The CD47-SIRP alpha pathway in cancer immune evasion and potential therapeutic implications CURRENT OPINION IN IMMUNOLOGY Chao, M. P., Weissman, I. L., Majeti, R. 2012; 24 (2): 225-232


Multiple lines of investigation have demonstrated that the immune system plays an important role in preventing tumor initiation and controlling tumor growth. Accordingly, many cancers have evolved diverse mechanisms to evade such monitoring. While multiple immune cell types mediate tumor surveillance, recent evidence demonstrates that macrophages, and other phagocytic cells, play a key role in regulating tumor growth through phagocytic clearance. In this review we highlight the role of tumor immune evasion through the inhibition of phagocytosis, specifically through the CD47-signal-regulatory protein-a pathway, and discuss how targeting this pathway might lead to more effective cancer immunotherapies.

View details for DOI 10.1016/j.coi.2012.01.010

View details for Web of Science ID 000303187600017

View details for PubMedID 22310103

View details for PubMedCentralID PMC3319521