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EFFECTS OF HYPOXIA AND HYPEROXIA ON THE HUMAN STANDING POTENTIAL DOCUMENTA OPHTHALMOLOGICA Marmor, M. F., Donovan, W. J., Gaba, D. M. 1985; 60 (4): 347-352

Abstract

We report that the human standing potential, measured by the EOG, rises slowly when oxygen saturation is lowered to near 80% by breathing a controlled oxygen-nitrogen mixture. The standing potential falls abruptly by 20-30% of its amplitude when the oxygen saturation returns to 100%. These changes can be generated reproducibly, with minimal discomfort, under conditions that could be adopted for clinical use. Animal experimental studies by Linsenmeier and Steinberg suggest that this hypoxia-hyperoxia response may be a delayed response to potassium concentration changes in the subretinal space. Since there is no requirement for light and no involvement of the Müller cells, the hypoxia-hyperoxia response may be more specific for pigment epithelial pathology than the c-wave.

View details for Web of Science ID A1985AUA2000002

View details for PubMedID 4064875