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William Robinson

Associate Professor of Medicine (Immunology and Rheumatology)

Summary

Summary

Professional Education

Board Certification: Rheumatology, American Board of Internal Medicine (2002)
Fellowship: Stanford University Medical Center (2002) CA
Residency: UCSF Medical Center (1998) CA
Internship: UCSF Medical Center (1997) CA
Medical Education: Stanford University School of Medicine (1996) CA

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Publications

Demyelinating and neurologic events reported in association with tumor necrosis factor alpha antagonism - By what mechanisms could tumor necrosis factor alpha antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis?
Robinson, W. H., Genovese, M. C., & Moreland, L. W. (2001). Demyelinating and neurologic events reported in association with tumor necrosis factor alpha antagonism - By what mechanisms could tumor necrosis factor alpha antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis? ARTHRITIS AND RHEUMATISM, 44(9), 1977–1983.
Autoantigen microarrays for multiplex characterization of autoantibody responses
Robinson, W. H., DiGennaro, C., Hueber, W., Haab, B. B., KAMACHI, M., Dean, E. J., … Utz, P. J. (2002). Autoantigen microarrays for multiplex characterization of autoantibody responses. NATURE MEDICINE, 8(3), 295–301.
Proteomics technologies for the study of autoimmune disease
Robinson, W. H., Steinman, L., & Utz, P. J. (2002). Proteomics technologies for the study of autoimmune disease. ARTHRITIS AND RHEUMATISM, 46(4), 885–893.
Millennium Award. Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease. Robinson, W. H., Garren, H., Utz, P. J., & Steinman, L. (2002). Millennium Award. Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease. Clinical Immunology , 103(1), 7–12.
Autoantibody profiling for the study and treatment of autoimmune disease Hueber, W., Utz, P. J., Steinman, L., & Robinson, W. H. (2002). Autoantibody profiling for the study and treatment of autoimmune disease. ARTHRITIS RESEARCH, 4(5), 290–295.
Protein and peptide array analysis of autoimmune disease Robinson, W. H., Steinman, L., & Utz, P. J. (2002). Protein and peptide array analysis of autoimmune disease. BIOTECHNIQUES, 66–69.
Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis Robinson, W. H., Fontoura, P., Lee, B. J., de Vegvar, H. E. N., Tom, J., Pedotti, R., … Steinman, L. (2003). Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. NATURE BIOTECHNOLOGY, 21(9), 1033–1039.
Microarray profiling of antibody responses against simian-human immunodeficiency virus: Postchallenge convergence of reactivities independent of host histocompatibility type and vaccine regimen de Vegvar, H. E. N., Amara, R. R., Steinman, L., Utz, P. J., Robinson, H. L., & Robinson, W. H. (2003). Microarray profiling of antibody responses against simian-human immunodeficiency virus: Postchallenge convergence of reactivities independent of host histocompatibility type and vaccine regimen. JOURNAL OF VIROLOGY, 77(20), 11125–11138.
Protein arrays for autoantibody profiling and fine-specificity mapping Robinson, W. H., Steinman, L., & Utz, P. J. (2003). Protein arrays for autoantibody profiling and fine-specificity mapping. PROTEOMICS, 3(11), 2077–2084.
Genomic and proteomic analysis of multiple sclerosis - Opinion Robinson, W. H., Utz, P. J., & Steinman, L. (2003). Genomic and proteomic analysis of multiple sclerosis - Opinion. CURRENT OPINION IN IMMUNOLOGY, 15(6), 660–667.
Autoantibodies in early arthritis: Advances in diagnosis and prognostication Hueber, W., Utz, P. J., & Robinson, W. H. (2003). Autoantibodies in early arthritis: Advances in diagnosis and prognostication. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 21(5), S59–S64.
Unlocking the "PAD" lock on rheumatoid arthritis Utz, P. J., Genovese, M. C., & Robinson, W. H. (2004). Unlocking the "PAD" lock on rheumatoid arthritis. ANNALS OF THE RHEUMATIC DISEASES, 63(4), 330–332.
Microarray profiling of antiviral antibodies for the development of diagnostics, vaccines, and therapeutics de Vegvar, H. E. N., & Robinson, W. H. (2004). Microarray profiling of antiviral antibodies for the development of diagnostics, vaccines, and therapeutics. CLINICAL IMMUNOLOGY, 111(2), 196–201.
Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice Hueber, W., Zeng, D. F., Sharpe, O., Robinson, W. H., Strober, S., & Utz, P. J. (2004). Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice. EUROPEAN JOURNAL OF IMMUNOLOGY, 34(6), 1654–1662.
High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases Graham, K. L., Robinson, W. H., Steinman, L., & Utz, P. J. (2004). High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases. AUTOIMMUNITY, 37(4), 269–272.
Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis Fontoura, P., Ho, P. P., DeVoss, J., Zheng, B. H., Lee, B. J., Kidd, B. A., … Steinman, L. (2004). Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. JOURNAL OF IMMUNOLOGY, 173(11), 6981–6992.
Antigen microarray profiling of autoantibodies in rheumatoid arthritis Hueber, W., Kidd, B. A., Tomooka, B. H., Lee, B. J., Bruce, B., Fries, J. F., … Robinson, W. H. (2005). Antigen microarray profiling of autoantibodies in rheumatoid arthritis. ARTHRITIS AND RHEUMATISM, 52(9), 2645–2655.
A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease Ho, P. P., Fontoura, P., Platten, M., Sobel, R. A., DeVoss, J. J., Lee, L. Y., … Steinman, L. (2005). A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease. JOURNAL OF IMMUNOLOGY, 175(9), 6226–6234.
Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite Platten, M., Ho, P. P., Youssef, S., Fontoura, P., Garren, H., Hur, E. M., … Steinman, L. (2005). Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. SCIENCE, 310(5749), 850–855.
Suppression of autoimmunity via microbial mimics of altered peptide ligands Steinman, L., Utz, P. J., & Robinson, W. H. (2005). Suppression of autoimmunity via microbial mimics of altered peptide ligands. MOLECULAR MIMICRY: INFECTION-INDUCING AUTOIMMUNE DISEASE, 296, 55–63.
Lipid microarrays identify key mediators of autoimmune brain inflammation Kanter, J. L., Narayana, S., Ho, P. P., Catz, I., Warren, K. G., Sobel, R. A., … Robinson, W. H. (2006). Lipid microarrays identify key mediators of autoimmune brain inflammation. NATURE MEDICINE, 12(1), 138–143.
EXTENSIVE POLYMORPHISM IN THE EXTRACELLULAR DOMAIN OF THE MOUSE B-CELL DIFFERENTIATION ANTIGEN LYB-2/CD72 Robinson, W. H., Ying, H., Miceli, M. C., & Parnes, J. R. (1992). EXTENSIVE POLYMORPHISM IN THE EXTRACELLULAR DOMAIN OF THE MOUSE B-CELL DIFFERENTIATION ANTIGEN LYB-2/CD72. JOURNAL OF IMMUNOLOGY, 149(3), 880–886.
