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PHARMACOKINETICS AND TISSUE PENETRATION OF FLUCONAZOLE IN RABBITS ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Walsh, T. J., Foulds, G., Pizzo, P. A. 1989; 33 (4): 467-469

Abstract

Fluconazole is a new bis-triazole antifungal compound which has in vivo and in vitro activity against Candida spp. and Cryptococcus neoformans and excellent penetration into cerebrospinal fluid. However, little is known about the penetration of fluconazole into tissue sites other than cerebrospinal fluid. We therefore studied by high-pressure liquid chromatography the penetration of fluconazole into nine different tissue sites at times of peak and trough concentrations in plasma in rabbits. Fluconazole penetrated into all tissue sites. Tissue/plasma concentration ratios were greater at time of trough concentrations in plasma than at times of peak concentrations in plasma. The finding that fluconazole penetrated into target organs commonly infected by Candida spp. and C. neoformans further supports the therapeutic potential of fluconazole for disseminated candidiasis or cryptococcosis in immunocompromised hosts.

View details for Web of Science ID A1989T976600012

View details for PubMedID 2543281