A SUBSET OF MEMORY CD4+ HELPER LYMPHOCYTES-T IDENTIFIED BY EXPRESSION OF PGP-1 JOURNAL OF EXPERIMENTAL MEDICINE Butterfield, K., Fathman, C. G., Budd, R. C. 1989; 169 (4): 1461-1466

Abstract

The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin were contained nearly exclusively in the minor Pgp-1+ subset.

View details for Web of Science ID A1989T962500019

View details for PubMedID 2564418