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PROPHYLACTIC PARENTERAL CEFUROXIME - SUBCUTANEOUS CONCENTRATIONS IN LAPAROTOMY WOUNDS JOURNAL OF HOSPITAL INFECTION Huizinga, W. K., Hirshberg, A., Thomson, S. R., ELSON, K. I., SALISBURY, R. T., BROCKUTNE, J. G. 1989; 13 (4): 395-398

Abstract

Plasma and subcutaneous adipose tissue cefuroxime concentrations were measured in laparotomy wounds, by means of high-pressure liquid chromatography, in 12 patients undergoing elective abdominal operations. After intravenous administration of 1.5 g cefuroxime at induction of anaesthesia, the measured concentrations in serum and wound tissue during a 2 h period were above the MIC 90 of most micro-organisms derived from the alimentary tract. Tissue peak levels were reached within 15 min and the tissue half life was 1.5 h.

View details for Web of Science ID A1989U955200008

View details for PubMedID 2567770