg Vs Th2 to Th1 in Non Rush Vs Rush Food OIT
Lyu, S.-C., & Nadeau, K. (2013). Mechanisms of Th2 to Treg Vs Th2 to Th1 in Non Rush Vs Rush Food OIT. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(2), AB196.
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Mechanistic correlates of clinical responses to omalizumab in the setting of oral immunotherapy for milk allergy
Frischmeyer-Guerrerio, P. A., Masilamani, M., Gu, W., Brittain, E., Wood, R., Kim, J., … Sampson, H. A. (2017). Mechanistic correlates of clinical responses to omalizumab in the setting of oral immunotherapy for milk allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(4), 1043-+.
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Enhanced Efficacy and Confirmed Safety of a Two-Year Epicutaneous Immunotherapy (EPIT) Treatment of Peanut Allergy with Viaskin (R) Peanut: The Continuation of the Vipes Phase IIb Randomized Controlled Trial (RCT)
Sampson, H. A., Agbotounou, W., Thebault, C., Ruban, C., Martin, L., Sussman, G. L., … Dupont, C. (2016). Enhanced Efficacy and Confirmed Safety of a Two-Year Epicutaneous Immunotherapy (EPIT) Treatment of Peanut Allergy with Viaskin (R) Peanut: The Continuation of the Vipes Phase IIb Randomized Controlled Trial (RCT). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), AB408.
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Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects
Renand, A., Farrington, M., Whalen, E., Wambre, E., Bajzik, V., Chinthrajah, S., … Kwok, W. W. (2018). Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects. FRONTIERS IN IMMUNOLOGY, 9.
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Realizing the Paris Climate Agreement to Improve Cardiopulmonary Health Where Science Meets Policy
Rice, M. B., Malea, N. M., Pinkerton, K. E., Schwartz, J., Nadeau, K. C., Browner, C. M., … Thurston, G. D. (2018). Realizing the Paris Climate Agreement to Improve Cardiopulmonary Health Where Science Meets Policy. ANNALS OF THE AMERICAN THORACIC SOCIETY, 15(7), 791–98.
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New tree nut allergens
Zhang, Y., Du, W.-X., Lee, B., Fan, Y., Lyn, S.-C., Nadeau, K., & McHugh, T. (2016). New tree nut allergens. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 251.
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Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges
Purington, N., Chinthrajah, R. S., Long, A., Sindher, S., Andorf, S., O'Laughlin, K., … Nadeau, K. C. (2018). Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges. FRONTIERS IN IMMUNOLOGY, 9.
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Peanut-specific T cell responses in patients with different clinical reactivity.
Birrueta, G., Tripple, V., Pham, J., Manohar, M., James, E. A., Kwok, W. W., … Schulten, V. (2018). Peanut-specific T cell responses in patients with different clinical reactivity. PloS One, 13(10), e0204620.
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Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy.
Nowak-Wegrzyn, A., Wood, R. A., Nadeau, K. C., Pongracic, J. A., Henning, A. K., Lindblad, R. W., … Sampson, H. A. (2018). Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy. The Journal of Allergy and Clinical Immunology.
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IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies.
Stranks, A. J., Minnicozzi, S. C., Miller, S. J., Burton, O. T., Logsdon, S. L., Spergel, J. M., … Oettgen, H. C. (2018). IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology.
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The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States.
Gupta, R. S., Warren, C. M., Smith, B. M., Blumenstock, J. A., Jiang, J., Davis, M. M., & Nadeau, K. C. (2018). The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. Pediatrics.
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Differences in multiple immune parameters between Indian and U.S. infants.
Rathore, D. K., Holmes, T. H., Nadeau, K. C., Mittal, P., Batra, A., Rosenberg-Hasson, Y., … Maecker, H. T. (2018). Differences in multiple immune parameters between Indian and U.S. infants. PloS One, 13(11), e0207297.
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Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy
Wright, B. L., Fernandez-Becker, N. Q., Kambham, N., Purington, N., Tupa, D., Zhang, W., … Chinthrajah, R. S. (2018). Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy. FRONTIERS IN IMMUNOLOGY, 9.
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Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens
Sindher, S., Long, A. J., Purington, N., Chollet, M., Slatkin, S., Andorf, S., … Chinthrajah, R. S. (2018). Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens. FRONTIERS IN IMMUNOLOGY, 9.
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Laundry detergents and detergent residue after rinse directly disrupt tight junction barrier integrity in human bronchial epithelial cells.
Wang, M., Tan, G., Eljaszewicz, A., Meng, Y., Wawrzyniak, P., Acharya, S., … Akdis, C. A. (2018). Laundry detergents and detergent residue after rinse directly disrupt tight junction barrier integrity in human bronchial epithelial cells. The Journal of Allergy and Clinical Immunology.
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Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles.
Suarez-Farinas, M., Suprun, M., Chang, H. L., Gimenez, G., Grishina, G., Getts, R., … Sampson, H. A. (2018). Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles. The Journal of Allergy and Clinical Immunology.
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High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes.
Croote, D., Darmanis, S., Nadeau, K. C., & Quake, S. R. (2018). High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes. Science (New York, N.Y.), 362(6420), 1306–9.
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Prevalence and Severity of Food Allergies Among US Adults.
Gupta, R. S., Warren, C. M., Smith, B. M., Jiang, J., Blumenstock, J. A., Davis, M. M., … Nadeau, K. C. (2019). Prevalence and Severity of Food Allergies Among US Adults. JAMA Network Open, 2(1), e185630.
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Report from the National Institute of Allergy and Infectious Diseases Workshop on "Atopic Dermatitis and the Atopic March: Mechanisms and Interventions".
Davidson, W. F., Leung, D. Y., Beck, L. A., Berin, C. M., Boguniewicz, M., Busse, W. W., … Plaut, M. (2019). Report from the National Institute of Allergy and Infectious Diseases Workshop on "Atopic Dermatitis and the Atopic March: Mechanisms and Interventions". The Journal of Allergy and Clinical Immunology.
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Identification of Almond (Prunus dulcis) Vicilin As a Food Allergen
Che, H., Zhang, Y., Lyu, S.-C., Nadeau, K. C., & McHugh, T. (2019). Identification of Almond (Prunus dulcis) Vicilin As a Food Allergen. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 67(1), 425–32.
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Allergen Specific CD8+ T cells in Peanut Allergic Individuals.
