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BETA-GALACTOSIDASE AS A MARKER IN THE PERIPHERAL AND NEURAL TISSUES OF THE HERPES-SIMPLEX VIRUS-INFECTED MOUSE

BETA-GALACTOSIDASE AS A MARKER IN THE PERIPHERAL AND NEURAL TISSUES OF THE HERPES-SIMPLEX VIRUS-INFECTED MOUSE VIROLOGY Ho, D. Y., Mocarski, E. S. 1988; 167 (1): 279-283

Abstract

We have inserted a modified Escherichia coli lacZ gene, placed under the control of herpes simplex virus alpha 4 or beta 8 regulatory signals, into the HSV-1 genome disrupting the viral thymidine kinase gene. Using beta-galactosidase as an in situ indicator of viral gene expression, we detected expression from these recombinant HSV in dermal and neural tissues of the BALB/c mouse. Our detection of beta-galactosidase expression in neuronal cells indicates that TK-deficient viruses are capable of invading mouse neuronal cells and expressing up to the beta class of gene product.

View details for Web of Science ID A1988Q895500033

View details for PubMedID 2847416