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Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan JOURNAL OF CANCER SURVIVORSHIP-RESEARCH AND PRACTICE Sprod, L. K., Janelsins, M. C., Palesh, O. G., Carroll, J. K., Heckler, C. E., Peppone, L. J., Mohile, S. G., Morrow, G. R., Mustian, K. M. 2012; 6 (2): 146-154

Abstract

Breast cancer survivors experience diminished health-related quality of life (HRQOL). We report on the influence of tai chi chuan exercise (TCC) on HRQOL and explore associations between changes in HRQOL and biomarkers.Breast cancer survivors (N?=?21) were randomly assigned to TCC or standard support therapy (SST) for 12 weeks (three times/week; 60 min/session). Interleukin-6, interleukin-8 (IL-8), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein (IBFBP)-1, IGFBP-3, glucose, insulin, and cortisol were measured pre- and postintervention. Overall HRQOL and subdomains were assessed at preintervention (T1), midintervention (T2) and postintervention (T3) and biomarkers at T1 and T3.The TCC group improved in total HRQOL (T1-T2:CS?=?8.54, P?=?0.045), physical functioning (T1-T2:CS?=?1.89, P?=?0.030), physical role limitations (T1-T2 CS?=?1.55, P?=?0.023), social functioning (T1-T3:CS?=?1.50, P?=?0.020), and general mental health (T1-T2:CS?=?2.67, P?=?0.014; T1-T3:CS?=?2.44, P?=?0.019). The SST improved in social functioning (T1-T2:CS?=?0.64, P?=?0.043) and vitality (T1-T2:CS?=?0.90, P?=?0.01). There were relationships between changes in IGF-1 and overall HRQOL (r?=?-0.56; P?

View details for DOI 10.1007/s11764-011-0205-7

View details for Web of Science ID 000302419700002

View details for PubMedID 22160628

View details for PubMedCentralID PMC3664952