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Gerlinde Wernig
Pathologist, Hematopathologist
Assistant Professor of Pathology at the Stanford University Medical Center
Practice Areas
- Pathology
Professional Education
- Board Certification: American Board of Pathology, Anatomic Pathology (2013)
- Board Certification: American Board of Pathology, Hematology (2013)
- Residency: Stanford Hospital and Clinics (2013) CA
- Fellowship: Stanford Hospital and Clinics (2012) CA
- Residency: Stanford Hospital and Clinics (2011) CA
- Fellowship, Friedrich-Wilhelms-University Bonn, Germany, Hematology/Oncology (2004)
- Residency, Friedrich-Wilhlems-Uniersity Bonn, Germany, Internal Medicine (2001)
- Medical Education: Medical University of Vienna (1999) Austria
Publications
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The vast majority of bone-marrow-derived cells integrated into mdx muscle fibers are silent despite long-term engraftment
Wernig, G., Janzen, V., SCHAFER, R., Zweyer, M., Knauf, U., Hoegemeier, O., … Wernig, A. (2005). The vast majority of bone-marrow-derived cells integrated into mdx muscle fibers are silent despite long-term engraftment. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(33), 11852–57. -
EXEL-8232, a small-molecule JAK2 inhibitor, effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L
Wernig, G., Kharas, M. G., Mullally, A., Leeman, D. S., Okabe, R., George, T., … Gilliland, D. G. (2012). EXEL-8232, a small-molecule JAK2 inhibitor, effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L. LEUKEMIA, 26(4), 720–27. -
Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells
Kim, D., Wang, J., Willingham, S. B., Martin, R., Wernig, G., & Weissman, I. L. (2012). Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells. LEUKEMIA, 26(12), 2538–45. -
Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells
Mullally, A., Lane, S. W., Ball, B., Megerdichian, C., Okabe, R., Al-Shahrour, F., … Ebert, B. L. (2010). Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells. CANCER CELL, 17(6), 584–596.
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Correction of CFTR malfunction and stimulation of Ca2+- activated Cl- channels restore HCO3- secretion in cystic fibrosis bile ductular cells
Zsembery, A., Jessner, W., Sitter, G., Spirli, C., Strazzabosco, M., & Graf, J. (2002). Correction of CFTR malfunction and stimulation of Ca2+- activated Cl- channels restore HCO3- secretion in cystic fibrosis bile ductular cells. HEPATOLOGY, 35(1), 95–104.
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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J. P., … Gilliland, D. G. (2005). Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. CANCER CELL, 7(4), 387–97.
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Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
Lu, X. H., Levine, R., Tong, W., Wernig, G., Pikman, Y., Zarnegar, S., … Lodish, H. (2005). Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(52), 18962–18967.
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Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
Wernig, G., Mercher, T., Okabe, R., Levine, R. L., Lee, B. H., & Gilliland, D. G. (2006). Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. BLOOD, 107(11), 4274–81.
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JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model
Mercher, T., Wernig, G., Moore, S. A., Levine, R. L., Gu, T.-L., Frohling, S., … Gilliland, D. G. (2006). JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. BLOOD, 108(8), 2770–2779.
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MPLW515L is anovel somatic activating mutation in myelofibrosis with myeloid metaplasia
Pikman, Y., Lee, B. H., Mercher, T., McDowell, E., Ebert, B. L., Gozo, M., … Levine, R. L. (2006). MPLW515L is anovel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLOS MEDICINE, 3(7), 1140–1151.
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Role of JAK-STAT signaling in the pathogenesis of myeloproliferative disorders.
Levine, R. L., & Wernig, G. (2006). Role of JAK-STAT signaling in the pathogenesis of myeloproliferative disorders. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 233-?
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The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes
Wernig, G., Gonneville, J. R. R., Crowley, B. J., Rodrigues, M. S., Reddy, M. M., Hudon, H. E., … Sattler, M. (2008). The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes. BLOOD, 111(7), 3751–59.
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High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia
Loriaux, M. M., Levine, R. L., Tyner, J. W., Froehling, S., Scholl, C., Stoffregen, E. P., … Druker, B. J. (2008). High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia. BLOOD, 111(9), 4788–96.