Antigen arrays for antibody profiling Robinson, W. H. (2006). Antigen arrays for antibody profiling. CURRENT OPINION IN CHEMICAL BIOLOGY, 10(1), 67–72.
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis Kuhn, K. A., Kulik, L., Tomooka, B., Braschler, K. J., Arend, W. P., Robinson, W. H., & Holers, V. M. (2006). Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. JOURNAL OF CLINICAL INVESTIGATION, 116(4), 961–973.
Fluid supported lipid bilayers containing mono sialoganglioside GM1: A QCM-D and FRAP study Weng, K. C., Kanter, J. L., Robinson, W. H., & Frank, C. W. (2006). Fluid supported lipid bilayers containing mono sialoganglioside GM1: A QCM-D and FRAP study. COLLOIDS AND SURFACES B-BIOINTERFACES, 50(1), 76–84.
Proteomic biomarkers for autoimmune disease Hueber, W., & Robinson, W. H. (2006). Proteomic biomarkers for autoimmune disease. PROTEOMICS, 6(14), 4100–4105.
SYNTHESIS OF VIRAL-SPECIFIC RIBONUCLEIC ACID IN RUBELLA VIRUS-INFECTED CELLS Wong, K. T., Robinson, W. S., & Merigan, T. C. (1969). SYNTHESIS OF VIRAL-SPECIFIC RIBONUCLEIC ACID IN RUBELLA VIRUS-INFECTED CELLS. JOURNAL OF VIROLOGY, 4(6), 901-?
Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines Hueber, W., Tomooka, B. H., Zhao, X., Kidd, B. A., Drijfhout, J. W., Fries, J. F., … Robinson, W. H. (2007). Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines. ANNALS OF THE RHEUMATIC DISEASES, 66(6), 712–719.
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis Paniagua, R. T., Sharpe, O., Ho, P. P., Chan, S. M., Chang, A., Higgins, J. P., … Robinson, W. H. (2006). Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis. JOURNAL OF CLINICAL INVESTIGATION, 116(10), 2633–2642.
Tolerizing DNA vaccines for autoimmune arthritis Ho, P. P., Higgins, J. P., Kidd, B. A., Tomooka, B., Digennaro, C., Lee, L. Y., … Robinson, W. H. (2006). Tolerizing DNA vaccines for autoimmune arthritis. AUTOIMMUNITY, 39(8), 675–682.
Imatinib for the treatment of rheumatic diseases Paniagua, R. T., & Robinson, W. H. (2007). Imatinib for the treatment of rheumatic diseases. NATURE CLINICAL PRACTICE RHEUMATOLOGY, 3(4), 190–191.
Identification of biomarkers associated with the development of hepatocellular carcinoma in CuZn superoxide dismutase deficient mice Elchuri, S., Naeemuddin, M., Sharpe, O., Robinson, W. H., & Huang, T.-T. (2007). Identification of biomarkers associated with the development of hepatocellular carcinoma in CuZn superoxide dismutase deficient mice. PROTEOMICS, 7(12), 2121–2129.
Protective and therapeutic role for alpha B-crystallin in autoimmune demyelination Ousman, S. S., Tomooka, B. H., Van Noort, J. M., Wawrousek, E. F., O'Connor, K. C., Hafler, D. A., … Steinman, L. (2007). Protective and therapeutic role for alpha B-crystallin in autoimmune demyelination. NATURE, 448(7152), 474–U7.
Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial Bar-Or, A., Vollmer, T., Antel, J., Arnold, D. L., Bodner, C. A., Campagnolo, D., … Garren, H. (2007). Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial. ARCHIVES OF NEUROLOGY, 64(10), 1407–1415.
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets Han, M. H., Hwang, S.-I., Roy, D. B., Lundgren, D. H., Price, J. V., Ousman, S. S., … Steinman, L. (2008). Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. NATURE, 451(7182), 1076–U2.
Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance Shachaf, C. M., Gentles, A. J., Elchuri, S., Sahoo, D., Soen, Y., Sharpe, O., … Felsher, D. W. (2008). Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. CANCER RESEARCH, 68(13), 5132–5142.
Regulation of tissue inflammation by thrombi n-activatable carboxypeptidase B (or TAFI) Leung, L. L. K., Myles, T., Nishimura, T., Song, J. J., & Robinson, W. H. (2008). Regulation of tissue inflammation by thrombi n-activatable carboxypeptidase B (or TAFI). MOLECULAR IMMUNOLOGY, 45(16), 4080–4083.
Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination Kidd, B. A., Ho, P. P., Sharpe, O., Zhao, X., Tomooka, B. H., Kanter, J. L., … Robinson, W. H. (2008). Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination. ARTHRITIS RESEARCH & THERAPY, 10(5).
Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements Li, H., Chen, W., Zhou, Y., Abidi, P., Sharpe, O., Robinson, W. H., … Liu, J. (2009). Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements. JOURNAL OF LIPID RESEARCH, 50(5), 820–831.
Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis Chung, L., Fiorentino, D. F., Benbarak, M. J., Adler, A. S., Mariano, M. M., Paniagua, R. T., … Robinson, W. H. (2009). Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis. ARTHRITIS AND RHEUMATISM, 60(2), 584–591.
Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis Hueber, W., Tomooka, B. H., Batliwalla, F., Li, W., Monach, P. A., Tibshirani, R. J., … Robinson, W. H. (2009). Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis. ARTHRITIS RESEARCH & THERAPY, 11(3).
Tyrosine kinases as targets for the treatment of rheumatoid arthritis Swanson, C. D. A., Paniagua, R. T., Lindstrom, T. M., & Robinson, W. H. (2009). Tyrosine kinases as targets for the treatment of rheumatoid arthritis. NATURE REVIEWS RHEUMATOLOGY, 5(6), 317–324.
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease Britschgi, M., Olin, C. E., Johns, H. T., Takeda-Uchimura, Y., LeMieux, M. C., Rufibach, K., … Wyss-Coray, T. (2009). Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(29), 12145–12150.
Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin Coffey, G. P., Rajapaksa, R., Liu, R., Sharpe, O., Kuo, C.-C., Krauss, S. W., … Levy, S. (2009). Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin. JOURNAL OF CELL SCIENCE, 122(17), 3137–3144.
A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis Monach, P. A., Hueber, W., Kessler, B., Tomooka, B. H., BenBarak, M., Simmons, B. P., … Benoist, C. (2009). A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(37), 15867–15872.
Thrombin-Activatable Carboxypeptidase B Cleavage of Osteopontin Regulates Neutrophil Survival and Synoviocyte Binding in Rheumatoid Arthritis Sharif, S. A., Du, X., Myles, T., Song, J. J., Price, E., Lee, D. M., … Leung, L. L. K. (2009). Thrombin-Activatable Carboxypeptidase B Cleavage of Osteopontin Regulates Neutrophil Survival and Synoviocyte Binding in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 60(10), 2902–2912.
