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DETECTION OF HEPATIC MALIGNANCIES USING MN-DPDP (MANGANESE DIPYRIDOXAL DIPHOSPHATE) HEPATOBILIARY MRI CONTRAST AGENT MAGNETIC RESONANCE IMAGING Young, S. W., Bradley, B., Muller, H. H., Rubin, D. L. 1990; 8 (3): 267-276

Abstract

A new hepatobiliary contrast agent (Mn-DPDP) was used in the detection of liver metastases in six rabbits with seven hepatic V2 carcinomas. This contrast agent is derived from pyridoxyl-5-phosphate which is biomimetically designed to be secreted by the hepatocyte. After Mn-DPDP administration, a 105% increase in liver signal to noise was obtained using a 200/20 (TR/TE) pulsing sequence, and a 62% decrease in intensity was observed using a 1200/60 pulsing sequence. Liver V2 carcinoma contrast enhancement increased 427% using the 200/20 pulsing sequence and 176% using the 1200/60 pulsing sequence. Four of seven V2 carcinomas were not detectable prior to the administration of Mn-DPDP (50 mumol/kg). Two neoplasms were only detectable in retrospect (after Mn-DPDP) on the 1200/60 sequence. The smallest neoplasms detected in this study were 1-4 mm. Mn-DPDP appears to be a promising MRI contrast agent.

View details for Web of Science ID A1990DL77400011

View details for PubMedID 2114511