Estrogen use and brain metabolic change in older adults. A preliminary report PSYCHIATRY RESEARCH-NEUROIMAGING Rasgon, N. L., Small, G. W., Siddarth, P., Miller, K., Ercoli, L. M., Bookheimer, S. Y., Lavretsky, H., Huang, S. C., Barrio, J. R., Phelps, M. E. 2001; 107 (1): 11-18


Because estrogen may influence brain blood flow and metabolism in older adults, we used positron emission tomography to evaluate cerebral glucose metabolic change in post-menopausal women and men. Women estrogen users (n=4), women non-users (n=8) and men (n=10) were scanned at baseline and two years later. Analyses focused on glucose metabolism in lateral temporal, inferior parietal and posterior cingulate brain regions, previously reported to decline in non-demented older persons. No metabolic differences in cerebral regions of interest were found among groups at baseline. At follow-up, women estrogen users showed significantly increased glucose metabolism in the lateral temporal region, whereas women non-users and men exhibited no significant metabolic change in this region. These findings suggest that estrogen use may protect against regional cerebral metabolic decline in postmenopausal women.

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View details for PubMedID 11472860