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Evidence for a role for transglutaminase in Huntington's disease and the potential therapeutic implications NEUROCHEMISTRY INTERNATIONAL Karpuj, M. V., Becher, M. W., Steinman, L. 2002; 40 (1): 31-36

Abstract

Transglutaminase (TGase) activity is increased in affected regions of brains from patients with Huntington's disease (HD). TGase activity is particularly elevated in the nucleus compared with the cytoplasm from these brains. Gamma-glutaminyl-lysyl cross-links have been detected in nuclear inclusions in HD brain, indicating that TGase may play a prominent role in the aggregation of huntingtin (htt). Attempts to ameliorate experimental disease, via inhibition of TGase in transgenic models of HD in mice, are under investigation.

View details for Web of Science ID 000173224600005

View details for PubMedID 11738470