Yu, W., Zhou, X., Dunham, D., Lyu, S. C., Manohar, M., Zhang, W., … Nadeau, K. (2019). Allergen Specific CD8+ T cells in Peanut Allergic Individuals. The Journal of Allergy and Clinical Immunology.
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Changing Patient Mindsets About Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial.
Howe, L. C., Leibowitz, K. A., Perry, M. A., Bitler, J. M., Block, W., Kaptchuk, T. J., … Crum, A. J. (2019). Changing Patient Mindsets About Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial. The Journal of Allergy and Clinical Immunology. In Practice.
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Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy
Zhang, W., Sindher, S. B., Sampath, V., & Nadeau, K. (2018). Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy. ALLERGO JOURNAL, 27(6), 22–30.
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Prenatal exposure to mercury in relation to infant infections and respiratory symptoms in the New Hampshire Birth Cohort Study.
Emeny, R. T., Korrick, S. A., Li, Z., Nadeau, K., Madan, J., Jackson, B., … Karagas, M. R. (2019). Prenatal exposure to mercury in relation to infant infections and respiratory symptoms in the New Hampshire Birth Cohort Study. Environmental Research, 171, 523–29.
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Mind the gaps: clinical trial concepts to address unanswered questions in aeroallergen immunotherapy. An NIAID/AHRQ Workshop.
Wheatley, L. M., Wood, R., Nadeau, K., Liu, A., Zoratti, E., Bacharier, L., … Togias, A. (2019). Mind the gaps: clinical trial concepts to address unanswered questions in aeroallergen immunotherapy. An NIAID/AHRQ Workshop. The Journal of Allergy and Clinical Immunology.
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Esophageal Eosinophilia is Present in Some Peanut Allergic Patients
Fernandez-Becker, N., Wright, B. L., Kambham, N., Shim, K. P., Purington, N., Long, A. J., … Chinthrajah, R. S. (2019). Esophageal Eosinophilia is Present in Some Peanut Allergic Patients. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB310.
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Desensitization rates to peanut protein during OIT among children, adolescents, and adults
Long, A. J., Purington, N., Woch, M., O'Laughlin, K., Tan, T., Kost, L., … Chinthrajah, R. S. (2019). Desensitization rates to peanut protein during OIT among children, adolescents, and adults. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB245.
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Immune Mechanism of Desensitization through Rapid Multi-food Oral Immunotherapy
Manohar, M., Andorf, S., Gupta, S., Dunham, D., Zhang, W., Maecker, H. T., … Nadeau, K. C. (2019). Immune Mechanism of Desensitization through Rapid Multi-food Oral Immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB254.
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The Impact of a Prescribed Burn versus a Wildfire on the Immune and Cardiovascular Systems of Children
Prunicki, M., Zhou, X., & Nadeau, K. (2019). The Impact of a Prescribed Burn versus a Wildfire on the Immune and Cardiovascular Systems of Children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB81.
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Epicutaneous Immunotherapy (EPIT) for Peanut Allergy in Young Children
Fleischer, D. M., Brown-Whitehorn, T. F., Jones, S. M., Kim, E., Nadeau, K. C., Wang, J., … Burks, A. W. (2019). Epicutaneous Immunotherapy (EPIT) for Peanut Allergy in Young Children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB247.
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Identification of Almond (Prunus dulcis) Vicilin as a Food Allergen
Zhang, Y., Che, H., Lyu, S.-C., Nadeau, K. C., & McHugh, T. (2019). Identification of Almond (Prunus dulcis) Vicilin as a Food Allergen. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB70.
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Alternative dosing of omalizumab as an adjunct therapy during multiallergen oral immunotherapy in food allergic patients
Sindher, S. B., Long, A. J., Purington, N., Kumar, D., Scheiber, A., O'Laughlin, K., … Nadeau, K. C. (2019). Alternative dosing of omalizumab as an adjunct therapy during multiallergen oral immunotherapy in food allergic patients. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB245.
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Effectiveness Of Clinician Dose Blinding In An Oral Immunotherapy Protocol
Woch, M., O'Laughlin, K., Tan, T., Long, A. J., Bunning, B. J., Kumar, D., … Nadeau, K. C. (2019). Effectiveness Of Clinician Dose Blinding In An Oral Immunotherapy Protocol. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB73.
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Association Between History of Epinephrine Use and Dose-Related Adverse Event Rates During Oral Immunotherapy
Scheiber, A., Chinthrajah, R. S., Long, A. J., Kumar, D., Skura, S., Shojinaga, M., … Sindher, S. B. (2019). Association Between History of Epinephrine Use and Dose-Related Adverse Event Rates During Oral Immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB247.
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Component IgE and IgG4 levels in patients with natural tolerance or oral immunotherapy treatment
Bunning, B. J., Long, A. J., Chinthrajah, R. S., Nadeau, K. C., & Andorf, S. (2019). Component IgE and IgG4 levels in patients with natural tolerance or oral immunotherapy treatment. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB246.
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Multi-Omic Profiling Of Asthma Using High-Throughput Sequencing
Dhondalay, G. K., Bunning, B. J., Nadeau, K. C., & Andorf, S. (2019). Multi-Omic Profiling Of Asthma Using High-Throughput Sequencing. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(2), AB203.
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Apoptosis and Pediatric Idiopathic Neutropenia
Garcia, M., Jeng, M., & Nadeau, K. (2011). Apoptosis and Pediatric Idiopathic Neutropenia. CURRENT PEDIATRIC REVIEWS, 7(4), 321–28.
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A perspective on the pediatric death from oral food challenge reported from the Allergy Vigilance Network.
Upton, J., Alvaro, M., & Nadeau, K. (2019). A perspective on the pediatric death from oral food challenge reported from the Allergy Vigilance Network. Allergy.
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Newly identified T cell subsets in mechanistic studies of food immunotherapy.
Sampath, V., & Nadeau, K. C. (2019). Newly identified T cell subsets in mechanistic studies of food immunotherapy. The Journal of Clinical Investigation, 129(4), 1431–40.
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Legends of Allergy: Stephen J. Galli.
Tsai, M., Chinthrajah, S., & Nadeau, K. C. (2019). Legends of Allergy: Stephen J. Galli. Allergy.
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Single B-cell deconvolution of peanut-specific antibody responses in allergic patients.
Hoh, R. A., Joshi, S. A., Liu, Y., Wang, C., Roskin, K. M., Lee, J.-Y. Y., … Boyd, S. D. (2015). Single B-cell deconvolution of peanut-specific antibody responses in allergic patients. The Journal of Allergy and Clinical Immunology.
