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INTRACEREBRAL HEMORRHAGE IN A PRIMATE MODEL - EFFECT ON REGIONAL CEREBRAL BLOOD-FLOW SURGICAL NEUROLOGY Bullock, R., BROCKUTNE, J., VANDELLEN, J., Blake, G. 1988; 29 (2): 101-107

Abstract

The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 +/- 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.

View details for Web of Science ID A1988L741800004

View details for PubMedID 3336844