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T-CELL RECEPTORS IN AUTOIMMUNE-DISEASE AS TARGETS FOR IMMUNE INTERVENTION 16TH INTERNATIONAL CONGRESS OF GENETICS : GENETICS AND THE UNITY OF BIOLOGY ACHAORBEA, H., Steinman, L., McDevitt, H. O. NATL RESEARCH COUNCIL CANADA. 1989: 656–61

Abstract

The optimal form of treatment for an autoimmune disease should be highly specific, have few side effects, and allow treatment of clinically apparent disease. One target that could fulfill these requirements is the T cell receptor. To answer the question whether treatment of autoimmune disease is possible with anti-T cell receptor antibodies, the heterogeneity of T cell receptor elements utilized in the T cell mediated autoimmune disease experimental allergic encephalomyelitis was analyzed. The limited heterogeneity of these elements allowed prevention and treatment of clinical autoimmune disease with anti-T cell receptor monoclonal antibodies. These results and their potential value for other autoimmune diseases are discussed.

View details for Web of Science ID A1989CL22100025

View details for PubMedID 2483695