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Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy.
Wright, B. L., Fernandez-Becker, N. Q., Kambham, N., Purington, N., Tupa, D., Zhang, W., … Chinthrajah, R. S. (2018). Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy. Frontiers in Immunology, 9, 2624.
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Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma.
Ma, J., Strub, P., Lv, N., Xiao, L., Camargo, C. A., Buist, A. S., … Rosas, L. G. (2016). Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma. The European Respiratory Journal, 47(1), 122–32.
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Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens.
Sindher, S., Long, A. J., Purington, N., Chollet, M., Slatkin, S., Andorf, S., … Chinthrajah, R. S. (2018). Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens. Frontiers in Immunology, 9, 2689.
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Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges.
Purington, N., Chinthrajah, R. S., Long, A., Sindher, S., Andorf, S., O'Laughlin, K., … Nadeau, K. C. (2018). Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges. Frontiers in Immunology, 9, 2057.
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The Impact of Prescribed Fire versus Wildfire on the Immune and Cardiovascular Systems of Children.
Prunicki, M., Kelsey, R., Lee, J., Zhou, X., Smith, E., Haddad, F., … Nadeau, K. (2019). The Impact of Prescribed Fire versus Wildfire on the Immune and Cardiovascular Systems of Children. Allergy.
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Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects.
Renand, A., Farrington, M., Whalen, E., Wambre, E., Bajzik, V., Chinthrajah, S., … Kwok, W. W. (2018). Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects. Frontiers in Immunology, 9, 1408.
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Newly identified T cell subsets in mechanistic studies of food immunotherapy
Sampath, V., & Nadeau, K. C. (2019). Newly identified T cell subsets in mechanistic studies of food immunotherapy. JOURNAL OF CLINICAL INVESTIGATION, 129(4), 1431–40.
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Epigenetically Mediated Pathogenic Effects of Phenanthrene on Regulatory T Cells
Liu, J., Zhang, L., Winterroth, L. C., Garcia, M., Weiman, S., Wong, J. W., … Nadeau, K. C. (2013). Epigenetically Mediated Pathogenic Effects of Phenanthrene on Regulatory T Cells. JOURNAL OF TOXICOLOGY.
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Prevalence and Severity of Food Allergies Among US Adults
Gupta, R. S., Warren, C. M., Smith, B. M., Jiang, J., Blumenstock, J. A., Davis, M. M., … Nadeau, K. C. (2019). Prevalence and Severity of Food Allergies Among US Adults. JAMA NETWORK OPEN, 2(1).
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Allergen-specific CD8(+) T cells in peanut-allergic individuals
Yu, W., Zhou, X., Dunham, D., Lyu, S. C., Manohar, M., Zhang, W., … Nadeau, K. (2019). Allergen-specific CD8(+) T cells in peanut-allergic individuals. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(5), 1948–52.
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Mind the gaps: Clinical trial concepts to address unanswered questions in aeroallergen immunotherapy-An NIAID/AHRQ Workshop
Wheatley, L. M., Wood, R., Nadeau, K., Liu, A., Zoratti, E., Bacharier, L., … Togias, A. (2019). Mind the gaps: Clinical trial concepts to address unanswered questions in aeroallergen immunotherapy-An NIAID/AHRQ Workshop. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(5), 1711–26.
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Changing Patient Mindsets about Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial
Howe, L. C., Leibowitz, K. A., Perry, M. A., Bitler, J. M., Block, W., Kaptchuk, T. J., … Crum, A. J. (2019). Changing Patient Mindsets about Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(5), 1550–59.
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Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles
Suarez-Farinas, M., Suprun, M., Chang, H. L., Gimenez, G., Grishina, G., Getts, R., … Sampson, H. A. (2019). Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(3), 1038–46.
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Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells.
Lee, W. H., Ong, S.-G. G., Zhou, Y., Tian, L., Bae, H. R., Baker, N., … Wu, J. C. (2019). Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells. Journal of the American College of Cardiology, 73(21), 2722–37.
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The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States
Gupta, R. S., Warren, C. M., Smith, B. M., Blumenstock, J. A., Jiang, J., Davis, M. M., & Nadeau, K. C. (2018). The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. PEDIATRICS, 142(6).
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A Phase 2 Randomized Controlled Multisite Study Using Omalizumab-facilitated Rapid Desensitization to Test Continued vs Discontinued Dosing in Multifood Allergic Individuals.
Andorf, S., Purington, N., Kumar, D., Long, A., O'Laughlin, K. L., Sicherer, S., … Nadeau, K. (2019). A Phase 2 Randomized Controlled Multisite Study Using Omalizumab-facilitated Rapid Desensitization to Test Continued vs Discontinued Dosing in Multifood Allergic Individuals. EClinicalMedicine, 7, 27–38.
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Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE
Tsai, C.-ting, Mukai, K., Robinson, P. V., Gray, M. A., Waschmann, M. B., Lyu, S.-C., … Galli, S. J. (2018). Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(5), 1901-+.
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Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy.
Zhang, W., Sindher, S. B., Sampath, V., & Nadeau, K. (2018). Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy. Allergo Journal International, 27(6), 153–61.
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ICER report for peanut OIT comes up short.
Eiwegger, T., Anagnostou, K., Arasi, S., Bégin, P., Ben-Shoshan, M., Beyer, K., … Nadeau, K. (2019). ICER report for peanut OIT comes up short. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology.
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Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study.
Chinthrajah, R. S., Purington, N., Andorf, S., Long, A., O'Laughlin, K. L., Lyu, S. C., … Nadeau, K. C. (2019). Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study. Lancet (London, England).
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Natural Tr1-like cells do not confer long-term tolerogenic memory.
Yadava, K., Medina, C. O., Ishak, H., Gurevich, I., Kuipers, H., Shamskhou, E. A., … Bollyky, P. L. (2019). Natural Tr1-like cells do not confer long-term tolerogenic memory. ELife, 8.
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The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses
Sindher, S. B., Long, A., Acharya, S., Sampath, V., & Nadeau, K. C. (2018). The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 55(2), 190–204.
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Conflicting verdicts on peanut OIT from the ICER and FDA Advisory Committee; where do we go from here?