Autoimmunity against Fibrinogen Mediates Inflammatory Arthritis in Mice Ho, P. P., Lee, L. Y., Zhao, X., Tomooka, B. H., Paniagua, R. T., Sharpe, O., … Robinson, W. H. (2010). Autoimmunity against Fibrinogen Mediates Inflammatory Arthritis in Mice. JOURNAL OF IMMUNOLOGY, 184(1), 379–390.
Autoimmune Disease Classification by Inverse Association with SNP Alleles Sirota, M., Schaub, M. A., Batzoglou, S., Robinson, W. H., & Butte, A. J. (2009). Autoimmune Disease Classification by Inverse Association with SNP Alleles. PLOS GENETICS, 5(12).
c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis Paniagua, R. T., Chang, A., Mariano, M. M., Stein, E. A., Wang, Q., Lindstrom, T. M., … Robinson, W. H. (2010). c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis. ARTHRITIS RESEARCH & THERAPY, 12(1).
A Multitude of Kinases-Which are the Best Targets in Treating Rheumatoid Arthritis? Lindstrom, T. M., & Robinson, W. H. (2010). A Multitude of Kinases-Which are the Best Targets in Treating Rheumatoid Arthritis? RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 36(2), 367-?
Biomarkers for rheumatoid arthritis: making it personal. Lindstrom, T. M., & Robinson, W. H. (2010). Biomarkers for rheumatoid arthritis: making it personal. Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum, 242, 79–84.
Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury Vargas, M. E., Watanabe, J., Singh, S. J., Robinson, W. H., & Barres, B. A. (2010). Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(26), 11993–11998.
Tyrosine kinases in inflammatory dermatologic disease Paniagua, R. T., Fiorentino, D. F., Chung, L., & Robinson, W. H. (2011). Tyrosine kinases in inflammatory dermatologic disease. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 65(2), 389–403.
Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis Soederstroem, K., Stein, E., Colmenero, P., Purath, U., Mueller-Ladner, U., de Matos, C. T., … Engleman, E. G. (2010). Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(29), 13028–13033.
Rheumatoid Arthritis: A Role for Immunosenescence? Lindstrom, T. M., & Robinson, W. H. (2010). Rheumatoid Arthritis: A Role for Immunosenescence? JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 58(8), 1565–1575.
Immune Complexes Containing Citrullinated Fibrinogen Costimulate Macrophages via Toll-like Receptor 4 and Fc gamma Receptor Sokolove, J., Zhao, X., Chandra, P. E., & Robinson, W. H. (2011). Immune Complexes Containing Citrullinated Fibrinogen Costimulate Macrophages via Toll-like Receptor 4 and Fc gamma Receptor. ARTHRITIS AND RHEUMATISM, 63(1), 53–62.
A model for harmonizing flow cytometry in clinical trials. Maecker, H. T., McCoy, J. P., Amos, M., Elliott, J., Gaigalas, A., Wang, L., … Yeh, J.-H. (2010). A model for harmonizing flow cytometry in clinical trials. Nature Immunology, 11(11), 975–978.
Fishing for Biomarkers with Antigen Mimics Lindstrom, T. M., & Robinson, W. H. (2011). Fishing for Biomarkers with Antigen Mimics. CELL, 144(1), 13–15.
Chaperone Activity of alpha B-Crystallin Is Responsible for Its Incorrect Assignment as an Autoantigen in Multiple Sclerosis Rothbard, J. B., Zhao, X., Sharpe, O., Strohman, M. J., Kurnellas, M., Mellins, E. D., … Steinman, L. (2011). Chaperone Activity of alpha B-Crystallin Is Responsible for Its Incorrect Assignment as an Autoantigen in Multiple Sclerosis. JOURNAL OF IMMUNOLOGY, 186(7), 4263–4268.
Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles Pearl, J. I., Ma, T., Irani, A. R., Huang, Z., Robinson, W. H., Smith, R. L., & Goodman, S. B. (2011). Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles. BIOMATERIALS, 32(24), 5535–5542.
Human peptidome display Robinson, W. H., & Steinman, L. (2011). Human peptidome display. NATURE BIOTECHNOLOGY, 29(6), 500–502.
Novel multiplex technology for diagnostic characterization of rheumatoid arthritis Chandra, P. E., Sokolove, J., Hipp, B. G., Lindstrom, T. M., Elder, J. T., Reveille, J. D., … Robinson, W. H. (2011). Novel multiplex technology for diagnostic characterization of rheumatoid arthritis. ARTHRITIS RESEARCH & THERAPY, 13(3).
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis Song, J. J., Hwang, I. Y., Cho, K. H., Garcia, M. A., Kim, A. J., Wang, T. H., … Robinson, W. H. (2011). Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. JOURNAL OF CLINICAL INVESTIGATION, 121(9), 3517–3527.
Tyrosine Kinase Inhibitors Ameliorate Autoimmune Encephalomyelitis in a Mouse Model of Multiple Sclerosis Crespo, O., Kang, S. C., Daneman, R., Lindstrom, T. M., Ho, P. P., Sobel, R. A., … Robinson, W. H. (2011). Tyrosine Kinase Inhibitors Ameliorate Autoimmune Encephalomyelitis in a Mouse Model of Multiple Sclerosis. JOURNAL OF CLINICAL IMMUNOLOGY, 31(6), 1010–1020.
Chemerin158K Protein Is the Dominant Chemerin Isoform in Synovial and Cerebrospinal Fluids but Not in Plasma Zhao, L., Yamaguchi, Y., Sharif, S., Du, X.-Y., Song, J. J., Lee, D. M., … Leung, L. L. K. (2011). Chemerin158K Protein Is the Dominant Chemerin Isoform in Synovial and Cerebrospinal Fluids but Not in Plasma. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(45), 39520–39527.
Identification of a central role for complement in osteoarthritis Wang, Q., Rozelle, A. L., Lepus, C. M., Scanzello, C. R., Song, J. J., Larsen, D. M., … Robinson, W. H. (2011). Identification of a central role for complement in osteoarthritis. NATURE MEDICINE, 17(12), 1674–U196.
Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis Lin, J. T., Stein, E. A., Wong, M. T., Kalpathy, K. J., Su, L. L., Utz, P. J., … Fathnnan, C. G. (2012). Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis. CLINICAL IMMUNOLOGY, 142(2), 127–138.
Development and deployment of antigen arrays for investigation of B-cell fine specificity in autoimmune disease. Sokolove, J., Lindstrom, T. M., & Robinson, W. H. (2012). Development and deployment of antigen arrays for investigation of B-cell fine specificity in autoimmune disease. Frontiers in Bioscience (Elite Edition), 4, 320–330.
Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4 Sohn, D. H., Sokolove, J., Sharpe, O., Erhart, J. C., Chandra, P. E., Lahey, L. J., … Robinson, W. H. (2012). Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. ARTHRITIS RESEARCH & THERAPY, 14(1).
Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis Hwang, S.-J., Choi, B., Kang, S.-S., Chang, J.-H., Kim, Y.-G., Chung, Y.-H., … Chang, E.-J. (2012). Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis. ARTHRITIS RESEARCH & THERAPY, 14(1).
