A common health care provider error is to assume that this form of edema mandates diuretic therapy.
However, in pure obstructive lymphedema, diuretics may transiently decompress the limb but, ultimately, will not ameliorate the condition and may have undesirable after-effects. In lymphedema, the driving force for edema accumulation is retained interstitial protein and other macromolecules.
No matter how much one contracts the extracellular space through Na+ and water clearance, the protein will remain and re-stimulate edema formation. In addition, concentrating the interstitial macromolecular concentration may be undesirable.
On the other hand, if the patient has concomitant venous edema, the venous component will respond favorably to a diuretic approach.
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.