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RESPIRATORY AND HEMODYNAMIC STUDY DURING WAKEFULNESS AND SLEEP IN MYOTONIC-DYSTROPHY SLEEP Guilleminault, C., Cummiskey, J., Motta, J., LYNNEDAVIES, P. 1978; 1 (1): 19-31

Abstract

Six young male patients with grade I (mild) myotonic dystrophy and a complaint of excessive daytime sleepiness were studied during wakefulness and sleep. Pulmonary function tests during wakefulness showed evidence of mild abnormality related to respiratory muscle weakness. During sleep, some patients developed a sleep apnea syndrome with high sleep Apnea Indices. There was no relation between hypoxic and hypercapnic ventilatory responses during wakefulness and sleep Apnea Indices. But hypoxemia and hypercapnia worsened considerably during REM sleep. Myotonic dystrophy patients with sleep apnea presented increased pulmonary and systemic arterial pressures during sleep. It was also during sleep that arrhythmias were observed.

View details for Web of Science ID A1978FY59100002

View details for PubMedID 227021