Eiwegger, T., Anagnostou, K., Arasi, S., Begin, P., Ben-Shoshan, M., Beyer, K., … Nadeau, K. (2019). Conflicting verdicts on peanut OIT from the ICER and FDA Advisory Committee; where do we go from here? The Journal of Allergy and Clinical Immunology.
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The impact of prescribed fire versus wildfire on the immune and cardiovascular systems of children
Prunicki, M., Kelsey, R., Lee, J., Zhou, X., Smith, E., Haddad, F., … Nadeau, K. (2019). The impact of prescribed fire versus wildfire on the immune and cardiovascular systems of children. ALLERGY, 74(10), 1989–91.
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Trends in egg specific immunoglobulin levels during natural tolerance and oral immunotherapy.
Andorf, S., Bunning, B., Tupa, D., Cao, S., Long, A. J., Borres, M. P., … Nadeau, K. C. (2019). Trends in egg specific immunoglobulin levels during natural tolerance and oral immunotherapy. Allergy.
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Phase 2a randomized, placebo-controlled study of anti-IL-33 in peanut allergy.
Chinthrajah, S., Cao, S., Liu, C., Lyu, S.-C., Sindher, S. B., Long, A., … Nadeau, K. C. (2019). Phase 2a randomized, placebo-controlled study of anti-IL-33 in peanut allergy. JCI Insight, 4(22).
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Can food allergy be cured? What are the future prospects?
Sampath, V., Sindher, S. B., Alvarez Pinzon, A. M., & Nadeau, K. C. (2019). Can food allergy be cured? What are the future prospects? Allergy.
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Global metabolic profiling to model biological processes of aging in twins.
Bunning, B. J., Contrepois, K., Lee-McMullen, B., Dhondalay, G. K., Zhang, W., Tupa, D., … Andorf, S. (2019). Global metabolic profiling to model biological processes of aging in twins. Aging Cell, e13073.
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Transcriptomic and methylomic features in asthmatic and non-asthmatic twins.
Dhondalay, G. K., Bunning, B., Bauer, R. N., Barnathan, E. S., Maniscalco, C., Baribaud, F., … Andorf, S. (2019). Transcriptomic and methylomic features in asthmatic and non-asthmatic twins. Allergy.
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Sustained Successful Peanut Oral Immunotherapy Associated with Low Basophil Activation and Peanut-Specific IgE.
Tsai, M., Mukai, K., Chinthrajah, R. S., Nadeau, K. C., & Galli, S. J. (2019). Sustained Successful Peanut Oral Immunotherapy Associated with Low Basophil Activation and Peanut-Specific IgE. The Journal of Allergy and Clinical Immunology.
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High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes
Croote, D., Darmanis, S., Nadeau, K. C., & Quake, S. R. (2018). High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes. SCIENCE, 362(6420), 1306-+.
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Th2A and Th17 cell frequencies and regulatory markers as follow-up biomarker candidates for successful multifood oral immunotherapy.
Luce, S., Chinthrajah, S., Lyu, S. C., Nadeau, K., & Mascarell, L. (2020). Th2A and Th17 cell frequencies and regulatory markers as follow-up biomarker candidates for successful multifood oral immunotherapy. Allergy.
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Legends of Allergy: Stephen J. Galli
Tsai, M., Chinthrajah, S., & Nadeau, K. C. (2020). Legends of Allergy: Stephen J. Galli. ALLERGY, 75(1), 243–45.
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Enhancing Data Reliability in TOMAHAQ for Large-Scale Protein Quantification.
Liu, F., Singhal, K., Matney, R., Acharya, S., Akdis, C. A., Nadeau, K. C., … Leib, R. D. (2020). Enhancing Data Reliability in TOMAHAQ for Large-Scale Protein Quantification. Proteomics, e1900105.
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Towards personalization of asthma treatment according to trigger factors.
Niespodziana, K., Borochova, K., Pazderova, P., Schlederer, T., Astafyeva, N., Baranovskaya, T., … Valenta, R. (2020). Towards personalization of asthma treatment according to trigger factors. The Journal of Allergy and Clinical Immunology.
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Mass cytometry reveals cellular fingerprint associated with IgE+?peanut tolerance and allergy in early life.
Neeland, M. R., Andorf, S., Manohar, M., Dunham, D., Lyu, S.-C. C., Dang, T. D., … Nadeau, K. C. (2020). Mass cytometry reveals cellular fingerprint associated with IgE+?peanut tolerance and allergy in early life. Nature Communications, 11(1), 1091.
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Immunologic effects of forest fire exposure show increases in IL-1ß and CRP.
Prunicki, M. M., Dant, C. C., Cao, S., Maecker, H., Haddad, F., Kim, J. B., … Nadeau, K. (2020). Immunologic effects of forest fire exposure show increases in IL-1ß and CRP. Allergy.
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Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy.
Hoh, R. A., Joshi, S. A., Lee, J.-Y. Y., Martin, B. A., Varma, S., Kwok, S., … Boyd, S. D. (2020). Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy. Science Immunology, 5(45).
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RNA-Seq of Gastrointestinal Biopsies During Oral Immunotherapy Reveals Changes in IgA Pathway
Zhang, W., Dhondalay, G., Hoh, R., Tupa, D., Bunning, B., Fernandez-Becker, N., … Nadeau, K. (2020). RNA-Seq of Gastrointestinal Biopsies During Oral Immunotherapy Reveals Changes in IgA Pathway. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB132.
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Peanut oral immunotherapy induces gastrointestinal eosinophilia in a longitudinal randomized controlled trial
Wright, B., Fernandez-Becker, N., Kambham, N., Purington, N., Cao, S., Tupa, D., … Chinthrajah, S. (2020). Peanut oral immunotherapy induces gastrointestinal eosinophilia in a longitudinal randomized controlled trial. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB84.
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Dose-related Allergic Reactions Decrease Over Time During Peanut Oral Immunotherapy in a Large, Randomized, Double-blind, Placebo-controlled, Phase 2 Study
Long, A., Purington, N., Andorf, S., O'Laughlin, K., Lyu, S.-C., Sindher, S., … Nadeau, K. (2020). Dose-related Allergic Reactions Decrease Over Time During Peanut Oral Immunotherapy in a Large, Randomized, Double-blind, Placebo-controlled, Phase 2 Study. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB134.
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Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study
Chinthrajah, S., Purington, N., Andorf, S., Long, A., O'Laughlin, K., Lyu, S.-C., … Nadeau, K. (2020). Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB181.
