New developments in the pathogenesis of pulmonary hypertension in the newborn and child. Acta paediatrica Japonica; Overseas edition RABINOVITCH, M. 1989; 31 (6): 631-640

Abstract

We have identified several features which appear to play a key role in the pathogenesis of pulmonary vascular disease. Future work will involve exploring the regulation of elastase and elastin synthesis, control of smooth muscle proliferation and production of extracellular matrix. Application of cellular and molecular techniques in vascular research should ultimately lead to new and improved therapeutic approaches.

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