[Endogenous opioid system in the realization of the analgesic effect of alpha-tocopherol in reference to algomenorrhea]. Biulleten' eksperimental'noi biologii i meditsiny Kryzhanovskii, G. N., BAKULEVA, L. P., LUZINA, N. L., Vinogradov, V. A., IARYGIN, K. N. 1988; 105 (2): 148-150


Beta-endorphin-like immunoreactivity was studied in 7 patients with algomenorrhea during pain attack and 15 minutes after alpha-tocopherol administration with a therapeutic aim (till the analgetic effect was reached). There was an increase in beta-endorphin-like immunoreactivity after alpha-tocopherol administration. Naloxone administration to 9 patients with algomenorrhea of various etiology resumed the pain. The effect of alpha-tocopherol application for pain relief depended on the pathogenesis of algomenorrhea. At the same time naloxone administration failed to resume the pain in patients, in whom alpha-tocopherol had a strong analgetic effect. It is assumed that the endogenous opioid system participates in alpha-tocopherol effect on pain relief in patients with algomenorrhea.

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