IMMUNIZATION WITH BACULOVIRUS-EXPRESSED VP4 PROTEIN PASSIVELY PROTECTS AGAINST SIMIAN AND MURINE ROTAVIRUS CHALLENGE JOURNAL OF VIROLOGY MACKOW, E. R., Vo, P. T., Broome, R., Bass, D., Greenberg, H. B. 1990; 64 (4): 1698-1703

Abstract

A baculovirus-expressed VP4 protein derived from the simian rhesus rotavirus (RRV) was used to parenterally immunize murine dams. VP4-immunized dams developed high levels of neutralizing antibodies against RRV and low levels of cross-reactive neutralizing antibodies against human strains Wa, ST3, and S2 and animal strains SA-11, NCDV, and Eb. Newborn mice suckled on VP4-immunized dams were protected against a virulent challenge dose of the simian strain RRV and against murine rotavirus Eb. The cross-reactive nature of the serum-neutralizing response generated by VP4 immunization and the protective efficacy of the immunization suggest that recombinant-expressed VP4 proteins should be considered as viable vaccine candidates.

View details for Web of Science ID A1990CT84500034

View details for PubMedID 2157052