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Role of regulatory T cell populations in controlling graft vs host disease BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY Negrin, R. S. 2011; 24 (3): 453-457

Abstract

Immune function is critical in health and disease. The control and regulation of immune reactions is an area of intense investigation that has important implications for allogeneic hematopoietic cell transplantation. Immune reactions are regulated in a number of important ways. Compartmentalization of immune responses and the production of both pro-inflammatory and anti-inflammatory cytokines play a major role. More recently several populations of T cells that regulate immune responses termed regulatory T cells have been identified. This manuscript will focus on CD4+CD25+FoxP3+ natural regulatory T cells (T(reg)) and aßTCR+CD4+NK1.1+ natural killer T (NK-T) cells which both suppress graft vs host disease but appear to function by distinct mechanisms.

View details for DOI 10.1016/j.beha.2011.05.006

View details for PubMedID 21925098