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Female hormones are known to affect bleeding of abnormal HHT blood vessels. For some women, nosebleeds vary through the menstrual cycle and become worse after menopause.
Most pregnant women with HHT can expect no serious HHT-related complications. For some, new skin telangiectases are detected, while others report improvements. There is great concern for pregnant women with an AVM in their lung. During pregnancy, there is a 60 percent increase in blood circulation that is essential to the development of the baby. This increase in pressure on weak abnormal blood vessels increases the risk of a life threatening rupture in the lung. Research shows that it is safe and efficacious to perform embolization on pulmonary AVMs during the second trimester of pregnancy.
Both HHT mothers and their babies can generally expect a safe pregnancy.