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DETECTION OF CELL-AFFECTING AGENTS WITH A SILICON BIOSENSOR SCIENCE Parce, J. W., Owicki, J. C., KERCSO, K. M., Sigal, G. B., Wada, H. G., MUIR, V. C., BOUSSE, L. J., Ross, K. L., Sikic, B. I., McConnell, H. M. 1989; 246 (4927): 243-247

Abstract

Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety of chemical and physical stimuli. A biosensor has been constructed in which living cells are confined to a flow chamber in which a potentiometric sensor continually measures the rate of production of acidic metabolites. Exploratory studies demonstrate several applications of the device in basic science and technology.

View details for Web of Science ID A1989AU63600035

View details for PubMedID 2799384