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[Clinical and genetic heterogeneity of rheumatoid arthritis]. Postepy higieny i medycyny doswiadczalnej Klimiuk, P. A., Weyand, C. M., Sierakowski, S., Goronzy, J. J. 2000; 54 (6): 845-853

Abstract

The diagnostic category of rheumatoid arthritis, a syndrome of chronic inflammatory disease of the synovial membrane and of extraarticular tissues, covers a broad spectrum of clinical phenotypes. Here we propose that distinct combinations of disease risk genes produce heterogeneity of rheumatoid disease. Recognition of this genetic and clinical heterogeneity has immediate implications as it provides the opportunity to develop selective therapies for the different variants of disease.

View details for PubMedID 11227380