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GASTRIN RELEASING PEPTIDE IS A SELECTIVE MITOGEN FOR SMALL CELL LUNG-CARCINOMA INVITRO JOURNAL OF CLINICAL INVESTIGATION Weber, S., ZUCKERMAN, J. E., Bostwick, D. G., Bensch, K. G., Sikic, B. I., Raffin, T. A. 1985; 75 (1): 306-309

Abstract

Human small cell lung carcinoma (SCLC) cells have been shown to contain significant levels of a bombesin-immunoreactive peptide. The 27-amino acid peptide, gastrin releasing peptide (GRP), has recently been shown to be responsible for the bombesin-like immunoreactivity found in SCLC cells. Among four lung cancer cell lines examined in vitro, GRP exhibited mitogenic activity for two SCLC subtypes, but not for a squamous carcinoma or adenocarcinoma lung cell line. The mitogenicity of the GRP molecule has been isolated to the carboxyterminal fragment, designated GRP 14-27, which is in part homologous to bombesin. The aminoterminal fragment, GRP 1-16, is no homologous to bombesin and exhibits no mitogenic activity. Thus, GRP may be an important growth regulating or autocrine factor in human SCLC.

View details for Web of Science ID A1985AAG6500043

View details for PubMedID 2981251