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Stanford Health Care

Pathobiology of pulmonary hypertension - Extracellular matrix CLINICS IN CHEST MEDICINE Rabinovitch, M. 2001; 22 (3): 433-?

Abstract

Changes in the extracellular matrix underlie the structural and functional abnormalities in the vessel wall that lead to progressive pulmonary vascular disease. Studies are reviewed aimed at addressing the cellular and molecular programs that regulate the production of the extracellular matrix describing new ways to arrest proliferation and migration of smooth muscle cells and to induce apoptosis. The latter can lead to the reversal of pathology at least in experimental animal models.

View details for Web of Science ID 000171324900006

View details for PubMedID 11590839