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MOUSE HEMATOPOIETIC STEM-CELL ANTIGEN SCA-1 IS A MEMBER OF THE LY-6 ANTIGEN FAMILY PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA VANDERIJN, M., Heimfeld, S., Spangrude, G. J., Weissman, I. L. 1989; 86 (12): 4634-4638

Abstract

Recently, hematopoietic stem cells were purified to homogeneity from mouse bone marrow. The protein structure of Sca-1, the cell surface antigen used in the isolation of hematopoietic stem cells, is described here. It is shown that the Sca-1 antigen is a member of the Ly-6 antigen family. The anti-Sca-1 antibody was used in immunohistochemistry experiments to define the structures in several tissues that had previously been shown to contain Ly-6 antigens. In thymus, spleen, and kidney, specific staining of parenchymal cells can be demonstrated, whereas only vasculature reacts with anti-Sca-1 in brain, heart, and liver and possibly in lung.

View details for Web of Science ID A1989AB24900063

View details for PubMedID 2660142

View details for PubMedCentralID PMC287325