Therapeutic Effects of Systemic Administration of Chaperone alpha B-Crystallin Associated with Binding Proinflammatory Plasma Proteins Rothbard, J. B., Kurnellas, M. P., Brownell, S., Adams, C. M., Su, L., Axtell, R. C., … Steinman, L. (2012). Therapeutic Effects of Systemic Administration of Chaperone alpha B-Crystallin Associated with Binding Proinflammatory Plasma Proteins. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(13), 9708–9721.
Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase Ameliorates Collagen-Induced Arthritis Swanson, C. D., Akama-Garren, E. H., Stein, E. A., Petralia, J. D., Ruiz, P. J., Edalati, A., … Robinson, W. H. (2012). Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase Ameliorates Collagen-Induced Arthritis. JOURNAL OF IMMUNOLOGY, 188(7), 3513–3521.
New tools for classification and monitoring of autoimmune diseases Maecker, H. T., Lindstrom, T. M., Robinson, W. H., Utz, P. J., Hale, M., Boyd, S. D., … Fathman, C. G. (2012). New tools for classification and monitoring of autoimmune diseases. NATURE REVIEWS RHEUMATOLOGY, 8(6), 317–328.
Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis Sokolove, J., Bromberg, R., Deane, K. D., Lahey, L. J., Derber, L. A., Chandra, P. E., … Robinson, W. H. (2012). Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis. PLOS ONE, 7(5).
Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation Ho, P. P., Kanter, J. L., Johnson, A. M., Srinagesh, H. K., Chang, E.-J., Purdy, T. M., … Robinson, W. H. (2012). Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation. SCIENCE TRANSLATIONAL MEDICINE, 4(137).
Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply. Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply. (2012). Arthritis Research & Therapy, 14(5), 406.
Genomics and proteomics: Applications in autoimmune diseases. Hueber, W., & Robinson, W. H. (2009). Genomics and proteomics: Applications in autoimmune diseases. Pharmacogenomics and Personalized Medicine, 2, 39–48.
Brief report: citrullination within the atherosclerotic plaque: a potential target for the anti-citrullinated protein antibody response in rheumatoid arthritis. Sokolove, J., Brennan, M. J., Sharpe, O., Lahey, L. J., Kao, A. H., Krishnan, E., … Robinson, W. H. (2013). Brief report: citrullination within the atherosclerotic plaque: a potential target for the anti-citrullinated protein antibody response in rheumatoid arthritis. Arthritis and Rheumatism, 65(7), 1719–1724.
Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis. Van Haren, K., Tomooka, B. H., Kidd, B. A., Banwell, B., Bar-Or, A., Chitnis, T., … Robinson, W. H. (2013). Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 19(13), 1726–1733.
HUMAN CD6 POSSESSES A LARGE, ALTERNATIVELY SPLICED CYTOPLASMIC DOMAIN Robinson, W. H., DEVEGVAR, H. E. N., Prohaska, S. S., Rhee, J. W., & Parnes, J. R. (1995). HUMAN CD6 POSSESSES A LARGE, ALTERNATIVELY SPLICED CYTOPLASMIC DOMAIN. EUROPEAN JOURNAL OF IMMUNOLOGY, 25(10), 2765–2769.
IDENTIFICATION OF A MOUSE PROTEIN HOMOLOGOUS TO THE HUMAN CD6 T-CELL SURFACE PROTEIN AND SEQUENCE OF THE CORRESPONDING CDNA Robinson, W. H., Prohaska, S. S., Santoro, J. C., Robinson, H. L., & Parnes, J. R. (1995). IDENTIFICATION OF A MOUSE PROTEIN HOMOLOGOUS TO THE HUMAN CD6 T-CELL SURFACE PROTEIN AND SEQUENCE OF THE CORRESPONDING CDNA. JOURNAL OF IMMUNOLOGY, 155(10), 4739–4748.
STRUCTURE OF THE MOUSE CD72 (LYB-2) GENE AND ITS ALTERNATIVELY SPLICED TRANSCRIPTS Ying, H., Nakayama, E., Robinson, W. H., & Parnes, J. R. (1995). STRUCTURE OF THE MOUSE CD72 (LYB-2) GENE AND ITS ALTERNATIVELY SPLICED TRANSCRIPTS. JOURNAL OF IMMUNOLOGY, 154(6), 2743–2752.
BIOCHEMICAL IDENTITY OF THE MOUSE LY-19.2 AND LY-32.2 ALLOANTIGENS WITH THE B-CELL DIFFERENTIATION ANTIGEN LYB-2/CD72 Robinson, W. H., LANDOLFI, M. M. T., Schafer, H., & Parnes, J. R. (1993). BIOCHEMICAL IDENTITY OF THE MOUSE LY-19.2 AND LY-32.2 ALLOANTIGENS WITH THE B-CELL DIFFERENTIATION ANTIGEN LYB-2/CD72. JOURNAL OF IMMUNOLOGY, 151(9), 4764–4772.
Allele-specific expression of the mouse B-cell surface protein CD72 on T cells Robinson, W. H., LANDOLFI, M. M. T., & Parnes, J. R. (1997). Allele-specific expression of the mouse B-cell surface protein CD72 on T cells. IMMUNOGENETICS, 45(3), 195–200.
Porphyromonas Gingivalis (P. gingivalis) is Associated with the Presence of Disease-Specific Autoantibodies in Individuals At Increased Risk for the Future Development of Rheumatoid Arthritis Mikuls, T. R., Deane, K. D., Payne, J., Thiele, G. M., O'Dell, J. R., Derber, L. A., … Norris, J. M. (2011). Porphyromonas Gingivalis (P. gingivalis) is Associated with the Presence of Disease-Specific Autoantibodies in Individuals At Increased Risk for the Future Development of Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 63(10), S300–S300.
Porphyromonas gingivalis and Disease-Related Autoantibodies in Individuals at Increased Risk of Rheumatoid Arthritis Mikuls, T. R., Thiele, G. M., Deane, K. D., Payne, J. B., O'Dell, J. R., Yu, F., … Norris, J. M. (2012). Porphyromonas gingivalis and Disease-Related Autoantibodies in Individuals at Increased Risk of Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 64(11), 3522–3530.
Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply Sohn, D. H., Sokolove, J., Sharpe, O., Erhart, J. C., Chandra, P. E., Lahey, L. J., … Robinson, W. H. (2012). Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply. ARTHRITIS RESEARCH & THERAPY, 14(5).
Evolution of Preclinical Autoimmunity in Individuals At Risk for Development of Rheumatoid Arthritis El-Gabalawy, H. S., Robinson, D. B., Smolik, I., Hart, D. M., Ferucci, E. D., Newkirk, M. M., … Robinson, W. H. (2012). Evolution of Preclinical Autoimmunity in Individuals At Risk for Development of Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 64(10), S722–S722.