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Pollution-Associated Exposure Signature in Teenagers
Haddad, F., Cauwenberghs, N., Movassagh, H., Maecker, H., Arthur, J., Wu, J., … Prunicki, M. (2020). Pollution-Associated Exposure Signature in Teenagers. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB82.
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Mass Cytometry Reveals Monocytes are Associated with Air Pollution and Blood Pressure in Minority Children
Prunicki, M., Nadeau, K., Lee, J., Zhou, X., Movassagh, H., & Wu, J. (2020). Mass Cytometry Reveals Monocytes are Associated with Air Pollution and Blood Pressure in Minority Children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB128.
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Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution.
Kim, J. B., Prunicki, M., Haddad, F., Dant, C., Sampath, V., Patel, R., … Nadeau, K. C. (2020). Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution. Journal of the American Heart Association, 9(6), e014944.
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Protein Composition Changes in Manufactured Penaeus aztecus Shrimp Powder
Chinthrajah, S., Johansson, J., Woch, M., Conn, T., Chen, E., Long, A., … Nadeau, K. (2020). Protein Composition Changes in Manufactured Penaeus aztecus Shrimp Powder. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB226.
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A CD25+cell suppresses the proliferation of peanut-specific CD8+T cells from nonallergic individuals.
Wong, Y., Zhou, X., & Nadeau, K. (2020). A CD25+cell suppresses the proliferation of peanut-specific CD8+T cells from nonallergic individuals. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB89.
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A Qualitative Exploration of Food Allergy Management among a Medicaid-Insured Population
Bozen, A., Zaslavsky, J., Cohn, D., Agnihotri, N., Davies, S., Samady, W., … Tobin, M. (2020). A Qualitative Exploration of Food Allergy Management among a Medicaid-Insured Population. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB86.
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Perceived Burden of Treatment and Quality of Life in Long-Term Follow Up after Oral Immunotherapy in Food Allergic Patients
Collins, W., Raeber, O., Tupa, D., Cao, S., Nadeau, K., Sindher, S., & Chinthrajah, S. (2020). Perceived Burden of Treatment and Quality of Life in Long-Term Follow Up after Oral Immunotherapy in Food Allergic Patients. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB147.
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Skin TEWL results show significant improvements with Trilipid emollient compared to controls in infants and young children
Nadeau, K., Sindher, S., Berdyshev, E., Shojinaga, M., Alkotob, S., Alonzi, S., … Leung, D. (2020). Skin TEWL results show significant improvements with Trilipid emollient compared to controls in infants and young children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB240.
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The benefits of playing interactive games on virtual reality headsets during procedures in food allergy clinical trials
Alonzi, S., Parikh, K., Varadharajulu, S., Chandra, S., Cao, S., Texeira, Z., … Chinthrajah, S. (2020). The benefits of playing interactive games on virtual reality headsets during procedures in food allergy clinical trials. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB147.
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Quality Of Life in Patients with Food Allergy: A Systematic Review and Meta-Analysis of interventions Food Allergy Diagnosis and Immunotherapy Studies
Cao, S., Borro, M., Sindher, S., Tupa, D., Long, A., Chinthrajah, S., … Alonzi, S. (2020). Quality Of Life in Patients with Food Allergy: A Systematic Review and Meta-Analysis of interventions Food Allergy Diagnosis and Immunotherapy Studies. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB245.
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A Phase 2 Study of Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Immune Markers after Minimum Maintenance Dose using Xolair
Sindher, S., Kumar, D., Purington, N., Tupa, D., Long, A., Cao, S., … Nadeau, K. (2020). A Phase 2 Study of Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Immune Markers after Minimum Maintenance Dose using Xolair. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB135.
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Pilot study measuring transepidermal water loss (TEWL) in children suggests trilipid cream is more effective than a paraffin-based emollient.
Sindher, S., Alkotob, S. S., Shojinaga, M. N., Brough, H. A., Bahnson, T., S, C., … Nadeau, K. C. (2020). Pilot study measuring transepidermal water loss (TEWL) in children suggests trilipid cream is more effective than a paraffin-based emollient. Allergy.
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Skin Barrier Dysfunction In Patients With Peanut Allergy Without Eczema
Leung, D., Goleva, E., Hoffman, B., Bronoff, A. S., Jung, J., Garcia, S., … Berdyshev, E. (2020). Skin Barrier Dysfunction In Patients With Peanut Allergy Without Eczema. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB46.
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Microfluidic methods for precision diagnostics in food allergy.
Castaño, N., Cordts, S. C., Nadeau, K. C., Tsai, M., Galli, S. J., & Tang, S. K. (2020). Microfluidic methods for precision diagnostics in food allergy. Biomicrofluidics, 14(2), 021503.
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Identification of cross-reactive allergens in cashew- and pistachio-allergic children during oral immunotherapy.
He, Z., Dongre, P., Lyu, S.-C., Manohar, M., Chinthrajah, R. S., Galli, S. J., … Andorf, S. (2020). Identification of cross-reactive allergens in cashew- and pistachio-allergic children during oral immunotherapy. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology.
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Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy.
Asai, Y., Martino, D., Eiwegger, T., Nadeau, K., Koppelman, G. H., Clarke, A. E., … Daley, D. (2020). Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy. Allergy.
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Increases in plasma IgG4/IgE with trilipid vs paraffin/petrolatum-based emollients for dry skin/eczema.
Sindher, S., Alkotob, S. S., Shojinaga, M. N., Hamilton, R., Chan, S., Cao, S., … Nadeau, K. C. (2020). Increases in plasma IgG4/IgE with trilipid vs paraffin/petrolatum-based emollients for dry skin/eczema. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology.
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A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples.
Goyard, S., Balbino, B., Chinthrajah, R. S., Lyu, S.-C. C., Janin, Y. L., Bruhns, P., … Rose, T. (2020). A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples. Allergy.
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Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?
Brough, H. A., Nadeau, K. C., Sindher, S. B., Alkotob, S. S., Chan, S., Bahnson, H., … Lack, G. (2020). Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented? Allergy.
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Barriers to Food Allergy Management Among Low-Income Americans.
Bozen, A., Zaslavsky, J. M., Cohn, D., Samady, W., Lombard, L., Nadeau, K., … Gupta, R. S. (2020). Barriers to Food Allergy Management Among Low-Income Americans. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology.
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Food Allergy from Infancy Through Adulthood.
