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Stanford Health Care

Inverse Vaccination to Silence Immunity to Myelin in Multiple Sclerosis CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES Steinman, L. 2010; 37: S49-S58

Abstract

The adaptive immune response in multiple sclerosis is complex. We have devised large scale arrays to measure the antibody response to myelin proteins and lipids. Despite the widespread immune responses to myelin, we have devised an inverse vaccine aimed at turning off key drivers of this diverse response. Clinical trials in patients with multiple sclerosis show that it is possible to constrain antibody responses to myelin on a large scale with this approach.

View details for Web of Science ID 000281822000007

View details for PubMedID 21246935