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NFAT Gene Family in Inflammation and Cancer

NFAT Gene Family in Inflammation and Cancer CURRENT MOLECULAR MEDICINE Pan, M., Xiong, Y., Chen, F. 2013; 13 (4): 543-554

Abstract

Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.

View details for Web of Science ID 000317117400007

View details for PubMedID 22950383