Sicherer, S. H., Warren, C. M., Dant, C., Gupta, R. S., & Nadeau, K. C. (2020). Food Allergy from Infancy Through Adulthood. The Journal of Allergy and Clinical Immunology. In Practice, 8(6), 1854–64.
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ARIA-EAACI statement on Asthma and COVID-19 (June 2, 2020).
Bousquet, J., Jutel, M., Akdis, C. A., Klimek, L., Pfaar, O., Nadeau, K. C., … Agache, I. (2020). ARIA-EAACI statement on Asthma and COVID-19 (June 2, 2020). Allergy.
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Remdesivir for the Treatment of Covid-19 - Preliminary Report.
Beigel, J. H., Tomashek, K. M., Dodd, L. E., Mehta, A. K., Zingman, B. S., Kalil, A. C., … Lane, H. C. (2020). Remdesivir for the Treatment of Covid-19 - Preliminary Report. The New England Journal of Medicine.
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Immunology of COVID-19: mechanisms, clinical outcome, diagnostics and perspectives - a report of the European Academy of Allergy and Clinical Immunology (EAACI).
Sokolowska, M., Lukasik, Z., Agache, I., Akdis, C. A., Akdis, D., Akdis, M., … Untersmayr, E. (2020). Immunology of COVID-19: mechanisms, clinical outcome, diagnostics and perspectives - a report of the European Academy of Allergy and Clinical Immunology (EAACI). Allergy.
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The Origins of Allergy from a Systems Approach.
Krempski, J. W., Dant, C., & Nadeau, K. C. (2020). The Origins of Allergy from a Systems Approach. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology.
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Increased diversity of gut microbiota during active oral immunotherapy in peanut allergic adults.
He, Z., Vadali, V. G., Szabady, R. L., Zhang, W., Norman, J. M., Roberts, B., … Nadeau, K. C. (2020). Increased diversity of gut microbiota during active oral immunotherapy in peanut allergic adults. Allergy.
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Development of a tool predicting severity of allergic reaction during peanut challenge
Chinthrajah, R. S., Purington, N., Andorf, S., Rosa, J. S., Mukai, K., Hamilton, R., … Nadeau, K. C. (2018). Development of a tool predicting severity of allergic reaction during peanut challenge. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 121(1), 69-+.
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Transcriptional changes in peanut-specific CD4+ T cells over the course of oral immunotherapy.
Wang, W., Lyu, S.-C., Ji, X., Gupta, S., Manohar, M., Dhondalay, G. K., … Maecker, H. T. (2020). Transcriptional changes in peanut-specific CD4+ T cells over the course of oral immunotherapy. Clinical Immunology (Orlando, Fla.), 108568.
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A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells is the Cell of Origin for Occlusive Pulmonary Vascular Lesions.
Steffes, L. C., Froistad, A. A., Andruska, A., Boehm, M., McGlynn, M., Zhang, F., … Kumar, M. E. (2020). A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells is the Cell of Origin for Occlusive Pulmonary Vascular Lesions. Circulation.
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Regulation of peanut-specific CD8+ T cells from nonallergic individuals.
Yu, W., Zhou, X., Davis, M. M., & Nadeau, K. C. (2020). Regulation of peanut-specific CD8+ T cells from nonallergic individuals. The Journal of Allergy and Clinical Immunology.
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Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.
Radzikowska, U., Ding, M., Tan, G., Zhakparov, D., Peng, Y., Wawrzyniak, P., … Sokolowska, M. (2020). Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors. Allergy.
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Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.
Nielsen, S. C., Yang, F., Jackson, K. J., Hoh, R. A., Röltgen, K., Jean, G. H., … Boyd, S. D. (2020). Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2. Cell Host & Microbe.
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Oral immunotherapy for peanut allergy: The pro argument.
Chinthrajah, R. S., Cao, S., Dunham, T., Sampath, V., Chandra, S., Chen, M., … Nadeau, K. (2020). Oral immunotherapy for peanut allergy: The pro argument. The World Allergy Organization Journal, 13(8), 100455.
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Identification of Pru du 6 as a potential marker allergen for almond allergy.
Kabasser, S., Hafner, C., Chinthrajah, S., Sindher, S. B., Kumar, D., Kost, L. E., … Bublin, M. (2020). Identification of Pru du 6 as a potential marker allergen for almond allergy. Allergy.
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Advances and novel developments in environmental influences on the development of atopic diseases.
Alkotob, S. S., Cannedy, C., Harter, K., Movassagh, H., Paudel, B., Prunicki, M., … Nadeau, K. C. (2020). Advances and novel developments in environmental influences on the development of atopic diseases. Allergy.
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Immune biomarkers link air pollution exposure to blood pressure in adolescents.
Prunicki, M., Cauwenberghs, N., Ataam, J. A., Movassagh, H., Kim, J. B., Kuznetsova, T., … Nadeau, K. (2020). Immune biomarkers link air pollution exposure to blood pressure in adolescents. Environmental Health : a Global Access Science Source, 19(1), 108.
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Advances and novel developments in mechanisms of allergic inflammation.
Han, X., Krempski, J. W., & Nadeau, K. (2020). Advances and novel developments in mechanisms of allergic inflammation. Allergy.
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Proinflammatory IgG Fc structures in patients with severe COVID-19
Chakraborty, S., Gonzales, J., Edwards, K., Mallajosyulla, V., Buzzanco, A. S., Sherwood, R., … Tan, G. S. (2020). Proinflammatory IgG Fc structures in patients with severe COVID-19. Nature Immunology.
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Mass Cytometry Phenotyping of Human Granulocytes Reveals Novel Basophil Functional Heterogeneity.
Vivanco Gonzalez, N., Oliveria, J.-P., Tebaykin, D., Ivison, G. T., Mukai, K., Tsai, M. M., … Bendall, S. C. (2020). Mass Cytometry Phenotyping of Human Granulocytes Reveals Novel Basophil Functional Heterogeneity. IScience, 23(11), 101724.
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The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts and sesame seeds.
Dreskin, S. C., Koppelman, S., Andorf, S., Nadeau, K. C., Kalra, A., Braun, W., … Schein, C. H. (2020). The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts and sesame seeds. The Journal of Allergy and Clinical Immunology.
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Addressing Climate Change and Its Effects on Human Health: A Call to Action for Medical Schools.
Goshua, A., Gomez, J., Erny, B., Burke, M., Luby, S., Sokolow, S., … Nadeau, K. (2020). Addressing Climate Change and Its Effects on Human Health: A Call to Action for Medical Schools. Academic Medicine : Journal of the Association of American Medical Colleges.
