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The exact cause of chondrosarcoma is not known. There may be a genetic or chromosomal component that predisposes certain individuals to this type of malignancy. Chondrosarcomas have been observed as a late consequence of radiation therapy for other cancers.
Chondrosarcoma risk factors
Most often, chondrosarcoma occurs from normal cartilage cells, but it may also stem from a preexisting benign (non-cancerous) bone or cartilage tumor. The following is a list of some benign conditions that may be present when chondrosarcoma occurs:
Enchondromas: A type of benign bone tumor that originates from cartilage and usually affects the hands (can also affect other areas).
Osteochondromas: An overgrowth of cartilage and bone near the end of the bone near the growth plate.
Multiple exostoses: The presence of multiple osteochondromas (an overgrowth of cartilage and bone near the end of the growth plate).
Ollier's disease: A cluster of enchondromas (benign cartilage tumors that usually affect the hands).
Maffucci's syndrome: A combination of multiple enchondroma (benign cartilage tumors that usually affect the hands) tumors and angiomas (benign tumors made up of blood vessels).
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