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VIDARABINE MONOPHOSPHATE AND HUMAN-LEUKOCYTE INTERFERON IN CHRONIC HEPATITIS-B INFECTION JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Smith, C. I., Kitchen, L. W., SCULLARD, G. H., Robinson, W. S., Gregory, P. B., Merigan, T. C. 1982; 247 (16): 2261-2265

Abstract

Ten young adult patients with chronic hepatitis B virus infection and positive hepatitis B e antigen and DNA polymerase (DNAP) levels were treated with alternating courses of seven to 28 days of 5 to 7.5 mg/kg of vidarabine monophosphate (adenine arabinoside monophosphate) and 28 days of human leukocyte interferon (IFN-alpha); three different regimens were given on an outpatient basis. All patients with a fall in their DNAP level, and the DNAP remained undetectable six months after treatment was stopped in one patient. The major side effect, which most often occurred in those patients receiving 7.5 mg/kg of vidarabine monophosphate, was severe muscular pains. This study demonstrated the feasibility of administering vidarabine monophosphate and interferon to outpatients. Based on data from this and other studies, it is now possible to use a relatively nontoxic regimen that includes 28 days of 5 mg/kg of vidarabine monophosphate in a larger controlled study to answer the question of efficacy.

View details for Web of Science ID A1982NL19400022

View details for PubMedID 6175774