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PYRUVATE-KINASE DEFICIENCY IN DOG AND HUMAN-ERYTHROCYTES - EFFECTS OF ENERGY DEPLETION ON CATION COMPOSITION AND CELLULAR HYDRATION AMERICAN JOURNAL OF HEMATOLOGY MULLERSOYANO, A., Platt, O., Glader, B. E. 1986; 23 (3): 217-221

Abstract

Pyruvate kinase-(PK) deficient human reticulocytes incubated 4 hr under conditions where mitochondrial oxidative phosphorylation is inhibited become ATP-depleted. Concomitantly, these energy-depleted red blood cells (RBC) lose massive amounts of potassium and water. PK-deficient reticulocyte-rich RBC from a Basenji dog, incubated under the same conditions, also manifest ATP-depletion and K-loss. In contrast to the cation changes in human cells, however, K-loss in PK-deficient dog reticulocyte-rich RBC is balanced by an equivalent Na gain, and consequently these canine erythrocytes do not undergo any change in cellular hydration. Potassium depletion and dehydration, which may be related to membrane injury in human RBC, do not appear to be involved in the hemolysis of PK-deficient dog erythrocytes.

View details for Web of Science ID A1986E650300004

View details for PubMedID 3766523