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Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia PEDIATRIC HEMATOLOGY AND ONCOLOGY Jeng, M. R., Feusner, J. 2001; 18 (2): 137-142

Abstract

A boy with acute lymphoblastic leukemia (ALL) experienced life-threatening vincristine neurotoxicity while simultaneously exposed to itraconazole. Five pediatric and six adult cases of itraconazole-enhanced vincristine toxicity have been reported, all with ALL. Upon cessation of the itraconazole, the patient's symptoms resolved, which is similar to the outcome of the previously reported cases: 10 of 11 patients had complete resolution of symptoms.

View details for Web of Science ID 000167123900008

View details for PubMedID 11255732