Differentially Cleaved Forms of Osteopontin by Thrombin and Carboxypeptidase B (TAF1a) Regulates Neutrophil Viability and Synoviocyte Binding in Rheumatoid Arthritis Sharif, S., Du, X.-Y., Myles, T., Song, J. J., Price, E. A., Lee, D., … Leung, L. L. (2008). Differentially Cleaved Forms of Osteopontin by Thrombin and Carboxypeptidase B (TAF1a) Regulates Neutrophil Viability and Synoviocyte Binding in Rheumatoid Arthritis. BLOOD, 112(11), 1219–1219.
Targeting mTOR and MAPK Pathways to Inhibit Naive and Experienced Effector CD4 T Cells in Autoimmunity Lin, J., Stein, E., Wong, M., Kalpathy, K., Su, L., Utz, P., … Fathman, C. (2010). Targeting mTOR and MAPK Pathways to Inhibit Naive and Experienced Effector CD4 T Cells in Autoimmunity. Presented at the 10th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, BOSTON,MA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
The Associations of HLA-DR Shared Epitope Alleles and Serum Cytokines Among Postmenopausal Women with Rheumatoid Factor and Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis. Talabi, M. B., Mackey, R., Moreland, L. W., Dorman, J., Deane, K. D., Sokolove, J., … Kuller, L. (2012). The Associations of HLA-DR Shared Epitope Alleles and Serum Cytokines Among Postmenopausal Women with Rheumatoid Factor and Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 64(10), S895–S895.
Anti-Citrullinated Peptide Autoantibodies to Rheumatoid Synovium Epitopes in Women and Risk of Future Rheumatoid Arthritis. Arkema, E. V., Goldstein, B. L., Robinson, W. H., Cramb, C., Sokolove, J., Cui, J., … Costenbader, K. H. (2012). Anti-Citrullinated Peptide Autoantibodies to Rheumatoid Synovium Epitopes in Women and Risk of Future Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 64(10), S685–S686.
A central anti-inflammatory role of carboxypeptidase B in autoimmune arthritis Song, J. J., Nishimura, T., Garcia, M., Myles, T., Du, X., Sharif, S., … Robinson, W. (2008). A central anti-inflammatory role of carboxypeptidase B in autoimmune arthritis. ARTHRITIS AND RHEUMATISM, 58(9), S264–S265.
Rheumatoid arthritis (RA)-related antibody positivity is associated with serum cytokine elevations in RA-free first-degree relatives (FDRs) of RA-probands Deane, K. D., Robinson, W. H., Majka, D. S., Parrish, L. A., BenBarak, M., Weisman, M. H., … Holers, V. M. (2008). Rheumatoid arthritis (RA)-related antibody positivity is associated with serum cytokine elevations in RA-free first-degree relatives (FDRs) of RA-probands. ARTHRITIS AND RHEUMATISM, 58(9), S615–S615.
Anti-GITR treatment in collagen-induced arthritis results in enhanced epitope spreading and increased antibodies to citrullinated protein antigens (ACPA) Cozine, C., Robinson, W. H., BenBarak, M., & Holers, V. M. (2008). Anti-GITR treatment in collagen-induced arthritis results in enhanced epitope spreading and increased antibodies to citrullinated protein antigens (ACPA). ARTHRITIS AND RHEUMATISM, 58(9), S405–S406.
Molecular framework for response to imatinib mesylate in systemic sclerosis Chung, L., Fiorentino, D. F., Benbarak, M. J., Adler, A. S., Mariano, M. M., Paniagua, R. T., … Robinson, W. H. (2008). Molecular framework for response to imatinib mesylate in systemic sclerosis. ARTHRITIS AND RHEUMATISM, 58(9), S819–S820.
Development of peptide microarrays to investigate autoantibody epitope specificity in Pemphigus vulgaris Hazelton, J., Patel, M., Furstenberg, G., Tyagi, S., Haab, B. B., Robinson, W. H., … Sinha, A. A. (2011). Development of peptide microarrays to investigate autoantibody epitope specificity in Pemphigus vulgaris. Presented at the 71st Annual Meeting of the Society-for-Investigative-Dermatology, PHOENIX,AZ: NATURE PUBLISHING GROUP.
Development of protein microarrays to investigate autoantibody profiles in pemphigus vulgaris Patel, M., Furstenberg, G., Hazelton, J., Tiagi, S., Seiffert-Sinha, K., Haab, B. B., … Sinha, A. A. (2010). Development of protein microarrays to investigate autoantibody profiles in pemphigus vulgaris. Presented at the Annual Meeting of the Society-for-Investigative-Dermatology, ATLANTA,GA: NATURE PUBLISHING GROUP.
Evaluation of an imatinib response gene signature in patients with systemic sclerosis Chung, L., Ruiz, P., Wood, T., Shoor, S., Robinson, W., Whitfield, M., … Fiorentino, D. (2010). Evaluation of an imatinib response gene signature in patients with systemic sclerosis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 28(5), S62–S62.
Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens Kuhn, K. A., Cozine, C. L., Tomooka, B., Robinson, W. H., & Holers, V. M. (2008). Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. MOLECULAR IMMUNOLOGY, 45(10), 2808–2819.
The Number of Elevated Cytokines and Chemokines in Preclinical Seropositive Rheumatoid Arthritis Predicts Time to Diagnosis in an Age-Dependent Manner Deane, K. D., O'Donnell, C. I., Hueber, W., Majka, D. S., Lazar, A. A., Derber, L. A., … Holers, V. M. (2010). The Number of Elevated Cytokines and Chemokines in Preclinical Seropositive Rheumatoid Arthritis Predicts Time to Diagnosis in an Age-Dependent Manner. ARTHRITIS AND RHEUMATISM, 62(11), 3161–3172.
Correlation between Circulating Plasmablasts and Disease Activity in Patients with ACPA plus Rheumatoid Arthritis Tan, Y. C., Sokolove, J., & Robinson, W. (2010). Correlation between Circulating Plasmablasts and Disease Activity in Patients with ACPA plus Rheumatoid Arthritis. Presented at the 10th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, BOSTON,MA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
Tyrosine Kinases in Autoimmune Demyelination Crespo, O., Kang, S., Daneman, R., Sobel, R., Ho, P., Steinman, L., & Robinson, W. (2009). Tyrosine Kinases in Autoimmune Demyelination. Presented at the 9th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, SAN FRANCISCO,CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells Chang, B. Y., Huang, M. M., Francesco, M., Chen, J., Sokolove, J., Magadala, P., … Buggy, J. J. (2011). The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells. ARTHRITIS RESEARCH & THERAPY, 13(4).
The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes Cloutier, N., Tan, S., Boudreau, L. H., Cramb, C., Subbaiah, R., Lahey, L., … Boilard, E. (2013). The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes. EMBO MOLECULAR MEDICINE, 5(2), 235–249.
Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems Tang, H., Lee, M., Sharpe, O., Salamone, L., Noonan, E. J., Hoang, C. D., … Shrager, J. B. (2012). Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems. FASEB JOURNAL, 26(11), 4710–4721.
Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes. Roep, B. O., Solvason, N., Gottlieb, P. A., Abreu, J. R. F., Harrison, L. C., Eisenbarth, G. S., … Steinman, L. (2013). Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes. Science Translational Medicine, 5(191), 191ra82-?
Elemental bio-imaging of calcium phosphate crystal deposits in knee samples from arthritic patients Austin, C., Hare, D., Rozelle, A. L., Robinson, W. H., Grimm, R., & Doble, P. (2009). Elemental bio-imaging of calcium phosphate crystal deposits in knee samples from arthritic patients. METALLOMICS, 1(2), 142–147.
Identification of acute phase reactants and cytokines useful for monitoring infliximab therapy in ankylosing spondylitis Romero-Sanchez, C., Robinson, W. H., Tomooka, B. H., Londono, J., Valle-Onate, R., Huang, F., … Yu, D. T. Y. (2008). Identification of acute phase reactants and cytokines useful for monitoring infliximab therapy in ankylosing spondylitis. CLINICAL RHEUMATOLOGY, 27(11), 1429–1435.
B Cells and Transplantation: An Educational Resource Small, T. N., Robinson, W. H., & Miklos, D. B. (2009). B Cells and Transplantation: An Educational Resource. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 15(1), 104–113.
Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis Zhao, X., Qureshi, F., Eastman, P. S., Manning, W. C., Alexander, C., Robinson, W. H., & Hesterberg, L. K. (2012). Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis. JOURNAL OF IMMUNOLOGICAL METHODS, 378(1-2), 72–80.
Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis. Lepus, C. M., Song, J. J., Wang, Q., Wagner, C. A., Lindstrom, T. M., Chu, C. R., … Robinson, W. H. (2014). Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.), 66(1), 101–106.
Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus Price, J. V., Haddon, D. J., Kemmer, D., Delepine, G., Mandelbaum, G., Jarrell, J. A., … Utz, P. J. (2013). Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. JOURNAL OF CLINICAL INVESTIGATION, 123(12), 5135–5145.
Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform Gottlieb, P., Utz, P. J., Robinson, W., & Steinman, L. (2013). Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform. CLINICAL IMMUNOLOGY, 149(3), 297–306.
High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination. Tan, Y.-C., Blum, L. K., Kongpachith, S., Ju, C.-H., Cai, X., Lindstrom, T. M., … Robinson, W. H. (2014). High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination. Clinical Immunology , 151(1), 55–65.
Serum inflammatory mediators as markers of human lyme disease activity. Soloski, M. J., Crowder, L. A., Lahey, L. J., Wagner, C. A., Robinson, W. H., & Aucott, J. N. (2014). Serum inflammatory mediators as markers of human lyme disease activity. PloS One, 9(4).
Identifying functional anti-Staphylococcus aureus antibodies by sequencing antibody repertoires of patient plasmablasts Lu, D. R., Tan, Y.-C., Kongpachith, S., Cai, X., Stein, E. A., Lindstrom, T. M., … Robinson, W. H. (2014). Identifying functional anti-Staphylococcus aureus antibodies by sequencing antibody repertoires of patient plasmablasts. CLINICAL IMMUNOLOGY, 152(1-2), 77–89.
Relatives Without Rheumatoid Arthritis Show Reactivity to Anti-Citrullinated Protein/Peptide Antibodies That Are Associated With Arthritis-Related Traits: Studies of the Etiology of Rheumatoid Arthritis Young, K. A., Deane, K. D., Derber, L. A., Hughes-Austin, J. M., Wagner, C. A., Sokolove, J., … Norris, J. M. (2013). Relatives Without Rheumatoid Arthritis Show Reactivity to Anti-Citrullinated Protein/Peptide Antibodies That Are Associated With Arthritis-Related Traits: Studies of the Etiology of Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 65(8), 1995–2004.
Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA) Hughes-Austin, J. M., Deane, K. D., Derber, L. A., Kolfenbach, J. R., Zerbe, G. O., Sokolove, J., … Norris, J. M. (2013). Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA). ANNALS OF THE RHEUMATIC DISEASES, 72(6), 901–907.
Optical imaging of articular cartilage degeneration using near-infrared dipicolylamine probes. Hu, X., Wang, Q., Liu, Y., Liu, H., Qin, C., Cheng, K., … Cheng, Z. (2014). Optical imaging of articular cartilage degeneration using near-infrared dipicolylamine probes. Biomaterials, 35(26), 7511–7521.
Rheumatoid Factor as a Potentiator of Anti-Citrullinated Protein Antibody-Mediated Inflammation in Rheumatoid Arthritis Sokolove, J., Johnson, D. S., Lahey, L. J., Wagner, C. A., Cheng, D., Thiele, G. M., … Robinson, W. H. (2014). Rheumatoid Factor as a Potentiator of Anti-Citrullinated Protein Antibody-Mediated Inflammation in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66(4), 813–821.
Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis Lepus, C. M., Song, J. J., Wang, Q., Wagner, C. A., Lindstrom, T. M., Chu, C. R., … Robinson, W. H. (2014). Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis. ARTHRITIS & RHEUMATOLOGY, 66(1), 101–106.
Periodontitis and Porphyromonas gingivalis in Patients With Rheumatoid Arthritis Mikuls, T. R., Payne, J. B., Yu, F., Thiele, G. M., Reynolds, R. J., Cannon, G. W., … O'Dell, J. R. (2014). Periodontitis and Porphyromonas gingivalis in Patients With Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66(5), 1090–1100.
Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor alpha-Induced Inflammatory Arthritis Shelef, M. A., Sokolove, J., Lahey, L. J., Wagner, C. A., Sackmann, E. K., Warner, T. F., … Huttenlocher, A. (2014). Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor alpha-Induced Inflammatory Arthritis. ARTHRITIS & RHEUMATOLOGY, 66(6), 1482–1491.
Role of Protein Phosphatase Magnesium-Dependent 1A and Anti-Protein Phosphatase Magnesium-Dependent 1A Autoantibodies in Ankylosing Spondylitis Kim, Y.-G., Sohn, D. H., Zhao, X., Sokolove, J., Lindstrom, T. M., Yoo, B., … Robinson, W. H. (2014). Role of Protein Phosphatase Magnesium-Dependent 1A and Anti-Protein Phosphatase Magnesium-Dependent 1A Autoantibodies in Ankylosing Spondylitis. ARTHRITIS & RHEUMATOLOGY, 66(10), 2793–2803.
Contribution of Mast Cell-Derived Interleukin-1 beta to Uric Acid Crystal-Induced Acute Arthritis in Mice Reber, L. L., Marichal, T., Sokolove, J., Starkl, P., Gaudenzio, N., Iwakura, Y., … Galli, S. J. (2014). Contribution of Mast Cell-Derived Interleukin-1 beta to Uric Acid Crystal-Induced Acute Arthritis in Mice. ARTHRITIS & RHEUMATOLOGY, 66(10), 2881–2891.
Barcode-Enabled Sequencing of Plasmablast Antibody Repertoires in Rheumatoid Arthritis Tan, Y.-C., Kongpachith, S., Blum, L. K., Ju, C.-H., Lahey, L. J., Lu, D. R., … Robinson, W. H. (2014). Barcode-Enabled Sequencing of Plasmablast Antibody Repertoires in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66(10), 2706–2715.
