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Chronic lymphocytic leukemia (CLL) is the only type of leukemia with well-defined stages.
The Rai system of staging
In that way, it is staged similarly to cancer of organs, such as breast or lung. The Rai system is the classification system used in the United States. It classifies leukemia into stages 0 through IV. Another system, called the Binet system, classifies leukemia into stages A through C. It is used in some parts of Europe.
Stage 0 CLL
In stage 0, your blood has too many lymphocytes, called lymphocytosis. You have more than 5,000 to 10,000 lymphocytes per cubic millimeter. You don't have any other signs or symptoms of leukemia. This stage is considered low risk, which means people tend to have longer survival rates and generally have no or few symptoms.
Stage 1 CLL
In stage 1 (I), your blood has too many lymphocytes, called lymphocytosis, and your lymph nodes are larger than normal. This stage is considered intermediate risk.
Stage 2 CLL
In stage 2 (II), your blood has too many lymphocytes, called lymphocytosis, and your liver may be swollen, called hepatomegaly. Or your spleen may be swollen, called splenomegaly. Or they may both be swollen. Your lymph nodes may also be larger than normal. This stage is also considered intermediate risk.
Stage 3 CLL
In stage 3 (III), your blood has too many lymphocytes, called lymphocytosis, and you have too few red blood cells, called anemia. Your lymph nodes, liver, or spleen may also be larger than normal. This stage is considered high risk.
Stage 4 CLL
In stage 4 (IV), your blood has too many lymphocytes and too few platelets, called thrombocytopenia. Your lymph nodes, liver, or spleen may be larger than normal, and you may have too few red blood cells. This stage is considered high risk.
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.