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Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera
Werning, G., Kharas, M. G., Okabe, R., Moore, S. A., Leeman, D. S., Cullen, D. E., … Gilliland, D. G. (2008). Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. CANCER CELL, 13(4), 311–20.
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STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2
Tam, W. F., Haehnel, P. S., Schueler, A., Lee, B. H., Okabe, R., Zhu, N., … Kindler, T. (2013). STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2. CANCER RESEARCH, 73(1), 373–384.
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Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
Moraga, I., Wernig, G., Wilmes, S., Gryshkova, V., Richter, C. P., Hong, W.-J., … Garcia, K. C. (2015). Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. CELL, 160(6), 1196–1208.
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Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types
Loh, K. M., Chen, A., Koh, P. W., Deng, T. Z., Sinha, R., Tsai, J. M., … Weissman, I. L. (2016). Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. CELL, 166(2), 451–67.
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Unifying mechanism for different fibrotic diseases
Wernig, G., Chen, S.-Y., Cui, L., Van Neste, C., Tsai, J. M., Kambham, N., … Weissman, I. L. (2017). Unifying mechanism for different fibrotic diseases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(18), 4757–62.
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Unifying Mechanism of fibrotic diseases
Wernig, G., & Weissman, I. L. (2017). Unifying Mechanism of fibrotic diseases. Proceedings of the National Academy of Science, 114(18).
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Doxycyline Improves Wound Healing via Nonantibiotic Associated Mechanisms
Moore, A. L., Murphy, M. P., Irizarry, D. M., Brett, E. A., Wernig, G., & Longaker, M. T. (2017). Doxycyline Improves Wound Healing via Nonantibiotic Associated Mechanisms. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 225(4), S162–S163.
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Stem cell therapy for treatment of ischemic optic neuropathy
Mesentier-Louro, L. A., Yang, N., Shariati, A., Domizi, P. D., Dodd, R., Wernig, G., … Liao, Y. J. (2018). Stem cell therapy for treatment of ischemic optic neuropathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(9).
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Reduced Scar Thickness Achieved by Topical Doxycycline Is Mediated by Specific Skin Fibroblast Populations and Not Immune Cell Infiltrate
Moore, A. L., Murphy, M. P., Irizarry, D. M., Des Jardins-Park, H. E., Duoto, B. A., Mascharak, S., … Longaker, M. T. (2018). Reduced Scar Thickness Achieved by Topical Doxycycline Is Mediated by Specific Skin Fibroblast Populations and Not Immune Cell Infiltrate. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 227(4), S210–S211.
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Mouse Model with cJUN Over-Expression Eludes to Deep Dermal Fibroblast Expansion and Immune Cell Recruitment as the Biologic Mechanism of Hypertrophic Scarring
Moore, A. L., Duoto, B. A., Des Jardins-Park, H. E., Mascharak, S., Wernig, G., & Longaker, M. T. (2018). Mouse Model with cJUN Over-Expression Eludes to Deep Dermal Fibroblast Expansion and Immune Cell Recruitment as the Biologic Mechanism of Hypertrophic Scarring. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 227(4), S208.
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Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers.
Tsai, J. M., Sinha, R., Seita, J., Fernhoff, N., Christ, S., Koopmans, T., … Rinkevich, Y. (2018). Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers. Science Translational Medicine, 10(469).
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Doxycycline Reduces Scar Thickness and Improves Collagen Architecture.
Moore, A. L., desJardins-Park, H. E., Duoto, B. A., Mascharak, S., Murphy, M. P., Irizarry, D. M., … Longaker, M. T. (2018). Doxycycline Reduces Scar Thickness and Improves Collagen Architecture. Annals of Surgery.
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DOXYCYCLINE REDUCES SCARRING BY MODULATING COLLAGEN ARCHITECTURE
desJardins-Park, H. E., Moore, A. L., Duoto, B. A., Mascharak, S., Murphy, M. P., Irizarry, D. M., … Longaker, M. T. (2019). DOXYCYCLINE REDUCES SCARRING BY MODULATING COLLAGEN ARCHITECTURE. JOURNAL OF INVESTIGATIVE MEDICINE, 67(1), 157–58.