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Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome.
Röltgen, K., Powell, A. E., Wirz, O. F., Stevens, B. A., Hogan, C. A., Najeeb, J., … Boyd, S. D. (2020). Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome. Science Immunology, 5(54).
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Epigenetics and the Environment in Airway Disease: Asthma and Allergic Rhinitis.
Long, A., Bunning, B., Sampath, V., DeKruyff, R. H., & Nadeau, K. C. (2020). Epigenetics and the Environment in Airway Disease: Asthma and Allergic Rhinitis. Advances in Experimental Medicine and Biology, 1253, 153–81.
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The future of omics for clinical practice
Long, A., Bunning, B., Borro, M., Sampath, V., & Nadeau, K. C. (2019). The future of omics for clinical practice. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 123(6), 535–36.
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High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma
Chinthrajah, R. S., Purington, N., Sampath, V., Andorf, S., Manohar, M., Prunicki, M., … Nadeau, K. C. (2018). High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 121(1), 117–19.
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Impact of allergen immunotherapy in allergic asthma
Zhang, W., Lin, C., Sampath, V., & Nadeau, K. (2018). Impact of allergen immunotherapy in allergic asthma. IMMUNOTHERAPY, 10(7), 579–93.
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Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study.
Duan, L., Celik, A., Hoang, J. A., Schmidthaler, K., So, D., Yin, X., … Eiwegger, T. (2020). Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study. Allergy.
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A novel patient-reported outcomes instrument assessing the side effects of peanut oral immunotherapy.
Turner-Bowker, D. M., Jalbert, J. J., Krohe, M., Yaworsky, A., Kelly, M. T., Padilla, B., … Nadeau, K. C. (2021). A novel patient-reported outcomes instrument assessing the side effects of peanut oral immunotherapy. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 126(1), 61–68.
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Inhibition of CpG methylation improves the barrier integrity of bronchial epithelial cells in asthma.
Wawrzyniak, P., Krawczyk, K., Acharya, S., Tan, G., Wawrzyniak, M., Karouzakis, E., … Akdis, C. A. (2020). Inhibition of CpG methylation improves the barrier integrity of bronchial epithelial cells in asthma. Allergy.
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Grass pollen immunotherapy alters chromatin landscape in circulating T follicular and regulatory cells.
Sharif, H., Acharya, S., Dhondalay, G. K., Varricchi, G., Krasner-Macleod, S., Laisuan, W., … Shamji, M. H. (2020). Grass pollen immunotherapy alters chromatin landscape in circulating T follicular and regulatory cells. The Journal of Allergy and Clinical Immunology.
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Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma
Breiteneder, H., Peng, Y.-Q., Agache, I., Diamant, Z., Eiwegger, T., Fokkens, W. J., … Akdis, C. A. (2020). Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. ALLERGY, 75(12), 3039–68.
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A compendium answering 150 questions on COVID-19 and SARS-CoV-2
Riggioni, C., Comberiati, P., Giovannini, M., Agache, I., Akdis, M., Alves-Correia, M., … Akdis, C. A. (2020). A compendium answering 150 questions on COVID-19 and SARS-CoV-2. ALLERGY, 75(10), 2503–41.
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Environmental factors in epithelial barrier dysfunction
Soezener, Z. C., Cevhertas, L., Nadeau, K., Akdis, M., & Akdis, C. A. (2020). Environmental factors in epithelial barrier dysfunction. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(6), 1517–28.
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Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19
Azkur, A. K., Akdis, M., Azkur, D., Sokolowska, M., van de Veen, W., Bruggen, M.-C., … Akdis, C. A. (2020). Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19. ALLERGY, 75(7), 1564–81.
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Combined immune and airway epithelial cell profiles define asthma severity phenotypes
Oriss, T. B., Zhou, X., Camiolo, M., Scholl, K. L., Gorry, M., Gauthier, M., … Ray, A. (2019). Combined immune and airway epithelial cell profiles define asthma severity phenotypes. JOURNAL OF IMMUNOLOGY, 202(1).
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Pru du 8: First member of a new food allergen family
Zhang, Y., Che, H., Jiang, S., Jin, T., Lyu, S.-C., Nadeau, K., & McHugh, T. (2019). Pru du 8: First member of a new food allergen family. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 258.
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Summary of the Keystone Symposium "Origins of allergic disease: Microbial, epithelial and immune interactions,'' March 24-27, Tahoe City, California
DeKruyff, R. H., Zhang, W., Nadeau, K. C., Leung, D. Y. M., & Wills-Karp, M. (2020). Summary of the Keystone Symposium "Origins of allergic disease: Microbial, epithelial and immune interactions,'' March 24-27, Tahoe City, California. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(4), 1072-+.
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Applicability of Skin Tape Stripping Methodology In Conjunction With LC-MS/MS To Detect Topical Emollients and Drugs Used in Atopic Dermatitis
Berdyshev, E., Bronova, I., Bronoff, A. S., Jung, J., Nadeau, K., Goleva, E., & Leung, D. (2020). Applicability of Skin Tape Stripping Methodology In Conjunction With LC-MS/MS To Detect Topical Emollients and Drugs Used in Atopic Dermatitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(2), AB70.
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The anti-IgE mAb omalizumab induces adverse reactions by engaging Fc gamma receptors
Balbino, B., Herviou, P., Godon, O., Stackowicz, J., Richard-Le Goff, O., Iannascoli, B., … Reber, L. L. (2020). The anti-IgE mAb omalizumab induces adverse reactions by engaging Fc gamma receptors. JOURNAL OF CLINICAL INVESTIGATION, 130(3), 1330–35.
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Cow's Milk and Vitamin D Supplementation in Infants-Timing Is Everything
du Toit, G., Elizur, A., & Nadeau, K. C. (2019). Cow's Milk and Vitamin D Supplementation in Infants-Timing Is Everything. JAMA PEDIATRICS, 173(12), 1129–30.
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Innovative pediatric clinical outcome assessment (COA) administration and reporting strategies
Turner-Bowker, D., Loftus, J., Yaworsky, A., Krohe, M., Radin, A., Palladino, A., … Jalbert, J. (2019). Innovative pediatric clinical outcome assessment (COA) administration and reporting strategies. QUALITY OF LIFE RESEARCH, 28, S9.
