Malignant fibrous histiocytoma: Changing perceptions and management challenges JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Henderson, M. T., Hollmig, S. T. 2012; 67 (6): 1335-1341


Malignant fibrous histiocytoma (MFH) is a rare neoplasm exhibiting a propensity for aggressive clinical behavior. This review seeks to provide the practicing dermatologist with a contemporary understanding of MFH in order to guide management decisions. An extensive review of the literature was conducted using PubMed and OVID databases, searching for articles regarding MFH and undifferentiated pleomorphic sarcoma. The modern conception of MFH has changed extensively from clinical and pathologic standpoints. Limitations of the study included the reliability of past studies given the changing nature of MFH as a diagnostic entity. MFH represents an aggressive neoplasm with unique molecular, immunohistochemical, and behavioral characteristics. Practicing clinicians would benefit from a contemporary understanding of these tumors, particularly as a discussion of advances in the conception of MFH is largely absent in the dermatologic literature.

View details for DOI 10.1016/j.jaad.2012.04.013

View details for Web of Science ID 000312131200060

View details for PubMedID 22677489