PRIMARY CENTRAL NERVOUS-SYSTEM LYMPHOMAS IN PATIENTS WITH AIDS ANNALS OF NEUROLOGY Rosenblum, M. L., Levy, R. M., Bredesen, D. E., So, Y. T., Wara, W., Ziegler, J. L. 1988; 23: S13-S16


Primary central nervous system non-Hodgkin's lymphomas are observed in approximately 1.9% of all patients with acquired immunodeficiency syndrome (AIDS). The yearly incidence of AIDS-associated tumors has surpassed the yearly incidence from all other causes and could become as frequent as low-grade astrocytomas by 1991. Patients' signs, symptoms, and radiographic studies are not specific for this lesion; brain biopsy usually is necessary to make a definitive diagnosis. Most tumors are high-grade lymphomas and are pathologically similar to the primary central nervous system lymphomas observed before the AIDS epidemic. AIDS-associated tumors respond readily to radiation therapy. However, patient survival remains limited owing to other manifestations of the syndrome.

View details for Web of Science ID A1988L991000006

View details for PubMedID 2894803