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MARGINAL VACUOLES IN METASTATIC THYROID-CARCINOMA - A CASE-REPORT DIAGNOSTIC CYTOPATHOLOGY Pitts, W. C., Berry, G. J. 1989; 5 (2): 200-202

Abstract

A case of metastatic follicular carcinoma to the iliac bone in a 78-yr-old woman is presented. Fine-needle aspiration biopsy (FNAB) smears showed numerous, cohesive tumor cell groups with moderately abundant cytoplasm and distinctive, peripherally situated pink-staining vacuoles on May-Grünwald-Giemsa stain. The presence of marginal vacuoles strongly suggested the possibility of metastatic thyroid carcinoma. Immunohistochemical studies performed on a concomitant needle core biopsy showed immunoreactivity for thyroglobulin, supporting a thyroid derivation for this metastasis. To our knowledge, this is the first reported case in which marginal vacuoles ("flame cells") have been identified in a malignant thyroid condition.

View details for Web of Science ID A1989AB53200015

View details for PubMedID 2776601