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Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
Czechowicz, A., Palchaudhuri, R., Scheck, A., Hu, Y., Hoggatt, J., Saez, B., … Rossi, D. J. (2019). Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. NATURE COMMUNICATIONS, 10.
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Modeling chronic Graft-vs-Host disease in MHC-matched mouse strains: genetics, graft composition and tissue targets.
Müller, A. M., Min, D., Wernig, G., Levy, R. B., Perez, V. L., Herretes, S., … Shizuru, J. A. (2019). Modeling chronic Graft-vs-Host disease in MHC-matched mouse strains: genetics, graft composition and tissue targets. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation.
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Direct targeting of the mouse optic nerve for therapeutic delivery
Mesentier-Louro, L. A., Dodd, R., Domizi, P., Nobuta, H., Wernig, M., Wernig, G., & Liao, Y. J. (2019). Direct targeting of the mouse optic nerve for therapeutic delivery. JOURNAL OF NEUROSCIENCE METHODS, 313, 1–5.
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JUN Drives Pathologic Scarring by Activating Key Fibroproliferative Pathways in Fibroblast Subpopulations
Borrelli, M. R., Garcia, J. T., Moore, A. L., Patel, R. A., Mascharak, S., Duoto, B., … Longaker, M. T. (2019). JUN Drives Pathologic Scarring by Activating Key Fibroproliferative Pathways in Fibroblast Subpopulations. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 229(4), E215–E216.
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Expansion of Bone Precursors through Jun as a Novel Treatment for Osteoporosis-Associated Fractures.
Lerbs, T., Cui, L., Muscat, C., Saleem, A., van Neste, C., Domizi, P., … Wernig, G. (2020). Expansion of Bone Precursors through Jun as a Novel Treatment for Osteoporosis-Associated Fractures. Stem Cell Reports.
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Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity.
Cui, L., Chen, S.-Y. Y., Lerbs, T., Lee, J.-W. W., Domizi, P., Gordon, S., … Wernig, G. (2020). Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Nature Communications, 11(1), 2795.
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Elucidating the fundamental fibrotic processes driving abdominal adhesion formation.
Foster, D. S., Marshall, C. D., Gulati, G. S., Chinta, M. S., Nguyen, A., Salhotra, A., … Longaker, M. T. (2020). Elucidating the fundamental fibrotic processes driving abdominal adhesion formation. Nature Communications, 11(1), 4061.
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CD47 prevents the elimination of diseased fibroblasts in scleroderma.
Lerbs, T., Cui, L., King, M. E., Chai, T., Muscat, C., Chung, L., … Wernig, G. (2020). CD47 prevents the elimination of diseased fibroblasts in scleroderma. JCI Insight, 5(16).
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Doxycycline Reduces Scar Thickness and Improves Collagen Architecture
Moore, A. L., desJardins-Park, H. E., Duoto, B. A., Mascharak, S., Murphy, M. P., Irizarry, D. M., … Longaker, M. T. (2020). Doxycycline Reduces Scar Thickness and Improves Collagen Architecture. ANNALS OF SURGERY, 272(1), 183–93.
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Wounds Heal by Tissue-Resident Fibroblast Progenitors that Proliferate Polyclonally and Mechanoresponsively
Foster, D. S., Chinta, M., Salhotra, A., Nguyen, A. T., Burcham, A., Mascharak, S., … Longaker, M. T. (2020). Wounds Heal by Tissue-Resident Fibroblast Progenitors that Proliferate Polyclonally and Mechanoresponsively. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 231(4), S236–S237.
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Detection, Scoring, and Classification of Solid Organ Fibroses with Machine Learning Analysis
Mascharak, S., desJardins-Park, H. E., Davitt, M., Foster, D. S., Chinta, M., Wan, D. C., … Longaker, M. T. (2020). Detection, Scoring, and Classification of Solid Organ Fibroses with Machine Learning Analysis. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 231(4), S222.
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Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
Wernig, G. (2021). Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors. Proceedings of the National Academy of Sciences, 118 (2)(Jan 2021).