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Almond (Prunus dulcis) Allergen Pru du 8, the First Member of a New Family of Food Allergens
Che, H., Zhang, Y., Jiang, S., Jin, T., Lyu, S.-C., Nadeau, K. C., & McHugh, T. (2019). Almond (Prunus dulcis) Allergen Pru du 8, the First Member of a New Family of Food Allergens. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 67(31), 8626–31.
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Genetic and environmental susceptibility to food allergy in a registry of twins
Kivisto, J. E., Clarke, A., Dery, A., De Schryver, S., Shand, G., Huhtala, H., … Ben-Shoshan, M. (2019). Genetic and environmental susceptibility to food allergy in a registry of twins. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(8), 2916–18.
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Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care
Breiteneder, H., Diamant, Z., Eiwegger, T., Fokkens, W. J., Traidl-Hoffmann, C., Nadeau, K., … Akdis, C. A. (2019). Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care. ALLERGY, 74(12), 2293–2311.
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Atopy Patch Testing for Food Allergies
Ta, V., & Nadeau, K. (2014). Atopy Patch Testing for Food Allergies. FOOD ALLERGY: ADVERSE REACTIONS TO FOODS AND FOOD ADDITIVES, 5TH EDITION, 289–95.
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Differences in multiple immune parameters between Indian and US infants
Rathore, D. K., Holmes, T. H., Nadeau, K. C., Mittal, P., Batra, A., Rosenberg-Hasson, Y., … Maecker, H. T. (2018). Differences in multiple immune parameters between Indian and US infants. PLOS ONE, 13(11).
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Peanut-specific T cell responses in patients with different clinical reactivity
Birrueta, G., Tripple, V., Pham, J., Manohar, M., James, E. A., Kwok, W. W., … Schulten, V. (2018). Peanut-specific T cell responses in patients with different clinical reactivity. PLOS ONE, 13(10).
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The Air We Breathe: How Extreme Weather Conditions Harm Us
Prunicki, M. M., & Nadeau, K. C. (2016). The Air We Breathe: How Extreme Weather Conditions Harm Us. EXTREME WEATHER, HEALTH, AND COMMUNITIES: INTERDISCIPLINARY ENGAGEMENT STRATEGIES, 293–310.
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Corrigendum: Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens.
Sindher, S., Long, A. J., Purington, N., Chollet, M., Slatkin, S., Andorf, S., … Chinthrajah, R. S. (2020). Corrigendum: Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens. Frontiers in Immunology, 11, 625796.
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Vitamin D insufficiency is associated with reduced regulatory T cell frequency in food-allergic infants.
Neeland, M. R., Tursi, A. R., Perrett, K. P., Saffery, R., Koplin, J. J., Nadeau, K. C., & Andorf, S. (2020). Vitamin D insufficiency is associated with reduced regulatory T cell frequency in food-allergic infants. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology.
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Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
Kalil, A., Nadeau, K. C., & Beigel, J. (2020). Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.
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Oral Immunotherapy and Basophil and Mast Cell Reactivity in Food Allergy.
Paranjape, A., Tsai, M., Mukai, K., Hoh, R. A., Joshi, S. A., Chinthrajah, R. S., … Galli, S. J. (2020). Oral Immunotherapy and Basophil and Mast Cell Reactivity in Food Allergy. Frontiers in Immunology, 11, 602660.
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Wildfire smoke exposure is associated with decreased methylation of the PDL2 gene
Prunicki, M., Miller, S., Hopkins, A., Poulin, M., Movassagh, H., Yan, L., & Nadeau, K. C. (2020). Wildfire smoke exposure is associated with decreased methylation of the PDL2 gene. JOURNAL OF IMMUNOLOGY, 204(1).
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Protein- and sequencing-based massively parallel single-cell approaches to immune profiling asthma-specific cell subtypes and related gene expression biomarkers
Ji, X., Acharya, S., Goncharov, I., Lyu, S.-C., Miranda, M., Padalon-Brauch, G., … Maecker, H. T. (2020). Protein- and sequencing-based massively parallel single-cell approaches to immune profiling asthma-specific cell subtypes and related gene expression biomarkers. JOURNAL OF IMMUNOLOGY, 204(1).
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EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines.
Sokolowska, M., Eiwegger, T., Ollert, M., Torres, M. J., Barber, D., Del Giacco, S., … Shamji, M. H. (2021). EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines. Allergy.
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Aging and CMV discordance are associated with increased immune diversity between monozygotic twins.
Yan, Z., Maecker, H. T., Brodin, P., Nygaard, U. C., Lyu, S. C., Davis, M. M., … Andorf, S. (2021). Aging and CMV discordance are associated with increased immune diversity between monozygotic twins. Immunity & Ageing : I & A, 18(1), 5.
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Fecal microbiome and metabolome differ in healthy and food-allergic twins.
Bao, R., Hesser, L. A., He, Z., Zhou, X., Nadeau, K. C., & Nagler, C. R. (2021). Fecal microbiome and metabolome differ in healthy and food-allergic twins. The Journal of Clinical Investigation, 131(2).
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Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy.
Zhou, X., Han, X., Lyu, S.-C. C., Bunning, B. J., Kost, L., Chang, I., … Nadeau, K. C. (2021). Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy. JCI Insight.
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Traffic-related Air Pollution is Associated with Glucose Dysregulation, Blood Pressure, and Oxidative Stress in Children.
Mann, J. K., Lutzker, L., Holm, S. M., Margolis, H. G., Neophytou, A. M., Eisen, E. A., … Balmes, J. R. (2021). Traffic-related Air Pollution is Associated with Glucose Dysregulation, Blood Pressure, and Oxidative Stress in Children. Environmental Research, 110870.
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Innate Lymphoid Cells: The Missing Part Of A Puzzle In Food Allergy.
Sahiner, U. M., Layhadi, J. A., Golebski, K., Istvan Komlosi, Z., Peng, Y., Sekerel, B., … Shamji, M. H. (2021). Innate Lymphoid Cells: The Missing Part Of A Puzzle In Food Allergy. Allergy.
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Air pollution exposure is linked with methylation of immunoregulatory genes, altered immune cell profiles, and increased blood pressure in children.
Prunicki, M., Cauwenberghs, N., Lee, J., Zhou, X., Movassagh, H., Noth, E., … Nadeau, K. C. (2021). Air pollution exposure is linked with methylation of immunoregulatory genes, altered immune cell profiles, and increased blood pressure in children. Scientific Reports, 11(1), 4067.
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