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. Wagner, C. A., Sokolove, J., Lahey, L. J., Bengtsson, C., Saevarsdottir, S., Alfredsson, L., … Robinson, W. H. (2015). Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. Annals of the Rheumatic Diseases, 74(3), 579–586.
Malondialdehyde-Acetaldehyde Adducts and Anti-Malondialdehyde-Acetaldehyde Antibodies in Rheumatoid Arthritis Thiele, G. M., Duryee, M. J., Anderson, D. R., Klassen, L. W., Mohring, S. M., Young, K. A., … Mikuls, T. R. (2015). Malondialdehyde-Acetaldehyde Adducts and Anti-Malondialdehyde-Acetaldehyde Antibodies in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 67(3), 645–655.
Associations of toll-like receptor (TLR)-4 single nucleotide polymorphisms and rheumatoid arthritis disease progression: An observational cohort study Davis, M. L. R., LeVan, T. D., Yu, F., Sayles, H., Sokolove, J., Robinson, W., … Mikuls, T. R. (2015). Associations of toll-like receptor (TLR)-4 single nucleotide polymorphisms and rheumatoid arthritis disease progression: An observational cohort study. INTERNATIONAL IMMUNOPHARMACOLOGY, 24(2), 346–352.
Biomarkers for rheumatoid arthritis: Making it personal Lindstrom, T. M., & Robinson, W. H. (2010). Biomarkers for rheumatoid arthritis: Making it personal. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 70, 79–84.
Quantitative Radiologic Imaging Techniques for Articular Cartilage Composition: Toward Early Diagnosis and Development of Disease-Modifying Therapeutics for Osteoarthritis Oei, E. H. G., van Tiel, J., Robinson, W. H., & Gold, G. E. (2014). Quantitative Radiologic Imaging Techniques for Articular Cartilage Composition: Toward Early Diagnosis and Development of Disease-Modifying Therapeutics for Osteoarthritis. ARTHRITIS CARE & RESEARCH, 66(8), 1129–1141.
Predictive Value of Autoantibody Testing for Validating Self-reported Diagnoses of Rheumatoid Arthritis in the Women's Health Initiative Walitt, B., Mackey, R., Kuller, L., Deane, K. D., Robinson, W., Holers, V. M., … Moreland, L. (2013). Predictive Value of Autoantibody Testing for Validating Self-reported Diagnoses of Rheumatoid Arthritis in the Women's Health Initiative. AMERICAN JOURNAL OF EPIDEMIOLOGY, 177(9), 887–893.
Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case-control study Arkema, E. V., Goldstein, B. L., Robinson, W., Sokolove, J., Wagner, C. A., Malspeis, S., … Costenbader, K. H. (2013). Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case-control study. ARTHRITIS RESEARCH & THERAPY, 15(5).
N-alpha-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis Willis, V. C., Gizinski, A. M., Banda, N. K., Causey, C. P., Knuckley, B., Cordova, K. N., … Holers, V. M. (2011). N-alpha-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis. JOURNAL OF IMMUNOLOGY, 186(7), 4396–4404.
Mechanistic biomarkers for clinical decision making in rheumatic diseases Robinson, W. H., Lindstrom, T. M., Cheung, R. K., & Sokolove, J. (2013). Mechanistic biomarkers for clinical decision making in rheumatic diseases. NATURE REVIEWS RHEUMATOLOGY, 9(5), 267–276.
Determinants of Mortality Among Postmenopausal Women in the Women's Health Initiative Who Report Rheumatoid Arthritis Kuller, L. H., Mackey, R. H., Walitt, B. T., Deane, K. D., Holers, V. M., Robinson, W. H., … Moreland, L. W. (2014). Determinants of Mortality Among Postmenopausal Women in the Women's Health Initiative Who Report Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66(3), 497–507.
Rheumatoid Arthritis in the Womens Health Initiative: Methods and Baseline Evaluation Kuller, L. H., Mackey, R. H., Walitt, B. T., Deane, K. D., Holers, V. M., Robinson, W. H., … Moreland, L. W. (2014). Rheumatoid Arthritis in the Womens Health Initiative: Methods and Baseline Evaluation. AMERICAN JOURNAL OF EPIDEMIOLOGY, 179(7), 917–926.
Reply: To PMID 24497204. Shelef, M. A., Sokolove, J., Robinson, W. H., & Huttenlocher, A. (2014). Reply: To PMID 24497204. Arthritis & Rheumatology , 66(9), 2644–2645.
Alveolar Bone Loss Is Associated With Circulating Anti-Citrullinated Protein Antibody (ACPA) in Patients With Rheumatoid Arthritis Gonzalez, S. M., Payne, J. B., Yu, F., Thiele, G. M., Erickson, A. R., Johnson, P. G., … Mikuls, T. R. (2015). Alveolar Bone Loss Is Associated With Circulating Anti-Citrullinated Protein Antibody (ACPA) in Patients With Rheumatoid Arthritis. JOURNAL OF PERIODONTOLOGY, 86(2), 222–231.
Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma Gartner, J. J., Parker, S. C. J., Prickett, T. D., Dutton-Regester, K., Stitzel, M. L., Lin, J. C., … Samuels, Y. (2013). Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(33), 13481–13486.
Sequencing the functional antibody repertoire-diagnostic and therapeutic discovery Robinson, W. H. (2015). Sequencing the functional antibody repertoire-diagnostic and therapeutic discovery. NATURE REVIEWS RHEUMATOLOGY, 11(3), 171–182.
Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease Giles, J. T., Danoff, S. K., Sokolove, J., Wagner, C. A., Winchester, R., Pappas, D. A., … Bathon, J. M. (2014). Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease. ANNALS OF THE RHEUMATIC DISEASES, 73(8), 1487–1494.
Optimal approaches to data collection and analysis of potential immune mediated disorders in clinical trials of new vaccines Da Silva, F. T., De Keyser, F., Lambert, P.-H., Robinson, W. H., Westhovens, R., & Sindic, C. (2013). Optimal approaches to data collection and analysis of potential immune mediated disorders in clinical trials of new vaccines. VACCINE, 31(14), 1870–1876.
Oral and topical boswellic acid attenuates mouse osteoarthritis Wang, Q., Pan, X., Wong, H. H., Wagner, C. A., Lahey, L. J., Robinson, W. H., & Sokolove, J. (2014). Oral and topical boswellic acid attenuates mouse osteoarthritis. OSTEOARTHRITIS AND CARTILAGE, 22(1), 128–132.
Mass cytometry analysis shows that a novel memory phenotype B cell is expanded in multiple myeloma. Hansmann, L., Blum, L., Ju, C.-H., Liedtke, M., Robinson, W. H., & Davis, M. M. (2015). Mass cytometry analysis shows that a novel memory phenotype B cell is expanded in multiple myeloma. Cancer Immunology Research, 3(6), 650–660.
CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis Huang, Q.-Q., Perlman, H., Birkett, R., Doyle, R., Fang, D., Haines, G. K., … Pope, R. M. (2015). CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis. NATURE COMMUNICATIONS, 6.
Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative Mackey, R. H., Kuller, L. H., Deane, K. D., Walitt, B. T., Chang, Y.-F., Holers, V. M., … Moreland, L. W. (2015). Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative. ARTHRITIS & RHEUMATOLOGY, 67(9), 2311–2322.
Mass Cytometry Analysis Shows That a Novel Memory Phenotype B Cell Is Expanded in Multiple Myeloma Hansmann, L., Blum, L., Ju, C.-H., Liedtke, M., Robinson, W. H., & Davis, M. M. (2015). Mass Cytometry Analysis Shows That a Novel Memory Phenotype B Cell Is Expanded in Multiple Myeloma. CANCER IMMUNOLOGY RESEARCH, 3(6), 650–660.
Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease Lahey, L. J., Panas, M. W., Mao, R., Delanoy, M., Flanagan, J. J., Binder, S. R., … Robinson, W. H. (2015). Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease. JOURNAL OF CLINICAL MICROBIOLOGY, 53(12), 3834–3841.
Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice Toivola, D. M., Habtezion, A., Misiorek, J. O., Zhang, L., Nystrom, J. H., Sharpe, O., … Omary, M. B. (2015). Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice. FASEB JOURNAL, 29(12), 5081–5089.
Local Joint Inflammation and Histone Citrullination in a Murine Model of the Transition From Preclinical Autoimmunity to Inflammatory Arthritis Sohn, D. H., Rhodes, C., Onuma, K., Zhao, X., Sharpe, O., Gazitt, T., … Sokolove, J. (2015). Local Joint Inflammation and Histone Citrullination in a Murine Model of the Transition From Preclinical Autoimmunity to Inflammatory Arthritis. ARTHRITIS & RHEUMATOLOGY, 67(11), 2877–2887.
A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients Ligocki, A. J., Rivas, J. R., Rounds, W. H., Guzman, A. A., Li, M., Spadaro, M., … Monson, N. L. (2015). A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients. ASN NEURO, 7(5).
Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus Sajda, T., Hazelton, J., Patel, M., Seiffert-Sinha, K., Steinman, L., Robinson, W., … Sinha, A. A. (2016). Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(7), 1859–1864.
The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression Kragstrup, T. W., Greisen, S. R., Nielsen, M. A., Rhodes, C., Stengaard-Pedersen, K., Hetland, M. L., … Deleuran, B. (2016). The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression. ARTHRITIS RESEARCH & THERAPY, 18.
Biomarkers to guide clinical therapeutics in rheumatology? Robinson, W. H., & Mao, R. (2016). Biomarkers to guide clinical therapeutics in rheumatology? CURRENT OPINION IN RHEUMATOLOGY, 28(2), 168–175.
Vascular calcifications on hand radiographs in rheumatoid arthritis and associations with autoantibodies, cardiovascular risk factors and mortality Solow, E. B., Yu, F., Thiele, G. M., Sokolove, J., Robinson, W. H., Pruhs, Z. M., … Mikuls, T. R. (2015). Vascular calcifications on hand radiographs in rheumatoid arthritis and associations with autoantibodies, cardiovascular risk factors and mortality. RHEUMATOLOGY, 54(9), 1587–1595.
Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes Kim, J.-H., Furrow, E., Ritt, M. G., Utz, P. J., Robinson, W. H., Yu, L., … Modiano, J. F. (2016). Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes. PLOS ONE, 11(3).
Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model. Yu, C., Burns, J. C., Robinson, W. H., Utz, P. J., Ho, P. P., Steinman, L., & Frey, A. B. (2016). Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model. Journal of Diabetes Research, 2016, 9083103-?
Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab: 2-year results from the AMPLE trial Sokolove, J., Schiff, M., Fleischmann, R., Weinblatt, M. E., Connolly, S. E., Johnsen, A., … Robinson, W. H. (2016). Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab: 2-year results from the AMPLE trial. ANNALS OF THE RHEUMATIC DISEASES, 75(4), 709–714.
Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology Abrams, G. D., Luria, A., Carr, R. A., Rhodes, C., Robinson, W. H., & Sokolove, J. (2016). Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology. JOURNAL OF SHOULDER AND ELBOW SURGERY, 25(6), 989–997.
B cell depletion with rituximab in patients with rheumatoid arthritis: Multiplex bead array reveals the kinetics of IgG and IgA antibodies to citrullinated antigens Cambridge, G., Leandro, M. J., Lahey, L. J., Fairhead, T., Robinson, W. H., & Sokolove, J. (2016). B cell depletion with rituximab in patients with rheumatoid arthritis: Multiplex bead array reveals the kinetics of IgG and IgA antibodies to citrullinated antigens. JOURNAL OF AUTOIMMUNITY, 70, 22–30.
CCL19 as a Chemokine Risk Factor for Posttreatment Lyme Disease Syndrome: a Prospective Clinical Cohort Study. Aucott, J. N., Soloski, M. J., Rebman, A. W., Crowder, L. A., Lahey, L. J., Wagner, C. A., … Bechtold, K. T. (2016). CCL19 as a Chemokine Risk Factor for Posttreatment Lyme Disease Syndrome: a Prospective Clinical Cohort Study. Clinical and Vaccine Immunology , 23(9), 757–766.
Associations of Circulating Cytokines and Chemokines With Cancer Mortality in Men With Rheumatoid Arthritis. England, B. R., Sokolove, J., Robinson, W. H., Thiele, G. M., Ganti, A. K., Sayles, H., … Mikuls, T. R. (2016). Associations of Circulating Cytokines and Chemokines With Cancer Mortality in Men With Rheumatoid Arthritis. Arthritis & Rheumatology , 68(10), 2394–2402.
Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis. Kinslow, J. D., Blum, L. K., Deane, K. D., Demoruelle, M. K., Okamoto, Y., Parish, M. C., … Holers, V. M. (2016). Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis. Arthritis & Rheumatology , 68(10), 2372–2383.
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Robinson, W. H., Lepus, C. M., Wang, Q., Raghu, H., Mao, R., Lindstrom, T. M., & Sokolove, J. (2016). Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nature Reviews. Rheumatology, 12(10), 580–592.
Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease Robinson, W. H., Garren, H., Utz, P. J., & Steinman, L. (2002). Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease. CLINICAL IMMUNOLOGY, 103(1), 7–12.
Citrullination Within the Atherosclerotic Plaque: A Potential Target for the Anti-Citrullinated Protein Antibody Response in Rheumatoid Arthritis Sokolove, J., Brennan, M. J., Sharpe, O., Lahey, L. J., Kao, A. H., Krishnan, E., … Robinson, W. H. (2013). Citrullination Within the Atherosclerotic Plaque: A Potential Target for the Anti-Citrullinated Protein Antibody Response in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, 65(7), 1719–1724.

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William Robinson

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